Methylphenidate vs Amphetamine Stimulants (ADHD Medication Differences)

Dr. Aly discusses the differences between the ADHD medications methylphenidate and amphetamine ***Link to Dr. Aly's FREE "Antidepressants: A Beginner's Guide" ➡️ free.dralywood...
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⏰ TIMESTAMP ⏰
0:00 Intro
0:32 What Are Neurons? (Neuron Structure And Function)
2:02 ADHD Neurotransmitters (Dopamine And Norepinephrine)
3:10 How Methylphenidate Works
3:53 The ADHD Brain Explained (2 Areas Affected)
4:53 Methylphenidate Isomers (Which Is More Potent?)
6:20 Amphetamine Isomers (How Are They Different?)
7:38 How Amphetamine Works
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[@LaniakeaDelRey]

This is the BEST explanation I've ever heard for the comparison of Methylphenidate and Amphetamine. It's given me better insight as to why I respond better to Amphetamine. Thank you!

[@dralywood]

You are SO welcome! I’m happy to hear that this was helpful. Dr. Aly

[@soniapelletier6071]

Yes! She's the best

[@AbuAnas2018]

How many mg a day are you on and what time do you take each

[@AbuAnas2018]

What calms down the side effect aggressiveness of adderall?

[@LaniakeaDelRey]

@@AbuAnas2018 I take a really low dose, 1.25mg dextroamphetamine, every 3 hours 4x a day. Simply because I get too many side effects when I go up in dosage. I still get some benefits from the 1.25mg. Though when I was on methylphenidate I could tolerate 27mg long release, quite well, but it didn't calm me down like dextroamphetamine. But it can vary for everyone :)

[@Sagittarius0nFire]

Methylphenidate/Ritalin causes me to have anxiety and causes dysphoria for me as Amphetamine and Dextroamphetamine, mixed salts/Adderall tends to be more calming for me and also provides a mood lift. These medications work wonders for the patients who need it. ❤

[@YourCapyBruv_do_u_rmbr_3Dpipes]

Indeed But the weird thing was Adderall didn't work for me at all. Nothing at all. In fact it worsened my depressive symptoms. Strange. I wonder if I had a bad batch or if my chemistry just isn't right for it.

[@sahraei1]

Thank you very much for this very informative video. Could you make a video about how you decide on the right medication and the right dose? Especially, if a medication doesn't work for someone, what does that mean in terms of the likelihood of effectiveness for other options. If Focalin doesn't work, would that mean that Concerta won't work either? Is it reasonable to take a combination of methylphenidate and amphetamine?

[@Fish-please]

I had to watch this 3 times...(I was distracted)

[@RiPp1er]

Excellent video Dr. Aly. I think in my case antipsychotic medications do a better job of managing my adhd symptoms. They have worked for me.

[@nnguy01]

Thank you for comparing these two stimulants. Will you please consider making a video for combination therapy for kids with ADHD and generalized anxiety (ie, Strattera with either stimulant)?

[@matt.108]

This information helped me and my nurse practitioner find what works for me. The levoamphetamine in the mixed salts gives me some physical side effects. Mostly muscle tension and dry eyes. Vyvasne didnt last but 4-5 hours and would make me overstimulated if we raised the dose. I brought this info up with my np and asked about trying Dexedrine. She moved me over to 4 small doses of Dexedrine and it’s been working really well. For me it’s not quite as effective as adderall but I’d say I get about 70% of the benefits of adderall without any other side effects besides some mild appetite suppression and dry mouth. I also find the crash is much more manageable. Most of the time I don’t even notice it. Only real downside is it doesn’t last as long as adderall. That being said I can easily get 11-12 hours out of 4 doses at 5mg each.

[@iworkoutlmfao]

Will Wellbutrin decrease the effectiveness of adderall due to the competitive action on DAT? Similar to two people walking through the a double swinging door in opposite directions? I know Wellbutrin and modafinil have been proposed for the treatment of Amphetamine abuse.

[@wani4774]

thank you for having the best explanation on this

[@jimmiandersen3099]

Read about MTHFR mutations and ADHD.

[@craigmakak1]

Any new research on stimulants and cardiac. Many cardiac patients suffer because lack of research?

[@kerryguarino]

Do you take new patients? i am looking for a new doctor, i am currently on 20 mg Ritalin, but i like how you have amazing knowledge, on adhd, better than most doctors that i have been to

[@sidka8435]

Dr, ,and also d-methylamphetamine and pemoline r still aprroved for add/adhd in the U.S.Can you compare also these two?

[@YourCapyBruv_do_u_rmbr_3Dpipes]

I'm trying to decide which adult ADHD medication might be best for me to request from my provider. I don't yet know if I would be better off starting with adderal, concerta, dexedrine, or Ritalin. I'm 40 and in very stable health otherwise.

[@nathanialbroadway2719]

Try Zendedi / Dexedrine

[@YourCapyBruv_do_u_rmbr_3Dpipes]

@@nathanialbroadway2719 ok I might

[@a.mary90]

fantastic explanation

[@Mohammadparvazi]

Great video good explanation

[@beeathome1064]

Which antidepressant woudl you say works best together with adderall between pristiq or Prozac ??

[@ritzkola2302]

Male, 5’11, Adult. Took my first Adderall pill 30 minutes ago. The extended release version. Thing is my pill bottle says “Amphetamine Resin Complex.” There’s zero information on what that even means on online. The paperwork that came with the medication has TWO different names on it: 1) Ampetamine Resin Complex XR 2) Dextroamphetamine/Amphetamine Extended Release In the appointment a few days ago my physc told me she was prescribing me Adderall XR. I’m confused by all these different names. Also, my actual pills all say “Lannett.” So far I don’t feel anything. It’s only 10mg. But can any Psychiatrists explain their thoughts? I have to wait a month to see my doctor again at the VA.

[@Care92]

😮😮😮

[@Care92]

What did your doc say, did you see them yet? I hope you get some clarity

[@ritzkola2302]

@@Care92 I did. The names on the medication are just generic names since “Adderall” is both a medication & and brand name. Other producers of that medication opt for generic names. Lannet is the competing company producing generic Adderall. My dosage was upped to 20 XR and will likely be increased to 30 XR next month.

[@AbuAnas2018]

Can you please make difference between Valium and Xanax

[@rayoflightcanada]

what is Vyvanse then? it has the D? Dexedrine I found it better less increase in heart rate and blood pressure ,

[@louisdanowsky1022]

Vyvanse is effectively time-release Dexedrine. It is exclusively D-Amphetamine, whereas Adderall is a combination of D & L-Amphetamine, the latter of which is responsible for those blood pressure/heart rate side effects you’re talking about. Dexedrine is pure D-Amphetamine. Vyvanse has an amino acid attached to the D-Amphetamine molecule that is removed when the liver processes it, which allows for a slower more consistent release of the medication and is the reason people say Vyvanse lasts quite a long time (12-18 hours). It also has the added benefit of reducing abuse potential. You cannot get high by crushing and snorting Vyvanse because the amino acid attached to the D-Amphetamine molecule effectively neutralizes it and can only be removed in digestion.

[@rayoflightcanada]

@@louisdanowsky1022 what about Biphentin®

[@twizitd8520]

Can I take it with 10mg celexa

[@iworkoutlmfao]

Yes, stimulants and antidepressant combinations are very common

[@twizitd8520]

@@iworkoutlmfao can I cut the Buspirone 5mg In half I’m scared to take it.

[@user-og7ge2yr7h]

amazing

[@mauddib3318]

Wow!😀compare Methamphetamine next please!!😮😊😅

[@retedil]

Is there an adult age where these should not be proscribed . . .

[@Care92]

I don't believe so, they are indicated for anyone over 6. I'm not sure if there is recommendation against prescribing to seniors, I haven't heard so but I have heard ADHD symptoms can improve with age.