DNA replication in eukaryotes 4 | Replication termination and telomerase

DNA replication in eukaryotes 4 | Replication termination and telomerase - This lecture explains the mechanism of telomerase enzyme to fix the end replication problem of the linear eukaryotic DNA. At the end of replication, linear DNA of eukaryotes get shorter and shorter which creates problem for the deletion of important information in the gene and may cause aging. Telomerase enzyme helps in elongation parental dna strand so that the newly synthesized DNA can be of proper length. This is known as the end replication problem in eukaryotes and telomerase enzyme fix this at the end of eukaryotic DNA replication also called the DNA replication temination.
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Thank you for watching the DNA replication lecture on telomere and end replication problem.

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Sir just clear one thing 9:57 the sequence TGGGGTTG present on dna strand is provided by telomerase or it was already present on parental dna strand???

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Sir you explained that DNA polymerase alpha replaces the RNA primers in the lagging strand but in your previous video you explained it to be the work of DNA polymerase delta and Fen

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The tandem repeats of telomere is TTAGGG.

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Sir, you didnot explain that alpha DNA polymerase and primase will use this parent DNA strand(extended by telomerase) and synthesizes remaining part of lagging strand

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@7:09 sir u have mentioned that DNA polymerase alpha will be used to fill the gap but in the last video u have mentioned that DNA polymerase delta will be used to fill the gap.. so which one is right??.-.

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delta

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Same issue..

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Sir, does the telomerase act at the end of the leading strand in the same way?

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The gap in the lagging strand is filled by delta polymerase or alpha polymerase?

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