Systemic Lupus Erythematosus (updated 2023) - CRASH! Medical Review Series

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(Disclaimer: The medical information contained herein is intended for physician medical licensing exam review purposes only, and are not intended for diagnosis of any illness. If you think you may be suffering from any medical condition, you should consult your physician or seek immediate medical attention.)

[@pwbmd]

Correction (4:38): I meant to say lupus, not RA

[@gamaltaher9714]

Thanks

[@AngelRoseAngel1980]

Excellent

[@user-jq9wz7ld7f]

Thank you ❤️🇸🇦

[@AngelRoseAngel1980]

Thank you

[@waelfadlallah8939]

Sorry for being late. Nevertheless, excellent as you are always, thank you!

[@diamondrose3242]

I tested 100% for neonatal lupus. Does that mean I can pass on neonatal lupus to my possible babies or that my mother gave me neonatal lupus?

[@pwbmd]

Neonatal lupus is something you have as a baby and it goes away within months. To my knowledge, it doesn't impact your risk of getting lupus. Although having a parent with lupus does. If you don't have an autoimmune disorder, you are highly unlikely to have a baby with neonatal lupus. Even in people at risk, having a baby with neonatal lupus isn't really common.

[@solemnwicked]

Is SLE still a possibility even if an ANA test comes back Negative (since this test is sensitive and not specific)? I have multiple high inflammatory markers as well as two forms of the rashes mentioned, swollen lymph nodes, high SED rate, unexplained fatigue and fever. Recently had a CT Scan, MRI and ultrasound, all came back with no concerns for cancer or other related issues. No allergies or bacterial infections either.

[@pwbmd]

Yes. It is possible. Unusual, but certainly possible.

[@nopressurenodiamonds5566]

How did they run your ANA? Was it IFA? That is the gold standard for ANA, mine was ran the basic way were you get only + or- with no pattern or titer twice and came back negative. They then ran the IFA method and it was positive.

[@solemnwicked]

@@nopressurenodiamonds5566 I believe it was IFA. They tested ANA, Double Stranded DNA and Anti-smith. All came back negative the two times they were tested. My flare ups can be very sporadic, so it’s hard to “prove” my symptoms. I keep a diary for those events and take pictures of what happens, but the only thing happening with my blood work is high inflammation and high WB cells :/ so I haven’t been diagnosed with anything (my symptoms align closely with SLE, but it could be anything). Currently looking into vascular issues to see if that’s the cause or if it can be ruled out, thankfully I have a wonderful family doctor who’s trying to get me some answers.