Tadalafil: Erectile Dysfunction Cure? Testosterone Booster? Non-Responders? [Study 147-154 Analysis]

[@ディアラン]

I’ve been taking Tadalafil for 10 months now, due to Benign Prostate Hyperplasma. These are my results: 1. My BPH symptoms have improved significantly 2. I have much less cold feet and hands 3. I get strong boners when sexually aroused 4. My gym pumps are crazy 5. My muscle mass has accelerated 6. My mood has improved, I am happier and more confident I’m 51, and couldn’t be happier with Tadalafil. While certainly no wonder drug it helps with blood circulation in general and I feel it has life-enhancing qualities.

[@naeemsheikh4597]

What dose? Do you take daily? If so, what time of day?

[@JW0143]

Some of this is definitely placebo effect. It has no direct effect on your mood but your mood might be better because of the things its helping with. Gym pumps would also be negligibly effected

[@Scott_Bradbury]

@@JW0143 Gym pumps are so much better on Tadalafil. Many in the TRT community take this at 5mg along side TRT. It lowers blood pressure, increases recovery and makes the pump much better. Its banned in the olympics because of this.

[@StevinTheGreat]

@physionic As a response to your question about why insulin increases with tadalafil supplementation: If you examine the mechanism of insulin release by the beta islet cells, it is cGMP dependent.

[@SteveSmith-zz4ih]

Tadalafil gave me chronic/severe heart burn yet Sildenafil didn't, why would that be?

[@Systemlord30]

Cialis gave me heart burn for the first 2 weeks, but then it subsided. I take 5mg Cialis daily. Everyone responds, metabolizes these drugs differently.

[@dondajulah4168]

I don’t know, two kilo gains in lean mass in less than 3 months is pretty impressive to me- assuming that is skeletal muscle and not other forms of lean mass. And all this just from taking a small pill once a day with no reference to change in physical activity. Sounds like you could market this product as a muscle mass gainer if it were not a drug.

[@pleeseno]

I'm re-subscribing in hopes that you do more videos like this. Super good and super informative. I can't sign up for your patreon, but I am a youtube premium member so hopefully my engagement does a little bit more for your channel and hopefully you'll upload more content like this for us nerds! I'm so grateful for people like you who do the work, not just for a temporary buck before you become forgotten, but to actually build a presence as a known-entity and a known-science educator. Thanks again!

[@DrFurb]

Finastride and Dutrastride next for enquiry?

[@davetherave4599]

Question about Cialis. Any danger of clotting issues with this drug? Also, any thoughts about raising Free T levels. Tried Boron, Stinging Nettles, Avena Sativa et.el. with no success, unfortunately. Excellent video. Well done. Subscribed! 🙂👍

[@richDonaldPump]

Use gorilla mind Sigma, cistanche, and hit your micro and macro nutrient needs each day and good sleep, ice your balls

[@dondajulah4168]

The primary reason I take many different supplements is not so much that I think that any one individual supplement is working, but if I am taking 30 different ones than the odds are at least a couple of them will be effective

[@mikenewman9977]

Did you ever mention even once in this video how much Tadalafil was used in these studies??? Was it 2.5, 5.0, 10, etc, etc. without that I learned nothing from this long video….

[@Physionic]

I'm assuming you skipped through a few parts, like 1:07:39 and 1:50... hehe

[@jackbuaer3828]

The drug is more interesting from a longevity perspective and its purported effect in decreasing the risk of CVD and alzheimers

[@Physionic]

Interesting, I didn't do any reading on that aspect.

[@jackbuaer3828]

@@Physionic Initial studies (though not RCTs) in these areas are intriguing. For example, "The research team found men taking PDE-5i drugs were 13% less likely to suffer a cardiac event, this was linked to a reduction in coronary revascularisation, heart failure, and unstable angina. Overall mortality was reduced by 25% in men exposed to PDE-5i and the team recorded a 39% lower risk of dying due to cardiovascular-related causes." Viagra, other ED drugs may lower cardiovascular risk in healthy men, Medical News Today, January 24, 2023.

[@jamescalifornia2964]

​@@jackbuaer3828 ❓️I wonder if that is due to the vasodialation effects ... 🤔

[@jackbuaer3828]

@@jamescalifornia2964 If the effect is real, it would likely be due to vasodilation /improved circulation. to extremities (not just the sex organs) Another article on the subject back from 2017: "The risk of death was 33 per cent lower for the patients who had been given impotence drugs compared with those who had not received this treatment. Apart from a lower mortality rate, the risk of being admitted to hospital for heart failure was also 40 per cent lower in the treatment group. The effects were only seen for patients who received the most common type of impotence drug, namely phosphodiesterase-5-inhibitors (PDE-5-inhibitors) such as Viagra, Cialis or Levitra, indicating that it may be specifically these drugs that contribute to the reduced mortality. Karolinska Institutet. "Impotence medicine associated with reduced long-term risk of death after heart attack." ScienceDaily. ScienceDaily, 9 March 2017.

[@richardbreeze7898]

Yes. There is a recent study ( named above ) found Cialis reduces alzheimer rates. It makes perfect sense and increased blood flow would assist in prevention. I'm also convinced it would help to reduce heart attacks. That was it's original purpose. Participants in the initial heart studies viagra got boners as a side effect and we'll, you know the rest.

[@forexstudent9084]

Would low cholesterol cause low testosterone?

[@AndyMcClements]

Tadalafil has been a game-changer for me. I'm now 14 months into curative treatment for Stage 3 prostate cancer, 12 months of that on daily Tadalafil. It's been instumental in what I, and any clinicians I speak to, consider to be an excellent outcome, in terms of EF. This is with NO TT ! I've had ADT, which I'm just coming off now. I had to get the Tadalafil privately, as the UK health service won't offer it for this purpose. I also took 80 sessions of HBOT which so far seems to have healed the radiotherapy damage. I've not posted about this in public forum before, but I feel I really should be sharing what I've learned because it may help many men, and TBH I'm proud of myself. I look forward to watching this video, good work !

[@Physionic]

Thanks for sharing, Andy!

[@christophdenner8878]

Andy, are you taking 5 mg tadalafil daily or a higher dose?

[@AndyMcClements]

@@christophdenner8878 Hi Christoph, the standard dose when taking it daily is 5mg. I was on ADT for prostate cancer, in this modality, the Tadalafil serves to maintain a background level of blood supply, which has a protective effect against the tissue atrophy that's a risk when on ADT. Plus, it has allowed a good degree of EF, when desired, which I think would be unlikely without it. The physical and emotional benefits of this have been massive. The individual response to Tadalafil will probably vary, so maybe a higher daily dose may be needed in some. I think the main risk is of hypotension, which clinicians are keen to avoid because it can cause blackouts etc and folks falling over and hitting their heads. Otherwise it has low toxicity, AFAIK. Personally, after my radical treatment I was on 5mg Tadalafil, plus 2x the normal dose of Tamsulosin, which is also hypotensive. I could tolerate this OK, but I did notice if standing up from squatting etc. I am quite fit, which helps.

[@christophdenner8878]

@@AndyMcClements Thank you Andy! I was prescribed tadalafil for prostatic hyperplasia as well as erectile dysfunction, however, the latter is partially caused by a massive burnout that I'm currently in. I'm taking 5 mg per day and it's planned to take it for a while. Hypotension is not a problem in my case, because I'm rather prone to slight hypertension, so that tadalafil's hypotensive effects are even a further benefit. Wishing you all the best on your recovery journey!

[@jmc8076]

For lay people or who can’t keep up with acronyms: TT: total testosterone HBOT: hyperbaric therapy ADT: androgen deprivation therapy

[@sleeplessforawhile]

First of all, thank you for sharing your detailed and hard work. Two things, first about the intriguin relationship between Tadafil daily intake and the Insulin levels... seems that there is a relationship between NO leveles increase and the beta cells activity but this relationship it´s not fully understood. And now the seconds one, just a sugestion ... would your do one of your amazing analisys, about modafinil? Not only focusing on the classic effects but also on aspects such as dyslipidemia, effects on the immune system, etc. ... Once again Thank you.

[@Physionic]

Yes, NO seems to have an affect in regards to insulin and possibly insulin sensitivity. I'll have to see if I can cover modafinil, because it's going to depend on how well this topic does - if it flops (view wise), then it's difficult for me to spend another 3 weeks analyzing literature on another drug when I know the result will likely be the same. We'll see!

[@willcook403]

⁠​⁠​⁠@@Physionicyes- please do modafinil and other nootropics that work !

[@blackjack6406]

The drop in estrogen should lead to an increase in total testosterone because the lack of negative hpta feedback. Was the estrogen measured via LC/MS or ECLIA? Eclia is very unreliable for male (relatively low) estrogen levels , maybe it's lab error?

[@HoneyboyDes]

I've read that if tadalafil is not working, you need to increase your intake of nitric oxide rich food. Add zinc through natural food, magnesium and Vitamin D3 and Vitamin C

[@marekstrutinsky6429]

There are also studies which suggests that it can increase AR expression and effect the "better use" of testosterone in that way.

[@Physionic]

Something else I didn't know - thanks for sharing, Marek.

[@marekstrutinsky6429]

Maybe a topic for a future video :) And congratulations for your channel, your scientific approach makes it outstanding from many others. It must be a lot of work.

[@germandohrmann7893]

Cialis works good on me but give me obsess stomach I don’t now is jost me

[@stevev2422]

Any non-prescription things to use?

[@jamescalifornia2964]

• I use Tadalafil for BPH. Improved flow and ugency. 👌

[@Physionic]

Thanks for sharing, James!

[@jamescalifornia2964]

@Physionic - Take a look at this. Another interesting side-effect. pubmed.ncbi.nlm.nih.gov/30292404/

[@rg-cb2wd]

​@@jamescalifornia2964is that not a other drug?

[@rg-cb2wd]

Nitric oxide got a nobelprice and l arginine is the main one that produce No

[@TheRickardJaeger]

Citrulline even better!

[@moietmesguitares]

Tadalafil is known for "oxandrolone" like look. Harder, denser muscle bellies.

[@ronaknanda6175]

Have you ran it solo ??

[@N330AA]

I have the opposite problem, my truncheon is too big and randy. Plz send help!

[@nfortehbruno2993]

Thank you very much

[@persistentone3448]

I am concerned that estrogen is dropping in some of these studies. Estrogen controls bone loss, so you might expect that the men taking this drug for extended periods of time, if estrogen stays lower, would accelerate any trend towards osteopenia / osteoporosis. Is there any long term study of daily Tadalafil? You might want to look for one that tracks bone mass.

[@richardbreeze7898]

Nick there's a point perhaps overlooked here. Total testosterone is not a good marker. Free testosterone is the thing that has an effect on male physiology. You get my point, a guy can have high test results and wander round like a Cockerell in season but it's the free test that is the secret sauce. That's where the money is.

[@Physionic]

An excellent point, Richard. I think some of the studies looked at free testosterone.

[@BestLifeMD]

You kind of mumbled who you were so I couldn’t tell what you were a PhD candidate in. It was something medicine…

[@Physionic]

0:09 :)

[@BestLifeMD]

@@Physionic I know where you said it but I can’t tell what you said. Maybe molecular?

[@Physionic]

Read the screen at 0:09.

[@g3nj1]

Any natural ways to achieve this? Obviously the internet is abuzz about tongkat ali and fadogia agrestis, but are there more natural supplements than can help in testosterone production?

[@jaa9228]

why do you have so many videos unlisted? :v

[@Physionic]

I removed over half the videos I created from back in the day (the first 8 years or so of Physionic).

[@YY6951]

what about the gym pump benefit?

[@Physionic]

Haven’t run across anything on that, but it fits with the mechanism.

[@kajusbajus]

I get pain in my legs when I take tadalif for several days in a row .

[@jamescalifornia2964]

​@Jostein That is one side-effect for some. I had that also, it went away in a few weeks . 👍

[@sebastian993]

Guanosine

[@sspmetal]

Are there cheapier alternatives of taladafil?

[@jackbuaer3828]

Online pharmacies offer it at an inexpensive rate. Fifteen dollars per month for 5mg. I started taking it for Raynaud's. It does not work for me for that purpose, but since it has some purported longevity benefits, I plan to keep taking it nonetheless. I did not have ED problems prior to taking the drug.

[@gstlynx]

Online pharmacies are good, also bodybuilding research chemical websites.

[@wigglywrigglydoo]

Which online pharmacies?

[@jackbuaer3828]

@@wigglywrigglydoo I know of one. Dirx.

[@fredboudreaux9663]

Great meta analysis!

[@bogse]

Is Tadalafil same as Sildenafil?

[@jackbuaer3828]

Tadalafil is cialis and Sidenfil is viagra. They are both PDE5 inhibitors. cialis has a longer half life (17.5 hours) and stays in your body longer than viagra (4-6 hours).

[@d4v1d5c0tt]

No

[@kxr203]

Tadalafil = Cialis Sildenafil = Viagra

[@mystrength5640]

I read that Zinc increases Testosterone.. ! Do you think this would only Be true if one does not absorb Zinc.. ? Would other Minerals.. ie.. Copper, be lowered by taking too much zinc? Thank you🎉

[@bastianm5478]

Always take copper with zink. That will be all.

[@mystrength5640]

@@bastianm5478 Thank you

[@CD-gh1uf]

Comment on this dudes videos and give him thumbs up. Best you tuber I've found

[@Physionic]

Thanks!

[@X1347C]

Day 4 of asking about the Energy Drinks. 🫠

[@Physionic]

What about them?

[@X1347C]

@@Physionic All the pros and cons of them. How much per day is safe? What ingredients are harmful? Is it the same as coffee? I absolutely love the taste of energy drinks, and that's why I drink them. I've done my part of the research and found it not to be harmful if drinking 1-2 cans a day (250-500ml). The sugar and caffeine content are usually lower than a starbuck coffee. The main thing I'd love to know about them is if they can cause heart attacks when taken 500ml a day for longer periods of time. And what is it exactly in them that makes it unhealthy for the heart. Thanks a lot! :)

[@Physionic]

Levon has the right idea. For us to get a complete picture, we should look at each ingredient (and my analyses take 1-4 weeks each, so...), BUT if there are studies on energy drinks, as a whole (and we ignore some of the little difference between them), we would still be able to get an idea on their health effects, as a whole. That said, my opinion is that in the context of an overall healthy diet, having an energy drink isn't going to do any harm in the grand scheme of things. As with anything, if it gets excessive, it can be problematic.

[@X1347C]

@@Physionic I have read about all the ingradients mentioned on the can, and haven't been able to find a single serious harm if drinking 500ml. But somewhere I read that the mixture of all the contents might do more harm to the heart than when taken individually. Even Jeff Nippard has a video on Energy Drinks where he mentions that it won't be damaging to healthy people who don't have any underlying conditions already.

[@mystrength5640]

@@X1347C They artificial., So they TOXIC Same as Sugar filled carbonated cola Drinks/ pop. They man made!