Talking with Docs: Nature’s Ozempic?

[@ember9747]

For anyone interested in Berberine, it''s useful to know that it seems to be the only known currently accessible somewhat potent oral PCSK9 inhibitor, the inhibition of which is highly desirable for lowering LDL and preventing atherosclerosis. Additionally, it's oral bioavailability is very low (around 0.37% iirc if not combined with bioavailability-enhancing molecules), so it doesn't really get past the liver. Thus, its action is located mostly on the liver (which I find to be good thing, as I'm only looking for pcsk9 inhibiton and the low bioavailability should reduce side effects). Btw, big fan of you Nic! Keep up the good work

[@notfound379]

I'm keen on an update to the thinking that berberine can reduce the size of arterial plaque. Thanks for your work.

[@Physionic]

I'll need to look into it again; only aware of that one study.

[@adamgasth]

So if their waist circumference lowered but not their weight, could it mean that they had more muscle growth?

[@Drgluee]

Your comment will get distorted to "it will increase muscle mass while reducing fat so you won't see a weight difference". So it will be a 'fact' to some people based on a question.. People suck.

[@NoLimitsNatty]

Thank you for explaining things in a way most can understand.

[@eerieforest9188]

Everyone I've gotten to take berberine has had good results and that's without exception. Anecdotal, but consistent ah too.

[@djayjp]

Very strangely worded comment.

[@DennisForbes]

Speaking of nature's , how do you feel the science holds up in support of ashwagandha?

[@ritamargherita]

Thanks for exploring Berberine more! First!

[@HarryJensen-kr4qz]

Taking berberine to clean my veins and arteries. I've lost 70 lbs BUT, it's from changing my diet, not berberine. I cut out processed foods/fast food, sugar/sweets and reduced starches. Mostly eat baked fish (salmon), shrimp or scallops with a vegetable. Eat a bit of chicken, pork and beef occasionally (less than once a week).

[@jay-remedy-plz]

I’d be interested in adding more fish but mercury content makes me hesitant. Mostly chicken and vegetables for me.

[@chuckkolb1270]

Wise approach. Maybe add lots of greens, i.e., salad.

[@LK-pc4sq]

did you check your A1c before and after and check blood pressure before and after ?

[@LK-pc4sq]

@@chuckkolb1270 vegans live much much longer then the general public.

[@robertusga]

Endogenous GLP-1 half life: minutes. GLP-1RA half life: 5 days. No matter how we stimulate endogenous GLP-1, two different universes.

[@Physionic]

Great point.

[@jay-remedy-plz]

I’m about to try Berberine to lower blood sugar, not necessarily to lose weight. My Waking glucose is over 100.

[@HateDietPepsi]

I thought allulose was being touted as nature's GLP-1 releaser.

[@larsnystrom6698]

Ozempic is of no interest for me, but a comparance between Metformin and Berberine would be. The best would be with groups with only Metform, only Berberine, and one group with both of them. Metformin and Berberine do much the same thing, but with different mechanisms. They might act synergistically! It's also interesting that Berberine is said to reduce some of Metformins side effects, such as intestine gas, and other discomforts. That incdicates combining them might work better than either alone. I guess Berberines weight loss effect is by somewhat redicing diabetes effect on blood sugar, which among other things I think is fattening. Much better to more directly reduce the cause 🙂

[@nonenone9527]

Please do one on BPC-157. Pretty please.

[@camarosspr]

The long transit time food in stomach Rarely causes gastroparesis: Gastroparesis is a medical disorder of ineffective neuromuscular contractions of the stomach, resulting in food and liquid remaining in the stomach for a prolonged period of time. Stomach contents thus exit more slowly into the duodenum of the digestive tract, a medical sign called delayed gastric emptying.

[@frankdahl5908]

Has there been any follow up studies regarding shrinking of plaque? Is that a direct effect of Berberine, or is it due to the lowering of LDL that Berberine causes?

[@benbernanke7701]

It's cocaine actually

[@sarasmile6071]

😂😂 love it

[@kaanozk]

My Ritalin just does it fine. (1kg a week without trying). Anything activating your parasympathetic system does the job.

[@mystrength5640]

Interview Professor Bikman. Loss of Muscle maybe an issue, with most GLP 1..s Vitamin B12 levels maybe lowered! 🎉

[@vanessagil3527]

As a Naturopath I wouldn't recomend taking berberine without supervision. Its a non selective antimicrobial, long term use can lead to dysbiosis. Makes we wonder if the reduction in waist circumference may be due to killing off microbes responsible for bloating and not actual fat loss. Body composition analysis would be a better way to measure outcomes here.

[@Christopher-b1p]

Any studies involving the effects of barberries as opposed to berberine? I eat an Iranian dish with chicken and barberries. You can buy a whole bag of dried barberries, just like cranberries and put them in food.

[@mystrength5640]

Sounds interesting 🎉

[@trentriver]

Great commentary ... those 2 docs work in a hospital just west of Toronto.

[@Physionic]

Cool!

[@alexanderabrashev1366]

My mom started berberine, and with literally the first dose, she started having intense GI side effects. Stomach pain, GI upset and so on. Seems this was the cause. Is there any way to mitigate these side effects doc? Having in mind that she took one pill a day, which seems to be the lowest dose

[@ykles24]

@alexanderabrashev1366 I don't think so. Tried two brands, had massive nausea for a whole day each time. It doesn't sit well with some people.

[@DesertDog8989]

Wonder if you should separate it from any other drugs by a couple hours and line the stomach with a little food or milk (if tolerated) first? I tend to do that when I believe a supplement is involved. Not a doctor. Just a. thought.

[@tracymullane8818]

@alexanderabrashev1366 sure, try some bismuth. Bismuth systemically tempers your appetite too

[@TheDeamonLo]

Have you had a chance to look at Dihydromyricetin (DHM)? Seems a little too good to be true for a liver supplement.

[@Physionic]

No, I haven't

[@gore-geousmombie4686]

I might try berberine but im mounjaro and metformin already so i think that's too much. The metformin is not for weight loss or diabetes though. Also, as for 10:40, perhaps that's why my weight loss stalls if im not eating carbs? It's a pattern ive noticed over and over. Everyone kept telling me to do keto to lose weight and manage diabetes but it never worked for weight loss. Especially on the mounjaro, i lose more when i eat healthy carbs.

[@danbanfan9524]

Even if not natures ozempic in terms of weight loss. Is it fair to say the studies on berberine for blood sugar and cholesterol specifically are more robust ?

[@silviahayakawa6655]

How does Inositol compare to Berberine?

[@camarosspr]

Read bout another GLP-1 mechanism. Significantly lengthens food time in the stomach, from 20 minutes to hours. Will feel full for hours, won't eat

[@vawiley4]

Does the type of Berberine matter? HCI isn’t the only kind. Maybe bioavailability makes a difference?

[@petrtelensky6828]

Very informative and well researched video, but here's a suggestion if I may. Imagine this: I will now save this in one of my playlists and two years down the line I will scroll through my playlist to find that vid where you were talking about Berberine. Can't you just put 'Berberine' in the title? Granted, I don't know bat $hite about how to clickbait, but still 🙂

[@kmook76]

Take a look at olive oil/extract? to see if it helps as well. That's what Bryan Johnson takes and says there is some evidence for a weight loss effect. (although distanced himself to not get sued).

[@ykles24]

Berberine is the best emetic though. One capsule, and i'm projectile vomiting for hours. There's a few of us, if you do a small research in the product reviews. Might be caused by a genetic polymorphism.

[@Physionic]

Well.... Thanks for sharing. 😅

[@ykles24]

@Physionic Yeah, very unfortunate and unpleasant side effect. I would have liked to know about it beforehand...

[@marikamariamagdalenam]

My horror enemy.. vomiting 😮

[@TaylorMade3906]

Dihydroberberine 500mg for high blood sugar as needed

[@whobdis77]

berberine reduced my glucose..but no weight loss or reduce appetite

[@Womanfromearth]

Are you funded by the supplement companies?? I have a drawer full of supplements I bought after watching your videos.. now I need to revisit all the videos and decide the ones I should absolutely take as I can’t possibly take all everyday.

[@Physionic]

Yes, I get paid by all the supplement companies simultaneously - at least 120 companies. "I have a drawer full of supplements I bought after watching your videos" - I'd encourage you to watch my videos more carefully, if that's true, considering my critiques of many supplements.

[@Womanfromearth]

@ I have adhd so I don’t really pay attention and take what I want to hear usually… anyway this month will be dedicated to berberine.

[@sarasmile6071]

I’ve been taking berberine for a year now, I don’t think it’s that strong.

[@Christopher-b1p]

I was looking at the herbicide rotenone the other day. Compare it to berberine :)

[@Physionic]

😛

[@tracymullane8818]

Berberine is a chemical, correct? I thought the mechanism of action was similar to insulin, emptying the blood system of glucose into tissues faster, in a way help ing insulin resistance.

[@Physionic]

Everything is a chemical :) No, it doesn't work like insulin, but it does reduce blood glucose.

[@tracymullane8818]

@Physionic haha yup chemical is kind of a broad term isn't it? Lol just woke up I'll listen to the video now.

[@DesertDog8989]

Thanks so much 😃 My body loves herbs, especially from MediHerb and Standard Process - keep going!

[@hitmusicworldwide]

I understand that placebo,random studies are important. And I am someone who in no way doubts the science. But I've come to the conclusion that these studies don't tell the whole tale. People aren't spending money on these things if they don't find any benefit from it. You can call it the wisdom of crowds if you want but these supplements are not cheap and if they don't produce results for people people will just stop taking them. They're not taking them because they're addicted to them. Whether you want to call it the placebo effect or whatever, sometimes it's making a difference and as sceptical as I am about conclusions that aren't drawn from a scientific method, I've found this to be the case in my own experience. so that's leading me to conclude reluctantly, that randomised, placebo control trials don't tell the whole story. That there might be individual variables that factor into this that our current studies don't take into account and as we further explore individual genetics and understand individual metabolism more we might find that this hypothesis has some merit.

[@david-jr5fn]

Any time I tried berberine it gave me an upset stomach so I'm pretty sure it does something to your digestion

[@liahurst8575]

Me too. I was so disappointed, had bought two bottles but have suffered from nausea and diarrhea : (

[@FirstLast-iv2tc]

Funny, I just told KZbin not to recommend that channel the other day.

[@sharkair2839]

i used to watch their videos. they had said they would share their continuous glucose monitor results, then they shelved the idea. the only possible reason is they are having terrible results. they suggest the best foods to eat for your health however it must not be working so great for them. if they have less than optimal results i can accept that however, not sharing them seems for lack of a better word, shady. if asked about it they simply ignore the question. sad if you ask me.

[@Mr.Chedda_]

What diet do they recommend?

[@Mr.Chedda_]

What diet did they recommend?

[@sharkair2839]

@@Mr.Chedda_ mostly low fat plant based.

[@lanar.7973]

Dr. Weening is vegan, so he's recommending what he eats.

[@waynehiebert3801]

Just to be clear Talking with Docs are two "board certified physicians" not "bored certified physicians - AND - they are Canadian (..a few credibility stars there)

[@Physionic]

You heard the difference between 'Board' and 'Bored' in my speech? Impressive. I still hear 'board' coming from my mouth.

[@MrFurious176]

I have to laugh that the actual alternative to ozempic is to just eat healthy food.

[@gore-geousmombie4686]

It's not though. I've been eating healthy and i didn't lose weight due to hormone issues. Lowered my blood sugar but no weight loss.

[@sammavitae114]

They misread the studies.. turns out it’s bourbon.

[@Physionic]

Ooooh, I misread them, too :)

[@frankenz66]

Even with the muscle wasting and all? I have a friend taking that med and he is wasting away in the muscle department. Even with him being active enough.

[@robertusga]

@frankenz66 not me. Gained 8% muscle while losing 20% of my starting bodyweight. Simply making sure I ingested enough protein plus strength exercises. "Being active" is a vague statement. Having a heart beat is active. Without adding strength exercises no surprise muscles are wasted.

[@frankenz66]

@robertusga He's still drinks some too.

[@Xmaslightsallyear]

Agreed

[@ericwarmath1091]

Body comp and circumfrence are much more useful than weight. A pound of muscle is smaller than fat and more metabolically useful.

[@XYZH1234]

Metformin was developed because you cant patend Berberine.

[@jasons4425]

These doctors don’t know much :/

[@rogertrygg5485]

I seem to hear more and more about the negative sides of Ozempic with muscle loss which Berberine doesn't seem to have at all. On the contrary, smaller waist without weight loss!!! Maybe something you should have added in the video?

[@DennisForbes]

Rapid weight loss always leads to a loss of muscle mass, temporarily at least. When you have a calorie deficit, the body catabolizes both fat and muscle stores in a 3:1 or so ratio, and it's just the nature of the beast. If Berberine avoids this it likely is simply that it leads to less weight loss.

[@TheCookiecupcakes]

😺

[@vincentrobben8121]

Much, much better haircut

[@JamesRouzier]

He is the new superman

[@Mr.Chedda_]

Nah he was just as cute before, not that this matters nor should be nitpicked

[@dudea3378]

Nature's ozempic is such a silly term. Ozempic is a bandaid on a bad diet. People be eating Soylent green out there all day every day.

[@bhut1571]

Hmm, I'm a little bit disappointed. It's almost like watching the Docs over again.

[@Herbit-k4j]

constipator5000

[@gordoncarr9747]

I lost weight with ozempic but berberine did nothing.

[@kathryns560]

I take Berberine daily and have both lost weight and maintain my weight-loss HEALTH-fully'

[@gore-geousmombie4686]

​@@kathryns560you seem to be indicating that losing weight on ozempic is not healthy... you're wrong of that's the case. I'm glad it works for you but please don't act like you're Superior for taking a different drug. If I read your comment wrong, I apologize but it just seemed a little high and mighty to me...