The Ageless Effect of Stem Cells on Muscle

[@williamhenry3337]

I am 76 years old. I exercised like a madman from age 11 to 21. At age 21 I started working long hours. From age 21 to age 70 I went to the gym a few times a week. I moved off the grid 5 years ago and did no formal exercise for the last 5 years. I am starting back on weight training. Let's see if it's really "permanent ".

[@noer0205]

Would love an update in about ½ a year 🙏😊

[@zenonvandeventer5229]

First rule, start slow.

[@nikosrosos5180]

He probably allready forgot ​@@noer0205

[@wpmitra7251]

Weight lifting is the closest thing to a miracle wrt health. Put my Hba1c in non diabetic range, improved all markers.

[@LK-pc4sq]

wpmitra, how much? what is your age? were you pre diabetic range? or in the diabetic range?

[@wpmitra7251]

@LK-pc4sq iam 41. My Hba1c was 9.6 when i treated it last year. Now it is 5.0

[@alcott122]

The concept of health in "The 23 Former Doctor Truths" book completely explains this. I wish I read it sooner

[@lukag3155]

Thanks for sharing that

[@lukag3155]

im checking it out

[@AnxiousCowboy]

Not in amazon

[@JakeB-Real]

Bot

[@darkpatches]

The world needs your analysis of the stem cell-stimulating claims of blue-green algae salesmen.

[@jenxsj3902]

Loving the new hairstyle. Great video. Love stem cells. ❤

[@Sid-bc8pn]

This explains a lot, thx for the insight

[@paulshepherd97]

Does this mean that taking anabolic steroids and then coming off would increase your muscle synthesis potential for life? (Muscle cells retain more nuclei)

[@Physionic]

Yep - already established, in fact

[@jedwards1792]

This sounds like it would be a good practice to encourage: everyone should undertake a course of training with steroids for a few months then go off the steroids.

[@paulshepherd97]

@jedwards1792 yeah, everyone should go to doping camp for a year after they finish high school, kinda like the mandatory military (jk ofc)

[@evanpeacock5567]

​@@Physionic Yes, an unfair lifetime advantage relative to clean athletes.

[@EVanDoren]

Yep, I actually argued that steroid users must be banned for life because of this

[@gasparsigma]

But at 11:47 do we have evidence of that outcome or just the mechanisms? Earlier in the video you mentioned no statistical significance in this study between the untrained and trained arm in muscle growth

[@macmackay2179]

I want to contribute to science education like you. You an inspiration

[@outpt]

Bodybuilders use to call this muscle memory

[@LK-pc4sq]

I am Diabetic but also, in the early to late 2000s, I worked out. I tell people "a person who works out and like, the law WWE wrestler, Randy Savage, who was muscular, it is a myth that you cant burn off the food you ate. He had cardiac arrest event and it was due to Plaque build up from Atherosclerosis. I want to also know, does high insulin levels cause accelerated aging? I have read that it does! Annette Larkins, on youtube is a 30 plus year raw vegan. Meaning her A1c and Insulin levels were so low, she aged 45% slower then the public.

[@EVanDoren]

Not just bodybuilders, it's a general term in the entire sport.

[@edl653]

Yes! I suspect this to be the case. Working out creates a higher baseline that makes future working out after a period of rest, to become more efficient. I never really researched the idea, but this video confirmes it. - This presents a good reason for working out early in life to help recuperate muscle mass later in life after extended sickness and non-exercise periods.

[@waynebasford9957]

I hit the gym a lo in my 20s and 30s not really trained for about 20 or so years, now I’m 57 just started back and I’m quickly gaining muscle mass quickly after a few weeks my missis said that’s mad I can see it coming back, so I agree muscle memory is a wonderful thing but let’s not forget I put the work in when I was younger 👍

[@MelloCello55]

“What gets measured gets managed”. Recommend a body composition scale fore everyone, to be aware of and track body fat, muscle mass, bone mass. Life changing when we see things going in the wrong direction and motivating when going the right way. And no, just assuming or guessing is not that same as seeing your actual trend lines over time. Before anyone jumps on the “they are not accurate” bandwagon, mine is, is all I can say.

[@James-mh8zd]

Very interesting. Thank you

[@livephysiology]

It would be interesting to see if myokine secretion also decreased along with the decreases in muscle mass associated with the lack of resistance training. Or could it be that the increased nuclei also lead to increased transcription and translation of the genes for certain myokines, leading to enhance myokine production per unit area of the muscle cell, including when muscle mass decreased?

[@mrfoodarama]

Very interesting! Thanks as always, I hope you and yours are having a very Happy New Year 🎉

[@rationalsage1084]

Does this apply to cardiac muscle?

[@LK-pc4sq]

good question. Cardiac muscles are critical as they do not have any stem cells. The key to remember, ALWAYS keep blood pressure low! That is from Diet. Then exercise helps to boost Mitochondria subdivision which means it helps to keep a1c low in the blood stream.

[@EVanDoren]

Nope. Cardiomyocytes generally don't grow. In fact, it would be pathological.

[@seattlegrrlie]

It makes sense. If paleo-humans got hurt or had a harsh winter, they're more likely to survive if they can bounce back

[@ksairman]

Great info again!

[@mikelevenson7271]

Nic i belive u to be correct..To my utter shock It sure as hell worked for me.. from 20 to 28 i worked out intensely.. laid of for 30 yrs..came back at 61 and although im not as strong i gained damn near all my lost muscle size within about a year..

[@Snerdles]

Looks like I'm going to start my excercise journey with 16 weeks of rest, just to be sure.

[@janineclemons746]

I've discovered that I can use a five pound weight while resting on my bed. It's the best of both worlds.

[@MrDjhealth]

Is it true a slower rep cadence when lifting activates a greater number of muscle satellite cells?

[@zhilahaghbin4766]

thanks Dr. Nick, this is really interesting, to hear even if we get injured during training there is bounce back reward when we heal and keep up with the training, ? a case of what injures you makes you stronger.

[@troncooo409]

What is the correlation coefficient and statistical significance of the graph at 7:47?. Correlation seems low and number if samples as well.

[@jvlbme]

I don't know if mentioned, but does this deplete the satellite cells on the outside of the muscles? Or are new ones constantly formed?

[@juliusjames6229]

Man, your pretty smart guy you and Chris masterjohn

[@IragmanI]

Does the stock of satellite cells replenish to replace the ones that became fused?

[@ancapde]

They divide first

[@verma.shaurya]

Are you related to 63orge Russell, the Formula 1 driver?

[@pridefulobserver3807]

zenkai boost is real?, there must be a limit right?

[@RS-ing]

None of these studies account for age?

[@ericmaclaurin8525]

This is just how it works with fat too. Your body builds "warehouses" to hold the fat and those warehouses sit there waiting to quickly store fat again as soon as you overeat again. I think they tear them down with about a year of non use.

[@SEAWORRIER]

Do they get torn down? The impression I had got from various channels (like RP) was that any additional fat cells are also there for life.

[@Mr.Chedda_]

@@SEAWORRIER I surely hope not... how depressing.

[@abdeliribas6247]

Dear Physionic, are 4.7 grs potassium enough for 4 visits per week at the gym ? Or are 6 grs tolerable ? Thanks a lot

[@ianjones7740]

How does muscle grow in length after stimuli to increase in length ? 100% of all martial arts students are asking you !

[@DesertDog8989]

Myositis interest

[@frowin2]

In my 20s, I tried to do 2 things: don’t gain weight (by fat) and build muscles. From what I heard, both, muscle and fat cells have kinda memory. If fat cells once formed, it will be harder to keep your weight the entire life. I’m no expert by any means but that’s what I observed on myself and on friends/family.

[@LK-pc4sq]

That is incorrect.

[@notaras1985]

What supplements raise stemcells?😊

[@EVanDoren]

I thought all this was established for quite some time.

[@anoniem9518]

It seems that it all comes down to the need to grow/ get new stem cells as our inventory of stem cells grow old, decline and get damaged.

[@LK-pc4sq]

Incorrect. Stem cells chromosome Telomeres shorten each time they go into Mitosis. It can only subdivide 50-60 times. Once that limit is reached for most crisis supporting cell, then death of the body occurs.

[@anoniem9518]

@@LK-pc4sq So, we need to find ways to get ourselves new stem cells with telomeres which are not shortened.

[@niklanu]

It would be interesting to check if body builders that use steroids have the same results. I suppose they are not.

[@EVanDoren]

Actually, steroids stimulate satellite cells. So BBs have a much more pronounced effect.

[@TheCookiecupcakes]

This legit happened to me except I did both arms at the same time. My muscles have great memories because of all the satellites around the atmosphere. Yep. #Probes

[@farhat5325]

Sounds like fat cells , you lose the fat but not the cells

[@astrol4b]

Commenting for the algo, but also, today I watched a video from the channel "what I've learned" on carnivore diet and every ten seconds I thought "I wonder what physionics would say about that"

[@lauraw.7008]

lol! Me too! Around cancer recovery claims.

[@dj.h7424]

That channel hasn't got a lot of credibility, apparently.

[@astrol4b]

@@lauraw.7008 that's not particularly controversial, it seems that many cancers are glucose dependent, but the thing for me is that I'm spoiled by this channel that dissects every research so when someone says "this research found this" I'm like "oh really, can we see if the big black diamond is right or left of the line?" 😀

[@Physionic]

Just keep in mind there's very, very little research on the carnivore diet, so anytime there's definitive claims around it, just know that's not based on actual scientific evidence (most of the time).

[@emveretarcon]

There are carnivore studies, just not published due to terrible health results 😂

[@Wstarlights]

Alright. Who here got one arm with more myo-nucliei ??

[@blank-964]

cool