25 Years From Discovery To Cure: The Hepatitis C Story | Nezam Afdhal | TEDxOxford

The discovery of the hepatitis C virus in 1989 and 25 years of has led to new treatments that can now cure almost all patients with hepatitis C and have the ability to reach almost 200 million people globally. Dr. Afdhal discusses how discovery of the virus lead to understanding the global epidemiology and modes of spread of hepatitis C and the recognition that it was the commonest cause of cirrhosis, liver cancer and need for liver transplantation. The development of model systems to look at viral replication led to treatments initially with injectable interferon with low cure rates and poor patient tolerability to new all oral direct acting anti-viral agents which can cure patients with a simple, safe and effective 8 - 12 week treatment. Finally Dr. Afdhal discusses how these treatments have changed the discussion in the US on the cost of new medications and the ongoing plans to bring these expensive treatments to developing countries with high hepatitis C burden.
Nezam H. Afdhal, MD, is a Senior Physician at the Liver Center at Beth Israel Deaconess Medical Center in Boston, Massachusetts. He is also Professor of Medicine at Harvard Medical School. Dr. Afdhal received his MD degree in 1981 from the Royal College of Surgeons in Ireland and did fellowship training at University College Dublin and at Boston University School of Medicine. He is the Chief Medical Officer of Spring Bank Pharmaceuticals.
Dr. Afdhal’s clinical expertise focuses on the management of the complications of liver disease, including cirrhosis and portal hypertension. His research has been on liver fibrosis, hepatitis B and C where he has led national and international teams on the treatment and cure of HCV and HBV. He is currently working on issues of global access and education for HCV in the developing world.
This talk was given at a TEDx event using the TED conference format but independently organized by a local community. Learn more at ted.com/tedx

[@Stellaher645]

I am from Ohio USA I am here to thank Dr. Obaedo for his good works I have been diagnosed with hepatitis for 5 years and I have been taking all kind of treatment until I came across Dr.Obaedo on KZbin who made me smile again thank you Dr for your greatness....

[@paulinesuggitt5430]

This is for me one of the best videos offering background information, overall picture of the amazing struggle to discover the new Hep C drugs. Fascinating and taught me so much when I was diagnosed 10 years after blood transfusion and was overwhelmed by fear and ignorance. I have almost completed my treatment with already phenomenal results but am left with advanced cirrhosis of the liver. God Bless all those who have suffered this illness and I salute the pioneers in research. But the financial cost.... !!!

[@lazaroastudillo6787]

I just got diagnosed not to long ago how was the treatment process?

[@ilovefredreika]

God bless these scientists. Their dedication saves lives.

[@cM-zm5kp]

Agreed! thankyou so much! Im actually starting treatment today for hep

[@matthewhawking4318]

I hope there is a cure for Hepatitis C. I once heard the latch-on generation changed the definition of the word cure to claim that there is a cure for Hepatitis C.

[@x-rays8800]

There are millions of people who can't afford this treatment. I am one of them. Thanks to Corporate Pharma companies....

[@matthewhawking4318]

@@x-rays8800 There are many doctor recommended-treatments that are unaffordable and ineffective. People should side with them.

[@StevenKHarrison]

I have Hep C. I was only recently diagnosed and I am told that it is in a passive state. No one can say how long I have had it, but I would guess many years. Tomorrow I will go to a clinic in Vienna, Austria and, if approved, I will begin the treatment. My house Physician told me that the treatment would cost about 50 thousand Euros. That is a hell of a lot of money and I could never afford to pay for it. BUT, I live in Austria and we have one of the best national health plans in the world. I will pay nothing. This is awesome! Science is amazing! THANK YOU TO ALL THE DOCTORS, RESEARCHERS AND CHEMISTS THAT HAVE MADE THIS POSSIBLE! And Thank you to the Austrian Health Insurance system!

[@iashuu]

Steven K Harrison So how are you doing Steven? Are you all cured and how has been your experience with the disease?

[@xsdata2009]

Please contact

[@speeddemon8977]

you will pay nothing if you have cirrosis but if your have fibrosis they do not give it for free i got my treatment from India and thank you to India am beating this virus

[@yannick245]

Same here in Germany.

[@paulinesuggitt5430]

This is brilliant presentation

[@chaosandisorder68]

I had hep C' I started 4 months of treatment at the end of 2019, I am so grateful for the medication & the support I got from the amazing liver nurses.I was homeless and still iv'ing drugs and they showed love & empathy. I am now part of a solution, volunteering with a hepatitis c organization,the whole recovery process was a catalyst for change in my life. I am eternally grateful

[@wellbodisalone]

Their dedication has saved thousands of lives.

[@brownbridget887]

God bless you for your professionalism and contributions towards my health Dr Obaz, i tested negative for hepatitis B, I'm grateful🙌🙌

[@lessonswithherbertenglish3207]

Thank you♥️👏

[@nandinigahlot8610]

Where will i have to go for treatment of grandmother from hypetitis c

[@larry5289]

RIP Larry. Good man

[@inesdejesus4719]

Thank you so much doctor May God bless you continually

[@jafersultan]

God bless you

[@marystuart1944]

The cure is a blessing!... Thank you!

[@ArunKumar-uy2jz]

One of my brother has inflected when he received blood from a men. He was met with an accident. When he found he is infected he consulted many kerala doctors and they tol tgere is no medicine for it. So he is so poor that he cant go abroad for treatment how can i get this medicine?

[@VictorMTFlomo]

Great intervention

[@tennysonmathew7019]

Who else is here after the announcement of Nobel prize? ^-^

[@cimathai6625]

Me!!😀

[@bilnitro]

Thanks

[@kateparadis9215]

Glad I’m in Canada, my treatment was free

[@alanlangley7246]

mine was too.i live in usa )

[@titseraw5397]

Is canada employers are every strict to the medical of foreign working?

[@arslano4531]

Did it work, when did u have it ???

[@stephenjordan7647]

@@alanlangley7246 Hello Alan, How did you get free treatment and where.

[@alanlangley7246]

i went thru my family doctor,and they sent a maverick rep out to see if i was ideal canidate,because the cost was 60k.they was making sure they wasnt waste their moneyon me .i had to take 3 pills a day for 5 months.thank god it was free.the docor was kumar out of forrest city ark.

[@yogendrasingh8342]

Can hcv antibody negative

[@bosestephen1860]

Thank you so much Dr. Umoru on KZbin you really helped me out with my hepatitis b issues I am now totally free.

[@anahilson7505]

I no longer feel pains and I wake up each morning feeling revived, thanks Dr Ayomede for the great herbal supplement that helped me sort out the hpv from my body system permanently

[@bolivianbillionaire1349]

no apologies for the tens of thousands of lives destroyed by interferon...thousands of suicides......look at yourself. been in the trough of greedy big pharma kick-backs for too long

[@chimpchowder5774]

Bolivian Billionaire doctors...... Just another name for an old term........ Sorcerer! Even the Lord had no good words for doctors! Yet he praised the work of the Physitions! These are the ones who physically manipulates the body to accommodate the natural healing process! Yet he was and still is today the greatest Physition! Still healing all who come to him believing. You should learn more

[@uniquechannelnames]

Why is everyone thanking dr.Igudia and Dr. Ayomeda when the presenter on the video here is Dr. Afdhal??

[@JAB4mx]

And here we are 2021 with COVID-19. Hope there is already a solution when you read this.

[@patriciadavid8825]

Hello, may I ask where I can get treatment for hepatitis C that can cure my boyfriend? He accidentally cut his finger while doing surgery on a patient with HCV. He was diagnosed with HCV yesterday. I have an idea that it costs a lot but we are still interested. We want him to be treated as soon as possible so please, if you can help us just send a message to me. I will appreciate your response. Thank you so much!

[@lukesmith3283]

Amazing medicine

[@miracleokon573]

Finally cured completely God almighty bless *Dr Omoh* you're a life saver.,,

[@uniquechannelnames]

I'm forever indebted to you Dr. Afdhal and to all the doctors/researchers/nurses who focused part of their career on this and patients who donated time and consented to drig studies in the name of a cure, everyone who contributed to this work and to this true wonder cure, and thanks to my government for negotiating with those greedy pharma companies so they could give this treatment fully covered to their citizens. They figured it out so we didn't have to go bankrupt ourselves getting cured. And if none of this had happened I'd probably be close or in the middle of liver cancer/liver failure... IOW dying, in my early 30s. You may not have official accolades but you have my eternal respect and admiration, along with the appreciation and love of every cured patient around the world. Thank you medicine for giving me a second chance at life.

[@kevinsolove458]

So where is this miracle drug and how do you get it? Would be nice to know as I dont believe he said anything about that or its name?

[@lacedhexes]

He did, the compound name is Sofosbuvir. Sold as Sovaldi for a very high price and also Soforal as generic drug in developing countries.

[@yannick245]

It's real. I did the therapy and I'm hepatitis free. Three pills per day for 8 _(12 for some)_ months and you're cured with a 99% possibility.

[@uniquechannelnames]

There's a few different cures now, all relatively the same (pill-form, once.a day, little to no sidd effects, 95%+ cure rate) but a doctor giving you a referral to a hepatologist will get you there. Theyre.nit OTC though

[@alimehdibaloch2997]

i have hepatitis c and i am 26 year old. i am from Pakistan plz i don't richest man any body can help me 😭

[@bekzodparpiev8471]

xsdata2009 do you know any treatments which are effective at low price ?

[@speeddemon8977]

@@bekzodparpiev8471 eclusa buy it from india

[@angeldew77]

Greg Jefferys on fb and fb hep c groups will help anyone get the medicine. He is an amazing person.

[@backofftheswag]

At 16:00 he quietly gives everyone in patent protected countries the framework for finding a cheaper cure.

[@linussamuel8748]

My heart just keeps thanking you and thanking you Dr Igudia for all you have done for me, you gave me your words that you could heal any sickness or disease, thank you for permanently curing me of my Hepatitis B you are amazing

[@utrube]

I just got informed about test being positive for HEP-c. What a bummer. Yeah not having a best week of my life.

[@maryherrera7893]

Who can afford treatment? Harvoni is $1,000 per pill. The USA pharmaceutical companies traditionally has higher prices

[@chibuikenwanyanwa8945]

I thought my body would never be the same again, but you fixed it. My heartiest gratitude to you Dr Igudia for helping me cure my Hepatitis B successfully.

[@jacklynemutongoi1875]

I'm hepatitis b positive. Can the medication heal me ? I'm from Kenya

[@georgiamilbourne938]

Sadly this is only a cure for hepatitis c and won't work for hepatitis b. If you have only had the infection for a short period of time then your body may naturally fight off the virus (within a couple of months) but if the infection is chronic then there are some antiviral therapies which can help slow down the virus and prevent liver damage.

[@jacklynemutongoi1875]

@@georgiamilbourne938 thankyou so much for getting back to me..yes its chronic been ailing from 2005 till date. Been taking antivirals for a year now. Thanks once again

[@lawrenceessien363]

You have my maximum respect Dr Igudia, I am now negative from Hepatitis B Infection after I did the test, I wonder what might have become of me it I didn't get the herbal cure From your KZbin channel. God bless you sir.

[@victorchinaza878]

Thank you Dr Omoh for being the reason I am Smiling today, I stil can believe I am cured from hepatitis b virus completely, keep up the good work doctor

[@clinsonemene6095]

Thank you dr Igudia on KZbin for all you do, just got my test result today and am now Hepatitis B negative. I will keep letting the world know about your good work sir

[@johnr7343]

Definitely NOT the most expensive substance on earth... But still amazing (and expensive!)

[@chinyeremary7749]

Thanks Dr OMOH for your professionalism with herbs, You made my well-being your primary focus, and I was always satisfied with the medication you provided.,

[@zuwairababawuro7721]

Dr Omoh natural knowledge is something else, I am glad I met him at the time I needed his help most.

[@GoddessRx]

I got mine through blood transfusion or my transplant. Because I been celebrant sinceI got my transplant

[@clinsonemene6095]

Thank you dr Igudia on KZbin for all you do, just got my test result today and am now Hepatitis B negative. I will keep letting the world know about your good work sir.

[@idrisbagaruwagwarzo4363]

I really do appreciate you Dr Igudia youtube,your commitment towards saving human lives is steadfast ,all the knowledge I got from you and,the help with the herbal meds, I was recently tested negative of Hepatitis B Virus,I’m so happy thanks doc.

[@saraking1545]

I live in Oregon, USA. I have had hep c since I was 12years old. I am 34 yrs old now. I am sick and I need this medication. But I can't afford it. How do I get it???

[@barneymel]

I hope you have found help by now. Only a doctor can prescribe the drug. If you haven't don't be scared by the cost help is there.

[@xsdata2009]

Please contact me asap

[@bekzodparpiev8471]

Richard Travis how to

[@ezzataylor3824]

plz contact me.

[@Nengpi_R]

Please contact Kris at 858-952-1077 if you still didn't get the help you need. He will help you get cured at affordable price. You won't be disappointed.

[@ejanyijoel88]

Great experience doc, you are a godsent dr odija on KZbin, keep up the good work, I am completely free from HSV2....

[@nnajingozikajane7978]

My heart just keeps thanking you and thanking you dr omoh for all you have done for me, you gave me your words that you could heal any sickness or disease!, thank you for permanently curing me of hepatitis you are amazing.

[@ashiruabbas4884]

Its super excited to know you're now free from hepatitis permanently all thanks to Dr.Ayomede.

[@ashiruabbas4884]

Its super excited to know you're now free from chronic cancer permanently all thanks to Dr.Ayomede.

[@linussamuel8748]

My heart just keeps thanking you and thanking you Dr Igudia for all you have done for me, you gave me your words that you could heal any sickness or disease, thank you for permanently curing me of my Hepatitis B Virus you are amazing.

[@linussamuel8748]

My heart just keeps thanking you and thanking you Dr Igudia for all you have done for me, you gave me your words that you could heal any sickness or disease, thank you for permanently curing me of my Hepatitis B virus you are amazing

[@linussamuel8748]

My heart just keeps thanking you and thanking you Dr Igudia for all you have done for me, you gave me your words that you could heal any sickness or disease, thank you for permanently curing me of my Hepatitis B infection you are amazing

[@mujahidyalhassan2481]

If the world had more people like you, it would be a better place. You make a difference, Dr Igudia thank you for curing my Hepatitis B disease and introducing your medical products to the worlds

[@tapanboro2348]

When hepatitis b will be curable?

[@isabellaamelia6226]

Dr igbe can cure your hepatitis b

[@isabellaamelia6226]

With the help of his natural herbs

[@havingee]

@@isabellaamelia6226 how

[@maryjaneneumann5225]

Thank you once again Dr Igudia for I'm completely free from Hepatitis B, all my life I will keep thanking you for the great help and for your herbal medication which actually works. thank you doc.

[@ryannicholas4182]

Honestly after much stress all thanks to *Dr.Ayomede* on KZbin for your genius work in eradicating Hepatitis B (HPV), completely.

[@Barnabas45]

Greed over human life!

[@chibuikenwanyanwa8945]

I thought my body would never be the same again, but you fixed it. My heartiest gratitude to you Dr Igudia for helping me cure my Hepatitis B disease successfully.

[@idrisbagaruwagwarzo4363]

I really do appreciate you Dr Igudia youtube,your commitment towards saving human lives is steadfast ,all the knowledge I got from you and,the help with the herbal meds, I was recently tested negative of Hepatitis B disease,I’m so happy thanks doc

[@dougshadrick3653]

I just read a comment it says thank God I'm in Canada my treatment was free what about me I live in United States I'm not wanted to be free but I can't afford it to be $150,000

[@uniquechannelnames]

I think its gone down to $80,000 or so. Theres different meds now too. Honestly if you need to I guarantee you should be able to find generics produced in India for a sane price. The pricing was really a insurmountable problem fom 2014 to 2019. Go look for generics of the drugs. Best of luck friend As a sidenote i cant believe you're dying of a curable disease and the only thing in your way is cost yet you still cling to private health care. To each their own. The canadian gov negotiated a deal and worked to distribute it for free to citizens... since Ibwas signed up with this govetnment clinic they covered it 100%. But, yeah i'd search for generics in your situation.

[@idrisbagaruwagwarzo4363]

I really do appreciate you Dr Igudia youtube,your commitment towards saving human lives is steadfast ,all the knowledge I got from you and,the help with the herbal meds, I was recently tested negative of Hepatitis B,I’m so happy thanks doc

[@ashiruabbas4884]

Its super excited to know you're now free from hepatitis permanently all thanks to Dr.Ayomede..

[@auuunold]

Generic...Harvoni, 12 weeks $1495.00 + $995.00 shipping.

[@maryherrera7893]

From where

[@amossamuel3935]

being recommended to doctor Igudia on KZbin has being a great blessing to my family his cure for hepatitis B virus is a genuine one thanks for your good deed toward humanity☺️.

[@joannewaite2]

I WAS AN INNOCENT PERSON I TRUSTED SOME ONE - I BECAME CONTAMINATED - DAWN TOLD ME BEFORE I WAS ABLE TO OPEN MY MOUTH!

[@xsdata2009]

Please Contact me I can help

[@amorroma7858]

In short: More Science, Less Capitalism.

[@mr-jam3055]

h

[@brownbridget887]

God bless you for your professionalism and contributions towards my health Dr Obaz, i tested negative for hepatitis B, I'm grateful🙌🙌

[@miracleokon573]

Finally cured completely God almighty bless *Dr Omoh* you're a life saver.,,

[@linussamuel8748]

My heart just keeps thanking you and thanking you Dr Igudia for all you have done for me, you gave me your words that you could heal any sickness or disease, thank you for permanently curing me of my Hepatitis B you are amazing

[@lawrenceessien363]

You have my maximum respect Dr Igudia, I am now negative from Hepatitis B Virus after I did the test, I wonder what might have become of me it I didn't get the herbal cure From your KZbin channel. God bless you sir.

[@anahilson7505]

I no longer feel pains and I wake up each morning feeling revived, thanks Dr Ayomede for the great herbal supplement that helped me sort out the hpv from my body system permanently

[@victorchinaza878]

Thank you Dr Omoh for being the reason I am Smiling today, I stil can believe I am cured from hepatitis b virus completely, keep up the good work doctor

[@chibuikenwanyanwa8945]

I thought my body would never be the same again, but you fixed it. My heartiest gratitude to you Dr Igudia for helping me cure my Hepatitis B successfully.

[@nnajingozikajane7978]

My heart just keeps thanking you and thanking you dr omoh for all you have done for me, you gave me your words that you could heal any sickness or disease!, thank you for permanently curing me of hepatitis you are amazing.

[@linussamuel8748]

My heart just keeps thanking you and thanking you Dr Igudia for all you have done for me, you gave me your words that you could heal any sickness or disease, thank you for permanently curing me of my Hepatitis B infection you are amazing

[@zuwairababawuro7721]

Dr Omoh natural knowledge is something else, I am glad I met him at the time I needed his help most.

[@chinyeremary7749]

Thanks Dr OMOH for your professionalism with herbs, You made my well-being your primary focus, and I was always satisfied with the medication you provided.,

[@mujahidyalhassan2481]

If the world had more people like you, it would be a better place. You make a difference, Dr Igudia thank you for curing my Hepatitis B disease and introducing your medical products to the worlds

[@ashiruabbas4884]

Its super excited to know you're now free from hepatitis permanently all thanks to Dr.Ayomede.

[@idrisbagaruwagwarzo4363]

I really do appreciate you Dr Igudia youtube,your commitment towards saving human lives is steadfast ,all the knowledge I got from you and,the help with the herbal meds, I was recently tested negative of Hepatitis B Virus,I’m so happy thanks doc

[@ashiruabbas4884]

Its super excited to know you're now free from hepatitis permanently all thanks to Dr.Ayomede.

[@ashiruabbas4884]

Its super excited to know you're now free from hepatitis permanently all thanks to Dr.Ayomede.