Why do people get cancer, how it spreads, and how to prevent it? | Sendurai Mani | TEDxProvidence

After heart disease, cancer remains the second most common cause of death in the US. Only around 5% of cancers are hereditary, and the remaining 95% are sporadic, contributed by environmental factors and lifestyle. Among these cancers, carcinomas account for over 80%, which develop in epithelial cells. Epithelial cells are attached to one another; therefore, when cancer starts in these cells, they are also attached to one another, confined to the local environment, and develop a benign tumor. At some point, when cancer progresses, the cancer cells activate a latent embryonic program known as epithelial-mesenchymal transition, gain stem cell properties, and start to behave like cells in an embryo. These cancer cells with stem cell properties are resistant to most therapies. They move around the body and develop metastasis. Advancements in sequencing, imaging, and precision oncology allow us to characterize these detrimental cells spatially and temporally at a single-cell level to find a cure for cancer. Sendurai A. Mani is a tenured Professor in the Department of Pathology and Laboratory Medicine and Dean’s Endowed Chair for Translational Oncology. He is also the Associate Director for Translational Oncology at Legorreta Cancer Center and Director of the Cancer Stem Cell Center at Brown University. After completing his Ph.D. at the Indian Institute of Science, Bangalore, India, Dr. Mani joined the Weinberg laboratory at the Whitehead Institute/MIT as a postdoctoral fellow. Dr. Mani and his colleagues at MIT demonstrated that the activation of latent embryonic epithelial-mesenchymal transition (EMT) promotes metastasis. In addition, Dr. Mani was the first to show that the activation of EMT provides stem cell properties to cancer cells. This highly cited finding provided insights into the presence of plasticity within the tumor and how cancer cells survive in the circulation and develop metastasis similar to the tissue of origin at the distant site. Dr. Mani received several prestigious awards, including the V-Scholar and American Cancer Society Research Scholar awards and Dean's Endowed Chair for Translational Oncology at Brown University. He is an elected member of the scientific research honor society Sigma Xi and an elected fellow of the American Association for the Advancement of Sciences (AAAS). This talk was given at a TEDx event using the TED conference format but independently organized by a local community. Learn more at www.ted.com/tedx

[@johnpattison9645]

One of the longest cancer survivors in the UK, delivers a triple award-winning book of inspiration. Me and My Shadow - memoirs of a cancer survivor, described as one of the most inspirational books of 2023.

[@user-vk6rm1rl8s]

Mr you give hope to a generation

[@AventKnain]

You are in the list of favorites

[@dmv_23_10]

Research is lucky to have you, I read about you in an article recently too

[@frankfernandez6424]

You are amazing. So inspiring

[@cerysmiller6716]

GREAT STORY TELLING

[@AwuinAndresAyalaGonzales]

Some incredible information in this one, I don't know how you remembered it all!

[@angelmauriciohernandezgarc9857]

Looked at your website too Mani, inspirational work you do!

[@wayoflife1059]

Your explanation of the difference between DNA and genes 5:10 is amazing.

[@miawilliamson1082]

Wow one of my favorite

[@jaikishansmspl39]

Happy to note the positive developments in Cancer Research.

[@FurnellWhite]

Excellent talk Mandeep

[@ElizabethGreen-kv6rx]

Appreciate💕 both you and your Shares Thank you

[@leonmason9981]

Value led leadership at its finest in this wonderful talk

[@dmv_23_10]

Important topic and work you, God bless you all in Providence

[@ZebuleeBass]

Love the anecdotel storytelling here, one of the best TEDx Talk I've heard of late !

[@ShaleighFerguson]

Thanks so much for sharing!

[@DentonGibson]

Excellent,your video just keep getting better & better All my favorites

[@maximewisoky9286]

Breathtaking

[@leifboyle994]

Fantastic,your video just keep getting better & better All my favorites

[@KeantayRoberson]

absolutely stunning video Wow

[@NormaBurks-ct3sz]

Your weekend shares are honestly my favorite. I look forward to them

[@hortensepouros4123]

Woow thanks for Sharing 🙏

[@terrysmith2883]

Such Amazing

[@prop3339]

One of the most clear, articulate, positive, powerful speakers i have seen

[@user-pp9ri4zc4t]

Thank you!

[@katlynsmitham1215]

One of Thee Best!

[@WaneesaGrant]

awesome I think Im crying Its that engaging

[@CarolStrickland]

Such Wonderful

[@JosieLaBord]

Thank you for sharing.

[@danicanicholson5058]

Thank you for inspiring me to better ❤️😍😍

[@renzabeto451]

Superb!

[@ShealynnMorton]

Thanks lovely Videos!!

[@ArioGraham]

Oh My God! Your video is really Enormous Graceful Frame

[@user-zz6we2uv9y]

Although the title of your video say "how to prevent it" you did not say how to prevent cancer. What is the point of giving us an overload of medical information, when we cannot even manage to see a doctor these days. What can we as patients do with that information? We need consciencious doctors who seriously care about their patients health.

[@user-uf1nf5tk1c]

He told u numb nuts - get early diagnosis to cure it Jeez it’ll be done way to go before they invent brain cell corrections

[@cocoanutte]

Dr. Jason Fung wrote The Cancer Code. For everyone interested in all the un-answered questions left by this speaker.

[@JT-jr3xh]

he said don't stress, take time to enjoy life. don't smoke, don't drink alcohol, don't eat junk food, stay away from pollution, be respectful of your microbiome. he told what to do and what not to do but you didn't listen.

[@yesno103]

He said how to prevent cancer around the 10 minute mark were you even listening

[@KC53557]

Sounds like you are looking for a pill ?

[@ElizabethGreen-kv6rx]

Pleasant video

[@molliesimpson3253]

Beautifully delivered, such stage presence Dr Rai.

[@DeveronMorrison]

Shade, gradient, idea, colour fantastic m8

[@ThuNgocong-xm5ux]

No words, only emotions

[@sarahdrio4623]

I learned a lot! Thank you

[@evebarry369]

💯Exceptionally amazing Videos

[@TaraLaFonGooch]

I love how you described the body as a community! This was such a powerful talk, my friend!

[@user-pp9ri4zc4t]

Thank you, Tara!

[@morespinach9832]

Yes, that's all you got out of it. Community. Rest was palaver.

[@FaithJohnston-rj7sm]

The Values Compass- I love this , thank you fort sharing, enlightened !

[@cerysmiller6716]

This looks incredible!!! ❤

[@Kashmiran100]

I know two people successfully on immunotherapy for melanoma. Both were given six months and both are fine and one is over three years on, the other about two years one. Absolutely brilliant for them and their families but it was very expensive.

[@morespinach9832]

Both must have been in early stages, and both would have been fine without establishment immunotherapy or chemo. Find better doctors.

[@anitayawale915]

Thank you Sir for sharing wonderful information. If we see the causes of cancer and try to get rid of those factors with help from inside family or outside help. And very important point is to be happy and be respectful towards everyone. Always use good words, all the time our cells are getting the signal of love and hate from us. If love is more, for others too then no cancer. This is what I could understand. Harmony in our cells and bacteria will promote healthy body.

[@siennachamberlain5994]

Omg wow! That's incredible💓 I appreciate your Videos

[@JamettaWillis]

I just want to name this Videos.."stunning"

[@RobCLynch]

Many of us are here for the same reason so therefore, i recommend that you look at the work of Dr Thomas Seyfried and how his Boston university clinic is tackling cancer using a metabolic approach. While cancer continues to be treated as a genetic disease, we will never get on top of it. It also goes without saying that standard of care (chemotherapy and radiation) is going to do us in anyway.

[@jaimienommik1578]

Dr Thomas is the best at cancer he changed my life for the better.

[@JamesMonroe-tr9zs]

Energetic

[@LyndaeTaylor]

Marvelous⏺

[@jackkunasagaran5646]

great ! thanks !

[@makaynmaydar7824]

This is Fascinating

[@user-pp9ri4zc4t]

Thank you!

[@klaraprice2355]

Very elegant💎💎💎

[@gsflomos]

Fantastic talk! Congrats!

[@user-pp9ri4zc4t]

Thank you!

[@YiannisHeard]

Superb❤️

[@TimoneSmith]

Very Wonderful ❤️

[@siennachamberlain5994]

So empowering, thank you

[@grainiac7824]

what is empowering for us though? He didnt talk about what WE can do besides sending them more money and volunteering for clinical trials. We don't have power here.

[@ianvillanueva8236]

I LOVE THIS

[@popotv9385]

Absolutely amazing many thanks for you work and superb presentation

[@user-pp9ri4zc4t]

Thank you, @popotv9385!

[@johntarantino5258]

Awesome talk, Mani.

[@user-pp9ri4zc4t]

Thank you, John!

[@KeantayRoberson]

Wow👌 Awesome!✌💪☝👏👏👏👏 Very different

[@emilybird9761]

Super🎯amazing mate

[@CalebBarnes-wp6jy]

Amazing 🔥🔥🔥

[@LyndauOtero]

This one is awsm❤❤

[@allaciagordon5117]

❤🌹 God bless you 🙏🙏

[@CatherinerDoe]

Amazing🔥

[@amygullette475]

It's fascinating not just cool!

[@JaymoreLucas]

your Snapshots really awesome, i like it, looking forward for you next Snapshots, keep it up!

[@poornimabhat5466]

Thank you, Mani, for making complex ideas in simple terms for everyone to understand.

[@user-pp9ri4zc4t]

Thank you!

[@normagardner9334]

fabulous😍😍😍

[@JosephMateo-sr6lv]

This one is awsm😘😘

[@JamettaWillis]

Very attractive❇

[@elaineallan9190]

So excited For This Supercool Videos

[@PeggyConway]

wonderful🌹

[@prasaths3911]

Super talk.....sendurai mani ... by Prasad Madurai

[@user-pp9ri4zc4t]

Thank you, Prasad!

[@DorothyeBerry]

My role model ❤

[@evebarry369]

Top Notch 🌷

[@ShaleighFerguson]

great🔥🔥

[@evebarry369]

You are a Star👏

[@SiniSimon]

Please make treatme t for chronic diseases cheaper. Our right to live shouldnt depend on how much money one has. 😢

[@devanshmessi4328]

Loved it

[@user-pp9ri4zc4t]

Thank you!

[@EthridgeRandolph]

exceptional😍💞

[@johntarantino5258]

Outstanding talk, Mani. Thank you.

[@user-pp9ri4zc4t]

Thank you, John!

[@WaneesaGrant]

your so Sweet😍 Thank you so much

[@DominicMontes-em5dy]

Divine😍

[@SkyeRobinson-pr7kv]

Such notification,many playfulness,so wonderful

[@thongquoc4390]

Very cool🎉

[@FlynnBishop-ge1zu]

I Love this video

[@osiris_300iq]

Deserves more views More people need to know

[@user-pp9ri4zc4t]

Thank you!

[@emilybird9761]

Silence is golden indeed !!!!!!!!!!!!!!!!!!

[@lhakpabhuti1514]

Why you say silence? I want to know

[@Feroza2575]

Please 🙏 also do something for hepatitus B positive patients 🙏

[@ArioGraham]

for all people of peace and love

[@emilybird9761]

Oh wow! That's Fabulous💋 I love your Video

[@namminh4331]

I love your posts so much

[@aliceross9961]

you are so Special thank you for this Videos

[@charlesross5898]

Very attractive👏 🤝 👍

[@marielatour1384]

Top Notch ✅

[@EthridgeRandolph]

✌✌Amazing 😍

[@pubgwtftv4115]

Nice one

[@user-pp9ri4zc4t]

Thank you!

[@RajaneceChambers]

OH! I like this one