Telomere Length Test #5 in 2023: Which Dietary Factors Are Significantly Correlated?

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[@chrisgiles5653]

Very interesting video and perfect audio volume. Thank you!

[@conqueragingordietrying123]

Thanks @chrisgiles5653!

[@MrStarchild3001]

Hi Mike, I've looked correlations for data mining purposes in my job for >7 yrs. Rank correlation (of any flavor) is very robust (spearman or kendall). More so than linear correlations (pearson). To compute rank correlations you just need to convert your time series into ranks, then do the same linear correlation analysis. Might be helpful to check it for robustness sometimes. Cheers.

[@conqueragingordietrying123]

I can send you the data-do you want to run that analysis?

[@nootri]

Could you please consider mining the data after adjusting by molar mass or something else? From my perspective, calories are unreliable and less or not-at-all-applicable. Not saying molar mass is better. It's also my birthday 😋and that would bring me great joy.

[@Vgallo]

dunno what this comment means, but sounds important lol

[@nootri]

@@Vgallo I think he's just offering a better way to account for time/pauses between measurements, time in itself skewing the data.

[@jamesgilmore8192]

​@@conqueragingordietrying123 That's a reasonable suggestion by Mr Starchild, and you might be able to use it for confirmation and here is the but... it throws away precious information and you shouldn't be doing that here. A better way is to try and account for the underlying correlated changes in diet and see what information that gives. I was thinking exploratory mediation analysis or PCA, and I can run those for you if you like.

[@richardheck3794]

I just recently scored very low on telomere length, but it’s my first test so will be curious to retest in a few months to check for consistency. In my case I think it’s related to chronically low wbc count.

[@conqueragingordietrying123]

Sorry to hear that, @richardheck3794, hopefully the next test is better.

[@timgrigorian6095]

thank you very much for such valuable info!

[@christiancrafoord]

i know this is mostly dietary factors and foods which correlate with longer telomeres, but it would also be pretty cool if u incorporated some supps like astragalus(notorious for telomere lenghtening) into the mix and see if something happens!

[@conqueragingordietrying123]

Hey @christiancrafoord, I prefer to go after foods first, to strengthen the foundation before adding supplements. Then, if all else fails, including supplements. For example, that's been the approach with homocysteine, as I've recently supplemented with serine + B6, folate, methyl12, and TMG (for prior experiments), because it's been resistant to dietary change.

[@davidgifford8112]

Mike, In a previous test report increasing flax seed intake appeared to be positively correlated with telomere length. Has that signal disappeared?

[@conqueragingordietrying123]

Hey David, it hasn't disappeared, but after adjusting for calorie intake, only Parmesan cheese is significant.

[@DBMMMMM]

Excellent job!

[@erwinrogers9470]

Great information👍

[@MixtrisUFOimages]

great stuff looking forward to your results.

[@maxborn7400]

Even though the p-value for Zn is pretty high so not trying to make a conclusion with that correlation, it is crazy that it has such a high negative correlation with Telomere length. When there are studies like these (cannot link on youtube, but "Potential effect of dietary zinc intake on telomere length: A cross-sectional study of US adults") that say Zn is beneficial for maintaining telomere length.

[@conqueragingordietrying123]

*In other people. We shouldn't rely on that without testing ourselves, that's a major focus of the channel Zn isn't significant after adjusting for calorie intake, so I wouldn't place much focus on it

[@MaxwellPietsch]

Wonder if longer fasting periods would be correlated, too, since maybe the lower calories are causing you to fast for longer.

[@conqueragingordietrying123]

They could be, but I'd have to lengthen the eating window to find out, as I don't have any data with a relatively long window...

[@monnoo8221]

Your work becomes more and more invaluable !! Thank you very much! It also opens the avenue for a different type of investigations, so to flipped orthogonally by 90 degrees.... the table at @6.00 shows that carotene has a strong negative influence on telomere length. Yet, in a recent video you showed that the beta carotene titer in plasma is highly associated with a decreased ACM risk. Same is for mushrooms..i do not remember the context, but the influence of mushrooms was not positive, but for telomere length it is positive. From that i have 2 questions: 1. Why do you start to correct for calorie intake when judging about micro nutrients, and not the other way round? IMHO, if you do the opposite, correct for B1, for instance, and then check the correlation of calories to telomere length, that has to confirm the other direction. You can also conclude which correction to apply as a primary one. 2. You have a lot of data for foods and micro nutrients across different metabolic contexts. You can flip the analysis again orthogonally, to the other direction, and ask about the grand total of influences of a particular food... eg, b-carotene reduces telomere length, but has a positive effect on 5 other important markers. And even more, what happens regarding those influences when you change the amount. Such an analysis would be very very interesting

[@conqueragingordietrying123]

These are correlations, I can't infer causation (yet). I recalculate the correlations after each test, so something can be significant early in the analysis and not be significant many tests later.

[@monnoo8221]

@@conqueragingordietrying123 Of course, i am aware of that. My questions were targeting sth different. for any argument involving causation one needs the differential: which changes occurred over time related to which change in the influencing variables. Kind of multivariate time series. Hence my questions.

[@jamesgilmore8192]

@@monnoo8221 Q1 is a fair question, and I think that comes down to what information Mike is using to make adjustments. Since he has access to foods, macros, micros to make decisions from, it would seem nothing is primary. I would then compute all models and adjust for each variable and put it in a matrix, a la correlation matrix style. If only say macros were being used to make decisions, then micros would be secondary and that would change the analysis approach.

[@peanutnutter1]

Really good work! It would have been great to see all of the adjusted p-values in your charts.

[@conqueragingordietrying123]

Thanks @peanutnutter1, I can do that for the next update...

[@peanutnutter1]

​@@conqueragingordietrying123 awesome!

[@user-yl7et3wi3g]

Very interesting. I would have thought high parmesan intake may be correlated with longer telemores rather than shorter as aged cheese has high spermidine content and spermidine has been associated with longer telomeres before. But maybe some negative effects (possibly saturated fat?) would outweigh this

[@conqueragingordietrying123]

I get a lot more spermidine from mushrooms (~190g/d), so I'm not sure that's what's driving the parmesan correlation. It could be SFA, as full-fat dairy (yogurt and cheese) have historically been correlated with more biomarkers going in the wrong direction than right (unfortunately for me!).

[@jamesgilmore8192]

A few more data points needed before p values become really useful. Another way to account for calories would be to adjust foods for their caloric density. Also writing out the linear model coefficients and standard error and would give another way to rank potential contributors without using p values.

[@conqueragingordietrying123]

Gotcha, thanks James

[@nootri]

What would happen if we'd adjust for molar mass instead of calories?

[@diamond_s]

Pistachios would be an interesting food to look at. They have good compounds including a tiny bit of melatonin.

[@conqueragingordietrying123]

I looked at correlations for pistachio intake, but they're not significantly correlated after adjusting for calorie intake.

[@diamond_s]

@@conqueragingordietrying123 Interesting one would have thought there was a good chance it'd be correlated. Cacao wasn't either, which is surprising as I've heard cacao is linked with improved stem cell function. Other potential superfood that comes to mind would be extra virgin olive oil.

[@barasra8847]

Looks like you are in good numbers! May be CR effect by free radical clean up and autophagy on telomere length? Is there any research study on CR and telomere length?

[@conqueragingordietrying123]

I haven't looked into it, but I'd bet that's a part of the CR-telomere length story, in my case.

[@jamesgilmore8192]

@@conqueragingordietrying123 The literature on TL and CR is mixed. In males, maybe there is an inverse association, but not in all trials. Similar story for micronutrients, e.g. Impact of Nutrition on Telomere Health: Systematic Review of Observational Cohort Studies and Randomized Clinical Trials Gaile 2020.

[@maestroharmony343]

I made 2 tests with Trudiagnostic this year. One was 7 kB and another one in a few months was 6 kB. I don't think these tests can be trusted. I live a more or less healthy livestyle. How do they claim I aged 43 years in 5 months? Their error margin is too large for your statistical computations.

[@conqueragingordietrying123]

My data in not inconsistent like that, but I'm detailed and consistent in terms of diet, supplements, etc. I wouldn't take the age prediction seriously, more important is avoiding an age-related decrease.

[@kaoulkae]

Hello Michael, I am searching your food list. Where can I find this list ? I am pretty sure you showed what you eat in several vidéos but I scrolled and watch several of them and can't find where is the list of foods.

[@conqueragingordietrying123]

Hi @kaoulkae, average daily diet composition (in-between tests) is posted in the tracking biological age playlists. Daily diet data is posted on Patreon.

[@kaoulkae]

Thank you for you answer@@conqueragingordietrying123

[@sebastianserrano3696]

Have you considered taking a supplement like TA-65? Would be great to know if it’s worth it

[@conqueragingordietrying123]

Possibly-first I want to follow correlations in my own data, so that's further down the line

[@MaxwellPietsch]

There's been research where meditation has caused increased telomere length. Not sure if you have such a strong interest in longer telomeres that youd want to spend the time meditating, but its an option if you are.

[@conqueragingordietrying123]

Hey Max, unfortunately, I don't have the time or attention span to meditate-I just end up falling asleep...

[@MaxwellPietsch]

@@conqueragingordietrying123 Walking meditation, where you just pay attention to your feet as you slowly walk, might be a good fit then.

[@KoiRun50]

How do you take your mushrooms and what type? Thanks.

[@conqueragingordietrying123]

Hey @KoiRun50, white button, and boiled up to ~15 minutes with other foods

[@vedransimic86]

@@conqueragingordietrying123 Just white button? That's great news as they are far more affordable compared to other species! Have you only eaten those or did you find out that just white button had the best correlations?

[@julianmeehan2781]

Have you looked at correlations for caffeine Intake from green tea and cacao?

[@conqueragingordietrying123]

I haven't-green tea is a contast (20oz/d), so examining its correlation wouldn't generate any meaningul data. Cacao, has caffeine, but it's not significant;y associated, after accounting for calorie intake.

[@jimking6484]

Enjoy your channel. Bought your merch, question regarding your calorie intake compared to your weight and BMR and also activity level/Exercise calorie burn. Keep up the work #KickAss100YrOld

[@conqueragingordietrying123]

Hi Jim and thanks. I don't pay much attention to BMR-a better method (imo) is measuring bodyweight for a long time in conjunction with tracking daily calorie intake, to see how may calories are needed for body weight maintenance.

[@jimking6484]

@@conqueragingordietrying123 thank you for the response. My interest is intrigued with respect to this experiment. I’m not concerned with your BMR or weight specifically just that if you weigh 140 lbs and your BMR is 1250 according to Cronometer with your exercise burn an additional 1000 then the avg CR daily of 200 maybe more significant if your CR either keeps you at your daily required calorie intake, or under. I find this topic fascinating because of both the specific foods as well as the degree of CR that you used. I use Cronometer daily to make certain I hit the micro nutrients and this Telemere study is a great way to demonstrate the effectiveness of specific line items. I was just curious what the 200 CR avg compared to your BMR. Would 400 be even more beneficial or too much to get a manageable difference. Also what in the Parmesan cheese made the difference, an amino acid in the dairy or enzymatic composition. Thank you for your work and dedication.

[@MsElaine122]

I'm not a statistician, just N=1 opinion. I ask this question; arent' the P values so small they are most likely just noise? IE attempts to coorelate to dietary micro nutrients is a folly? Just wondering. I have no insights into the sensitivity analysis for telomere length changes vs time AND vs diet. If telomere can change in minutes to days then maybe there might be something here. Guessing; telomeres have a long lag time and general association to micro's (my guessing) to be corrected anyone with more knowledge. Thanks so much for this channel and your time spent reporting infos! tnx

[@conqueragingordietrying123]

While that's possible, the only way to know is to do the experiment-i.e. reducing Parmesan cheese for the next test. I've used a correlation-focused approach that I've used for every biomarker on the channel, and my blood test data is mostly youthful. If anyone has a better approach, I'm all ears.

[@jamesgilmore8192]

Have you computed correlations with telomere length and the other biomarkers?

[@conqueragingordietrying123]

I did, and only 2 biomarkers are significant at p

[@nootri]

@@conqueragingordietrying123 Thanks for sharing!

[@jamesgilmore8192]

​@@conqueragingordietrying123 The uric acid is an interesting one because there solid evidence from the literature there is a negative association in large studies. There is even a mendelian randomisation "Associations between serum urate and telomere length and inflammation markers: Evidence from UK Biobank cohort". iollo has some of the upstream metabolites to uric acid and you might be able to investigate those as well.

[@InquilineKea]

Ugh I eat so many MUFAs. Aren't all nutrients somewhat correlated with calorie intake?

[@conqueragingordietrying123]

It's all about the data Alex, so MUFAs may be ok in your case. Testing (which you already do) is the only way to know one's best diet!

[@startingtoday4663]

QUESTION. do telomeres from the various organs " age" at the same rate?

[@conqueragingordietrying123]

At worst, I can try to optimize WBC telomere length, but does that reflect what happens in tissues? That's a great question, I'm not sure.

[@startingtoday4663]

@@conqueragingordietrying123 --thank you for your reply

[@nootri]

I for one find this fascinating, but if I may, I find I'm hard pressed to not criticize your adjusting the data for several reasons. Could you give that some more thought and maybe find an alternative? Looking at the unadjusted data, I can "rationalize" means as to why the correlations (in the first column) seem reasonable as they are and maybe I'm not alone with the biases contributing towards that. That would be reasons no. 1. Beyond that, fructose is a particularly problematic substrate for cellular energy, as with it you'd consume ATP to make ATP, it being known to create a dip in the activity of mitochondria, in some special cases contributing to cell injury. I don't see how we can slap an "X calories" label on fructose being metabolized, the caloric model being deficient in of itself. We've come a long way since the 1800s. Both B1 and selenium are in the mg and mcg ranges pertaining to daily intake and I'm not sure how these minute variations in foods ought be traceable and not smudge the data, especially since B1 ought be made by gut bacteria as well, and brazil nuts are know to vary wildly in their contents. If that's not an issue though, an adjustment factor might hold too much leverage over a few specks of substance? These are important cofactors and not only, and I really can't wrap my head around how anything pertaining to "bomb calorimetric" calculations apply, as one is just replenishing whatever was consumed or excreted and neither B1, nor selenium would amount to anything "calorically" even if they were to turn to about 5 ATP.s per mg each anyway. Also, I don't know the background for why Parmesan was chosen, but looking into this, it's menaquinone content is practically 0 and therefore is unlike most other cheeses. Loading up on calcium without the K2 to stack it away might be the issue here, but I really don't know. Appreciate your feedback! PS, I think I'm gonna start using black pepper with my steaks... 😅

[@conqueragingordietrying123]

Unadjusted correlations are a good starting point, but if their significance goes away when adjusting for calorie intake, then was it the nutrient, or calorie intake? Adjusting models for potential confounders is an important way to try to get to the truth, but the best way to to test each individual nutrient or food. That will take a lot more tests, but that's the goal!

[@nootri]

@@conqueragingordietrying123 "when adjusting for calorie intake" how much calories does thiamine have in your view?

[@jp7357]

Having a huge problem with equating Parmesan with longevity … it’s simply too stinky. What is the mechanism for calorie restriction increasing average telomere length ? New tel9meres being created at a faster rate ? Existing telomeres being lengthened ? I’d love to know the timeframe for CR and average telomere lengthening? 60 days ? I think I might just go against my principles and get the trudiagnistic Micmac pack p, starve myself for 60 days and see what happens … what was your levels of calories ? Ah .. ok 2100 .. I consume 1900 daily … not sure I can do 60 days at 1500 .. my RMR is 1520 …

[@conqueragingordietrying123]

I'm not equating eating Parmesan with longevity, this is what the data shows, and following correlations with diet has (to this point) led to my mostly youthful biomarker profile. The model is adjusted for calorie intake.

[@Earwaxfire909]

Does time restriction of eating play a role?

[@DBMMMMM]

I was exact about to ask the same. Teleomere length vs. OMAD?-time window

[@conqueragingordietrying123]

I aim for a relatively short eating window (< 8hr) every day, which is consistent, so I can't say if that's a factor or not, as I din't track telomere length when the window was window was much wider.

[@erwinrogers9470]

Love it🔥👏

[@conqueragingordietrying123]

Thanks @erwinrogers9470!

[@erwinrogers9470]

@@conqueragingordietrying123 Absolutely

[@ChessMasterNate]

I removed Parmesan Cheese from my diet 5 years ago, well, rare occasional use (and early on I did not realize Parmesan was in some things, like Alfredo sauce, which I probably should have been avoiding on other grounds). I removed Parmesan Cheese because it is absolutely loaded with Advanced Glycation End-products (AGEs). These, in my opinion, are largely what makes "processed foods" unhealthful. Though trans fat (which is supposed to be banned), palm oil, and some artificial colors, are clearly bad as well. Preservatives I am not that concerned about, though, I eat very few factory foods. In theory, if your kidneys are healthy and intake of AGEs is not too high, the kidneys can remove it, after only modest damage, however, one the kidneys can't remove: glucosepane. Glucosepane is a big actor in aging, especially in poor health in old age. AGEs are also made in the body. Some supplements can help prevent their formation, like benfotiamine, which is a form of B1. I have been eating well (low AGEs diet, anti-lead diet, and high carotenoid because of methylation correlations, that means--a lot of butternut squash, collard greens, and kale, because carrots and yams have lead), but I was eating too much, and doing only very modest exercise. I have turned that around, cutting my portion sizes, and if I get hungry past lunch (I try to avoid dinner), I just microwave and eat a bag of frozen vegetables. And I have started brisk walking 40+ minutes a day. Adding in the weight loss and the exercise (and I recently started a statin), my labs have cleaned up. Those were the missing pieces. Aging.AI 3.0 now says 27.0 years. In 2 months I will be 55. And, I really am not that healthy yet. I have only been exercising for nearing 3 months, and my fitness is still pathetic. I used to be much more muscular and actually competitive rowing. But that was 2 decades ago. Additionally, I noticed exercise has made my kidneys have to do more work, and as a result, I got lower, but still good GFR. It was 111.63 and fell to 95.62. It is almost certainly the exercise because serum Creatinine was 0.88, but urine Creatinine was 243.54 (anything over 166 is considered high. So, I am making a huge amount of Creatinine, which so far, the kidneys appear to be handling. According to my body composition scale, I have 160 lb of muscle. So, actually using it, or at least the lower body, is forcing my kidneys to do a lot more work. Before the exercise, serum Creatinine was .77 That was the only area that got worse other than some minerals like calcium and potassium, that are easy to address. I probably should drink more water, too, to make it a little easier on the kidneys, because I need to exercise every day to reach my goals.

[@conqueragingordietrying123]

I buy the Parmesan bricks, then grind it myself-I'm not eating the heavily processed version that is commercially available, but I get your point. I like the taste, it adds flavor, but in the name of health, I'll happily cut it to see if it moves the needle.

[@ChessMasterNate]

@@conqueragingordietrying123 AGEs are created 5 ways: 1. Already in the raw food. Most foods have a little. A few have quite a bit, pine nuts are an example. 2. High temperature cooking. By that, I mean the food itself getting much hotter than boiling water. 3. High speed or intense blending. Butter, margarine, mayonnaise, cream cheese, peanut butter... 4. FERMENTATION, especially a lot of fermentation. Mozerella, cottage, string, and ricotta are fine, as there is virtually no fermentation. Yogurt is fine, if it is not highly blended, and is actually yogurt, and not an imposter. The so-called hard cheeses which sadly includes my weakness Cheddar, and yours, apparently Parmesan, are high in AGEs. 5. Formed In the body. I don't know how that happens exactly, but higher blood sugar makes it worse. But there are a number of supplements and drugs that can reduce its formation. Diabetics should probably be taking some of those. We have to think about "processing" independent of modern factories, colorful boxes, and shaped meats. Churning butter is processing. Making cheese is processing. Roasting, grilling, pan frying, deep-frying, smoking, BBQing, broiling are all "processing." The Maillard browning reaction creates AGEs. I think this is mostly the reason meats have a strong association with poor health results, people tend to cook meats these ways in our society. But I think preparing meat in stews, chili, soups, and such where water prevents the meat and fats from getting very hot results in foods that are far more healthy. Even boiling is "processing," but it produces far less AGEs. We have to process, or we will get parasites, food poisoning, and wear down our teeth. Boiling and steaming are the best options. In theory, some processed meats may be much worse than others. Sausage, that is made with large pieces, might be fine if later boiled. Meats where it has been completely blended, such as in hot dogs, peperoni, baloney, Vienna sausage, and such, is clearly terrible. I still don't buy that more lumpy sausage, just because I can add spices to turkey burger and get the same taste without the grease, which tastes better to me, anyway. But if someone is addicted, there is a lesser evil. Bacon, simply, is the worst food ever tested. It has the most AGEs of anything. It could undermine a week of good eating. I have not cut out Cheddar completely. But if I am going to use it, I use roughly 1/3 and the other 2/3 is mozzarella. And, mozzarella has to have failed by itself in that dish, before I add the 1/3 Cheddar the next time. I still have ground beef burger, lamb burger and turkey burger. I put spices in the burger, and I boil it in 1/8 inch of water in a pan covered with a glass lid, so I can keep an eye on it, and replace boiled off water or remove excess water. I usually throw in mushrooms. And this comes out better than pan fried or grill fried. Another thing you can do to reduce AGEs from your diet is, when you do your peanut butter chocolate cheat, consider using fresh peanuts and just crush them. Add salt or whatever. Commercial peanut butter is roasted nuts, that are then heavily blended. Even the "chunky" is deception. They add the broken bits to the same highly blended peanut butter.

[@ChessMasterNate]

I just realized I was unclear on something, Glucosepane is ALWAYS bad, not just bad in old age. It accumulates in the intercellular matrix, stiffening tissues and contributes to the misery of old age, and degeneration in midlife. This is the main reason to avoid AGEs. There is currently no treatment, no drug, no activity that can remove glucosepane once it is in your body. The ONLY thing you can do about it is minimize its ingestion and creation within your body. Well, I suppose you can pray they come up with something before your health degenerates. But rationally, you can't really be serious about living to 100 and beyond in reasonable health and not take the reduction of Glucosepane deadly seriously. There are other things that accumulate. But it is less clear what can be done about them. This at least is a lever we can pull. And thankfully, they do have a treatment now for one of the troubling things that accumulates, often killing men especially, and is one of the main treason women outnumber men in the +100 year demographic, transthyretin amyloid. They want an arm and a leg, for the drug to remove the crud, but hopefully by the time I need that, it will be off patent, and widely available. That accumulates in the heart, stiffening the heart and leads to making it very tiring to walk or even stand. And because they can't be active, health declines more rapidly. It does not have much visibility, because when you die of that they just file it under heart disease, even though it is not the same thing killing 70-year-olds. One symptom is carpal tunnel syndrome that was not caused by repetitive movement, because it also accumulates there for some reason. The drug is tens of thousands of dollars a year...currently. I guess I went off-topic. Maybe it is useful to someone.

[@azadehkhajeheian9430]

Ok I’m not a scientist but looking at the numbers p-Vaud of Parmesan cheese is lower than yogurt and cacao but how come it is worse for the TL length?

[@conqueragingordietrying123]

Hey @azadehkhajeheian9430, the the value in the "Coefficients" column is negative, which means that a relatively higher parmesan intake is correlated with a shorter TL.

[@jamesgilmore8192]

I think what your saying is the parmesan coefficient of -0.14 is less than yogurt of -0.01 and cacao of -0.03. Thats dictated by how much telomere length is changing, but also the intake of parmesan, yogurt and cacao. parmesan is in the 1g range, yogurt 150g, cacao ~3g. You can see the coefficient of parmesan has to be larger to account for telomere length change because its intake is so much lower than yogurt.

[@azadehkhajeheian9430]

@@conqueragingordietrying123 thank you for your response

[@shiftgood]

Epitalon peptides are supposed to lengthen telomere.

[@jonathonmills3563]

I look forward to your Omic data and your analysis

[@conqueragingordietrying123]

Thanks @jonathonmills3563. Test#4 results are in, crunching the #s and figuring out the story is on the to-do list...

[@Blurns]

If I need to reduce my parmesan intake to extend my life, then a long life isn't worth it.

[@conqueragingordietrying123]

Ha, I hear that. i cut it from 10-11g to 7g yesterday, no loss of taste, so it's ok for now.

[@Schu2505]

Can you provide a few adjusted positive food correlations?

[@conqueragingordietrying123]

Aside from Parmesan cheese, nothing else was significantly associated with telomere length, after adjusting for calorie intake... Maybe after the test + analysis, it will be different, we'll see

[@InsolentVillager]

It's a shame you aren't carnivore because, aside from the salt, piperine, and circumin, you would get plenty of all your micro and macro nutrients in just ruminant meat and liver. All you eat sounds like a hassle full of antinutrients, which kinda defeats your purpose.

[@conqueragingordietrying123]

Most of my biomarker data is youthful, in support of the approach. There are many roads to optimal health-it doesn't have to be my way-but I'd recommend regular biomarker testing on any diet, to see what's good and what's not.

[@LVArturs]

Yeah, if the antinutrients were having any significant effect on the absorption and function of any beneficial compounds, then that would show up on the myriad of tests taken by Dr Lustgarten.

[@InsolentVillager]

@LVArturs there's nothing to say his results wouldn't be improved either. We already have wealthy vegetarians attempting to lengthen telomeres, etc, so he's not treading new ground.

[@JoeKickass324]

So not much matters but calories

[@conqueragingordietrying123]

Aside from the parmesan cheese data, that's what it shows, for now. I re-evaluate correlations after every test, so it may change, we'll see.

[@jamesgilmore8192]

Possibly, it seems something else is going on, because the model with parmesan and calories is still significant for parmesan, but not calories. This technically means the model isn't valid and you should eliminate calories. There is more going on in my opinion.