The 2017 Nobel Prize in Chemistry: Cryo-electron microscopy explained

Jacques Dubochet, Joachim Frank, and Richard Henderson have claimed the 2017 Nobel Prize in Chemistry for their development of cryo-electron microscopy. ↓↓More info and references below↓↓
This year’s winners surprised many people and stirred up the perennial “is this really chemistry?” debate. But the Nobel committee (and the president of the American Chemical Society, Allison Campbell) believes that cryo-EM’s development is firmly entrenched in the central science. Check out our explainer behind the work that’s enabling researchers to image large biomolecules with atomic precision, ushering in a new era of biochemistry.
And there was at least one person whom this pick did not surprise. Shout out to Gurunath Ramanathan, a viewer of C&EN’s Nobel Prediction Webinar who submitted this guess: “Cryoelectron microscopy is changing the way in biology. My bet is on analytical chemistry.” Watch the full webinar here: • ICYMI: Who Will Win th...
And be sure to check out these references for more on cryo-EM.
Cryo-electron microscopy innovators win 2017 Nobel Prize in Chemistry | C&EN
cen.acs.org/articles/95/web/2...
The first herpes capsid at atomic resolution | C&EN
cen.acs.org/articles/95/i27/f...
Uncovering The Spliceosome’s Secrets | C&EN
cen.acs.org/articles/93/i39/U...
New close-up views of the nuclear pore complex | C&EN
cen.acs.org/articles/94/i16/N...
Cryo-electron tomography provides first view of a cell’s nucleus in its natural, undisturbed environment | C&EN
cen.acs.org/articles/94/i9/Cr...
Bold, Probably Incorrect Predictions of the Future of X-ray Diffraction | C&EN
cen.xraycrystals.org/essay-on-...
The Nobel Prize in Chemistry 2017 | Nobelprize.org
www.nobelprize.org/nobel_priz...
Speaking of Chemistry is a production of Chemical & Engineering News (C&EN), the weekly news magazine of the American Chemical Society.
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[@Iquey]

Thank goodness for technology like this. I would not be surprised if it was integral to researching the 2020/2021 coronavirus pandemic and also helping to develop the vaccines, especially the mRNA molecule vaccines to stop the severity of SARS COV 2.

[@georgeholroyd709]

I think i saw that the spike proteins structure was determined by cryo EM.

[@ACSReactions]

Super awesome vid! Very informative.

[@johnrobertjefferson320]

It helps to look at the raw data to appreciate the resolution.

[@namarajasekhar]

Thank you very much for this informative note

[@user-ev9zc8dv3q]

It is nice Nobel prize !!! The benefit of this technique is investigation of real molecules ignoring any crystaliization steps... Nonetheless, H. Rose, M. Haider and K, Urban shoul be also awarded by the Nobel prize for invention of the aberration-corrected TEM. It is obvious that high resolution of Cryo TEM also is caised by this aberration correctors. Here i should note that using Aberration-corrected TEM provides by outstanding structural results in materials science as well...

[@namarajasekhar]

Very informative...thank youu

[@harinipreetha1494]

It's really a great invention its going to give great path in the chemistry as well as bio chemistry

[@InfiniteUniverse88]

Now what needs to be done is create a precise database of the secondary structure. There's no longer any need to approximate. Once the secondary structure is solved, then protein domains can be perfectly calculated. After that, comes the tertiary structure. After that, the quaternary structure. Then all diseases can be cured. TLR is already known to have a LxxN pattern. Where L is leucine and N is asparagine. The book "Cellular and Molecular Immunology" is random, however it will likely be proven that it's not actually random. TLR is also very small, ranging from 20-30 amino acids. For these reasons, TLR and other receptors vital to the immune system will likely be some of the first proteins solved.

[@MisterK9739]

Ever heard of RCSB PDB?

[@harinipreetha1494]

Very useful video

[@chengliangyeh2543]

Super useful video

[@guzforce]

Let's start a racing championship ! Awesome

[@youssoufkikah311]

Thanks but the sound is a bit weak.

[@sabrango]

I love virtual simulation from scratch!

[@heandy3318]

1:48 to 1:52 im like wth?

[@ckrispro4030]

How do. Make a crystalline by shocking

[@MisterK9739]

you don´t need a crystal for cryo-EM, that´s the biggest upside.

[@ErikS-]

So... this technique was used to get the structure of the Ribosome.... ... and the people publishing this structure also received the Nobel Prize. Thats a great deal dont you think?!

[@johnroberts9131]

Haha, you’re not wrong. Crystallography sounds like a really fun job.

[@mohitkulkarni5483]

Nice

[@yifanhu1546]

I think the most amazing work is spliceosome structures in 8 different states, you will find a review here www.nature.com/articles/nrm.2017.86

[@MattDavenportPhD]

Wow! Those are awesome. Thanks for sharing!

[@hemrajmeena4673]

Zika virus & niclear pore looks awesome , and they are the only one i heard...😅😅😅

[@grantreborn]

Beginning of the vid, the dude on the left looks like Brent spiner lol

[@efisgpr]

*MALECULES* 🤔

[@Falaxuper]

Human race is amazing

[@shawnosborne4503]

Totally awsome CGI. I wanna thank you for all the bull come obviously is an obvious major impact on helping to better understand... No.. more then just understand, I feel as if your information is even better without any of those weird images the thing took. Wow, i thought i knew it all. Flat earth,mud flood,dinosaurs not real hence not fuel,no forests on flat earth now electron microscopes arent real either... I mean... i wuv sceince...