The 2017 Nobel Prize in Chemistry: Cryo-electron microscopy explained

[@ACSReactions]

Super awesome vid! Very informative.

[@zachreyhelmberger894]

Would be really nice to see some images in this video. Unable to access the links inthe description.

[@Iquey]

Thank goodness for technology like this. I would not be surprised if it was integral to researching the 2020/2021 coronavirus pandemic and also helping to develop the vaccines, especially the mRNA molecule vaccines to stop the severity of SARS COV 2.

[@georgeholroyd709]

I think i saw that the spike proteins structure was determined by cryo EM.

[@johnrobertjefferson320]

It helps to look at the raw data to appreciate the resolution.

[@InfiniteUniverse88]

Now what needs to be done is create a precise database of the secondary structure. There's no longer any need to approximate. Once the secondary structure is solved, then protein domains can be perfectly calculated. After that, comes the tertiary structure. After that, the quaternary structure. Then all diseases can be cured. TLR is already known to have a LxxN pattern. Where L is leucine and N is asparagine. The book "Cellular and Molecular Immunology" is random, however it will likely be proven that it's not actually random. TLR is also very small, ranging from 20-30 amino acids. For these reasons, TLR and other receptors vital to the immune system will likely be some of the first proteins solved.

[@MisterK9739]

Ever heard of RCSB PDB?

[@ErikS-]

So... this technique was used to get the structure of the Ribosome.... ... and the people publishing this structure also received the Nobel Prize. Thats a great deal dont you think?!

[@johnroberts9131]

Haha, you’re not wrong. Crystallography sounds like a really fun job.

[@harinipreetha1494]

It's really a great invention its going to give great path in the chemistry as well as bio chemistry

[@АлександрПриходько-ъ8г]

It is nice Nobel prize !!! The benefit of this technique is investigation of real molecules ignoring any crystaliization steps... Nonetheless, H. Rose, M. Haider and K, Urban shoul be also awarded by the Nobel prize for invention of the aberration-corrected TEM. It is obvious that high resolution of Cryo TEM also is caised by this aberration correctors. Here i should note that using Aberration-corrected TEM provides by outstanding structural results in materials science as well...

[@namarajasekhar]

Very informative...thank youu

[@namarajasekhar]

Thank you very much for this informative note

[@youssoufkikah311]

Thanks but the sound is a bit weak.

[@heandy3318]

1:48 to 1:52 im like wth?

[@harinipreetha1494]

Very useful video

[@chengliangyeh2543]

Super useful video

[@guzforce]

Let's start a racing championship ! Awesome

[@ckrispro4030]

How do. Make a crystalline by shocking

[@MisterK9739]

you don´t need a crystal for cryo-EM, that´s the biggest upside.

[@sabrango]

I love virtual simulation from scratch!

[@yifanhu1546]

I think the most amazing work is spliceosome structures in 8 different states, you will find a review here www.nature.com/articles/nrm.2017.86

[@MattDavenportPhD]

Wow! Those are awesome. Thanks for sharing!

[@hemrajmeena4673]

Zika virus & niclear pore looks awesome , and they are the only one i heard...😅😅😅

[@mohitkulkarni5483]

Nice

[@efisgpr]

*MALECULES* 🤔

[@grantreborn]

Beginning of the vid, the dude on the left looks like Brent spiner lol

[@Falaxuper]

Human race is amazing

[@shawnosborne4503]

Totally awsome CGI. I wanna thank you for all the bull come obviously is an obvious major impact on helping to better understand... No.. more then just understand, I feel as if your information is even better without any of those weird images the thing took. Wow, i thought i knew it all. Flat earth,mud flood,dinosaurs not real hence not fuel,no forests on flat earth now electron microscopes arent real either... I mean... i wuv sceince...