The Biggest Fraud in Stem Cell History

[@kdbublitz88]

This is why scientific rigor and scrutiny is important. We could have wasted decades of time and research if this wasn't caught, just like what happened with alzheimer research..

[@Dave_of_Mordor]

They manipulated their data because it's the only way they can get the grant to continue their research. This practice is pretty damn common in a capitalist society

[@sweatergod5386]

tf happen with Alzheimer's?

[@Wingzero5555]

Context?

[@NaparoniAndZzs]

Seriously don’t leave us hanging

[@_Chessa_]

I’d love to know what you mean by Alzheimer’s research. Thanks for educating my curiosity lol Updating: it’s easy to search on google actually and now I know a little bit about Amyloids and the shifty research practice we have had since the early 2000’s of plagues of the brain. And how so much funding has gone into it with with little results and in fact has even been found that many photos they used to justify their research into the brain plagues were fabricated. Interesting stuff. I didn’t get it all in here because it’s easy to type into the search bar and just read.

[@beowulf2772]

We were forced to manipulate our results in research in highschool because the teacher wouldn't accept that in our research we found no results after the experiments, we wouldn't have a grade. It shows how deep this goes. Our society focuses on success and big headlines instead of experiments that serve to verify if something is true or not. OMG 5k likes I did not expect that 😵

[@sweatergod5386]

Yeah you fudge data in the lab for a grade lol not for getting paid and getting checked by scientists across the country bruh 😭 😭 😭 why don't u just use chegg and chatgpt to get a Nobel my nihg

[@aleahlrb]

I had flashbacks to my old research classes. I immediately checked out of the whole process after we were told the first time we submitted a "no significant difference" outcome project, and we were told we did it wrong because you're supposed to get "something" and made us redo the whole thing. This was the first year of those classes and I started so excited for the whole thing. I immediately lost interest then and there and did the bare minimum to pass the class.

[@markelder6497]

​@ALRB❤ was it a lab? Because maybe they are trying to train you on how to use the equipment properly/ avoid contamination ect. I did science fair for 8 years when I was in grade school. After your experiment and procedure is approved you should just be able to present it and that's that. But im assuming you're talking about science fair... I haven't even started the video yet but I have a feeling this is about greed, not the scientific community. (Hopefully)

[@aleahlrb]

@@markelder6497 Pretty sure it was a lab class since I remember our teacher once told a different group that they had to be sure that their chosen topic will yield results since they wouldn't want to go through the whole process of renting a univeristy lab/equipment only to get "nothing results."

[@submarooo4319]

This is far more common in all research than one might think, can be quite political in motive

[@oxylepy2]

This stuff always gets me. I understand the cutting edge, strong reputation, difficult to try to replicate lies in science, people can manage to get away with it for years. But... people are going to try to replicate your work, that's part of the whole process. If people can get to your level, they'll try to replicate it, then when they can't you're going to be called in on ethics

[@infiniteloopcounter9444]

Probably the same reason Lance Armstrong did drugs to win, etc. The buzz and feeling of fame in some people may override common sense thinking about the future.

[@GregConquest]

I *think* Ms. Obokata may have taken a shortcut or two that she didn't think was consequential early on in the process, and then she found herself on a slippery slope. Unable to admit she had misbehaved earlier, she just wove a larger and larger web of lies to cover for earlier missteps. At least that is the most innocuous explanation.

[@vangcruz4442]

Imagine this is also required for Chips Technology.....other countries must be able to replicate...😂😂😂

[@rkv88kanyan39]

Dr. Ort-Meyer already accomplished this and more many years ago

[@Dave_of_Mordor]

@@infiniteloopcounter9444 I think it has more to do with scientists trying to get grant money to continue their research. They have to manipulate their data to show positive results otherwise they won't get the money. Isn't science about progressing from failures? You can't treat science like a business and expect things to go smoothly.

[@Rice0Cake]

I work in regenerative research. While I remember the shock of learning about this fraud, the whole thing was caught fairly quickly and not a lot of scientists in the field believed the original publication in the first place. Scientific fraud like this ultimately damages the image, progress, and legitimacy of the field; but the biggest thing for me and for everyone really was Sasai's death. While going through grad school I read many great papers published by him and had profound respect for the scientists at Riken. This was a tragic loss of life and an unnecessary loss of great human potential.

[@8koi245]

japanese backlash is no joke..

[@allisonavery7273]

It doesn’t even sound like he was in the wrong. He was just a mentor, trying to help and push research further I don’t believe based on this video that he was actively engaged in defrauding people.

[@ahmedhussain5515]

hey, i just finished my alvls with the subjects Maths, Chemistry, Physic and Biology. I'm taking a gap year to figure out what i like and what i want to do. Could i please get your email so i can ask you more about your field! Please

[@louzo5175]

​@@allisonavery7273 true :[

[@sirrenn1936]

@@ahmedhussain5515 Seriously, don't ask for emails

[@ginnyjollykidd]

Science is not business. In business one can expect fruitful outcomes. In scientific research, fruitful results are often not possible. Sometimes, research produces null results that eliminate inaccurate hypotheses. These results are as important as positive results, but they are often dismissed as not scientifically or publicly worthy. But we should praise them for what they are: null results. _The_ famous null result changed scientific understanding and is studied by every science student (or if it isn't, it should be): the Michelson-Morley result, that velocity of light does not change from the coming and going of the Earth around the sun.

[@sonarbangla8711]

Einstein's GR was a confirmation of a fruitful null result. Similar confirmation is necessary for stem/stap cells.

[@UniDocs_Mahapushpa_Cyavana]

Everyone should just obsessively publicise everything. Not in a journal, but still.

[@morejoy5188]

Another of the problem are invalid and inhumane animal mutilation /'research '

[@Flash020201]

@@UniDocs_Mahapushpa_Cyavana Only if it is accurate, truthful, and justifiable. Incorrect null results are just as dangerous as incorrect positive results

[@UniDocs_Mahapushpa_Cyavana]

@@Flash020201 Only if you believe them.

[@TVtheTV]

I’m a biology student and if stress induced a change into pluripotent stem cells then we would see them in the sites of injury. If acid exposure does it, then we would see pluripotent stem cells in people with chronic stomach injuries and cancers. At least, that’s my guess. Either way, acid turning cells back into pluripotent stem cells is just a weird hypothesis to begin with.

[@janycebrown4071]

I'm not a biology student, and I know that acid would destroy any cell😂

[@TVtheTV]

@@janycebrown4071 stomach acid bro…

[@kumokundomo9705]

That’s not how it works 😅

[@markozivic5959]

Then what is the cause of chronic diseases, parasite, virus, heavy metals?

[@LEARNING-67]

(BIO)ELECTRICITY, has been known for inducing healing in injuries! They shouldve focused more on the bioelectricity part rather than just solely on chemistry!

[@spacecate]

I watched this unfold in real time when I was in Japan! I was a middleschooler back then, I didn't understood fully what was going down, but this was all over the news and my science teacher talked about this in class. It's nice to see a video breaking down things coherently like this!

[@artemisia457]

In my masters theorem my professors guided me in entirely different direction than my research was pointing. My teachers at school hated it when i questioned some of the things we learned even though i presented proof. We werent allowed to criticize books we had to read. This is a problem of entire system that we're supposed to manipulate our findings and opinions to fit one theory or another

[@essennagerry]

I got a lower grade even for disagreeing on what we were taught about Hamlet in an interpretative essay even though I demonstrated that I knew and understood what we were taught and had layed my arguments for the statements I was making in my essay. It was the only time I did that because we were always given titles for our essays and this was the only time the title technically allowed it. Honestly maybe it's an overall societal thing and not just a problem in education. I think people raise their kids this way too. I got treated like I was doing things "the wrong way" a lot from adults and peers alike and it really wasn't the wrong way, there was no right or wrong way for those things.

[@lifeline_]

I work in IT, a bit different, but this is a field you usually would associate with communication skills. The problem is that you either work in the field and get paid well because you are a top programmer or because you made strong connections through strong communication skills. This is similar to how I see other STEM fields.

[@haleyw5677]

academia is so results focused that a lot of young talented scientists feel more pressure to get specific results than to figure out the truth. science takes both skill and luck, and we need to be doing more to recognize skill in emerging scientists regardless of their luck

[@hautakleightontam771]

From the Wikipedia article on Obokata: *In a note to Vacanti, Sasai wrote that Obokata had discovered "a magic spell" that led to their experimental success, described later in The Guardian as "a surprisingly simple way of turning ordinary body cells…into something very much like embryonic stem cells" by soaking them in "a weak bath of citric acid."* The moment you hear words like 'magic' and 'miraculous' in science, start sniffing! If magic is the product of mystery, a replicable process cannot stay mysterious nor magical.

[@burntgyoza]

I'm so thankful for my teacher. She told the students to make a presentation about something she choose. I decided to make a dramatic presentation about why I hate to talk about that topic. She gave me straight A. I didnt have to pretend that I like the topic or doing useless research to impress anyone. I hope many teachers are like that. Sometimes it's not about the result.

[@NickolaiPetrovitch]

What kind of science teacher would ever give a good grade to a student for not actually writing a scientific paper. What an awful teacher.

[@marianojunioralcondoregosa9067]

​@@NickolaiPetrovitch its a presentation though, not a scientific paper assignment

[@NickolaiPetrovitch]

@@marianojunioralcondoregosa9067 what kind of science teacher would let a kid say “I don’t want to do this,” and just… say “okay.” That’s legit one of the most asinine things I’ve ever heard. Why would you reward that Behaviour. “I don’t want to do this because I don’t like this subject in school.” “No problem!” what kind of school is this

[@burntgyoza]

@@NickolaiPetrovitch Not about rewarding a "i dont wanna do this" behaviour. Its about how I manage to explain logically why I think it was unecessary for me to do that. And it's about a teacher who also willing to learn from the student that not every assignment is "up to date" to the next generation. Just because I say "dramatic" doesnt mean I didnt explain it logically or only speaking gibberish and screaming nonsense.

[@Problemsolver434]

​​@@NickolaiPetrovitchrom the story, she asked for a presentation, the student gave one. It didn't have to be positive, just well thought out. I think that is something that should be rewarded . That is, if the story is true

[@do3807]

4:25 "They heckled him" Bro imagine getting roasted by PhD holders, while you're presenting your ideas and dreams 😭😭

[@thevillainousqueenofhearts4976]

I would probably feel hurt and might even want to cry

[@OGAngie]

Sure, but also imagine walking into a room of scientists and presenting utter nonsense and being too delusional to stop and admit that smacking cells or putting them in acid wouldn't magically make them do the same thing as an extremely complicated biological process...

[@GabrielleduVent]

That's basically every academic conference ever. You either develop a thick skin in this industry or you leave.

[@myme8208]

That's normal. Because scientists would always question delusion from reality and ground you. It's not bad. It pushes you to do better and prove you actually can do it but it takes alot of years and studying.

[@justcommenting4981]

​@@OGAngie I can imagine why he might have thought that based on healing after injury. It seems like you could dispose of that idea pretty quickly though. Also certainly wouldn't use mouse cells to start.

[@victorkmlee]

A good research is a well conceived, prepared, constructed and run research that produce accurate consistent results, which can be negative or positive. Too much emphasis on publication and grants are based on 'positive results'. The temptation to commit fraud is strong because the stakes (losing grants, promotion and tenure) are just too high. There is also a temptation to push for many publications.

[@jasperism27]

Calling it the biggest stem cell fraud is a bit too much - the South Korean incident involved big US government funding (bypassing Bush's restrictions), became a household national icon, and had involvement with officials in the highest echelons of South Korea's government.

[@rosaolivares7888]

A fellow BobbiBroccoli enjoyer?

[@javierherrera125]

I just watched both his new videos lol

[@indian_doc]

Just got here from bobbybroccoli as well

[@Ovijit001]

@@rosaolivares7888 yea

[@potato-gx8cw]

we all watched his vid huh

[@lifeline_]

I work in IT, and Ive found this: You either stick in the field and get paid well from being a top programmer/architech/etc or you have really strong communication skills, are average at programming (at best), and made good connections. Communication skills are important, but they can also lead to someone in a position that they don't have the skills to be in. This is how I expect a lot of STEM fields work.

[@patternwhisperer4048]

Imagine we held politicians or even economic leaders half as accountable for misconduct as we do with scientists

[@XX-bn9sf]

How did they think they would get away with that? It must have been clear to them that it was only a matter of time till the truth would come out.

[@estusshart6470]

It's cool that youtube recommended me this, one of my favorite youtubers uploaded a two part series about a stem cell cloning fraud, except this one was in korea. Feels like a cool way to complete the series!!

[@JeanPaulBeaubier]

Even as a layperson I can't comprehend how stressing a cell by bathing it in acid would ever turn it into a stem cell rather than just killing it.

[@maryannwilliams8506]

This makes me feel terribly sad for those like one of my Son-in-laws who need stem cells to help regain normal sight. I remember hearing about how they could take cells from your own body, create stem-cells from it than inject it into a diseased or failing organ and it would start producing healthy cells and that organ would become like new. All the wishful thinking, hopes & dreams cannot make a truth from a lie. The lie is a dead end with no where to go. A truth has unlimited possibilities and bring hope into the failing hearts of those who are getting tired enough to give up. Hope is eternal because the Spirit within each of us is who we truly are and is eternal. Whether in this world or the world to come, hope gives us life eternal and brings us all back to our begining. It is the end of sadness and the continuation of Love, Light & Truth Eternal where Time & Space become one & the same!!! Hope to see you there!!😇

[@cronostvg]

We in general do not view failure as necessary step for success. Likely because customer only pay for success.

[@ch.4904]

This story is kinda like a meme in Japan. I never heard anyone else talk about it so thanks for bringing this up!

[@militantpacifist4087]

Same 😂

[@sergiovr3]

let me guess, she cried at some point in interviews

[@msunje9862]

@@sergiovr3why would she cry ?

[@Molist]

I've just discovered your channel today, thanks so much for your videos :) I did my PhD in biochemistry and I can absolutely relate to the extreme anxiety related to results, etc.- not justifying what they did, though, but I am not surprised. Especially in societies as competitive as Japan and the US.

[@ІринаПанасюк-я4у]

What was your thesis about?

[@souvikmitra4357]

Once our ELISA results were shown negative despite the sample being positive, but our professor told us to interpret what actually happened and we just predicted the possible troubleshooting that lead to the false negative results.

[@fareastmanside5f4in]

If Obokata fabricated papers why did she blame the other researcher? Its a good example of how assumptions lead to catastrophic failure.

[@Globalscanningeyes]

Its rather strange that a lot of medical research fraud seemed to be coming out of Japan then again saw a video on such cases already.

[@hyperion8382]

What's the video title?

[@ryanwillingham]

if you're talking about the bobbybroccoli video, that's south korea. very different

[@Globalscanningeyes]

@@ryanwillingham take a look👆

[@boaaintnowayboa3002]

it’s coming from everywhere unfortunately, a global race for recognition in scientific breakthroughs

[@militantpacifist4087]

“Never let yourself be diverted, either by what you wish to believe, or what you think could have beneficent social effects if it were believed; but look only and solely at what are the facts.”- Bertrand Russell

[@benmcreynolds8581]

I find stem cell science as some of the most facinating cutting edge science in all of humanity. If we can advance this field of science, who knows what might be possible to us in the future? (Have scientists researched how octopus handle physical trauma? Since they have shown to grow back fully usable tentacles after they have been bitten off? Their Tentacles are such complex structures. If we could figure out how they go about that process, then maybe we could figure out even a slight possibility of how to fix Normal human injuries? Idk? Just a thought 💭

[@tedchapple5991]

Google Dr. Michael Levin.

[@Moncrom]

Issue with is that the bodies and genetics are so extremely different that you cann't just include octupus genes into a human and it's done.

[@stormer9952]

It's much more complicated than that to make a long story short. Human DNA isn't comparable to most animals DNA except primates and mice (If I'm remembering correctly). Stem cells can be used to regrow tissue like organs and limbs for example, in artificial environments.

[@kumokundomo9705]

Obokata allegedly copied most of her 2011 dissertation from a U.S. National Institutes of Health website on stem cells😅. Someone who is able to easily plagiarize might not care about integrity. It impacts not only herself but those around her and the university/country/ future patients that could benefit from the research 😢

[@benmcreynolds8581]

When u see a company gets to review itself. It reminds me when a 5 yr old is lying, and they get a chance to "analyze" if they are lying? And then the 5 yr old proves they aren't lying 🤥🤡👍🏻😄

[@Find-the-Devil]

Great story on stem cell technology! Can I share a link to my own video about stem cell therapy and tourism in the comment section once it's uploaded this week? I really want to spread awareness about the problem around stem cell tourism.

[@Sciencerely]

Sure, no worries! Links are automatically blocked by YT but I'll try to manually allow your comment!

[@Find-the-Devil]

@@Sciencerely That would be Awesome. Thank you.

[@celestialstar124]

Not sure if you can share the link on comments because yt doesn't allow url. But after this comment and this video i will check your profile and page to see if i can find any video about stem cell

[@Find-the-Devil]

@@celestialstar124 I will upload the video in 2 or 3 days in my channel.

[@celestialstar124]

@@Find-the-Devil really appreciate that 😊

[@giselletdc1871]

My friend's dog died recently, she paid so much money on this stem cell therapy for nothing! It's really sad!

[@MysterySmell]

What?…stem cell therapy on dogs?.. really?

[@indian_doc]

This got recommended right after watching BobbyBroccoli's new video on the South Korean stem cell research fraud. It ended where this video begins - 4 genes inserted making any cell pleuripotent. Felt like a good continuation of the story 😅

[@jamesc5751]

Except this one discusses inducing pluripotency through changes in environmental acidity, this is entirely different from genetic modification.

[@jaydenwilson9522]

should look at abiogenesis.... they love making big sensational claims but offer little in the form of true evidence that life can originate from unconscious particles lol

[@Idontgothatway]

As a research scientist myself, these stories are unbelievable and disgusting. How dare they.

[@Patriarchy_69]

_belieb all wahmen_

[@marcomalo02]

Elizabeth Holmes could make it happen?

[@malakatan3235]

it is often 🙄

[@aoikishi99]

its common isnt, epsc ure result driven in research. Only very few got breakthrought in their papers. Also not many get the funds unless ure making something. I thought as someone who is a research scientist themself would understand the whole situation.

[@Yewtewba]

​@@Patriarchy_69"translate to English" on your comment gives "feel free to watch"

[@tnijoo5109]

Wow!! How crazy. Makes you wonder how much scientific data is manipulated. Excellent video! Thoroughly enjoyed how well told the story was.

[@catmoore2443]

Way more than you can imagine . "Money" writes peer review papers and scientific articles .

[@Itried20takennames]

I don’t think it is super common, as science likes “reproducibility” and will fairly quickly ask to see others get the same results if following the same technique….so especially today, a big chance of being caught. But many cases before, from “Piltdown man” being a clear forgery, to one of the first transplant “breakthroughs” (in fighting rejection) turning out to be faked…with the “transplanted” patches of dark fur on white mice just being ….from a brown magic marker.

[@hectornonayurbusiness2631]

Probably a lot.

[@Jinkypigs]

Dude the video itself tells you a bit about the requirements for peer review in any scientific publication. Unless your's is an obscure field of research that no one else look into ... it is very unlikely that any mistake will go unnoticed, not to mention total scam

[@tnijoo5109]

@@Jinkypigs are you talking to me? Dude? LOL. In the field of psychology there was a major issue about ten years ago maybe with failures to replicate findings. And of course, we’ve all heard about stories of academics basing their entire theses on research that was later found to be falsified. I’m sorry, but I’m not sure what you’re attempting to say. I think it’s well established that data is sometimes manipulated. There’s been plenty of stories similar to this one. What really struck me about this one, though, is that she faked such a huge discovery that she had to assume everyone would try to replicate. That’s the part that stunned me and made me wonder how much data has been manipulated, the type of findings other scientists wouldn’t bother replicating. I’m not sure what point you’re making about the peer review process, either. A study can be peer reviewed without anyone scrutinizing if any aspect of it has been tampered with, falsified, or otherwise manipulated. If you cloud, please clarify what it is you’re saying about the peer review process. Could you try to be more clear about what points you’re trying to make overall? It almost sounds like you’re saying that any “mistakes” would be quickly found and that no one would get away falsifying their findings. That’s not what you’re saying, is it?

[@Eirexeyes]

I remember a good few years ago now, that a French group had a press conference that they had the first cloned human. Nothing was heard of them since.. I wonder what became of this 🤔

[@stormer9952]

Most likely false, I believe the UN or one of those organizations have outlawed human cloning, seeing it as against the laws of nature. Though a sheep was cloned in Scotland named Dolly.

[@h.yadigarece1446]

I advice to check on the biggest fraud in chemistry that occured at Columbia University.... The person is from my major and country, as a scientist in chemistry I feel shamed already...But this shows how much is easy to create fradualent results....😢

[@thedaredevilincognito9581]

I think the big question to be asked is how the hell did the paper passed the review hence it being published?

[@terriplays1726]

Paper reviewers never check against wilful deceit. If they did they would have to reproduce the entire work. They complain if you arrive at conclusions that your experiments did not show, or request certain complimentary experiments to verify claims, but they never assume experimental data might be faked or samples mislabelled. If someone in the team secretly swapped the sample, then a paper might well be accepted. You performed a valid verification of your claims after all.

[@Fr3d0mC0nsum3d]

This is why I absolutely hate when people say “the science is settled” or “don’t question the science”. It was a huge thing over the COVID pandemic. Even some pubs in huge journals can have fabricated data. Always question science, and the best data will survive the questioning.

[@danielh.8602]

To an extent, the thing is, the argument you're espousing is often used by people who know nothing about science who try to question it with baseless claims and hypothetical scenarios ("what if everything is fabricated!!!???!!!") instead of legitimate questions. So yes, for the average person questioning science is going to be a fruitless endeavor and can even be damaging, it can be like giving a blind person a shotgun. That's why the REAL questioning is done by other scientists in the same field, like in this video.

[@souvikmitra6161]

It's so stupid to say "don't question the science" when, in the first place, we have advanced this far by the scientists over the centuries... questioning science!

[@raulthepig5821]

Don't look up.

[@-TheUnkownUser]

The problem with that is that it leaves the door open to bad criticism. And no, what I say can’t be refuted by saying that the bad criticism is rare or non-important…

[@MlewIs-qr5ot]

"I AM the Science"----Anthony Fauci

[@PersimmonHurmo]

The reward system in society is wired the wrong way around.

[@Wokskdiskjss]

:OO lain?

[@snowimayko659]

I can imagine they are just taken advantage of or gained in the wrong wayc but still wired right

[@Gatinois]

That ending with the funny and happy music was so brutal.

[@Trihalo42]

Read "The Body Electric" by Robert Becker MD and Gary Selden. Starts off with research on why some amphibians and reptiles can regenerate lost limbs, not just a tail but a full limb, touches on old Soviet research showing that when a plant is clipped there is a change in electric charge at the point where it starts growing back, further research showed a change in the electric charge on stumps of newts capable of regeneration, different manipulations including surgically rerouting a nerve that caused the new limb to grow in the wrong place showing that the nerves were the source of the electric charge leading to limb regeneration, and talks about cells reverting to a simpler state that then develop into more specialized cells being triggered by electric charge. And THAT is where the Japanese research went sideways. It wasn't the acid itself. It was a tiny electric charge formed from the reactions with the acid. Chemistry is all about the movement of electrons, and unsurprisingly to me, so is medicine. Problem is, the Big Pharma owned medical establishment doesn't want to acknowledge this legitimate repeatable scientific research on electric charge because it would cut deeply into profits.

[@ProfessionalBirdWatcher]

We need more scrutiny to find deep issues like this to make holistic solutions that address the symptoms and root cause

[@younghan3573]

According to Huberman, most Doctors who do their own research, tend to alter their results to fit their hypothesis

[@hodolski]

Obokata was nothing more than a character, like Elizabeth Holmes in the Theranos scandal. While Holmes was a Steve Jobs copycat but more toxic, Obokata claimed herself to be a passionate female scientist, but her appearance in the media was well... nothing scientific and terrible. She, at least her marketing scheme was all about Japan's traditional ideal for obedient woman, a cute anime mascot for the government-funded research. Who in the right mind wears a kitchen apron in the facility? Do we need the "good wife, wise mother" imagery in science?

[@palyddon]

Excellent explanation of the controversies without being overly technical. BTW, I love the Rubik’s cubes in the background: Just goes to show that the 4x4x4 is worlds harder than the original!

[@lindyloohoo]

If i remember correctly, you can grow stem cells but it is a long, hard process with a massive failure rate. I effing love biology, especially micro. I cant remember completely how the process goes tho

[@Vault1337]

"But what if you don't get your big breakthough?" 15:07 That's why I chose the engineering path. It's possible that you are just unlucky and never make a great discovery. That's depressing AF.

[@fluffypuff766]

Weird how in the same year, there was a 'breakthrough' for Alzheimer's research, and that one lasted over a decade.

[@o0Hidden0o]

I gonna be honest, there is little surprise here, I’ve 100% penciled in completely fabricated results for a grade. Put money on the line and it’s a wrap. The difference is whether or not you’re willing to bet some else’s life on lies. For some the money is worth it the gamble.

[@marcelo55869]

Please do a video on cell eletricity via ion pumps. There is a paper on regeneration based on it from Michael Levin . I wish to know if it is true or not.

[@anthonyjh02]

If you’re planning to power leds the size of atoms it looks promising

[@marcelo55869]

@@anthonyjh02 No, the paper is about bioelectricity and it's use by the cells as a kind of "communication protocol" using ions pumps of the cells. This was the guy that regenerated a frog's leg some time ago. Frogs don't usually regenerate, but he was able to trigger the regeneration using some drugs that induced electric potentials following certain patterns recognized by the cells. It was like a message about what part of the body they were and what to do. It seems very interesting but still did not explode enough in the news...

[@Find-the-Devil]

@@marcelo55869 Hey. I would like to make a video about this topic Just send me the link of this article.

[@marcelo55869]

@@Find-the-Devil there is an introduction here: kzbin.info/www/bejne/jpnIcoCoiJ2EZ8U

[@marcelo55869]

Another one with more details : kzbin.info/www/bejne/d3SVkIZjrMh9m9U

[@chrislaezur730]

I know about this, actually. This woman…has run from her responsibility and in effect shamed the many, many people she shared her field with, not to mention the intelligent gentleman that took his own life after being viciously criticized due to her actions. I am curious to know if there is anything redeeming about her. I will return to see if there is any such data later.

[@stevemartin4249]

Applied linguist and former undergrad bio lab director here (Temple University Japan). Good, summary and timely. A year or two ago, I read Robert Friedman's "The Politics of Excellence: Behind the Nobel Prize in Science", and just bought the book "The Death of Science", by Doddard and Galgleish. Minor point, the company "Rikin"s name with the "i" as in "hit".

[@panostriantaphillou766]

The Earmouse is NOT the Onco mouse. The earmouse photo was published in the media because there was no interesting picture for the oncomouse and therefore the two were conflated. It is best to disentangle them for scientific clarity and channel credibility.

[@NicolasMiari]

"Obokata, what are you doing...? Obokata... STAP!"

[@thefoundationagent61]

Like I always say, sensationalism is the most poisonous substance to mix with science. It's a complete embarassment to the practice, which should be the pure pursuit of knowledge.

[@Frank-bg7yd]

Excellent scientists are the ones who are honest. Extraordinary scientists are the ones who are honest and making important discoveries.

[@mikescarlet4261]

RIP Mr Sasai. He believed the wrong people

[@jai_nasu]

Just one thing, the institute - RIKEN - is pronounced "Ree-ken" as it is a short form for "Rikagaku Kenkyujo(理化学研究所)". Great video, enjoyed very much!

[@advchtube8208]

What about South Korea's Hwang Woo Sook?

[@marjhuncantago9476]

they should use different acid. like acidic yet poisonous?

[@mrunderhill3970]

2 problems off the bat - nobel and harvard

[@williambrasky3891]

Came here b/c I was pissed somebody ripped off BobbiBroccoli’s most recent video. Left a new subscriber with a whole new respect for science’s knack for rooting out frauds.

[@pyxylation]

Good to know this is different than his video

[@sanghyunhwang1297]

This is exactly happened with Lesne’s amyloid beta

[@stefunnylim]

I wonder what happened to Vacanti, was he also fired from Harvard?

[@reicarlos975]

i manipulated my research paper too in order to be graduated 😂

[@whiskeyjackedup]

This is a cool story but I don’t think you can remotely call it the biggest fraud in stem cell history, Hwang Woo-suk will forever hold that title.

[@KaiseruSoze]

So how do you motivate a diploid stem cell to divide into haploid cells then into a zygote and prove the identity of a stap = stem cell. I.e., grow a stem/stap cell into a fully functional animal.

[@lesliestandifer]

its amazing the issues humans have with admitting they were wrong and just moving on from it.

[@heliocentric2223]

How did the last person in charge of injecting stap cells into the mouse embryo not know?

[@KeithCooper-Albuquerque]

Great video! Thanks for all you do!

[@jeromebarry1741]

I first learned of pluripotent stem cells from John Mauldin. LifeLine had skin cream product claimed to be made of pluripotent stem cells.

[@stevenbrenner2862]

Unfortunately, sometimes scientists convince themselves of something in error.

[@primarkbargainbin9847]

the effect is still real until today. Images needs to be checked for publication because of this.

[@truth.speaker]

This shatters my trust in modern labs and corporations Think carefully about big claims. Have they been true recently?

[@angryfishy8183]

What he doesn't mention is how the fraud was found within days. Scientific frauds do not go unnoticed for more than a week

[@shubhantpandey4962]

One technical point I would like to make. There is nothing as bringing embryonic gene, rather you should say manipulating the expression of the set of genes that are marker of stem cell ( developmental genes). Its like reversing cell fate (skin cell to stem cell) by genetic reprogramming.

[@Kioki1-x8p]

This teaches us to never take anything at face value, always do independent investigations & research on something that sounds too good to be true.

[@black.sasuke.uchiha]

What exactly is a stem cell? Is it different from a normal cell? And what is its purpose? Sorry, I’m a novice at this subject.

[@obsideonyx7604]

Being educated doesn't make you intelligent. Case in point, this video.

[@mikescarlet4261]

Being educated doesnt make you have moral

[@LAJAP]

Finally, the videos that will demonstrate us all that medical science is not what you think at all!

[@DrSnehaKumar]

Even in college, if our research doesn’t align with some other research/pilot’s findings then the guides ask us to manipulate our results. That isn’t a very great thing, considering some things could be disproved.

[@madprophetus]

It's never the wrong time for skepticism.

[@martinsoos]

Or maybe an assistant wanted revenge. There is more than one way to destroy someone and others in the group would just be collateral damage. Chemists may have superior measuring techniques, but their procedures are lacking.

[@TravellerZasha]

I only have minimum level science so i'm super naive to this but does the concept of STAP cells, specifically converting a cell back into a stem cell (maybe under stress) have potential outside of this fraud?

[@hulahula6182]

Didn't you watch the video, stahp cells don't exist, dipping cells into acid just makes them glow green

[@musthaf9]

I believe so, if true

[@stolenmonkey7477]

4:46 you put MS for Massachusetts rather than MA, MS is Mississippi

[@Gandalf47]

Sounds like the Theranos of stem cell research.

[@deprivalli]

well-timed recommendation right after i watched a video about the south korea stem cell scandal, thank you haha

[@dr0g_Oakblood]

5:46 - well that sets off a number of alarms for me, since I know from my classes that a lot of the stuff involving human tissues and fluids tends to be closer to acidic over neutrality or basic in terms of pH. (There's actually some interplay here from certain infections that prefer basic environments, which during the course of their infection increase the pH of the infected area, and typical basic soaps are less effective on them than say, a mild acid bath from dilute pharmacy-grade ~3% Hydrogen Peroxide) Edit: I completely forgot my end point: that being that if cells really did flip back to being stem cells purely from a mild acid, a number of cells would cease to function in normal human tissue conditions by virtue of flipping to stem* cells, which is clearly not happening......

[@UtaShirokage]

I mean, have they tried soaking cells in goat milk mixed with paprika and soy sauce? No? Thought so.

[@artemirrlazaris7406]

I think this is how I would go at it, this si with no research or study. Certainly, here's a simplified point-by-point explanation of how blood cells form in the bone marrow: Hematopoiesis Start: Hematopoiesis is the process of blood cell formation. Stem Cells: Hematopoietic stem cells (HSCs) are the starting point. They reside in the bone marrow. Differentiation: HSCs differentiate into two main cell lines: Myeloid Line: Forms red blood cells (erythrocytes), white blood cells (granulocytes, monocytes). Lymphoid Line: Forms lymphocytes (a type of white blood cell). Erythropoiesis (Red Blood Cells): Erythropoietin (EPO) hormone stimulates the production of red blood cells. Immature red blood cells (reticulocytes) mature into red blood cells. Red blood cells transport oxygen. Granulopoiesis (White Blood Cells): Granulocyte-colony stimulating factor (G-CSF) and other factors stimulate granulocyte production. Granulocytes include neutrophils, eosinophils, and basophils. Monopoiesis (Monocytes): Monocytes mature from myeloid progenitors. Monocytes eventually become macrophages in tissues. Lymphopoiesis (Lymphocytes): Lymphocytes, including T cells and B cells, develop from lymphoid progenitor cells. Platelet Formation: Platelets (thrombocytes) are formed from megakaryocytes. Megakaryocytes fragment into platelets, which are essential for blood clotting. Release into Bloodstream: Mature blood cells are released from the bone marrow into the bloodstream. Blood Circulation: Blood cells circulate throughout the body, performing various functions, including oxygen transport, immune response, and blood clotting. This process ensures a continuous supply of blood cells to maintain the body's vital functions. // Stem cells that reside in the bone marrow, known as hematopoietic stem cells (HSCs), are not "manufactured" but rather naturally generated and maintained within the body. Hematopoietic stem cells are crucial for the continuous production of blood cells throughout a person's life. Here's an overview of how hematopoietic stem cells are produced and sustained in the body: Embryonic Development: Hematopoietic stem cells are initially formed during embryonic development, particularly in the yolk sac and later in the fetal liver. Migration to Bone Marrow: During fetal development and shortly after birth, some of these stem cells migrate and colonize the bone marrow. The bone marrow becomes the primary residence for adult hematopoietic stem cells. Self-Renewal: Hematopoietic stem cells have the unique ability to self-renew. This means they can divide and give rise to more stem cells while maintaining their own population. Differentiation: Hematopoietic stem cells can also differentiate into various types of blood cells, including red blood cells (erythrocytes), white blood cells (granulocytes, monocytes, lymphocytes), and platelets (thrombocytes). Steady State: Throughout a person's life, hematopoietic stem cells reside in the bone marrow and continuously produce blood cells to replace old, damaged, or dying cells. Regulation by Cytokines and Growth Factors: The production and behavior of hematopoietic stem cells are regulated by various cytokines and growth factors in the bone marrow microenvironment. For example, hormones like erythropoietin (EPO) stimulate the production of red blood cells, while factors like granulocyte-colony stimulating factor (G-CSF) stimulate the production of certain white blood cells. Response to Demand: The bone marrow can adjust its production of specific blood cell types in response to the body's needs. For example, during an infection, the marrow may increase the production of white blood cells to bolster the immune response. Aging and Decline: As a person ages, the efficiency of hematopoiesis may decline, and the composition of the blood cell population may change. In summary, hematopoietic stem cells are naturally generated during embryonic development and later reside in the bone marrow. They possess the remarkable ability to self-renew and differentiate into various blood cell types, ensuring the body's continuous supply of blood cells throughout life. The regulation of stem cell activity in the bone marrow is a complex process involving various factors and signals from the surrounding environment. // Hematopoietic stem cells (HSCs) are created during embryonic development through a process known as hematopoiesis. Hematopoiesis is the formation of blood cells and takes place in several stages during early development. Here's an overview of how hematopoietic stem cells are created in the embryonic state: Yolk Sac Hematopoiesis: In the earliest stages of embryonic development, the yolk sac plays a crucial role in hematopoiesis. The mesodermal cells within the yolk sac differentiate into the first blood cells. These primitive blood cells include erythrocytes (red blood cells), which are essential for transporting oxygen. Aorta-Gonad-Mesonephros (AGM) Region: As development progresses, hematopoiesis transitions to the AGM region, which is situated near the dorsal aorta, gonads, and mesonephros (an embryonic kidney-like structure). In the AGM region, specialized endothelial cells give rise to hematopoietic stem cells (HSCs). This process is often referred to as the endothelial-to-hematopoietic transition. Hematopoietic Stem Cell Emergence: Within the AGM region, certain endothelial cells undergo a transformation, becoming hematopoietic stem cells. These newly formed HSCs have the remarkable ability to self-renew (produce more stem cells) and differentiate into various types of blood cells, including red blood cells, white blood cells, and platelets. Liver and Spleen Hematopoiesis: As development continues, HSCs migrate to other locations in the embryo, such as the fetal liver and spleen. These organs become additional sites for hematopoiesis during the embryonic and fetal stages. Bone Marrow Colonization: After birth, HSCs continue to migrate and eventually colonize the bone marrow, where they reside throughout adulthood. The bone marrow becomes the primary site for hematopoiesis in adults. It's important to note that hematopoietic stem cells are multipotent, meaning they have the ability to differentiate into a range of blood cell types. This flexibility allows them to continuously produce the various blood cells needed to maintain the body's functions. The development of HSCs in the embryonic state is a complex and highly regulated process involving multiple signaling pathways and interactions with surrounding tissues. The ability of HSCs to generate blood cells of different lineages is crucial for supporting the body's immune system, oxygen transport, and blood clotting throughout a person's life. // The criminal market extracts stem cells from youthful fetal state or dead humans from the marrow, value. is around 6 to 8 figures depending on size batch and means. This ishte lawless sect, their idealogoy only proves it... THe myths eh. /// However the intelligence side can look at the mechanisms and mechanical state and nature. To produce synthetic stem cells, which synthetic means in this case alternative way to trick, produce an exact product through simliar means. SO it is possible to take and mimic the roles of these organs with hormonal conversations and movements in a system to stimluate a stem cell production and its renewing abilties. THis also would also an easier telemere change to the body and a new cell system itself. The programign of the stem cell would need to be udenrstood, because its like... two different companies produce a base unit, coudl have some falts in it before it chooses its direciton. This has wide spread applications in medical and industry and nearly all reletive fields of human life. So an embryionic system is one way ot go about it, but oftne we onyl have words to describe what we see. so there is a chemical and biolgoical state of these steps missing.. So a more refined detail view of the birth of stem itself.. and evne the ocmmunciatable systems in the egg and spermoza.. to figure out trigguring langauge, and hten we cna jsut purely grow them from mimicry of communicative bonds at the intercellural level.. and produce as many as we want... this sounds easy, but much like flying.. its dependent on data to fly well... so data first is more important to put forth a process and hten that process may reveal other avenues ot come to the same process easier and so forth until we can produce stem cells simpyl adn hte nits like a common as a nail or something... lol

[@alyssiataylor546]

I don't understand what the plan was. Wouldn't others not get the same results and realize it was fake soon enough anyways? I mean that is what happened, but did they not *realize* it would?

[@wkgurr]

It looks like the "cooler" or "sexier" a scientific hypothesis is the more modest the requirements for what is considered necessary proof become. It should be the other way round. Exceptional claims require exceptional evidence. It's not only scientists who fall for the sexy hypothesis but also journals because they also want to be the first to publish. And for the journals the risk is much smaller than for scientists. A cheating scientist who gets caught usually destroys his or her career whereas a learned journal which publishes humbug gets away with a retraction notice.

[@Sciencerely]

That's definitely true - I'm just preparing a video on scientific publishing and when things got wrong (why people feel that they have to only publish "grounbreaking" stuff) - it's for sure an interesting story!

[@jtmediaholdings7877]

Genetic induction, not genetic insertion, is used in the yamanaka ipsc model.

[@joepeake8972]

This is the natural consequence of science being a business where your career is determined by producing positive results, regardless of whether they're fake. Nobody gets a research grant by disproving something

[@TheAleBecker]

I can't avoid thinking of South Park when hearing of stem cell research hahaha

[@krakoosh1]

Just curious but I was wondering if you had Bell’s palsy before. I’m suffering from it now. I’ve had it for 3 weeks now. I see similarities between your face and mine. I’ve gotten some use of my facial muscles back but still can’t close my eye or smile fully. Sorry if it’s too private and you don’t want to answer.

[@heatherweiss7507]

Theraphi

[@GoldenEDM_2018]

I had before. I was scared as f. Lol. I cant move half of my face, can't smile, wink. Took around a month or more for me to fully recover with therapy. There are tutorials on KZbin for this. Just follow them and do them 3x a day. Also eat vegetables and more meat and eggs to help your nerves regenerate and sleep a complete 8 hours or more a day. You'll get better. Don't worry too much.

[@nothereforit.605]

Wait, so that fat with the ear was fake? I’m confused.

[@rangecutie]

This whole story reminds me of Theranos

[@niranjanr8075]

I was always told in my UG that it is a great feat to get published in Nature, for it is the most influential or something. If that's the objective for a research, then better to leave it or end up with stupid moves like this

[@animangafan342]

Haruko Obokata is the Japanese Elizabeth Holmes