The Dark Science of Chronic inflammation

[@Zeuskazoo]

“I wait for new Dark Science videos the way some people wait for the next Star Wars movie”

[@rafailpanagiotidis6567]

So you don´t wait for them at all cause you know it´s gonna be trash? That can´t be true, dark science videos are awesome!

[@Felis.silvestris27]

Same tbh

[@FREAKCROW]

Rude

[@friedrichjunzt]

NOT Disney Star Wars, that is 😅

[@yemmohater2796]

Who are you quoting? A stolen comment?

[@meierboy97]

I have 4 autoimmune inflammatory diseases, I've been sick for 10 years. The two big ones are Crohn's disease and a seizure disorder called encephalitis. Thankfully my seizure disorder is in remission and I'm doing much better

[@darkscienceyt]

I have ulcerative colitis, and it sucks. I can't imagine Crohns plus 3 others. Hope you better!

[@earthwombat]

Have you considered fasting and changing your diet?

[@inverted_real_it_y]

Look into 'Randle cycle' and 'effects of glycation'.

[@darkscienceyt]

@@earthwombat I just started fasting yesterday! Is it really a good strategy for UC? My diet consists of low fiber carbs and protein.

[@brookedoesstuff]

hello, fellow Crohn's sufferer. hopefully yours is in remission!

[@Potrimpo]

Schools -- especially medical schools -- really need this channel. Though glossing over intricate details, it gets right to the point and made simple without being condescending or too oversimplified. I learned more about engineering on The Engineering Mindset than I did in engineering school.

[@homesick_angel]

I dislike the way schools go into the theory part first instead of explaining the core concepts first. Learning basics and prerequisite knowledge is important but it’s much easier for me to see the whole thing first and then break down the details

[@alialseddiqi388]

My Med School taught us a fair amount about chronic inflammation, but the problem was that it was information scattered as fragments across multiple subjects and many lectures. I managed to study chronic inflammation quite well, but it took a very long time to piece together a more complete picture of the science of it due to just how scattered everything was. And there is also the fact that core mechanisms were seldom mentioned in med school. I had to delve deeper to find most information on pretty much every topic myself.

[@Kydaser]

I can always count on you to brighten my day.

[@mossie6188]

I've had juvenile idiopathic arthritis for about 2 years now, and I'm glad to finally have an explanation as to the 'how' of my disease. It's not always easy to cope with knowing I'll have this for the rest of my life, but understanding what's going on makes me feel more on top of my health

[@inverted_real_it_y]

Look into 'the Randle cycle' and change your diet accordingly.

[@mossie6188]

@inverted_real_it_y I'm not sure the randle cycle is related to autoimmune types of arthritis.... unless I'm missing something

[@inverted_real_it_y]

@@mossie6188 If you understand the Randle cycle, you'll also understand that mixing carbs with protein and fats is what is causing problems in the body. Do that for a long time and disease is guaranteed.

[@S3lkie-Gutz]

@@mossie6188 it’s not related you don’t need unsolicited advice from randos online, just listen to your body and do what you and your care team feels best

[@inverted_real_it_y]

@ Hmm, my response got deleted. Let me type it again. Basically this cycle talks about the problems of mixing carbs with proteins/fat, as is our modern diet. Our bodies don't perform well on this fuel source and we see this in our every day life. Try carnivore for a month, get your body to run on ketones and see what it does for you. Of course, investigate it for yourself, don't take my word for it.

[@plnkfloydian7814]

My sister is constantly sick, swollen legs and feet, breaking out in hives and having allergic reactions. She’s been to multiple specialists and has yet to find a root cause or any type of relief. I really find it hard to believe she has something that doctors haven’t seen 1,000 times before. I think I good deal of it is mental stress and anguish manifesting itself in the body at least partly. I have always thought it was some sort of autoimmune disorder but she’s seen plenty of doctors already with nothing conclusive outside of a list of things she’s allergic to.

[@JackieOwl94]

That type of inflammation could be a massive overproduction of histamine?

[@2xkayymarie]

MCAS: Mast cell activation syndrome. It's something doctors (not just researchers) have only in the last ten years really began knowing more about and can be difficult to diagnose because of the lack of knowledge about it.

[@S3lkie-Gutz]

like others have suggested it sounds like mast cell activation syndrome or mastocystitis, i have MCAS and experience similar things as your sister does. wishing more flare up free days for you both

[@blvckhelicopters]

I've been living with RA for two years now and its been complete havoc on my body. I haven't had a single day without pain. The absolute worst part about it is getting your employer to sympathize with you and allow you more time off which is difficult because arthritis isn't visible so employers often think you're just trying to get out of work even if you're the hardest working employee. I've legitimately been worried about my future because of it. I'm only 41.

[@Megadextrious]

I hear you on that one! I’ve been fired twice while in hospital because I have a severe bleeding disorder that no doctor can seem to fix. It leaves me so anemic, last year I had to have blood transfusions every month for 5 months and then iron infusions for the rest of the year because the whole anti-body thing was getting too much for my body to handle (that’s the gist of what I was told anyways). I went into heart failure, had a hemoglobin of 5, couldn’t breathe because my iron was so low, caught pneumonia, was suffering for a long time, and then, “Surprise! You’ve been terminated!” Now I’m working a shitty job that I hate and my manager refuses to give me more than three days a week because if I start bleeding and nobody is there to help me then I’m pretty much screwed. And god forbid I have to call his lazy ass to come work, oh heavens no. And of course I don’t qualify for disability benefits either…. Ugh. I had imagined my life would turn out much better than this. Sorry for the rant, I didn’t intend for this comment to be so long 😅.

[@bindiboo1]

I have RA too, it's not actually an arthritis it's a disease. I suppose they call it arthritis because it attacks the joints and causes pain like arthritis. But it is your immune system attacking itself. I have a lot of pain too and even though the medication I'm on helps, it doesn't stop it all. I am not able to work so I don't have that to worry about. I don't know where you live but your employer should be helping you. I would also suggest you see your rheumatologist if your pain or disease is not under control.

[@bang3929]

Your videos are great, I'm pleased to even re-watch the older ones.

[@juhokleemola5961]

Props for making such high quality videos on such a regular basis.

[@azza5332]

I love how ADHD friendly these videos are. The simple explanations and visual imagery are more interesting than any lesson I had at school.

[@DerekKanakaraj]

My guilty pleasure for the month has arrived 🙏

[@MechaGod]

I'm picturing Cells At Work

[@Toga_Reventon]

indeed

[@adventurousclash6323]

The 2D drawings are cooler then whatever that is

[@MechaGod]

@adventurousclash6323 You're not gonna believe it, but it is also 2D drawings!

[@unknownman5090]

Yeah 30 minutes episode showing what cell did within 10 seconds💀

[@orly780]

Reddit-tier Anime

[@Marcel-oq4th]

Finally a good old dark science video with the good old dark science quality

[@inix63]

I have PsA (Psoriatic arthritis) at 20 and got diagnosed 2 weeks ago, was suffering from this for nearly 3 years, insane inflammation, pain and so forth, been watching your videos since the start and got amazed when saw this title because it reminded me of my own situation, thanks !

[@carollollol]

Wauw a youtube video that gets to the point! Well done!!! I have had chronic inflammation for over 25 years and never have I seen a text or video explain it this well. Im seriously impressed!

[@totallynotdelinquent5933]

I have an as-of-yet unknown autoimmune disease, and it sucks. I've been seeking diagnosis for ~10 years, and still have yet to find one because of how new the field is, and how difficult it is to find a doctor specialized in it. The gut inflammation, the joint pain, the muscle damage and the fatigue is awful, my wounds take long to heal, and when they do they scar. I can't even take NSAIDs because of how they affect my kidneys. I hope that some kind of breakthrough can be made so that we can start working on cures, because I know I'm not the only one suffering. I've seen at least a hundred others just like me during my journey. Autoimmunity is truly insidious because of how it turns your own body against you, and there must be a way to fix it.

[@mysterioustiings9909]

wait omg your symptoms sound like the same symptoms my mom has. she’s been to so many specialists & they have no idea what’s going on

[@cx9882]

There could be many reasons tho

[@Guenter34]

I was just looking earlier today to see if you had uploaded. So thank you 😊

[@silvernode]

Saw you on The Danny Jones podcast and I'm loving the channel here. My girlfriend has had chronic inflammation for 15 years with nothing showing up on tests and no hope. Lately I have seen some promising studies on Methylene Blue when it comes to treating Alzheimer's disease and mitochondria restoration but also inflammation and cancer treatments. Since your channel gets to the point with facts very quickly, I hope to see an episode on this 1800s invention to lay out it's benefits and side effects. Thank you for your service to the internet.

[@laratheplanespotter]

Rheumatoid arthritis, lupus and Sjögrens here. My joints and kidneys are screwed. 😢

[@garnix6390]

Having Multiple Sclerosis I am very glad for this video. It really explains a lot of stuff better than other videos - even by MS-Specialized sites. And now I do understand the role of my medication better!

[@olliebarns2132]

Good video! pls do one on death by starvation

[@youssefmoustafa3271]

I study medicine and I like how the video is very detailed yet put together in a way to make it as simple as possible

[@thatprogramer]

Your explanations are amazing and well thought trough!

[@beans2939]

Hi, I have ulcerative colitis (most updated diagnosis is ulcerative pan-colitis with complication(pseudo-polyps)). I just wanted to put my two cents in this great video going over one of my worst symptoms. For those morbidly curious, chronic inflammation of the colon feels like getting stabbed in the gut over and over again + the blood loss, but the pain originates from muscle spasms caused by chronic inflammation. Also, just a quick reminder, the healing process isn't always as fast as it is on your skin, after being in full remission for 3 years for example, there are still signs of healing going on in my gut. And if you didn't know, they're the pseudo-polyps. That's the colon equivalent of scar tissue. One more thing, when the disease was in full-swing, I went to the hospital to get a blood transfusion, and my hemoglobin count was at a 4. Normal range is supposed to be between 12-15 Do a video about anemia next. Interesting thing is that there are different types too...

[@TehPwnerer]

I have it too but worst for me has been the inflammation in hands and feet. As long as I avoid my trigger item the gut problems are minimal, hardly even noticeable, it's all the other associated inflammation that is the worst part in my experience.

[@beans2939]

@TehPwnerer I couldn't even imagine, nor do I want to try. Must be painful to even move your fingers

[@toridonaldson8400]

Always have to try to watch these as fast as I can incase KZbin decides to censor some good science.

[@constantinedimopoulos1110]

Great video. Very informative.

[@JackieOwl94]

Can you do a video about adhesions, how scar tissue meant to help us can go overboard sometimes?

[@SuperUvix]

i was concerned at first. But when A KZbin Channel called 'Dark Science' told me he had some drinks too a week, i now have nothing to worry about

[@darkscienceyt]

Everything in moderation

[@Lucifer_the_fell-666]

5:40 it looks deep fried

[@greyATK]

Such good animation! :D Thank you for sharing!

[@syahrulakbarr]

wake up babe, dark science uploaded new video

[@pixeldragon6387]

I have the lovely combination of chronic inflammation (manifesting mainly as chronic tendonitis) and an allergy to NSAIDs.

[@johnnysilvercloud4470]

I wonder if you can cover Diabetic ketoacidosis soon.

[@b2617]

Our bodies are so cool and so fragile

[@rhetoricalrayne]

I have a disease that's thought to be inflammation related (very little research has been done on it, they know there's a link to inflammation and autoimmune but little else). Good to see information out there about this.

[@Turntablist_Mk2]

I have hurley 3 severe HS, but I refuse to use Humira as stopping TNF-a results in much more dangerous symptoms. Something new needs to be developed as it's not very effective in my scenario, less than 30% chance to reduce tunnel size.

[@JackieSwisher619]

‘Too much inflammation driving me insane’ Police lyrics.

[@dumbbirdwayne]

My dad has rheumatoid arthritis, it’s been in his family too, he’s had a finger amputated, 1 knee replaced, and is now having to look at the other knee and one hip being replaced, he’s 62, had the finger removed at about 50, literally the finger was horrific, he’s couldn’t move it, and it was practically powder inside his skin, basically no useable bone left whatsoever, think his knee was the same (you could see it shift out of place when he walked) genuinely a horrible condition

[@Washington-Dreaming]

I have been DNA tested multiple times, gotten many blood tests, and have had numerous CT Scans, MRIs and X-Rays. Unfortunately I have at least three autoimmune diseases - I know I have more but don’t even bother getting tested for those nowadays - which creates problems. My mom and siblings had the same symptoms but died before learning the truth. My sister and brother were young and I was alone by the time I was 50. But the problem really is, when you’re young and you have inflammation you can fight through it with diet and exercise. And most of the time you won’t feel “great” but it’s tenable. But then, when you hit, oh, 40 or 50, the pain starts to take over which makes exercise difficult at best. When you hit 60 you simply want to preserve the joints you have left. I believe you can fight as long as you can properly exercise. Most people are absolutely clueless as they don’t understand science but I tell those people, “When I wake up in the morning I feel like I was tackled by Dick Butkus.” (I played football when I was young so I know pain from being tackled, and it’s similar to that, although it doesn’t go away.)

[@abdrahim2076]

Isn't less B-Cells in the blood a bad thing, since it lowers the capacity of the immune system to defend from viruses and bacteria?

[@guacamoly-.]

Yes, it's why those with autoimmune diseases are immunocompromised, as the medication weakens the immune system. But in most cases, the benefits to weakening the immune system outweigh the risks of having a weak immune system in the long run.

[@benmcreynolds8581]

This channel has to be one of my favorite channels on KZbin. The way that you cover different subjects, how you cover them, the visuals, just A+ work 👍🏻 *(could you consider covering different parasites? I saw something about a rare condition i think called PANDAS were the subject gets exposed to the common strep throat bacteria but it causes their immune system to go hay wire and it not only attacks the strep bacteria their immune system attacks their own brain cells as well. At some point do you think you would ever consider covering the possible advancements of CRISPR? Also it would be interesting if one day you made unique videos that covered rare conditions such as that mutation that causes massive muscle growth, or that condition that causes a person's skeleton to harden up over time.. it's such a scary condition. Anyways i was just brainstorming. I just thought i would toss this out there)

[@Psychx_]

5:04 it's nice that you show a microscopic sample of liver tissue (seen here: H&E stain; subsection of a lobule, a repetitive organizational unit of the liver. in picture: hepatocytes and sinusoids), but the scarring/fibrosis doesn't happen at that level. You'll see the exessive creation of connective tissue around the central vein of each lobule, aswell as around the portal fields - this prevents blood from circulating through the sinuses inbetween the hepatocytes and thus, they can't metabolize sh!t. The connective tissue is also infiltrated with leukocytes, promoting further chronic inflammation. Changes involving the hepatocytes themselves are usually fatty degeneration (steatosis - vesicles of fat forming within the hepatocytes, destroying them). I happened to have just finished a microscopy course involving various pathological samples of human tissues at uni today :)

[@koenjansen7141]

I wish you had talked about impaired epithelial barrier function and its effect on the brain.

[@gooxo9894]

Interesting as always

[@HahaDamn]

Can you do a video on CAR T cell therapy and lupus

[@Yyyyzyyy]

Someone who didn't know what they were talking about tried explaining this to me. When I corrected him, I began with, "well for your inflammation..."

[@freesheep0]

This is a great video

[@VladislarKoyaldik]

Thank you so much ..❤

[@b2617]

Can you do a video on Addison's disease or adrenal glands not working.

[@angelmeier4382]

Quick, watch it before yt bans it xd

[@alexeecs]

That was too short! What about Omega 6 fatty acids?

[@BariumCobaltNitrog3n]

Step right up, hurry hurry, see the saddest show in town for only fifty cents. Step right on in, guaranteed to make you cry...

[@christianhoffman7407]

3:59 - can you link to that video? Are those real? Regardless I would like to see that. Great job on the whole thing. Starting in September 2022 I started to become really health conscious. I lost 80 pounds, just over a third of my body weight at the beginning and Ive kept it off. I spend the extra money for real food and I eat very little processed food, cooking nearly everything. Chronic inflammation is indeed super bad and there is so much we do now, or don't do now that causes it.

[@pound9799]

yaay the goat uploaded 🎉(btw I quit smoking due to your video)

[@Athenianz]

Fascinating. *sips beer*

[@DontCancelMeBro]

Interesting. Eats an cannabis edible.

[@RealQueenBowsette]

@@DontCancelMeBro interesting. smokes a blunt.

[@mastershooter64]

@@RealQueenBowsette Interesting. eats uranium chunks.

[@Thisispow]

Another factor much more prominent after the pandemic was covid, and long-covid patients (like me). If you're sick for a long enough time there's a chance it becomes PVF (post-viral fatigue). It's still not entirely understood, however there's evidence that has shown the virus to some extent can become latent in the host, and then continuously becomes reactivated upon certain triggers. Triggering an inflammatory sick-like response. It sucks man

[@quakeknight9680]

I was just binge watching The Sopranos before this and Dark Science just said "Compromise" at 0:50

[@Afledhenry]

My sister has stage 4 Breast cancer as diagnosis with mets to lymph nodes, diabetes and later developed a rare form call Medullary thyroid cancer,she have just 2 years to live and she never been this scared to die, she just 37, i cry everyday wishing for a miracle to happen. i don't know why I'm saying this here. put me in your prayers.

[@GrantJacobs-vt4zn]

im really sorry. i've was in such situation 15 months ago. i had just 2 months to live till a friend told me about a healer who helped me. She cured me, I don't know how she did it. but i owe her my life. she's the reason i'm alive today.

[@Afledhenry]

That's wonderful, how do i get in touch with the healer?

[@GrantJacobs-vt4zn]

Her name is Prophetess Regina Kuma,and she is a great healer who can heal you. you can look her name up online and you will find all you need.

[@Afledhenry]

Thank you for this valuable information, i just looked her up now online. impressive

[@Owlzz_]

5:24 i hope they will not touch this section of this video, this section is so important people need to know about this

[@randomdude4360]

A simple example of how you should see this is Let's say your organ is a city, your immune system the army. Whenever something happens, the army just sends out air strikes since the first response (with neutrofiles) isn't very specific, but it's fast. Normally the town should go on and repair itself, but if you keep airstriking it. That simple won't happen and now it's broken. Unlike with auto-immune diseases, which are specific since that's when the adaptive immune system starts to play. It would be like sending a spy to a place (the antibody) the spy on the other hand always goes to a specific place, like say a small orange square like building. So every town that has this building, will have the spy and thus an airstrike will happen, because the spy informs the army that he has found the targeted area. Normally the spy should say that he found something like a bacteria, but in this case it won't since the plasma cells (A type of effector B cells that produce the antibodies (=spy)) have escaped the auto-immunity control points. An interesting example where this happens as said in the video is with rheumatoid arthritis, in this example the bacteria Proteus mirabilis can do something called molecular mimicry. Basically, the bacteria has proteins that resemble the body's own protein's so much that if the antibodies were to be made of those protein's it would have a greater chance of attacking itself, since the joints also have said protein. Auto immune diseases are very interesting especially how they exactly evade control, since with molecular mimicry it's after all the control points. Along with it not having a set in stone cause, it can be caused through lifestyle and genetics, but there is no clear cause, not even with molecular mimicry is it 100% guarantee to give you rheumatoid arthritis. Anyhow, that's it, hope you had fun reading. 😊

[@Benji-zv5ev]

I have this after getting my covid 19 vaccine

[@noodlery7034]

I have ulcerative colitis. None of the TNF-A Inhibitors worked for me even though I never developed antibodies against the drug. This means the immune system can be extremely stubborn and cause uncontrolled inflammation despite inhibiting the very molecule that's exacerbating the inflammatory process

[@lostmojo]

Self repairing machine, brilliant technology

[@OstlerH6V]

great

[@lotus_flower2000]

not getting ads for this video. you werent demonitized were you?

[@Monicaruthcw]

Commenting for the algo 💖 Also Sweet thumbnail 😉

[@MsSturbuck]

Man I've been eating all fhe berries omega 3, fish,legumes,olive oil,fermented food, whole grains,green tea, green veggies tumeric extract with pepperine,nigella sattiva oil and nothing helped 😢 Only meds helped me.

[@ayoCC]

medicine many times is a purified and concentrated form of the "natural medicines" is my way of thinking about it. And also the correct combination to have a chain of effects

[@Big_Chungus935]

Back when i kid, like 3rd grade kid i got electrocuted from my hand. And wound got recovered but inside my palm where cable pierced through my skin the scar looks out of place. It didn't healed up like the normal cut. I feel less pain in that part of the palm. I dont know why it didnt heal normally

[@Phoenix-ov5gg]

I mean you can check for this by checking for C reactive protein right? Would that give a conclusive answerv

[@fluttzkrieg4392]

I don't know if it's related, but my mom has arthritis and every day one of her ankles and sometimes one of wrists swell up painfully. She said there is no cure.

[@friedrichjunzt]

"a few drinks per week" 😳 isnt that a bit... much? 😅 Imho that's not to be recommended, actually

[@darkscienceyt]

About 2-3 a week for me

[@friedrichjunzt]

@darkscienceyt Imho too much - stay vigilant, bro

[@Rudy-y2b]

Tales of the Chronical imflamation

[@Robert21432]

I have been following this channel for a while, and I still love it! Do you think you will revive the questions for pseudoscience? I won’t mind a video about those himalayan salt humidifiers. And to be honest I kinda miss when you used to draw yourself as a scientist and a normal guy, like you did before (back when the channel was named: “questions for science”. Keep up the good work!

[@darkscienceyt]

@@Robert21432 yeah I miss it too. I’m trying to start a dark pseudoscience series soon. I’m happy to hear you liked it. To be totally honest, my biggest bottleneck is time. I work a 9-5, and this is more of hobby for me. But I will start a pseudoscience series, pretty much with the same format.

[@Battttt]

KZbins automatic translator is ASS.

[@helpkuda0]

i like that ending, but its too raw

[@Owlzz_]

Im glad being smoke and alcohol free in my entire life

[@homesick_angel]

2:58 no need to call me out like that ;-;

[@toiletfx5679]

So the DAMPS are how the body knows where damage has occured. I've always wondered how the body does that, now I know!

[@darkscienceyt]

@@toiletfx5679 yeah, there’s always immune cells in your blood. When a cell gets lysed open, DAMPs pour out of the cell and eventually bind to a nearby immune cell.

[@pedromontalvojr476]

I take humira. Very good video

[@on_spikes6867]

Watching this while taking my anti-histamines 🙂

[@MrKrusten]

long covid sends wishes

[@thatprogramer]

Weird line on screen btw at 8:32

[@Eminetics]

This is why you drink tea 😅

[@darkscienceyt]

and eat blueberries (no joke)

[@jwinthepro]

@@darkscienceytbecause of the anthocyanin or for other reasons?

[@Monnimiesxdlol]

@@darkscienceyt I love blueberries and in my country they are widely used from juices to desserts. Why are blueberries good?

[@darkscienceyt]

@@jwintheprolots of antioxidants

[@jayz023]

gud vido

[@ericcraddock4619]

[@niltonql]

I expected the video to talk about obesity.

[@darkscienceyt]

that is in the pipeline

[@AslansMane88]

The sound mixing needs work. The narration is harsh.

[@HighMagnitudeGT]

Disappointed you didn’t mention CRP or ESR at all.

[@FilipNiecikowski]

zoo wee mama a new video

[@kyeraff]

Hey, NEVER feed your dogs ham of any kind. Just lost my dog after giving him a treat. Led to severe pancreatic inflammation, pancreatitis, kidney and liver damage, and ultimately multiple organ failure. Don't give your dogs ham.

[@mizaryousef2126]

Do more videos

[@superhands290]

"WHERE IS MY FREE CONTENT WORKER BEE?"

[@darkscienceyt]

Yes, master

[@IS400-z6h]

+

[@brovid-19]

I have this condition.. IN MY PANTS

[@Arionid]

zero mention of overly processed oils automatic L vid 💀

[@Jan12700]

Can you disable the automatic translation of your titles? It's annoying

[@orktv4673]

7:31 Please don't use AI art, it's both horrifying and misinformative (and lazy)

[@Horologist-zu5vq]

CREAMPIE LOGO!!!!!

[@crashcraftyt]

tf?

[@Horologist-zu5vq]

@crashcraftyt Look at the logo! Look at it......Dats a creampie.... 😂😂🤣

[@Spudawg]

That’s some gooner ass brain

[@siddhartacrowley]

Bro what

[@ywtv6]

bro?

[@farticles04]

I like cheese