The Environment and Inflammatory Bowel Disease

This is a recording of the talk I gave on Wednesday 7th September 2022 at the international Paediatric Inflammatory Bowel Disease (PIBD) meeting at Edinburgh International Conference Centre.
My talk was in a session that contained talks on the immune system, genome and microbiome in IBD. I was talking about the IBD Exposome - which means the environmental factors associated with IBD.
This talk put the IBD Exposome into context, discusses modifiable factors and then a deep dive into dietary factors.
I outline the PREdiCCt Study we are running looking to understand which aspects of the environment, diet, genetics and the microbiome are associated with and predict disease flare in IBD. PREdiCCt has finished follow-up and we are in the process of cleaning and analysing the data.
Video Editing by @IBDNathan Nathan Constantine-Cooke
charlielees.su... ATOMIC IBD
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www.predicct.c...
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PROFESSOR CHARLIE W LEES FRCP(Ed) PhD
Charlie is Professor of Gastroenterology at the University of Edinburgh, a UK Research and Innovation Future Leaders Fellow (UKRIFLF) and Consultant Gastroenterologist in the Edinburgh IBD Unit. His clinical, teaching and research interests have been focused on inflammatory bowel disease (IBD) since 2003. He was awarded his PhD in the Genetics of IBD and the prestigious UEG Rising Star award in Gastroenterology, both in 2009. Following this he spent 10 years working as a full-time consultant gastroenterologist leading an increasingly busy and complex IBD clinic.
In 2019 Charlie was awarded a personal fellowship from UKRI - worth £1.7m - that enabled his transition to full-time academic gastroenterology. His research team are based in the Centre for Genomics and Experimental Medicine within the Institute of Genetics and Cancer in Edinburgh.
Charlie’s core mission is to improve outcomes for people living with IBD.
His team are working on predicting outcomes in IBD, using routinely collected NHS data (the Lothian IBD Registry) and dedicated multi-modal prospective cohorts to build predictive models.
He is Chief Investigator of the PREdiCCt study, which has recruited 2650 patients in clinical remission with detailed baseline phenotyping (clinical, psycho-social, lifestyle, environmental, dietary, microbiome and genomics) and a minimum of 24 months longitudinal follow-up.
Conflicts of Interest
Professor Charlie Lees has acted as a speaker and/or consultant to Abbvie, Janssen, Takeda, Pfizer, Galapagos, GSK, Gilead, Vifor Pharma, Ferring, Dr Falk, BMS, Boehringer Ingelheim, Novartis, Sandoz, Celltrion, Fresnius Kabi, Tillotts, Trellus Health and Iterative Scopes.

[@simontucker4632]

Good to know there’s a lot of studies going on. Good work. Thank you.

[@jonnydodo7555]

Thank you for the presentation and for taking more about diet and lifestyle. Changes in these two things is what we can all do to maintain remission.

[@mariusrazvanoglejan8778]

Thank you for all the info.We need people like yourself!

[@SDayMB]

Thank you for this informative presentation. Looking forward to hearing the study results as well. 🇨🇦

[@Tysonbax]

Stress. If im majorly stressed the next day i will bleed, every single time. Not getting enough sleep, poor diet, eating intolerant foods. Its a combination of a lot of things.

[@butching6665]

Superb!😀 Thank you for providing such information in a great presentation. I'm really looking forward to the PREdiCCt results. Now onto a couple of your other vids that I've just noticed are available.

[@shar935]

Thank you so much for a spectacular presentation 🙏🙏

[@howaboutno7980]

You're doing an exceptional job, keep it up.

[@kami-cotler]

Great content, beautifully presented. I envy your animated graphics.

[@kurtbayley5946]

Great video, thanks. A video on the list of new medication approved for IBD treatment would be good. Also looking forward to the study results 👍

[@susannam1172]

Looking forward to the results of the Predicct study. I am a PI for it at our Trust albeit now work as an IBD CNS 👍

[@gustavokurachi4946]

Congratulation for your job great presentaion , I hope watch one lecture here in Brazil

[@danielr213]

What happened to the Predicct study doctor? The website seems to be down. Would have been a very critical piece of info for a lot of us to manage this disease - even if not perfect.

[@chrisfleming5732]

Hi Charlie I am Chris from central Scotland and I have pans colitis IBD and doing well on the mezevant. Any advice would be great the tablets make me only go to the bathroom 1 or 2 times per day but i usualy have a flare up once every 2 years and I have had this for 5 years now. Any advice would be great as we need to get a cure for this now and fast steroids can help get out of a flare buit how long for

[@doctor.111]

Doctor ...u resmble the kiwi cricketer Daniel Vittori

[@wocket42]

28:20 When looking at medication, you need to look at mouthwash use as well. Mouthwash is the antibiotics for the microbiom in the mouth. Microbiom doesn't begin in the large intestine. Many people wipe out their mouth microbiom twice a day and think that's healthy.

[@johnfarag33]

Something wrong here 🙄 You said the red meat 🥩 increases the risk for Crohn’s disease ??! Everyone I have meet include myself on Carnivore diet , and this makes so many people with IBD feeling better!!

[@wocket42]

22:12 If "many many" people with "fantastic diets" develop IBD, maybe that's a hint that the diet wasn't really so "fantastic"? Often ideology is in the way here. Nobody really has proven that any diet is "fantastic" and certainly not the diet that was recommended to everyone over the last 40 years (the food pyramid).

[@parikshantkashyap4967]

This disease is curable.

[@Gun665]

It’s the food. Duh.. Not “reduce,” ELIMINATE all processed food! I can’t believe he is not stressing the so-called “vegetable oils” and what they do to people’s intestines…. There are much better videos on the subject.

[@npc9207]

Can you suggest a video?