The Gorgeous Symmetry in Your Blood Chemistry

[@combustion2559]

I really like it when youtubers make their own (aesthetic) animations, instead of only using images from the internet or writing/drawing everything on a board, because, to me a KZbin video is like a dish, sure, the most important part is the information/taste, but the presentation also REALLY matters. The only thing I didn't like was how hydrogen was represented by red circles and oxygen by white circles instead of the opposite. Still, great video, can't wait for the next one ;-)

[@Clockworkbio]

I realized that mistake approximately 15 minutes after I uploaded this animation and I felt like the world's biggest idiot. I'll have it fixed for all future episodes. Gotta keep it consistent with the community. I have no idea how I didn't notice that the whole time I was making this. Literally every resource I have ever read has had white hydrogen and red oxygen.

[@combustion2559]

No problem, mate

[@martineizinger1511]

Arguably, the most important part of a dish are the nutrients xP

[@luka4561]

Thank god i am colorblind (i'm not, i just didn't notice)

[@garettmcafee707]

I'm ashamed KZbin just showed me this KZbinr yesterday 3 years after last release this stuffs a gold mine

[@Clockworkbio]

KZbin only showed you because season 2 comes out in a month! Now you don’t have to wait like everyone else!

[@azavier-a]

@@Clockworkbio 😮😮😮😮😮😮😍😍😍😍😍😍🥳🥳🥳🥳🥳🥳🥳🥳🥳🥳🥳🥳🥳🥳

[@moumous87]

Same

[@LFTRnow]

@@Clockworkbio Good to know there is more coming. I subbed anyway just to tell the algo I like the work and want to see more - but getting fresh vids too is just gravy. Thanks for the work!

[@joefarrow1599]

Oh awesome! This channel si really cool

[@VertDiderScience]

Спасибо за прекрасное видео!

[@enriqueDFTL]

As a biochem graduate, this channel is *chef's kiss* exceptional.

[@Clockworkbio]

As someone who was too much of a coward to step outside of just vanilla biology--I'm real excited that I'm able to communicate biochem at a biochem graduate level. Thanks so much for your time and the comment!

[@sawnic_rapt0r572]

This is the best bio/science content channel on the planet. Cant wait for S2

[@R0YA1GUARD]

I’m in year 11 now, and I’ve recently just got into biology and I regret not choosing it for my subject, including chemistry. I only chose physics as my science. YOU earned my like and subscribe. This was concise and appealing. Love it!

[@andrewvee563]

Very nice and clear presentation! I'll be sharing this with my biochem undergrads. Little fixer-upper is that 3:29 --> state "interaction between hydrogen and oxygen molecules in an atom" where its "interactions between oxygen hydrogen and oxygen atoms within or between molecules". Great work though

[@Clockworkbio]

These are the exact comments I need to get better! Thank you so much for taking the time to help me get more precise! PChem was always my downfall.

[@andrewvee563]

@@Clockworkbio Very welcome! I'll keep an eye out for new videos. I think enzyme mechanics or something like that would be a good followup - maybe something showing the lock and key model/induced fit or something like that!

[@Sgrunterundt]

There's also a good reason that it is a tetramer. Each subunit binding oxygen enhances the binding strenght of the others. That makes the binding curve steeper, so it gets more saturated in the lungs and more depleted in the body. So more oxygen gets delivered. This would not be thermodynamically possible as a monomer.

[@tobydunne1342]

I was hoping he’d talk about cooperative binding!!

[@sefpico5110]

Your speech at the end gave me chills!!! Learning biology makes being alive that much more special because you can understand the amazing mechanisms and appreciate the millions of years of evolutions that allow our brief but wonderful existence. Thank you for sharing :)

[@JessieGender1]

Hell yeah, that's how the body works!

[@mattBLACKpunk]

Thank you so much! Super excited to hear season 2 is coming out as well

[@AT-zl6xi]

This is really well done! Since I know you're reading the comments I have a few humble suggestions :) - Music is a bit loud and voice is a bit soft. - I'm someone that needs to hear something described a few different times in a few different ways before it really clicks. While your delivery is good and the content is clear, sometimes "pivotal information" is quickly introduced and then left behind. One of the reasons 3blue1brown is very popular is because he tends to dwell on the key points. If you approach things in a few different ways, people who already "get it" won't be bored and people who need some reinforcement can have some time for the information to sink in. Like at 5:40, no actually, I forgot where you're going with this lmao. Anyway, just some thoughts. Great animation, good content, and I like that you also put things into perspective: "Life just works" "Structure equals function"

[@Clockworkbio]

Hey, I really appreciate you taking the time to help me make the channel better! I want to run through all your points because I'm working to improve a lot of these already! -It's not even that the music is too loud, what's worse is that I did SUCH a lazy job of EQing the tracks. I need to take a lot more of the mid-range out of the music so that the songs and my voice don't compete as much for attention. I already saved a preset that should completely sort this for future episodes! -I'm exactly the same way as a learner, to the point that I would get REALLY obnoxious about repetition and finding different angles to explain the same processes back when I was a teacher. Literally the only reason I didn't do that here was because I ran out of time. I was really worried that the style of this channel wouldn't resonate with anyone that I didn't want to take another two weeks making a review of what I covered here--I just wanted it out in the world. I think I've figured out a better animation workflow that'll help me make longer videos in the future though--and I definitely want to lean on the side of over explaining in the future! Either way, your comment rules and I can't thank you enough for taking the time to help me get better! This place feels more like 2007 youtube than anything.

[@brianrubin2069]

Really great way to explain how hemoglobin works! Better than most Biochemistry classes that just show you a graph with x and y axis of O2 concentration and pH. I look forward to seeing more of your work coming out (also the Glorious Clockwork is a really good name)

[@bogcom]

Please do a video on the convergent evolution of blood. Why some animals use copper and others use iron!

[@brianthibodeau2960]

Looks and sounds great! I study physics and love biochem. I always play find the gradient but it gets harder as things get more complex. This is a concise, well organized presentation - thanks.

[@ThaiSoup39]

The central biological principle of structure and function being two sides of the same coin is endlessly entertaining, and applicable in every aspect of living systems. Nice to see you highlight this core pillar of biology.

[@agnosticmuslim6341]

Man, Im addicted to the channel. KZbin somehow does find the right channels for me albeit a bit late. Thank you for the wonderful animation, loveeeee what you are doing TGC!

[@EricHorchuck]

Thanks!

[@ladyathenaofowls]

this video made me cry. we are so lucky that life formed in such a way. we take this kind of stuff for granted so much, but there is basically a constant miracle happening inside of us that we just ignore.

[@kibblemom]

Very concise and clear!

[@PrashantMaurice]

Wtf, how underrated this channel is, this is gonna explode soon

[@semaj_5022]

I hope in the first of many thousands of people brought here by John Green. Awesome channel. Great vibe, good narration, obviously amazing animation. It feels like a high school science project with scissors and construction paper except you really know what you're talking about. I love it.

[@Clockworkbio]

Thank you so much! I learned this aesthetic from tutorials made by Ben Marriott! Still genuinely cannot fathom how incredible the response has been. I really appreciate your time!

[@kumquats2842]

i just started my biochem undergrad degree and this was a great summary of what i just learned in my labs. thanks!

[@monkey_man70-1]

I've watched like 5 vids from this channel now, I'm almost certain it's underrated. Very good quality

[@EverythingScience]

Nice video! Nice meeting other small edu creators

[@bravebrush5057]

This is a diamond presentation! More videos like this!

[@Clockworkbio]

Thank you so much! Working hard to keep putting out videos like this

[@HafsaBatool-tg1rs]

my biology was dusty but this guy explain things soo well with such amazing animations keep it up. Proud to be an early subscriber !

[@kukumopo]

Привет от Vert Dider))) по больше ваших видосиков

[@Andrei-vv2tk]

Just found your channel and wow! Great quality, great explanations. I never thought about how oxygen was delivered other than "red blood cells and hemoglobin help distribute oxygen throughout your body", but this is a truly beautiful system

[@squessi]

don't know how I haven't found this channel before! love this kind of content.

[@Clockworkbio]

long form channels take a little longer to get pushed into the recommendation engine! We only really became discoverable about a week ago! technically speaking--you're still VERY early. Season 2 launches next month!

[@the_eternal_student]

I heard a nobel prize winning chemist say that there were too many chemical compounds, instead he was interested in properties. I think that value extends to relationships as well. So, the question is how many chemical relationships between chemical compounds do we need to know before we can start to consciously bind with the environment. Also for someone with poor health it can be trying to watch biology videos because they talk about all the things that can go wrong. It is easier to watch videos about engineering, but ultimately engineers draw inspiration from biology. This video did a good job of not making me have a panic attack while stimulating my interests.

[@mosaic3414]

Well explained!!!

[@jabu5427]

You deserved more views

[@Clockworkbio]

working on it!

[@chrisingb1]

Just found your channel, and thought that your content was on par with some of the better known channels.

[@sergeminakov8228]

In simple words, about a complex world. Thank you for the video!

[@RBmusic2000]

great video. i have found my new love & passion. I have started following all i can too understand the anatomy and physiology. Love this type of content. I'm here via Corporis channel,

[@MyGenericURL]

Do you have a video that covers how my lungs sort the gasses and take the oxygen into my bloodstream out of the gas i inhale? It's been a huge point of pondering on me for a long time, and the way you put your videos together is absolutely marvelous. The way you can take it apart to biomechanical principals while remaining legible is truly admirable.

[@wailingalen]

I love these depictions of molecular bio!!! As a kid I always imagined that’s what life at the quantum and atomic level looks like Edit: I wish I had these videos when I was an inquisitive youngster growing up in the 90s. I used to have to ride my bike to the public library or watch documentaries on PBS or some channel whenever they came on, to fully my desire for learning. And no it’s available thanks to people like you. Thank you from the bottom of my heart.

[@huuhoangnguyen574]

I came here because Hank gave this channel a shout out. Instant subscription for me! This is almost on the level of Kurtzgesagt. Keep up the good work.

[@Clockworkbio]

Wait... ...Hank?

[@huuhoangnguyen574]

I'm so sorry, I got them mixed up. It's John....

[@Clockworkbio]

@@huuhoangnguyen574 No big deal! Im really sleepy and had a heart attack thinking I got double shouted out by both vlog brothers in a single day. No way to survive that.

[@huuhoangnguyen574]

We must tell Hank not to do that then, otherwise there would be no more content from you :)

[@landonkwok6716]

More people need to see this

[@GothAmaterasu]

Really appreciate this video! It's very clear and nicely set up c: I wanna say ease up a little bit on the visuals so they're not too distracting though!

[@dulatirzhanov1217]

Just WOW! Thank you so much for this work! It is great!

[@jtktomb8598]

I'm glad you posted on Biocord, that's awesome

[@griggiorouge]

far better than seeing a hemoglobin disociation chart.

[@Cav_Man]

This was absolutely fascinating! Would love to see more videos!

[@colmryan9289]

Underrated channel alert! I was here before it blew up.

[@Clockworkbio]

I screenshotted this for proof.

[@Parasyteee]

Просто невероятно захватывающее видео. Меня буквально пробрало до мурашек. А об анимации я вообще молчу, просто нет слов. Шедеврально

[@aykcavusyan2001]

Amazing work ❤ thanks 🙏

[@molegraphy484]

Great job explaining all of this! I remember learning a lot of this a couple of years ago, but this is quite a nice refresher. Keep up the good work!

[@tremendous6669]

Thank you!

[@michinefavs]

That was fascinating and very insightful, thank you!!! Please keep them coming!

[@alunicat]

love your vids so much

[@kamenev812-karel]

It's amazing, thank for your video!

[@graemelaubach3106]

Amazing, never stop

[@SquallHart05]

Maaaan I love your Vids!

[@rngwrldngnr]

That is quite excellent!

[@carlosjohncosta]

Very good, excellent videos

[@TimRobertsen]

Great video!

[@Ecotasia]

I really love your animation style

[@Clockworkbio]

Only gets better from here! This video was a little frantic because I didn't super understand how to pace myself as an animator. Way too flashy and manic--things have gotten way better over the last year!

[@ondrejstolar]

Great video, hope you get more attention.

[@manfredlindfield9592]

I never subscribe, but I have for you, this was very good, can’t wait for more, I will show this to my granddaughter, she is only nine, I know she will ask is there any more. Well done and thank you.

[@quashawnchadwick2334]

Commenting for the algorithm and to get more content like this!

[@ypanso]

wow dude this is so on point and creative , ty so much! -ma student who cant figure this without animation =)

[@Hamza-vw6yo]

very cool

[@Clockworkbio]

No, you are!

[@MT-ry7nx]

Отличное видео!

[@mattBLACKpunk]

For real though, why is your website not archived? All of this high quality work, lost to the world? If it was a paid service I'll buy it but omg don't let it get lost

[@Clockworkbio]

Woah my bad-moved the website to watch clockwork.com and forgot to re-up this domain!

[@mattBLACKpunk]

@@Clockworkbio the additional material doesnt seem to be on the new site anymore - couldnt find any links and trying /episodes/the-georgeous-symmetry-in-hemoglobin returns 404 as well 😭

[@poozlius]

Love it. Enough detail that I feel I learned something, not so much as to make my brain hurt. :0

[@winslowdumaine]

Blood is full of psychic hair, got it.

[@DanielAusMV-op9mi]

Biochem is so awesome

[@nogladpuns7759]

I was going through my watch later playlist and was utterly delighted to come across your content again. I love the emotional aspect of your work and especially love your animation! Are you planning on making more? Totally respect it if not/not right now; just know that you'll have at least one very excited scientist-turned-gender-studies-scholar in your audience should you start uploading again

[@EricHorchuck]

Wow!

[@rustinusti]

*This* is the kind of sponsored content we need.

[@ОлегАлександров-ъ2з]

thanks from Верт дайдер!

[@daconssc]

The link to your website isn't working

[@ЕвгенийПопов-г8з4р]

Good

[@nbnbx3604]

amazingly strong start, 119th subscriber (:(: excited to see what you do next!! what do you have planned?

[@Clockworkbio]

For the rest of my life, I'm going to call you 'Nick 119.' Thanks so much for the thoughtful comment too! I have a LOT planned, but I'm starting out slow so I can keep my videos accurate. I'm going to dip into physical chemistry on my next video to talk about our teeth--and from there I think I'll have the confidence to start tackling some more complex structures like Photosystem 1 and ribosomes!

[@drasco61084]

Insta sub, fascinating!

[@mikethespike056]

0:30 "How does your blood" Thanks KZbin. You're very smart 🤭

[@sim_aware]

LOVE these animations! Great video! #SimTribe

[@Clockworkbio]

Glad you like them!

[@MrPsychicNoodles]

Great video!! I just have a minor pet peeve with vocal fry but you do you lol

[@Clockworkbio]

yea I know right? Drives me nuts when Im editing the audio too. I gotta stop recording these in 1 long take--I just completely run out of gas by the end and fry it UP.

[@maxim-zf7ix]

Комментарий для продвижения видео ✔️

[@Clockworkbio]

Спасибо!

[@fespa]

We can look up at the night sky and wonder all we want, as long as those few angstroms are being bent. 🍀

[@Clockworkbio]

And--even more insane--we can look ever-more inward and see those angstroms being bent as well. The universe really does cry out to be beheld.

[@ЮрийАндрейцев-й1з]

How does your blood know where to deliver oxygen in your body? Let's explore the basics of how hemoglobin works and how it serves as an awesome intro to biochemistry.

[@из_сказки]

Greetings from Russia. Very interesting video

[@caspian8650]

The reason I zoned out of bio in high school was they always tried to make things a metaphor. "It's like a little bus!" No it isn't. It's so nice to have proteins explained to me without all that excess baloney. I've always wanted to learn more about this stuff, but never found the right explanations I guess. I appreciate that your artwork isn't overly stylized too, it helps me picture what's happening more. I'm looking forward to watching the rest of your videos; thank you.

[@Clockworkbio]

Yea that always bothered me too! The theory of this channel is most people don't need all that extra veneer to understand how COMPLETELY NUTS it is that life just works like this. Let me know how the rest of the videos work out. I'm really glad you're here!

[@TehPwnerer]

Life is inherently physical like all things in our reality. Once we can master where Adams are in the physical reality down to very small scales and in complex systems such as our own we will have discovered the secret to infinite life

[@justtolivecomment]

Not enough views)

[@Clockworkbio]

We'll get there soon enough :)

[@leshommesdupilly]

Our biochem teacher used to say: "CO2 is NOT waste"

[@SongOfSongsChapterTwoVerseFour]

Is this Noah? So basically, when the UV rays during the long days of summer damage the leaves, the leaves build up a color as a shield. This is why tropical plants are often striped yellow, orange and red. ⏱️Now that you’ve explained this… how about explaining the various shapes, smells, medicinal qualities and colors of flowers? 😅 As an incentive, you’ll have plenty more processes to name. 🌺😂 I see your ♠️cytochrome b6f and raise you ♦️🦴piezoelectricity. 😊❤

[@Clockworkbio]

If you mention Cyt b6f in a comment -- I'm basically going to do whatever you say. That's the rules.

[@John14-6...]

You said it " Design. "

[@_joac]

Discovering this in 2024 🎉

[@eliannam.5700]

John Green brought me here, hello!

[@Clockworkbio]

Hi! Super excited you're here--hope you like these videos. Feel free to comment if you have any questions!

[@nikolaristic9509]

My thalassemia being seen 🤗

[@emigoldber]

I wonder how neuropathy works

[@simpl6775]

Structure = Function

[@clownphabetstrongwoman7305]

The question is: if oxygen was discovered only in 1772, how were people breathing before that?

[@Clockworkbio]

You may also notice that life expectancy started skyrocketing worldwide after the late 1770's. Breathing means you live longer. It's just science.

[@pteeps]

Who’s here cuz of vlogbrothers?

[@Clockworkbio]

Like, everyone. Even me! I wouldn't be making these videos if the vlogbros and Crash Course hadn't been so inspiring for so long!

[@whowhowhowhocomeon]

Biology class but interesting, listening to while mining netherite lol

[@JohnBrown-vn2qw]

shits crazy

[@Basic_Cat]

Don’t you mean Emoglobin?