The Incredible Mechanics That Make You Hear

Рет қаралды 54,247

3 жыл бұрын

Support the channel by joining our newsletter: bit.ly/watchclockwork
How does sound actually get inside your head? How can little vibrations in the air turn into nerve impulses? Let's meet the 100 nanometers of protein that connect you to sound
Sources are cited in this ever-growing Twitter thread: bit.ly/cadherin
This channel is created with the support of all our patrons on Patreon: / clockworkshow
Support the channel directly with a one time donation: www.paypal.me/clockworkshow
This channel is dedicated to sparking your curiosity about biochemistry, not to being a definitive resource. To help you continue you biochem journey, I'm really excited to partner with Biocord , a Discord server dedicated to bringing together biologists from around the globe! Join the conversation with over a thousand life sciences professionals and enthusiasts here:- / discord
All music is by Jeremy Blake( / redmeansrecording , released on the KZbin Audio Library.
Intro music: Let's Go Home (bit.ly/rmrlgh)
Outro music: Lost and Found (bit.ly/rmrlnf)
The style of this video was largely developed based on tutorials by Ben Marriot: (bit.ly/posterizethis)
Consciousness is super weird--how do we take all these signals from the outside world and make them make sense enough to like...be alive?
However--if you examine hearing from a molecular perspective--you’ll begin to see how simple and elegant it is as a sense. We’re traveling deep into your cochlea to meet your inner ear cells and the stereocilia that make it possible for you to hear. Here, you’ll discover that hearing is just a hundred nanometers of protein tugging on a membrane. It is such a small and simple process with incredibly complex consequences.

Пікірлер: 349

@Whyiseverythingthesame Ай бұрын

The reason you don't have any subscribers is not because of the quality of your content, but because of the context of your content. But this is the most important work that you can do. Please come back.

@FriesOfTheDead Ай бұрын

Damn, KZbin was like "Check this out" so I subscribed for more, then saw the last upload was 3 years ago x.x This content is really good.

@ryanpmcguire Ай бұрын

It's a shame when the algorithm abandons a channel. Completely screws over both the creator and the audience.

@joseywales6168 Ай бұрын

He has already done his work, go watch the ATP Synthase video :)

@FriesOfTheDead Ай бұрын

@@ryanpmcguire The algorithm is so bad. Lately it's been recommending me hundreds of videos with 10-50 views, and its always either AI or someone with a $2 microphone and a $10 webcam, stuttering into the microphone. So it's recommending me that garbage when there is stuff like this channel to watch, but he left youtube because no one was watching his stuff. Sad.

@ryanpmcguire Ай бұрын

@@FriesOfTheDead Tell me about it. The algorithm seems to be blend of astroturfing certain videos or channels and short-term "watch and forget" type content. Imagine all the people that don't even try to start a channel because they know it's an uphill battle. Even for established creators it's hard. Woe to the thousands of great channels we're missing out on because they never started in the first place.

@w4439 Ай бұрын

Anyone else finding this channel for the first time in 2024? Love the art style and his enthusiasm for biology

@TehPwnerer 29 күн бұрын

Save the excitement in the voice & the matter of fact is amazing

@jasongarcia2140 29 күн бұрын

Yes

@Neptoid 26 күн бұрын

I wish he got to the points more quickly

@maconcamp472 26 күн бұрын

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An opened mind!! 🤯 The earth purring more!! Purrrrrple rain!!☔️ 🐈‍⬛ 🧶 Each thought to me is a solar flare, which shifts us into parallel worlds!! It’s hard here!!! I’m a peaceful dude, yet my life here has been super difficult!!🥹 Alpha Centauri represents a shift in consciousness!! Dog planet!! We’re riding the alpha waves!! Woof woof!!🐶 🐾 This is our world peace and enlightenment for the world and universe!! All is one!!😇🥳🥰🤩 We’re each a mini universe!!🌌 The 3 Body Problem represents our gut brain, 🍱 heart,❤️ and mind!! 🧠 The moon is a black hole!! 🕳️ A neutrino!! The planet is a colonized moon!!😇🌍👽 The sun is a shapeshifter!! 🌞 Are you and I sculpting together as a team or as individuals??? 🧑‍🎨 Using the moon as a tool!!! 🪨 The Sun is the eye!!👁️ I love the tool/word grinder!!!😮 We’d be Bumping and Grinding!!😂 The Earth is like a refrigerator and the atmospheric pressure is melting or defrosting the stars above, as if they’ve been in the freezer!! 🥶 It would also reflect us krystalyzing and becoming diamonds in the sky!! 💎 💎💎 Lucy becomes Maisie!! 🐒 👽 We could be stars from above aka heaven, melting everything from above, as well! Like a River Running Through It!!! 🌊🌊🌊🌊🌊 Gravitational waves or our thoughts raining down on us!! 🌧️ Unlocking a Secret Garden within and outside of us!!🤫 An Oasis!!!🏝️ 🏝️🏝️🏝️🏝️ Flowing!!! It helps a lot to flow!!!🌊🌊🌊🌊🌊🌊 Letting go, so we can concentrate more and work on our project!! Heaven On Earth!!🌍 👼 Flowers!! 🌺 🌸 💐 and Flow-Ers!!🌊🌊🌊🌊🌊 I know energy is still impurrtant!! 😻 And of course imagination!!! Love!!!💗 🐶 🎾 🧶 🐈‍⬛ To create heaven On Earth, the galaxies collide!! 🌌 Twin flames connect!! 🔥 🔥 We’re creating quantum entanglement!! Ghost particles merging, becoming more like the Stay Puft Marshmallow Man!!👻👻👻👻👻👻👻👻 The universe is still the Earth!!⭐️🌍⭐️ We’re seeing it from the insides!! 🕵️ Like we’re inside a volcano 🌋 or wishing well!! The stars and galaxies are like coins!!🪙 The Goonies vibes!! 💀 We’re treasure!! Antarctica is treasure island!! 🐧🇦🇶 Unlocking antimatter!! 🐜 Booby and booty traps exposed!! Planet X!! Hubba Hubba!!🥰 Everything and everyone has been our teacher!!👩‍🏫 3D is like the murky bottom of a bong or volcano!!🌋 The fourth dimension, representing Mars is like the stem of the bong or the volcanos vent!! 👽 Experiencing higher dimensions is like the smoke or magma reaching our mouths 😋 and then circulating through our bodies!! We are the Earth!!🌍 👼 The road less traveled!!!🧳 🌹 Straight up!! 🎈 🎈🎈🎈🎈We’d be super condensed or extremely packed neutron stars!! Like Rigel!! Blueberries!! Antioxidants!! Betelgeuse has evolved into a neutron star!! 🍊🫐 Our long winding road, exploring different dimensions, finally straightening out!! I’m getting Pee Wee vibes!! Large Marge sent me!!🚴😂 We’re vaporized, as if we’ve been smoked or roasted!! 💨 The smoke representing again those compressed neutron stars climbing the higher dimensions of the universe like a chimney!! I’m Mary Poppins, y’all !! ☂️ 🧞‍♀️ It would also represent us as a comet traveling through a wormhole!! 💫 Who me, I’m just a worm!!🐛 🫖 Solving a labyrinth!! 🦉 Solving amaze!!! 🦋 Different energies tell a different story!! 📚 We’re storytellers!! Artists!!🧑‍🎨 We’re energy first!! 🐝 A 12 inch boner is like receiving a foot of snow!!⛄️ 😂 When powered by neutrons and a magnetar energy field, one is like the energizer bunny!!🐰 They’ll keep going and going and going!! 🐇 🐇🐇🐇🐇 If you’re destined to have more than one twin flame, you’re like Frogger, playing leap frog!! Lucy is a sucker for Lillies!! 🐸 🍀 🐸 🍀 🐸🍀🐸🍀🐸 G Force!!!🥳👙🥳👙🥳👙🥳👙🥳 Dorothy’s Ruby red slippers!! ❤❤ Something here in 3D land has to change, yes, mmmmm! Dark Crystal Series!!😍 🧚🏼 We need to get this show rolling!! 🎥 We need our second moon!! Two moons!!! Two Mercurys!! Two black holes!!🕳️ 🕳️ They’ll need some color!! 🌈 Two blood moons!! 🩸 🩸 Two Ruby red slippers!!🥿 🥿 We have to die and become reborn!! Dye!! Dye those slippers red!!😮❤❤😂 Makes complete sense!! 🤯 There’s no place like home!! Home is where the heart is!! Jupiter and the 5th dimension!! 🐸 🍀 Clover Field!!👽 🛸 Time speeds up real fast once we’re there because seeing is definitely believing!! We get excited, hearts start pumping!! 💕 Minds start to open up!! 💜 Oxytocin pumping through our blood!! A love signature!! ✍️ Removing our writers block!! We’re storytellers!! 📚 The two blood moons also like draculas fangs!! Or the fangs of a snake and spider!! Increasing our Spider-Man/Women senses!! An anti venom!! Creating a super ego!!🐍🕷️😳🩸🩸 My story just gets juicier!! When is it juicy enough for you, I guess, is the question!! Strawberry Hill!! Cherry Blossoms!!🍒🍓We even got hills named after chocolate!!🍫 Purrthquakes!! 😻

@xzayler7311 24 күн бұрын

Yeah I pretty much instantly subscribed

@thethoughtemporium 3 жыл бұрын

Wow this was super well done. Great channel

@Clockworkbio 3 жыл бұрын

Unreal to see you commenting on my channel! Love your work also--your spider silk video was incredible and I really admire how down-to-earth you make the actual work of doing science look. Thanks so much for stopping by!

@bintanglintangerlangga1983 Жыл бұрын

@@Clockworkbiowhy are you stop making video?

@charadremur333 Ай бұрын

Hey, @@Clockworkbio I just found your channel. I really enjoy learning, I Believe that if a person stops learning, they start to give up on life. Your content is an amazing tool to continue to learn. I wish you would consider returning to KZbin and making more content. If you get 3 people into biochemistry and one of them makes a breakthrough, you were indirectly responsible for that person's success. Or even just educating the public on this topic. It's a bit niche but there are thousands of people that still watch your content. I hope that you consider returning to KZbin and making more content.

@sebastianascencio9714 28 күн бұрын

@@Clockworkbio Hope that you can return at some point. Love your content. Even though, thanks for your work.

@SillySpaceMonkey 27 күн бұрын

@@sebastianascencio9714 community notes says more videos soon!

@Zeldafan1009 25 күн бұрын

Biochemistry is *truly* one of the most fascinating subjects in life. How lucky are we to live in a time where we don’t just know about this stuff, but we have videos made by creators that break it down into such easily understandable segments??

@Sanquinity Ай бұрын

I hate that I never found this channel before. This content is amazing! Such good explanations for such complex things. Its criminal that KZbin never recommended this to me despite me watching quite a bit of science stuff...

@graemelaubach3106 Жыл бұрын

Hope you will be back one day. This content is so next level, there's nothing else even close.

@Sanquinity Ай бұрын

He's apparently coming back next month!

@joshyoung1440 29 күн бұрын

Oof, respects for those who found this channel during his hiatus and have had to wait. A lot of us have just recently been recommended this channel, right in time for the creator to resume his work.

@maconcamp472 26 күн бұрын

@webx135 28 күн бұрын

The cool part for me is the design of the cochlea. When you hear a sound at say 440Hz, you aren't sensing something 440 times per second. Instead, the cochlea is designed like a "Mechanical Fourier transform". For those who know what a Fourier transform is, you know what's up. But basically, the cochlea like a prism for sound. It splits it up into all of its different frequencies, and each frequency resonates at a particular location. By having 2 chambers filled with fluid of different density, each pitch will focus around a specific location. High frequencies at the start, and low frequencies towards the end. So when you hear a pitch, it isn't a "vibration rate" that you are interpreting, but a location. Different pitches would be like touching your arm in different locations. If you like audio visualizers, your brain doesn't see the waveform, it sees the spectrum analyzer. This is useful because while the brain is powerful, it is abysmally slow. Think of it like a giant processor running at like 100Hz. So it wouldn't be able to interpret a wave form. By analyzing the spectrum instead, it can instead process sounds as "shapes". As I understand it, the human audio cortex is one of the few that is powerful enough to do echolocation. We don't use it much, but you can train it. Blind people are especially good at it because it can more easily link up with an under-stimulated visual cortex and process sound as visual/spatial information. Some people trained in it can see with a high enough resolution to identify cracks in concrete. And the cool part is that it's a 360 degree view, albeit much better towards the front than the rear.

@Clockworkbio 28 күн бұрын

You have no idea how much I wanted to explain this and how frustrating it was to cut that whole bit when my math-writing skills simply weren't strong enough to pull it off. Genuinely appreciate this summary--great way to visualize the geometry of how this happens.

@PinkeySuavo 22 күн бұрын

When you think about it everything performs kind of fourier transform accepting some frequencies and rejecting others. Thats how Glass can break from some exact frequency, cause Glass performs FT on a signal and leaves only small part of it (resonate frequency). Human ear doesnt accept for example 30kHz.

@93vk 16 күн бұрын

This made my head explode for the second time tonight. Thanks to both of you!!!

@hindenberg25557 Ай бұрын

3:00 I just learned the cochlea is a squishy piece of biology that's performing a Fourier transform, and I can't stop thinking about it.

@SukacitaYeremia 29 күн бұрын

NOOOOo You know too much

@adcraziness1501 28 күн бұрын

Reminds me how we merely "discover" these principles.

@PinkeySuavo 22 күн бұрын

@dylancarter4928 Ай бұрын

please come back to making these this is the field i want to go into and this is so much more fun than a textbook. sometime's it's more indepth too

@Clockworkbio Ай бұрын

Season 2 drops in June! Can't express how jealous I am of folks like you who are about to enter this field. Opportunities are proliferating wildly right now. See you with new stuff soon!

@randomperson1955 Ай бұрын

@@Clockworkbio Take your time making these videos! I can't express how amazing these videos are as a student that wants to have a more in depth understanding of biology. For me these videos are better than any textbook could ever be. Honestly the only flaw with these videos is that the small movements are bit fast(while it makes you remember that in chemistry molecules are always moving it also makes the shapes slightly harder to understand, so maybe halve the speed? But feel free to continue how you do it right now if you feel that it's better this way). Other than that I honestly can't find anything that can be changed to improve them. I'm really excited for season 2!

@Oxygenationatom 29 күн бұрын

@@Clockworkbiopin this comment for others to see your reply or make an community post

@lemonlizard1 28 күн бұрын

@@Clockworkbiocan't wait!

@stoliknakawe743 Ай бұрын

Holy hell man. I'm so glad KZbin algorithm brought me to your channel. It was shock when after watching your video i looked at your sub count and it wasn't in milions. The quality is amazing and videos are super clear and i teresting. Keep up and numbers will come. I subscribed immediately.

@timothyupham1475 25 күн бұрын

Right!!!!!!

@GabrielSantAnaCarrijo 3 жыл бұрын

EXCELLENT video. Nowadays biochemistry is taught with boring powerpoint slides that don't come even close to portraying how beautiful these tiny things really are. You are being part of a very important revolution in this field.

@ShadesOfMisery 3 жыл бұрын

How this channel doesn't have many, many more subscribers, I have no idea!

@enriqueDFTL 3 жыл бұрын

You have a have a pretty good background in biology/biochemistry to really understand/appreciate channels like this one. It's amazing to me, but I have a bachelor's in biochem.

@Clockworkbio 3 жыл бұрын

It's pretty new! No matter what, it takes time to grow on youtube. Compared to most other youtube timelines, I'm WAY ahead!

@Asdayasman 9 ай бұрын

@@enriqueDFTL I have zero background in it whatsoever and I am perfectly able to appreciate it.

@fadingbeleifs 20 күн бұрын

@@Clockworkbiowhat happened? It's been 3 years since you posted your last video...

@Clockworkbio 20 күн бұрын

@@fadingbeleifs I took time to redevelop my animation style so I could produce more scientifically accurate videos! New season releases in a few weeks. Check out what I'm posting on Insta for a preview!

@twothreebravo 3 жыл бұрын

"We're not just mounds of meat like a sea sponge" I feel called out. 2020 was rough though, cut me some slack.

@Clockworkbio 3 жыл бұрын

No matter how rough 2020 was--even just staying locked down, you're way cooler and doing way neater things than a sea sponge.

@lewisokemwa2968 Ай бұрын

You fail to see the beauty, the mechanics. we are a complex machine

@tarassu 3 ай бұрын

"Touch me gently" gets whole another meaning 😊

@germaniumdiode Ай бұрын

So excited for season 2 in june this year!

@corwin32 3 жыл бұрын

“Is this too meta?” M’man, I think you broke, like, the 6th wall or something.

@Clockworkbio 3 жыл бұрын

Oh we're breaking walls you've never even SEEN before.

@SukacitaYeremia 29 күн бұрын

Is it the ceiling or the floor?

@matthewclaveria8348 6 ай бұрын

This channel produces such great content! It so sad the last videos were two years ago. I wish the algorithm has advertised this better. Its honestly so well made!

@timothyupham1475 25 күн бұрын

Where is he? These are so good he only has like 12 or 13 videos, and I want more! So well done, and his voice, attitude, and interest in the subject matter keep me watching. I hope he comes back and reads these comments and makes more videos.

@Clockworkbio 25 күн бұрын

Season 2 launches in June!

@joacofogel7756 Жыл бұрын

Hey, just discovered your channel. I noticed you haven’t uploaded in like a year. I hope you’re doing well, and hopefully you come back to this, although I understand it can be really disheartening

@diamondminer81 Жыл бұрын

I just found this channel too. These videos are incredible

@avery8852 22 күн бұрын

Your videos are seriously my favorite. You have a much better way of explaining than so many channels

@corvobranco6896 2 жыл бұрын

i miss your content so much daddy please come back with the beautiful colored animations for my smooth brain

@Clockworkbio 2 жыл бұрын

I'll be home soon.

@HSamee Жыл бұрын

@@Clockworkbiojust subscribed to your channel. Hope to get a notification of a new upload soon.

@KjeldSchmidt 2 жыл бұрын

This is incredibly beautiful. This channel is criminally underappreciated.

@austyn8942 3 жыл бұрын

Brilliant video man. Really enjoyed. Do you make your own models for everything?

@Clockworkbio 3 жыл бұрын

I mean technically I simplify models from PDB using PyMol and Adobe Illustrator--but these are all my own abstractions, yeah!

@idkthatxool749 26 күн бұрын

That is fucking wild, the idea of that ion channel changing shape because of the tugging on of the membrane it’s embedded within, just wowza! This is A+ world class educational content and it’s a shame I’m only just now seeing this.

@Clockworkbio 26 күн бұрын

Nah I think you lucked out! Everyone else had to wait while I revamped the channel-but now there’s only a month left until season 2!

@idkthatxool749 26 күн бұрын

@@Clockworkbio holy crap, near instantaneous reply from the creator themself. Color me impressed. Can’t wait for season 2. Much love. ❤️

@xyomga 25 күн бұрын

It's so funny people talk about protein like it's boring but proteins are one of the the coolest things in our bodies

@suruxstrawde8322 23 күн бұрын

They're legit one of the most intricate and important parts of anything alive, even your bones have them.

@Nanamowa 28 күн бұрын

As someone with synesthesia, I feel incredibly valid now knowing that touch and hearing are essentially the same sense because it's often hard for me to tell the difference between sounds and sensations.

@Clockworkbio 28 күн бұрын

In ~10 weeks my video on visual receptors will come out and hopefully I can validate this for you further. In a way, sight too is another 'touch' sense. Only your sense of balance and position really aren't.

@Daniel-pd2zn 10 ай бұрын

I was a biology and chemistry major in college, and I really miss biochemistry classes! Now I am a physical therapist who educates patients on inner ear issues and how they affect balance, and fall risk for elderly patients. Although that is a different set of structures in the inner ear (otoliths and benign paroxysmal positional vertigo BPPV), from my experience as a PT, the ability to hear sound is essential to your balance and how you orient yourself in space. I view hearing sounds as analogous to depth perception. I think spatial awareness becomes gradually more impaired without hearing. I also think that for patients with dementia, it is particularly detrimental to their orientation to time, place, and even themselves, if they cannot hearing sounds to ground them to reality. It is so nice to refresh myself on the physiology with an even deeper understanding of chemistry than when I was taking those classes! thanks for your videos.

@TojiFushigoroWasTaken 10 күн бұрын

I randomly discovered this channel and every video blew my mind. It's seriously insane how random molecules fit together and make extremely specific tasks work so well....it kind of redefines the definition of consciousness to a whole another level As a kid i was so obsessed with science that i used to wake up till 3 in the morning just to catch an episode of curiosity by Neil d tyson. The videos in your channel awakens that same childlike fascination in me 🥰

@Spectre4490 2 жыл бұрын

lol, first qustion was is human can lose hearing by decrising potassium level - i google it, and it does (mostly for older people) I love your explanation, it blow my mind

@readjordan2257 22 күн бұрын

"right up to the edge of what science has found so far." my favorite roller coaster ride.

@theRealEvoLife 16 күн бұрын

This video is 3 years old??? Insane presentation, very interesting topic, clear presentation!!!!

@ecby5269 23 күн бұрын

From what i see, This channel is about to blow up HEAR MY WORDS

@Randomchickensmoo 3 жыл бұрын

I've always been very interested in biochem, and your channel explains the concepts and finer details perfectly! Well done!

@CaptivaLP 7 күн бұрын

I really hope this channel will come back. The videos are amazing

@gabrielhacecosas 27 күн бұрын

What surprises me most is the filtering software that must be after those sensors. The signal has to have a lot of noise: The Brownian motion in the liquid is probably already louder than any vibration that has managed to reach the liquid in the cochlea. Apart from blood pressure variations and a lot of other internal noises, however, we hardly hear any of that.

@sebek12345 26 күн бұрын

Thanks!

@CanOSpamX 3 жыл бұрын

Another awesome video! You've got a knack for picking fascinating topics!

@Clockworkbio 3 жыл бұрын

Not really! It's just ALL really fascinating down here in Molecular Town! But thanks so much for the kind words!

@maxwoods286 2 жыл бұрын

Thanks for making this! I'm looking forward to watching your next video.

@Khmerstreets 27 күн бұрын

How does this only have 18k views???

@Crim1Del1Cielo 19 күн бұрын

Just got reccomended this vid and honestly glad youtube finally graced me with it. This quality is amazing and very understandable. Instantly subed!

@namm0x326 Жыл бұрын

You stopped making these? Why? Only 12... if you kept going the algorithm definitely would have rewarded you :c

@bintanglintangerlangga1983 10 ай бұрын

This is just my guess but he either decided to stop making video in KZbin and start making video in TikTok instead of KZbin or he take a long break in KZbin or in both KZbin and TikTok but the worst case scenario is that he completely left

@T11923 6 ай бұрын

I read on the youtube wiki that he took a paternity leave

@Voxelstice 29 күн бұрын

This is REALLY interesting stuff. I am glad the KZbin algorithm hit and started recommending this to everyone else, definitely some content you don't get to see usually

@enriqueDFTL 3 жыл бұрын

Bro, I LOVE this channel. Hope you keep the vids coming!

@Clockworkbio 3 жыл бұрын

That's the plan! Thanks so much for this!

@altonwilliams17 Ай бұрын

Just found it and I love it. Wish the video was longer.

@travish5284 3 жыл бұрын

Awesome video! I actually work in a lab that researches the tip link and ion channel. So cool to stumble across this on YT and see names I recognize on the source. Keep it up 👍🏼

@hammerth1421 3 жыл бұрын

The cochlea is so awesome because it does a Fourier transform with biophysics instead of math.

@FortisKnight 24 күн бұрын

Thank you! I thoroughly enjoyed this!

@zyn5487 16 күн бұрын

KZbin just recommended this to me... this is amazing

@kvnjcby Ай бұрын

This channel should have at LEAST a million subs!!!!!!!! Such great content. Thank you for making these videos. Come back!

@miproduction6196 29 күн бұрын

I absolutely love learning about the interactions between our environment and our body, by flow of energy distributed into different places.thanks for explaining so clearly a subject I’ve wondered as a kid, and learned about, but no methods of teaching really made it click!

@parable2788 Жыл бұрын

Please do a video on our voice boxes!!! I love the way you explain everything

@stevestarcke Ай бұрын

Awesome analysis! I had no idea we know so much, yet have so much left to know.

@TheTyTyXD Ай бұрын

Just saying this showed up in my algorithm and I subbed. All of your videos are fantastic.

@sylvirson 21 күн бұрын

this is so comprehensive!! love it

@Tech_Planet 29 күн бұрын

I like the animations and you are very fluent, I almost think that you can make YT shorts as well to help get your channel going.

@Clockworkbio 29 күн бұрын

I legitimately didn't think there was a meta for science videos in shorts until I stumbled across your bacterial flagellar motor video a few weeks back. Completely wild to see you in my comment section. Definitely have shorts content in the pipeline. Appreciate all the good you do over on your channel. Thanks for stopping by!

@b.a.sbadassugar5007 Ай бұрын

Amazing video man! Definetly deserves more likes!

@ZEROxDEADDEAD 28 күн бұрын

Love how KZbin can deduce I'm listening to music on another device (not connected to the internet) while I use my Pixel and recommend to me this video, front and center on my refreshed home page, atop months of other strange and increasingly frequent coincidental synchronicities produced by the algorithm over the last year. This really contextualizes the 'camera in use' bug Google covertly induced in a minority of their Pixel devices, I think

@MAKiTHappen Ай бұрын

Outstanding video, It's so impressive

@jinghaoliu9432 21 күн бұрын

Thanks for the animation and explanation of hearing at molecular level. Keep up the good work!

@Anaesify 3 жыл бұрын

This video! **chefs kiss** Amazing job explaining the fundamentals of this, and 10 mins is perfect for my attention span tbh, although your other vids are so good I get hooked in for the whole series every time so what am I talking about :P

@Clockworkbio 3 жыл бұрын

So glad you liked this one too! Honestly I thought this one was going to be too short

@VictorCilleros 3 жыл бұрын

The storytelling, the cute papercut protein structures... What you are doing is sth unique 💙 thank you for getting to the molecular level and make everyone enjoy it! I admire you!

@Clockworkbio 3 жыл бұрын

That means a lot--thank you. Love the style you bring to your lectures as well!

@sethsoarenson7414 3 жыл бұрын

One of my favorite lessons in school, really helped me understand how mechanoreceptiom works

@Clockworkbio 3 жыл бұрын

Yea--this was a really important piece in the puzzle for me too. This really helped me wrap my head around the idea that we're a biological SYSTEM--instead of just a singular entity.

@user-fz1nh3mt1c 3 жыл бұрын

what an amazing video, that teaches a lot

@uwuwuewuewueunjetjemuwueub2385 Ай бұрын

Love this channel!

@ryanhegseth8720 29 күн бұрын

“I’m going to take you through this one model I read in this one paper.” That’s so refreshing, instead of people just saying “This is how it is.” When they really don’t know.

@VapidVulpes Ай бұрын

Hheeeecckk yeah! Wish I had this to show during my lecture section on the biomechanics of hearing in my intro to audio engineering class back in the day!

@lost4468yt 25 күн бұрын

This is why I subscribe to panpsychism. So far literally everything we've discovered in science IS a sum of it's parts. The idea that there's emergent properties of a system that can't be just a sum of it's parts is not just unsupported by anything, it would fundamentally change our concepts of the universe. Also the idea that these emergent properties only appear in biological systems that are either us, or incredibly like us is very very convenient. And would pretty much require a universe designed for life like us. It'd also be an incredibly complex to explain universe, looking much much much more like a really complex and optimised computer system, rather than anything physics has given us. And if argue would almost require a creator(s) as it seems bug free for such a long running complex code. I think instead that perception/experience/qualia/whatever you want to call it - essentially the actual experience of being alone - let's just call it perception (so that would include internally generated perceptions as well, though I would argue the model is always internal, just using the external raw data sometimes). I think instead if we model perception as a raw property of the universe, either a single/all of/some combination of bosons/fermions or an entirely different field/particle/etc we don't understand. So most people then ask "so you think rocks have a perception of reality?". Well I think they probably have a perception of something, but it's just a jumbled mess because it has no feedback loops, or memory, or repeating meaningful computations. Instead what I think separates out us is a computer trying to model what's around it. We have structures that take in data over time in a meaningful and semi-ordered way. We have storage space that then stores this data over time in a way that allows other structures to repeatedly access and make new copies of of it. And we have feedback loops that use the past recent inputs on order decide on outputs etc. This alone would be enough for life with simple perception like following chemical/light signatures and avoiding others - it'd always be stuck in a small instance of time though, essentially it'd always be living (and only be arguing to) live in the now). Also worth noting that these beings will have no individualism at all as they have no long term memory. It's worth noting the above type do not have to be neural networks. They can be single celled, multicellular, silicon/tube/relay/etc CPUs hooked up to small to large outputs running a huge set of programs, etc and plenty of other examples. Then the next level would be systems that have longer term storage, and attempt to also use that in their models of what to do next. Essentially learning. They could also build circuitry (or programming) that internally triggers it. Although you'd want to know whether internally or externally generated else you'd essentially get something like schizophrenia (I wonder if this might be a good model for schizophrenia? You could also abstract it out entirely like a virtual machine and run dreams this way, or run the imagination (day dreaming to internal monologue to problem solving - e.g. sometimes you suddenly figure out the answer to a problem you've been working on while you're doing something completely unrelated, perhaps it has been running in the background). Or course the past few sentences are conjecture - but it's interesting to think that the brain might run virtualised like that. This is why I really like panpsychism and think it fits in much better with our understanding of nature.

@Piocoto123 Ай бұрын

Excelent explanation!! Youve got a new subscriber

@babyoda1973 20 күн бұрын

I love all things science never thought about chemistry and hearing you open a whole new rabbit hole😮

@SojournerDidimus 27 күн бұрын

Awesome video! The first time I *heard* the details of how haircells really work!

@Iceflkn 27 күн бұрын

Well done dude!

@ThaScruffShop 22 күн бұрын

KZbin did well recommending this. Fantastic video🎉

@marcelomartins1218 28 күн бұрын

Fantastic!

@gyr1994 3 жыл бұрын

Great video! Although I didn’t really get why such a staircase configuration of stereocilia helps detect sound. These threads with little handshakes just connect them, understood. So what, how does it help at all? It seems like I miss the main point.

@hjjfffaa Ай бұрын

It’s geometric, the staircase configuration allows the movement of the taller cilia to pull on the top of the lower cilia and facilitate the ion transfer.

@Scarybug 18 күн бұрын

I just discovered this channel to find it hasn't updated in years. Subbing anyway just in case.

@Clockworkbio 18 күн бұрын

Good timing! See you when season 2 launches at the end of the month!

@VampSpam 28 күн бұрын

My brain... it understood! Life's a trip! Thanks fir the video!

@user-de3xq3zw4k 2 жыл бұрын

Where are you?(You made a lot of great videos...

@The9thDoctor 29 күн бұрын

this is so awesome

@Les-themations 25 күн бұрын

You're so underrated. Pls come back 🙏🏽

@GenomeNinjaScience 12 күн бұрын

Hi @Clockwork! Your content is awesome. I find it engaging and informative! I also really like the animations you use in your video. I was curious, What software do you use to make them? Thank you for any time and attention that is provided to this comment!

@Asdayasman 9 ай бұрын

I'd love to see more.

@ricardasist 3 жыл бұрын

Amazing

@willemvandebeek 3 жыл бұрын

Thank you for making this video! :) I myself have tinnitus and I was wondering if you are going to touch on that subject on a molecular level in a future video too please? I am now very curious how this problem happens.

@Arnaz87 25 күн бұрын

It is indeed meta and weird, during the whole video lol

@SukacitaYeremia 29 күн бұрын

6 years ago I was procrastinating moving forward in learning my material by trying to perfectly understand this mechanism. A new thing I learned from this video is that there really might be a difference between the function of the inner hair cell, and the outer haircells. But, I'm missing the role of the tectorial membrane that is said to sit atop those hairs (and probably is somewhat blocking pores at the top? I'm unsure, it's been 6 years). Also, maybe there's a relation between the locality of the vibration with how sound resonates along tubes. Especially because different object dimensions cause different frequency to resonate. And If I've always assumed that cochleas are like actual snail houses, where the further along you go from its base, the smaller it's diameter will proportionally become.

@Emanon389 3 жыл бұрын

Fascinating

@Clockworkbio 3 жыл бұрын

Just you wait--this only gets wilder.

@shormy4716 3 жыл бұрын

This is mind-blowing. 😌

@Clockworkbio 3 жыл бұрын

Hopefully not TOO meta!

@zombitshe 3 жыл бұрын

I really wasn't expecting to come across an OP-Z in one of your videos :') Great work as always, we're so lucky to have such high quality biochemistry videos on this website

@Clockworkbio 3 жыл бұрын

OPZ folks are everywhere! It's the Deluge dorks you really gotta watch out for

@kazmakesnoise 2 жыл бұрын

Started with an OP-Z and now I am a Deluge Dork as well. There's dozens of us!

@billdwyer2522 18 күн бұрын

great explanation of the general mechanism. i'd be curious to know more detail about how the RATE of impulses on that single inner hair cell (e.g. one of the presumably many cells responding to 440Hz) get translated to signals to the cochlear nerve. i'm pretty sure it's not doing the complete translation, like simply signaling "I hear 440Hz". but maybe it's "fire", "fire", "fire" at a 440Hz rate and the auditory center does the translation

@unkind6070 26 күн бұрын

Please come back ❤ your content is amazing

@prschuster 20 күн бұрын

To illustrate how the middle ear bones amplify sound, I have my students rest their heads on the table top as I tap on the table.

@eaudesolero5631 Ай бұрын

would like to see more

@Dr.Kraig_Ren 26 күн бұрын

I found out that CLOCKWORK IS COMING BACK IN JUNE!

@jayronyucker4272 23 күн бұрын

Super interesting

@Tinky1rs 3 жыл бұрын

This is like music to my ears!

@Clockworkbio 3 жыл бұрын

lol I'm glad to hear!

@peters972 5 ай бұрын

It looks like the large cillia is pulling on its smaller neighbor causing it to sweep a larger angle I.e. producing leverage. By the fourth hair the angle is quite pronounced. I’d assume this cascade helps to open the ion channel a little more amplifying the signal. It’s easy not to appreciate the strings of protein linking the cillia together like ropes on a tall-ship. Speaking of which it’s astounding this channel did not get more view relative to the effort. Very grateful, thank you.

@theworldhardestgame Жыл бұрын

Great job! Animations like this improve understanding biochemistry. One question: why you did not mention oval window and tectorial membrane? You don't need to animate them. I consider them important because the first is the region where the stapes pushes the perilymph and then transmits the mechanical wave from a solid to a liquid, and the second because it is the structure that touches the stereocilia and helps to transforms the mechanical stimulus into a chemical signal. My sugestion it to write in the description of the video that the animation is simplified to put in evidence the role of stereocilia in the transduction. I didn't read the paper you mention in the video before I posted my comment. Probably in this paper the authors don't talk about the tectorial membrane and that's why you didn't mention in the video. Besides that, it's still a great video and helps to better visualize (and understand) this incredible phenomena!!👏👏