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The human body is like clockwork: finely tuned, intricate, and complex. Just like a clock, things go awry when its inner mechanisms, proteins, begin to malfunction. This is what happens to us as we age, but as Giuliano says in this episode, there may be ways around it.
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Music:
Intro jingle courtesy of Kevin MacLeod - Incompetech.com
"Hungarian Rhapsody N.2" by Franz Listz, licensed under cc-by-sa Germany license by Bernd Krueger, www.piano-midi.de
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Sources and further reading:
Hallmarks of aging
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013). The hallmarks of aging. Cell, 153(6), 1194-1217. (www.ncbi.nlm.n...)
Implication of dysfunctional proteins in Alzheimer's, Parkinson's, and heart failure
Bloom, G. S. (2014). Amyloid-β and tau: the trigger and bullet in Alzheimer disease pathogenesis. JAMA neurology, 71(4), 505-508. (www.ncbi.nlm.n...)
Stefanis, L. (2011). α-Synuclein in Parkinson’s Disease. Cold Spring Harbor Perspectives in Medicine, 2(2), a009399-a009399. (www.ncbi.nlm.n...)
Ruberg, F. L., & Berk, J. L. (2012). Transthyretin (TTR) cardiac amyloidosis. Circulation, 126(10), 1286-1300. (www.ncbi.nlm.n...)
Ubiquitine-proteasome degradation system
Lecker, S. H., Goldberg, A. L., & Mitch, W. E. (2006). Protein degradation by the ubiquitin-proteasome pathway in normal and disease states. Journal of the American Society of Nephrology, 17(7), 1807-1819.
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Prions ("infective" proteins)
Watts, J. C., & Prusiner, S. B. (2017). β-Amyloid Prions and the Pathobiology of Alzheimer’s Disease. Cold Spring Harbor Perspectives in Medicine, 8(5), a023507. (www.ncbi.nlm.n...)
Grifols
www.prnewswire...
GAIM
www.proclarabio...
Arethusta
www.leucadiatx...
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About glucosepane:
www.leafscienc...
Monnier, V. M., Sun, W., Sell, D. R., Fan, X., Nemet, I., & Genuth, S. (2014). Glucosepane: a poorly understood advanced glycation end product of growing importance for diabetes and its complications. Clinical chemistry and laboratory medicine, 52(1), 21-32.
(www.ncbi.nlm.n...)
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#Proteins #Biotechnology #Aging #LifeExtension #Biology #Proteostasis #Rejuvenation
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