The molecular machinery that keeps bacteria on course

Many bacteria use a whip-like 'flagellum' to move around their environment - away from danger and towards food. New research reveals the molecular machinery behind bacteria's ability to rapidly change direction.
Read more at www.chemistryworld.com/flagel...

[@joanzone4930]

imagine solving this unbelievably cool structure and the press puts this music over it

[@tomasfrybert]

I was looking for this comment

[@yikebendan]

carousel, I think this is the link between the two things

[@It.s-just-me]

I think it's supposed to go with the merry-go-round resemblance of the mechanism.

[@joanzone4930]

Ah yes... *woosh*. It's even oriented to look like a carousel. I thought it was just randomly chosen stock music. @@It.s-just-me

[@kwebis3014]

The press lol

[@chexo3]

Oh my god it’s literally just a fucking microscopic gear

[@hirofox85]

Some scientist will be working on a transmission in no time. "Today on Tiny Gear!"

[@seniorbob2180]

Ya, at the sub-cellular level, it's all nanotechnology, dude, seriously. It's crazy. Biochemistry is wild.

[@Tremor244]

there is also the intercellular signaling via motor proteins literally walking on two legs along a microtubule, shits crazy

[@AmryL]

Today the algorithm blessed me with this knowledge.

[@LFTRnow]

This rotation looks exactly like the ATP manufacturing system (from ADP and another phosphate). I just recently saw this vid (lUrEewYLIQg) by Clockwork, showing a rotating mechanism essentially assembling ATP and the rotation being caused by H+ ion concentration and repulsion. Fascinating. Would love to see a longer version of this flagellum motor vid. Maybe Chemistry World might want to colab with someone, perhaps Clockwork, perhaps even Kurtgestat?

[@CJBurkey]

I saw the paper a week or so ago, so when youtube showed me that video you mentioned (today!), I was like "3 years ago??, didn't that just come out?" and now here I am on this video

[@espanadorada7962]

Important difference is the static portion that makes up a lot of ATP synthase and ensures correct direction of rotation. Only a chunk of ATP synthase actually moves

[@alex.g7317]

Did you just say Kurtzgezagt?

[@Gelatinocyte2]

I'm more of a WEHI/Drew Berry kind of guy.

[@FutureAIDev2015]

Interesting, the way that mechanical switch protein changes the direction of the output while keeping the direction of the input the same reminds me of how a car transmission can switch from a forward gear to a reverse gear.

[@br3nto]

I love how RNA leads to the creation of 3D structures which can then do useful things and further combine into more useful things. It’s like a 3D Turing machine but where the output has physical functionality so is infinitely more useful. It’s like the ultimate programming language and computer combined into a single complex process. It’s stunning.

[@RoboArc]

What controls the structures being put in the right place ans formed at the correct time. I know it's physics, but is there a protein for that ?

[@Gelatinocyte2]

RNA themselves can also form into 3D structures, examples: ribosomes, tRNA and spliceosomes.

[@Gelatinocyte2]

@@RoboArc there are many different proteins for that. The ones I can think of are Chaperonins and the Signal Recognition Particle (which is a protein-RNA macromolecule).

[@jatigre1]

Gotta give credit to all those engineers trillions of years ago, in a galaxy far, far away...

[@crisleightning6158]

But then what engineered the engineers?

[@jatigre1]

@@crisleightning6158 I'm what you call an atheist, and I know we're all immortal spiritual beings, we're older than the physical universe, so we came first. kzbin.info/www/bejne/mnauaWxjo7Wsi5Y

[@rabidL3M0NS]

Midichlorians are the powerhouse of the force

[@lukemeck]

Boy, if only we had proof or an explanation as to how life began... 😒 🤔 oh wait, we do 😮

[@zat5176]

Huh?

[@sephirothcloud3953]

We didn't invented anything, we just remembered how we are made

[@PushyPawn]

I *knew* I heard something squeaking while trying to get to sleep.

[@georgeofhamilton]

Does this mean there are more wheels than doors?

[@leoshork]

Let me introduce you to: bacteria porins

[@ericvandenavond8748]

Unfortunately, you must also take into consideration the many "ports" that permit the diffusion of certain molecules through the cell membrane.

[@hirofox85]

This stuff blows my mind. Molecular machines are so amazing.

[@ashrocks8443]

I am interested in understanding how they have negotiated with the rear earth metal holding countries for continuous supply for the sake of creating permanent magnets to ensure efficient locomotion, it is also important for us to know how they could have stayed profitable for so many years, and I presume they might have made a killing in earning carbon credits

[@moistmike4150]

I find it amazing that it all this highly-refined, seemingly purpose-built, nano-level structure all just happened by random accident.

[@podcastwithpastorjesse9367]

Do you believe that or are you being sarcastic ?

[@AdrianOkay]

Have you seen what computers are able to achieve by brute force and random chance?

[@taukid421]

What's up with the off-brand circus music?

[@Gelatinocyte2]

Because it's like a merry go round. Get it? (Yeah, it's stupid.)

[@kma3647]

Interesting visual. The music overlay was obnoxious and too loud. I did learn something, but this was unwatchable with the sound on.

[@doridore1234]

AHHHHHAHAHAHAHAHAHHAHAHAAAAHH

[@user-di7tg7qf6u]

I keep replaying this for the song

[@existereOracle]

this is how i get around btw

[@roystonlodge]

Where are the axles for these wheels?

[@vaakdemandante8772]

there are none - it's an inner wheel, more like a ball bearing assembly than a wheel on an axel. The "axel" is pointing outwards and it's the flagellum that is being spun by this nano-motor.

[@Gelatinocyte2]

It basically just "floats" in the membrane. The flagellum whip itself is the axle.

[@seniorbob2180]

@@Gelatinocyte2 anchored in the membrane. It wouldn't surprise me if there were other trans-membrane proteins involved.

[@davethetaxevader]

strange

[@davethetaxevader]

but very interesting, id like to know more about how this works and how we found this out

[@RoboArc]

How in the fck does this get assembled ?

[@vaakdemandante8772]

yep, it has to be assembled by even more interesting machinery than the nano-motor itself. The DNA/RNA sequence is the key. Mind that it's being produced en masse because it's part of many species of bacteria. By the numbers it has to be THE MOST common engine on the whole planet.

[@RoboArc]

@vaakdemandante8772 what chemical is being monitored by the protein for timing ? Like it has to have a clock ?

[@ricardocalderon9823]

Hmm but what is turning motA/B? Very interesting. I believe nature knows mechanics better than us so if we study nature we can innovate our technology too.

[@misteral9045]

The ATP reaction within the mitochondria.

[@roycrippen9617]

​@@misteral9045The powerhouse of the cell?

[@lemonade2706]

Hmm... Now do it 😂

[@subwaytoiletgaming762]

@@misteral9045wdym, respiration?

[@FutureAIDev2015]

I think the motA/motB complex is powered by a proton gradient similar to what powers the ATP synthase.

[@kriegjaeger]

What's remarkable to me is people cannot deny intelligent design in this, but reject the designer.

[@yikebendan]

If you cannot accept miracles that are not designed, you must accept the miracle of the existence of a designer. Doesn't the existence of the designer of such miracles need to explain its origin? Isn't its existence ingenious? Isn't it the result of wisdom? Then there must be a designer above the designer. Unless wisdom comes out of thin air. This assumption is even more bizarre than the ingenuity of life coming from billions of years of evolution.

[@moistmike4150]

@@yikebendan Blah, blah, blah... and in summation, There Is No God. In other news, we'll be praying for you.

[@seniorbob2180]

"Unless you people see signs and wonders, you will never believe" -Christ It's just the way we are, don't blame them.

[@kriegjaeger]

@@yikebendan The creator isn't subject to the rules of his creation. God exists before time, before matter, in the same way a person might start a computer program, your existience isn't reliant on the program running and your program runs with the rules you've designed. When the program closes, you still are just as you were before it began. It's far simpler than the idea of complexity arranging itself from chaos, which we never observe.

[@mirfan-2020]

Prove it​@@kriegjaeger

[@Chad-Giga.]

Somebody is on that mota

[@vaakdemandante8772]

Is the exact DNA/RNA sequence for producing this mechanism known already? If not, it should be a priority to discover it because it opens the doors to biological nano-machines.

[@Gelatinocyte2]

It already is. I suggest looking at databases such as the Protein Data Bank.

[@nomnomnom5732]

🤣

[@Jonas-Seiler]

idk honestly seems fake

[@goldmaskfiend]

Obey the ancient biomachinery

[@tl5429]

​@@goldmaskfiendFor the flesh may be weak but always persistent

[@wdwadindwatri]

you seem fake XD why not google or check or just go into the profile and turn on the braions? are the influencers only crappy people you belive in?

[@martinsimeonov1563]

Meh that's pretty strong instead. Compared to its size its like having it made out of HAIR. Trust me its like steel compared to the size of the entity​@@tl5429

[@misteral9045]

It does?

[@abumarabumar7489]

Blessed is Allah, the best of creators!

[@wdwadindwatri]

are you normal? It's emergent evolution, not made up god who allows killing and promotes terrorism and self glorification after suicide... Religion is for people who constantly need to live in fear of unknown, and don't want to learn about world...

[@williamchamberlain2263]

I'm not sure you realise, but your phrasing means that you acknowledge that there are other creators, which I think counts as blasphemy in most forms of monotheism

[@miloelite]

Yes but Allah is still the best of them.

[@God7ODTaxationIsTheft]

🦖

[@Dumb-Comment]

@@miloelite so allah's creation is the best you're implying? so you're bascially racist?

[@luketracey3269]

You can see diagrams of this in the voynich manuscript at Yale . It's a medical school I heard . Shame they're clearly incompetent.