The MOST UNDER-RATED HEROS in Our Body: Anticoagulant Factors

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Video Summary:
Preventing unnecessary clot formation at normal healthy vasculature is function of endothelial cell lining of the blood vessel, endogenous antiplatelet factors and endogenous anticoagulant factors. Endothelial cells have negative charge which repels platelets and prevents platelet adhesion. They separate tissue factor (factor III) from factor VII present in blood. Also, they are source of NO and PGI2 and many anticoagulant factors. In antiplatelet squad we have NO and PGI2. They inhibit platelets. Now the anticoagulant factors. Antithrombin III inhibit thrombin, factor Xa and also factor IXa, XIa and XIIa. Heparan sulphate and heparin have no intrinsic anticoagulant activity. However, they potentiate antithrombin III. Thrombomodulin complexes with thrombin and thereby removes it from circulation. Also, it alters the behaviour of thrombin which then activates an anticoagulant, protein C. Protein C inactivates factor Va and VIIIa. Protein S serves as cofactor for protein C. Tissue factor pathway inhibitor first inhibits factor Xa, and then factor VIIa. Fibrin absorbs thrombin and prevents it from spreading into the circulation.
● Hemostasis Physiology:
• Platelet Plug Formation: • Platelet Plug Formatio...
• Blood Coagulation Cascade: • You Will FALL IN LOVE ...
• Clot Retraction & Fibrinolysis: • Clot Retraction & Fibr...
• Anticoagulant Factors: (Current video)
• Vitamin K: Biochemistry/Pharmacology: • Vitamin K: Functions, ...
● Drugs affecting Hemostasis:
• Heparin, LMWH & Fondaparinux: • You Will Know EVERYTHI...
• Warfarin (Vitamin K Antagonists): • I Will LEAVE KZbin I...
• Fibrinolytics & Antifibrinolytics: • Fibrinolytics & Antifi...
• Antiplatelet Drugs: • Antiplatelet Drugs: As...
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DISCLAIMER: This video is for education purpose only. Although every effort is made to ensure accuracy of material, viewer should refer to the appropriate regulatory body/authorised websites, guidelines and other suitable sources of information as deemed relevant and applicable. In view of possibility of human error or changes in medical science, any person or organization involved in preparation of this work accepts no responsibility for any errors or omissions or results obtained from use of information in this video.

[@Simplensweett]

Crystal clear in explanation. U have made it very interesting .thank you.

[@Neilliam]

I'm literally in the program Boron and Baulpaep designed and ur vids line up with our lectures so well and help a lot thank you!

[@NonstopNeuron]

Most welcome

[@kanchanjangid6723]

Content is very good .... 👍🏻👍🏻 Thanks

[@NonstopNeuron]

Welcome 👍

[@mazharalikhan3020]

God bless you

[@NonstopNeuron]

Thank you😊

[@tota9868]

Perfect explanation, thank you so much 😢🦋🦋🦋🦋

[@masumrejaskroll-4749]

This is very helpful sir.. Thank you so much🥰

[@NonstopNeuron]

I always feel happy when I see comment in this video. This is interesting and important and yet usually overlooked topic.

[@ta3k1]

Thank you for this information. I have antithrombin 3 and was wondering if it would be safe to take vitamin K2 ( history if kidney stone and osteoporosis). I know vitamin K1 is responsible for clotting but not sure about vitamin K 2. Thank you for your response.

[@ali-ik6gj]

Thank you! This video help me alot. 🌸 Can you write the references in the comments please cause I need them.

[@NonstopNeuron]

Physiology by Boron and Baulpaep, Bern and Levy, Gayton and hall etc are the books that I refer. I also refer other books from time to time but these are referred almost always. For this video I referred Pharmacology by Goodman and Gillman also. I hope it helps.😊

[@NonstopNeuron]

Btw I am happy to see someone interested in natural anticoagulants 👍🏼

[@keechangyou2970]

I admire your method of teaching

[@NonstopNeuron]

Thanks. You can support by sharing the videos 😊

[@collinswahinga4206]

Thanks a lot..this video have been of great help in understanding the complex mechanisms involved.

[@NonstopNeuron]

You are welcome!