The Nuclear Pore Complex: Nuclear Import, Export, & RAN

[@lesoul700]

Wow this is so clear! Thank you so much for making this video

[@juliariordan6082]

great explanation thanks!😄

[@muniz2]

You explained this so thoroughly! thank you! you got a new subscriber :)

[@izabellafeliciano4356]

Explain how nuclear pore complexes can be responsible for regulating both translation and transcription processes, and why this process does not happen in prokaryotes.

[@Mmm-tb6zq]

best explanation

[@khadijaakter5000]

Thanks a ton!

[@Ghaza_00]

Fantastic 🥺💜💜💜💜

[@oluwanifemiadeoti4595]

Thank you✨

[@haddadmj96]

You've helped me a lot with anatomy and now with cell biology. Thanks a lot! your videos are appreciated.

[@ramaabdulkafi1494]

Thank you, your explanation was amazing

[@nihalahmed1403]

Splendid! Loved every bit of the video. You've set a gold standard. But you mentioned that most proteins have NES and not NLS. Since all proteins are essentially synthesised inside the cytoplasm (ribsomes) from the mRNA, don't you think the proteins that are meant to enter the nucleus (imported to execute the function, per se DNA polymerase) and thereafter exit the nucleus must have both NLS AND NES? Moreover, if a protein just has an NES without NLS, it points to two things: 1) the protein was synthesised inside the nucleus to just get exported (highly unlikely as proteins are synthesised outside the nucleus) 2) such a protein can never enter inti the nucleus because of lack of NLS.. Please clarify. If my question carried some weight, please let me know if you have post doc positions. Thank you.

[@williammcelleney1060]

What is the purpose of importing and exporting of these proteins? And what would happen to the cell if this process were blocked ?

[@ozgedly]

Do proteins that return to the cytoplasm after entering the nucleus contain both NLS and NES?

[@susmitakhatun7842]

Yes ,they return to cytoplasm

[@nihalahmed1403]

Hello, I posed a similar question. Splendid! Loved every bit of the video. You've set a gold standard. But you mentioned that most proteins have NES and not NLS. Since all proteins are essentially synthesised inside the cytoplasm (ribsomes) from the mRNA, don't you think the proteins that are meant to enter the nucleus (imported to execute the function, per se DNA polymerase) and thereafter exit the nucleus must have both NLS AND NES? Moreover, if a protein just has an NES without NLS, it points to two things: 1) the protein was synthesised inside the nucleus to just get exported (highly unlikely as proteins are synthesised outside the nucleus) 2) such a protein can never enter inti the nucleus because of lack of NLS.. Please clarify. If my question carried some weight, please let me know if you have post doc positions. Thank you. Looks like you and I really think well. I'd love to get in touch with you. Are you a PhD student as well?

[@SerratusNL]

Hi, I'm very curious to know how with the help of this model, the proove can be given that the mRNA vaccin can not enter the nucleus. (Just hypothetically could it be possible to bind the mRNA vaccin with an import protein so it can enter the nucleus?) what will happen to these cells?

[@AyushRaj-gb5kq]

It was clear but how does the exportin comes back to the nucleus.

[@hareeshscifi13]

exportin can normally move across NPC