The Truth About Lactate: It’s Not What You Think | Dr. Ben Bikman

[@PudgyCurmudgeon]

Dr. Bikman is almost as amazing as the human body! Not quite, but he's getting there!

[@lindarichmond7814]

The human body is just astounding! A healthy liver is simply incredible.

[@antonbelsky]

It tastes great too :))

[@CitizenKETO]

Yay! My biochemistry lectures were 50 years ago. Nice to freshen up!

[@fronniebealer7808]

These lectures are intriguing and understandable because of Dr. Bikman's style of presentation.

[@michellewelch6013]

Im so grateful for all the educating you do and all the learning! Thank you so much!

[@raykinney9907]

Thank you for clarification about lactate and 'lactic acid'. I have been trying to visualize the tumor environment, and knew that lactate is elevated frequently there. And, since acidity in that environment is a feature, I was assuming much of that was due to the 'lactic acid presence'. More to think about, more clearly. Thanks.

[@przemkowaliszewski3290]

Both cancer cells and cancer mitochondria are different than their normal counterparts! Mitochondria in cancer cells do not work properly. They are damaged. Their DNA contains mutations. Cancer cells work in the situation of the energy crisis and produce their ATP mostly by fermenting glucose during the non-oxidative glycolysis; a primitive primary process of generating ATP.

[@jamesgordon8867]

Could you talk about mitochondrial function and how to maximize health of these "motherboards", not just the power cord for cellular function ?

[@iyabodeadeyefa1010]

Kindly shed more light on metformin and increased lactate production. Thank you.

[@davidh9638]

m.kzbin.info/www/bejne/Y57Eh4SYmd5phZo

[@bakeronthefly8332]

Thank you for providing these outstanding educational videos. Keep it coming!

[@docbrooks1098]

Awesome topic to cover. Very nice clarification in the intro. Thanks!

[@scottheitmanmarinesurvey3557]

A lot of high-performing athletes are dosing sodium bicarbonate to buffer lactate. It would help for lectures like this if we could see a white or chalk board

[@manojlogulic4234]

Can you elaborate please, how they use it before or after trading and how much? Thanks.

[@JYAN2852]

Thank you Ben! There is the myth in this health space that minimizing proteins in fear of gluconeogenesis. I recall you stating that Lactate is priority over glycerol and amino acids for gluconeogenesis in that particular order

[@lucimeiresantanna6334]

I am so grateful for your lectures! The carnivore diet improves liver function and optimal lactate use for a healthier celular metabolism! That's awesome! Congrats from Brazil🇧🇷

[@denimb2024]

Love to hear you Professor Bikman !!!!

[@AI-vs7sm]

Just started watching a video with Jason Fung and Thomas Seyfreid being interviewed on cancer and fermentation of glucose to feed cancer growth and Seyfreid specifically mentions lactic acid rather than lactate in regard to fermentation fueling. I watch this video this morning ,so, I remembered your explanation of the difference. Can't imagine that Seyfreid doesn't know the difference, as you talked about, but , maybe you should compare notes with Fung and Seyfreid. Just a suggestion maybe worth pursuing!

[@AI-vs7sm]

Sorry, the video is Target Cancer: Breaking Myths Ep.71

[@SHlELDS]

wish I discover this channel a long time ago

[@olaeriksson9714]

Brilliant. Thanks. Loved the history lession 😊

[@vadimkravets9209]

In presence of exogenous glucose, more precisely chronic glucotoxicuty , does the mitochondria “unlearn” to use lactate as fuel leading to the mitochondrial dysfunction? And does this mean that in an individual with such a dysfunction the storage pathway dominates leading to obesity?

[@judehart6895]

Thank you for this lecture. I just discovered you. It is so appreciated that you include history and research going back a while. I began my research into weight management in 1984. Bioenergetics is such an apt title for the study. Just thrilled.

[@zorinaganpaul1598]

Great lecture, learned a lot ❤

[@johnbierma9834]

I really appreciate your work👍. It helps me read scientific papers so much and personally I lost 8 inches on my waist following your fat reduction suggestions‼️

[@meatdog]

When I hear lactate I automatically go to muscles working to fatigue. I was even taught that in med school. So I find this very enlightening and I wish I had been able to catch thus live so I coukd ask a question. You have turned everything I learned , granted 50 years ago, on its head. we measure LDH for several reasons which I understand well however there are other implications that are swimming in my mind now.

[@1mmerry]

Thank you! Fighting my way out of type two at 76 years old. Love the extra understanding of how awesome God created these bodies!!!

[@donrad]

Are high lactate levels correlated with diet? A high carbohydrate diet is correlated with developing type 2 diabetes. And you are saying that high lactate is correlated with developing type 2 diabetes. Are there any studies showing that high carbohydrate diets are correlated with high lactate levels in the body? Or, does going on a low-carb diet lower lactate levels?

[@jorgeescobar7981]

Great explanation about the role of lactate in metabolism. One question for Dr. Bikman. Metformin is known to raise lactate in the human body. What is the implication of this related to the role of this medicine in reducing glucose levels?

[@cynthiabahena9721]

Doesn't metformin inhibit the gluconeogenesis in the liver?

[@Philusteen]

Thanks for the lactaid, doc!

[@kalipolisNow]

What about Glutamine? Isn't that also a fermentable nutrient outside of the mitochondria?

[@blackswanrising2024]

Conversion of pyruvate to lactate gives an nad+ and glycolysis gives 2atp and requires a nad+. Highly inefficient but keeps cell going

[@umeshg9107]

Thsnk you Dr Bikmam. i asked this question about how RBC get their energy to many doctors. Not one knew the answer.

[@-LocoBolon]

Hey Doc I feel that with this lecture we are getting very clone to connecting the dots on how cold therapy works in helping with metabolic health. I think that would make a great class.

[@ematise]

Fascinating as usual. Thank you!

[@jamesgordon8867]

So if you have a fatty liver, seems this would hinder lactate and contribute to complications leading to type 2 diabetes?

[@JosephRover]

Listen to this Professor the thought of lactose came to mind and how it interacts with the human body compared to the other sugars, fructose, glucose. Would you be able to discuss and tease this out please. And thank you for this informative lecture.

[@cynthiabahena9721]

How would you uncrease mitichindria?

[@farmer_donny]

So if lactic acid isn't causing the burn in our muscles, what is?

[@cynthiabahena9721]

I was wondering the same.

[@russellcrowder7241]

The burning sensation in your muscles during intense exercise isn’t primarily caused by lactic acid, as was once widely believed. Instead, it's due to the buildup of hydrogen ions (H⁺) that accompany the breakdown of adenosine triphosphate (ATP), which is the primary energy currency of your cells. Lactic acid itself is actually converted into lactate and hydrogen ions, and while lactate can be used by the muscles as an energy source, it’s the accumulation of the hydrogen ions, not the lactate, that contributes to muscle acidosis and that burning feeling.

[@farmer_donny]

@@russellcrowder7241 thank you.

[@davidh9638]

How is the buildup of H+ different than the acidity of lactic acid?

[@russellcrowder7241]

@@davidh9638 They occur through different processes and have distinct roles in muscle metabolism and fatigue. Lactic acid production is related to the overall process, it’s really the accumulation of H⁺ ions from both ATP breakdown and lactic acid dissociation, this is the increase in acidity and the sensation of muscle burn.

[@lewynld]

I guess I know what I will be doing for the next 4 or 5 years. This is really just fascinating. I am very curious about how other tissues use energy, aside from the liver and muscle. Although perhaps there is a lot more to talk about just in these organs.

[@joanneferndale101]

Yesyesyes, you do that Honeypie🎉❤🎉

[@Thundercloud1969]

Ben, always a pleasure watching your science, if the red blood cells only can use glucose is being in ketosis a good thing? Is it enough that the liver can make glucose as a fuel for them or are we at risk (even though its said that ketosis is a good thing) I myself am a carnivore over two years and i do well. But your explanation got me wondering about something that i never thought about. thank you and greetings from the Netherlands

[@ematise]

Good question, I thought about this when I heard the statement. Would be nice to have an answer to your question. Greetings from Denmark!

[@rongqut7576]

Fantastic knowledge.

[@KenJackson_US]

Wait. If the transformation of glucose to lactate in muscles releases energy, then the transformation of lactate back into glucose in the liver must require an energy INPUT. Where does that energy come from?

[@diablominero]

Human metabolism generates lactate and acidic protons at the same time. It's not unreasonable to think of that as the generation of ionized lactic acid rather than two unrelated ions.

[@milantoth2045]

Amazing episode, thanks a lot 👌

[@rudytrianamd6246]

Amazing lecture as usual. Utilizing Dr Bickmans knowledge in my functional medicine practice! So why do muscles cramp with activity? Is it a mitochondria dysfunction? Thank you

[@stephenn3727]

Thank you sir!

[@rao249]

Thank you

[@heminmhamd]

🎉🎉🎉🎉 thank you , impressive.

[@yehonatan2020]

I watched one of your videos done about 6 years ago on Insulin and Glucagon. Really appreciated that Ben. Are you still of the same opinion on those two hormones now as you was back then? Would love to listen to a newly done video on those two and the I:G ratio etc. So interesting

[@davidprice7224]

So if I understand it correctly, the mitochondria "make" and export lactate, but at a later time will also import it for use as energy. Is that right? That seems like a waste of energy. Why doesn't it just keep it and use it itself?

[@grochef]

You are truly amazing, Dr. Bikman. Since two pyruvate are created during glucose glycolysis, thereby creating two lactate molecules with non-oxidative glycolysis, does that mean that non-oxidative glycolysis creates two glucose molecules from one?! If that is the case, does intense exercise produce an insulin spike? Does that lead to more Insulin Growth Factor (igf1), and more muscle growth? Am I going off the rails?

[@omarsbaih4999]

Generally... Cancer patients have got high levels of lactate dehydrogenase......is it aresult of Worburg effect only ...?

[@ScienceAppliedForGood]

It was an interesting lecture and this book can be complementary to it 'Ketones, The Fourth Fuel: Warburg to Krebs to Veech, the 250 Year Journey to Find the Fountain of Youth' by Travis Christofferson.

[@willemvanriet7160]

Another incredibly clear talk conveying a very complex topic to ave Joe and Jill. Thank u dr Bilman. Healing thru knowledge indeed!

[@lisachelton4599]

Now they'll have to make a new episode of The Magic School Bus!

[@lenoralenor5135]

If type 2 diabetes has mitochondrial dysfunction, then does type 1 diabetes also have mitochondrial dysfunction?

[@JasonBuckman]

Type 1 Diabetes has pancreatic beta cell dysfunction.

[@paulhagiantoniou530]

Thank you for this Dr Ben, very informative. I’m curious as to after the recycling of the lactate by the liver through gluconeogenisis and the muscles then using the newly made glucose, does insulin now play a role in getting the new glucose into the cells of the muscle as the usual pathway?

[@smooth_pursuit]

I believe the muscles are able to suck the glucose up directly, without insulin

[@paulhagiantoniou530]

@@smooth_pursuit It would be very interesting if that’s the case

[@smooth_pursuit]

@@paulhagiantoniou530 yes… I’m pretty sure I’ve heard him explain it… the muscles have to need it though, i.e. you have to exercise and drain the glycogen for the muscles to suck it up, otherwise you need insulin to put it in the fat cells!

[@duanepack1017]

Lactate making white fat tissue become beige, may explain why sprinting and HIT exercises have a greater impact on fat loss, then other exercises......mmmmm.

[@earthangel2590]

So how do you fix mitochondrial dysfunction?

[@paulb4985]

Any connection to lactose?? I'm very interested and very little info on lactose / galactose!

[@JasonBuckman]

Lactic acid and lactate are in fermented dairy.

[@KuumbaOnline]

Since you said lactate can cause white fat town act like brown fat could that be a sign of fat reduction in specific areas? Also if you are exercising and then you get into a state of high lactate production is it possible to stay in that state for as long as possible to make your body more efficient at turning lactate to glucose and maximize the white fat to act like brown fat ?

[@lenaeschneider9596]

A high lactate level in an ill person can indicate sepsis. How does that fit into this?

[@stephensimon7621]

does the recycling of lactate generate a net positive energy on a system level? this looks lke creation of energy. The body doesn't typiclly do things for no reason, it sounds more like the liver detects too much lactate and converts it into a more usuable molecule by adding energy and transports the energy in form of glucose.

[@haroonmirza1286]

So good SOOOOOOOOOOOO GOOD !!!!

[@livelearnandteach7402]

Why do all cells have mitocondria except red blood cells? Why is one cell type different?

[@russellcrowder7241]

Red blood cells (RBCs), or erythrocytes, are unique in the body because they lack many organelles, including mitochondria, and this distinction is key to their specialized function: transporting oxygen. Red blood cells are different because they have evolved to optimize their one key function: oxygen transport. By losing mitochondria and other organelles, they can carry more oxygen and avoid using any of it themselves, making them highly specialized compared to other cell types.

[@livelearnandteach7402]

@@russellcrowder7241 thank you

[@diablominero]

Red blood cells have to be as small as possible so they can carry oxygen through tiny capillaries without getting stuck. So when they're mature, they shed every structure they don't need to do their job, including nucleus and mitochondria. There's actually a second cell type that doesn't have mitochondria. Some of the cells in the lens of the eye don't have mitochondria because mitochondria would scatter light and make the lens less transparent.

[@stephenn3727]

Thank you sir!