The Viral Origins of the Placenta

[@tesconstamylo]

The animations are not really helpful but the info is mind blowing.

[@recklessroges]

I found some of the animations confusing, (but I like the style and the info and narration were excellent.) It might have been a directing or editing problem that could have been fixed by lingering longer on certain images, (or maybe I'm just a bit thick?)

[@tesconstamylo]

@@recklessroges it's a descend effort maybe the editing as you said and drawings that resemble more the real things. Shapes and lines are distracting me at least

[@someoneyouknow525]

I guess I'm a nerd bc I rather it have been more realistic/scientific/educational animations that went with it lol

[@Infernovogel]

I like the animation from an artistic standpoint, but it wasn't helpful at all.

[@stevenutter3614]

@@tesconstamylo A "descend" effort? You must mean decent.

[@ozdergekko]

Back in '91, we called our daughter 'the endoparasite' during the first few months of pregnancy. Well, actually, until the delivery. oh, and... we both worked in molecular biology research back then.

[@Oracojisan]

This video makes more sense if you keep your eyes closed

[@edthoreum7625]

I was cooking,, Watch while cooking!

[@scottm2553]

The animations were an art piece of their own. Love it!

[@r3g4rds]

I spent the majority of the time trying to work out what the animations were trying to represent.

[@stevenutter3614]

Yes I just watched it a second time. Perfect sense, everything she says is synced with the animations. I mean if you don't like the style, who the fuck cares, when she says x happens, it shows x happening. What more could you want?

[@anotherpointofview222]

Interesting comments. I will often listen to a video presentation before watching it. Putting things together in my mind, seeing what understanding I get without watching it. Then I'll watch the video presentation. For me it somehow creates a better understanding of the subject.

[@anotherpointofview222]

@aloof This is why I sometimes listen before I watch a presentation. I'm trying to correlate, make sense and understand the speakers words and the charts, graphics, animations being presented at the same time. It doesn't always work well. I'm a very 'visual' person. A visual learner. But I'm a good listener to. Words can readily invoke insight and understanding for. So for me it can be like trying to do two different things at once. Which I can do,..look, listen, and learn. But some times the way the information is presented doesnt work out well with what's being said.

[@AtlasReburdened]

Cool explanation, but the visuals were an incoherent trip that contributed nothing functionally and possibly detracted from the understanding of those with less of a knowledge base in the subject.

[@theDudeAbid3s]

I liked this; my brain was scrambling to make a sense of the artistic alongside the scientific narrative, then at some point I was just like 'ahh this is a trip', cool.

[@superj1e2z6]

The animations are amazing but it's too overpowering Edit: although if there was a song about the placenta, this would like a sick music vid

[@KomradJenrol]

Yeah. Such a music video would probably go VIRAL. ...I'll see myself out now...

[@cdreNightshift]

Very interesting and informative content! Although the animations were less than helpful as the weirdness kept distracting me from the narration. Next time, please choose something less psychodelic.

[@Jesse__H]

Disagree. I like it.

[@tomifiju]

It was distracting, but please give me more

[@eugenemartone7023]

Yeah, artwork was very enjoyable, but it did obscure the message quite a bit. So from a functional design point of view it wasn’t very good, but as art it was nice, depends on what you want out of it (it’s not like the information is that hard to grasp on it’s own anyway, just close your eyes).

[@CarthagoMike]

Now if only this video would go viral

[@TurningSeasonWithin]

Love the art style, not at all what I was expecting!

[@thetrevor861]

I agree, the animations could have been scrambled, shown in any order, and/or reversed, without adding to, or detracting from their meaning. If anything, they were a distraction, obscuring the meaning of the narration.

[@sabofx]

*Very fascinating! I could watch videos like this all day long and never be bored!* But I wonder how embryos were protected against mother's immune system prior to this ingenious solution by evolution?

[@Dragrath1]

given other animals which carry their offspring inside of them they do so by effectively turning their womb into a nest i.e. the eggs develop as separate eggs often with the supply of nonviable eggs to serve as food for the babies and in many cases the first to hatch will try to eat their siblings meaning many more eggs are fertilized than will ever hatch because the most fit babies ate their siblings At least that is how many snakes and sharks give live birth. Quite macabre isn't it?

[@stevenutter3614]

@@EmberCitrine Natural selection isn't about what is the best solution to a problem, it's about what is good enough to survive just one more generation. It can't think ahead, and it can't go back and undo previous changes. If it could we wouldn't have a blind spot in each of our eyes, and Giraffes wouldn't have one of their main arteries go all the way up their neck just to come all the way back down. It couldn't have known it would end up with long necks, it was stuck with the path it already took. We have no idea how many millions of genes had to be selected for by environment, viral invasion, bacterial invasion, or a long list of other factors. Dragath1 answers it quite well I think. Mothers whose immune system killed their offspring, OBVIOUSLY didn't have any offspring that could go off and make their own offspring. However it worked, all we know is that it did, because well...we're sitting here talking about it.

[@edthoreum7625]

@@Dragrath1 nothing divine about this entire existence,,,

[@rafox19]

Remarkable strange animations😵

[@theresegalenkatttant]

awesome information but the animations was distracting. beautiful but distracting. i had to try to listen rwther then watch to follow the story

[@khhnator]

this is like something out a 80's british documentary, i love it :D

[@samharper5881]

Had absolutely no idea. Thank you so much.

[@freedommascot]

I’ve never seen such horribly confusing video imagery before! How did this ever pass inspection?

[@xonx209]

They are the graphics equivalent of "lorem ipsum" but someone forgot to replace them.

[@abhinavtripathi3119]

Glad to see the Monty Python back.

[@drewfisher1619]

Simply mindblowing

[@piengeng]

i think the narrator could sound even more creepier to scare off more people, and turn this into a horror genre.

[@scottm2553]

Lots of comments about the animations being a bit much, but I actually really like them. Thanks!

[@hybridelectric7174]

maybe it's because i've done a lot of psychedelics but i thought the animation really complemented the info

[@Jesse__H]

That animation was wicked cool. Reminds me of something Felix Colgrave would do.

[@seanmortazyt]

Excellent essay and graphics!

[@Heresheis0818]

Genes are the ultimate terminators as they control the switching mechanism impacting the kind of designated components to grow in size of ideal population.

[@DamianReloaded]

Agent Smith was totally right

[@saa82vik]

How was gestation possible before the alleged repurposing of sensitine?

[@anotherpointofview222]

@saa82vik I considered it attributing "purpose" where there is none proven to be. Part of a narrative fantasy. Not much different from what some atheist say about people who subscribe to the idea that there is a conscious purposed agent (god, being, etc) that created life, non-life, and all that we see it to be.

[@saa82vik]

@@anotherpointofview222 yes, very well, although I'm not sure this philosophical disquisition answers my question on gestation...

[@anotherpointofview222]

@@saa82vik Oh, I wasn't proposing to answer your question. I was simply expressing a thought your question inspired. My perspective is that the science reveals expressions of purpose. The evidence of a purposed act of a "maker." I can't answer your question. I can only express my thoughts, and what I believe to be true. I have similar questions, i.e., what is the origin of what I know and see, How did it come to be, Why? Science plays a vital role in addressing those questions for me. But everything will ultimately still be processed accirding to what you choose to believe, i.e., accept as true.

[@Erik-rp1hi]

Nice story telling. I like the graphics.

[@jeromevuarand3768]

Both the title and description are gross exaggerations. It's one single protein among many many others that make up a functioning placenta, and I'd bet there were proto-placentas before that protein became a part of it. And it wasn't embedded in the human genome: it wasn't human when the viral DNA got into the genome, and it still wasn't human when the gene got reactivated.

[@PalimpsestProd]

I like this format, people complaining about the animation probably think that a Rutherford Bohr model is "realistic". I would have liked a bit more info as to when the the viral DNA got there. Before all placental mammals but how far before? Before all sexual reproduction?

[@b.griffin317]

nice. so we're going to see more of these RI nuggets?

[@PedoDorf]

Agh, I have been bamboozled again, please remind me that placenta is not a placebo.

[@StaringCompetition]

There is nothing wrong with the animation per se, only that I struggled to connect any of what was represented with what was being said. Abstract indeed. The auditory information was complex enough grasp that I had to pause or go back many times, due to conflicting visual content.

[@fritsgerms3565]

fantastic. quality production. the placenta was crucial as an advantage for mammals.

[@fritsgerms3565]

@Sandcastle • It's how mammals could spread everywhere. beautiful presented by David Attenborough's "rise of animals".

[@AtlantisChannel]

This sounds like something I would come up with when high. I don't believe it.

[@randomdude9135]

Was the animations done by felix Colgrave?

[@pedrovidales3670]

So what was the original animal that was laying eggs and got infected then got the plesenta

[@nouraissaoui5150]

So helpful 👌🏻

[@cierafrancesca2708]

that is prettty cool stuff. also the animator rulez

[@FranBunnyFFXII]

Whoever did these animations was tripping balls on acid.

[@mosamaster]

Very interesting 👍🏼👍🏼👍🏼

[@digiryde]

So, as a follow on question, what is the biological history of the placenta as we understand it now. It looks like it is research time!

[@Tony-Blake]

In other words, the root "cause" of placental mammals.

[@scottm2553]

All I can say is wow.

[@jimmyezra5451]

MMMMMagical.......!!!! Loved it ...thanks

[@b.griffin317]

any idea of when this cinciten (sp?) infection originally took place?

[@Tony-Blake]

""Syncytin-1 also known as enverin is a protein found in humans and other primates that is encoded by the ERVW-1 gene (endogenous retrovirus group W envelope member 1). Syncytin-1 is a cell-cell fusion protein whose function is best characterized in placental development. The placenta in turn aids in embryo attachment to the uterus and establishment of a nutrient supply. The gene encoding this protein is an endogenous retroviral element that is the remnant of an ancient retroviral infection integrated into the primate germ line. In the case of syncytin-1 (which is found in humans, apes, and Old World but not New World monkeys), this *integration likely occurred more than 25 million years ago*."" The animation would have been improved by labeling.

[@b.griffin317]

@@Tony-Blake thanks! so other mammals would have another way of doing this?

[@fullforward8637]

Does anyone know?... What is the oldest ERV in humans and how many mutations does it have? Actually, what ERV has the most mutation in humans and how many does it have, it might not even be the oldest ? I am so curious.

[@b.griffin317]

I gather from this immunity evolved before the placenta.

[@STUCASHX]

Interesting and informative. I wouldn't be surprised if it went viral.🤔

[@budd2nd]

Opin-Eon lol 😂

[@johncgibson4720]

This video came out on the same month the deadliest viral disease of our generation started.

[@stanbinary]

The animation is really confusing and detrimental to the value of the content presented at the same moment.

[@VortexMotiveVision]

Fascinating!

[@giuliabonino2794]

Very interesting. But the animations were totally unhelpful

[@NurseHancock]

So what would you suppose would happen if the female body developed antibodies or immune responses AGAINST syncytin?

[@edthoreum7625]

Like spike proteins (from MRNA vaccines)invading the placenta?

[@miro6470]

In the worst case, her genes will not be passed on to future generations, so this mutation will cause its own end. The only concern would be if this happened to all women at the same time i guess.

[@natural2]

That was weird as f*ck, but so cool. Thanks for sharing!

[@dhayes5143]

The animations are so trippy and confusing! 😂

[@piranha031091]

The subject discussed is fascinating, but the animation is really unhelpful. It's just weird and confusing.

[@DNTMEE]

I don't know why everyone is going on about the animation. I found it entertaining. And, no, I was not smoking anything at the time. There is even more on this general topic as well. Such as how the mother's and father's contribution are actually at odds with each other on a genetic level. Each doing their own thing towards their own self-centered ends. It is not a perfect cellular union. The male wants his offspring (be it either male or female) to get the maximum possible amount of nutrients from the mother. This, even to her detriment. The mother, on the other hand, wishes to pass on her genes but , of course, wants to live to produce more offspring. This reproductive tug-of-war has led to what is termed genetic imprinting. That is to say, paternally supplied genes tend to promote growth while maternal ones tend to reduce it. For example, in the placenta, the fathers allele for the Insulin Growth Factor 2 is expressed while the receptor for Igf2 is controlled by the allele of the mother. Our genes are compatible for the sake of reproduction, but, even on the cellular level, we are at odds with our final objectives. To say our genes are compatible is not really saying much. Most of the genes for all mammals are compatible. It is only in small ways they differ, making producing offspring unlikely or impossible. Thus, men and women can be thought of as different as humans and cats at the genetic level.

[@zverh]

Interesting topic but horrible graphic presentation. The topic is too complex and the graphics is played too fast. Hard to understand anything. Or perhaps I am just too dumb for this.

[@etyrnal]

These are the worst graphics I have ever seen and are not representative of anything obvious. And this is a video full of assertions after assertion after a surgeon after assertion was absolutely no discussion whatsoever of how any of these conclusions were arrived at. Not even the most basic concepts are mentioned.

[@RonvanMiddendorp]

Next time, try to keep the distracting background noises more to the ... background. Please. Thank you.

[@James-ip7zk]

Man that animator was high

[@jessedampare1379]

Am i the only one trying to understand the animation? Cause it didn’t help at all. Great content though

[@NARODIAZ]

Subtitles please!

[@rollinwithunclepete824]

Very interesting subject. The animation was some.... ah... let's just say rather abstract!

[@someoneyouknow525]

Only 4 minutes? =(

[@b.griffin317]

RI nuggets! so tasty!

[@AdamBechtol]

Intereresting.

[@photonicpizza1466]

Good topic, and the narration is nice, but the animation is unhelpful, and at points just confusing and disorienting.

[@Ethan7s]

You mean it came from a MEME?!?!

[@57thorns]

No, it was the result of a preventable disease.

[@dismissing]

Yeah, Damn Daniel 😎😎😎

[@null_carrier]

This was way more creepy than it should have been! (impressed&confused slow clapping)

[@ashleyvaughn5213]

I love life 💖 sooo interesting all on its own

[@drackbolt]

It's the Legendary Black Beast of Aaaaarrrrrrggghhh

[@nandodando9695]

WTF was with that animation? :)

[@freudba1578]

Too short of presentatiom for animation to work

[@drusha]

Agent Smith likes this video.

[@Sagacity61]

Courtesy of Mr Aesop.............

[@guycomments]

Animation reminds me of felix colgrave

[@dragonslayerornstein387]

Actually no, we still invading our parents by being their borned children. Basement anyone?

[@b.griffin317]

RI nuggets, so tasty!

[@Nekomesha]

So what was the process before the placenta? This whole subject is fascinating

[@shermanhoman6666]

The creation of the placenta was also the creation of mammals. So, birds and bees and fish.

[@coolbreeze2.0-mortemadfasc13]

Eggs. Egg laying animals do not have a placenta.

[@anotherpointofview222]

Mixed feelings. While Great story telling, the semantics in the narrative,...the virus as some alien sentient organism, "personifies" this marvelous piece of coding, and the role it plays in the biomolecular software architecture of living organisms, distorts the purposed role it plays in the creation of life as we know it.

[@rimilmurmu10]

After 2 billion years someone is going to explain how covid 19 is the reason humans developed wings...

[@KateeAngel]

I have always found a mode of reproduction of placental mammals to be rather disgusting. Thanks for making me even more convinced that birds (and other theropods) are a superior life form LoL

[@dzhiurgis]

Damn this is way too psychedellic

[@cybermbebe]

Does it mean the motherhood is a form of a stockholm syndrome?

[@enotdetcelfer]

Meh, I actually liked the animation! :D

[@alechill3286]

My opinion is...the visuals complemented the audio. Overall I had a great time.

[@AdetheRare]

The animations are like some awful French conceptual artwork, but the information is interesting

[@anrade86]

animation and sounds are useless, distracting and disturbing

[@xBris]

The animations in this video are terrible. I've got a PhD in biochemistry and understood maybe half of them (the script was good though). The animations are both too detailed and too artistic. They're more or less useless.

[@PSHomeVideo]

Animations is really bad!

[@MappaPetts1999]

All the more reason to liken humans to viruses... nice.

[@fslknsadglkdahawerykljwa3aw643]

Not really sure how you got that take-away from this.

[@foolishafraid562]

Great info, terrible animations

[@johnjosephlonergan]

Irrelevant and distracting animations.

[@DNTMEE]

I don't know why everyone is going on about the animation. I found it entertaining. And, no, I was not smoking anything at the time. There is even more on this general topic as well. Such as how the mother's and father's contribution are actually at odds with each other on a genetic level. Each doing their own thing towards their own self-centered ends. It is not a perfect cellular union. The male wants his offspring (be it either male or female) to get the maximum possible amount of nutrients from the mother. This, even to her detriment. The mother, on the other hand, wishes to pass on her genes but , of course, wants to live to produce more offspring. This reproductive tug-of-war has led to what is termed genetic imprinting. That is to say, paternally supplied genes tend to promote growth while maternal ones tend to reduce it. For example, in the placenta, the fathers allele for the Insulin Growth Factor 2 is expressed while the receptor for Igf2 is controlled by the allele of the mother. Our genes are compatible for the sake of reproduction, but, even on the cellular level, we are at odds with our final objectives. To say our genes are compatible is not really saying much. Most of the genes for all mammals are compatible. It is only in small ways they differ, making producing offspring unlikely or impossible. Thus, men and women can be thought of as different as humans and cats at the genetic level.