This years biggest breakthroughs in longevity (2023 edition) !!!

[@TheSheekeyScienceShow]

Happy New Year!

[@kismet5857]

same to you :)

[@Theodorus5]

Thanks Sheeky. New subscriber here 😊Watching the old ones

[@kingsize1182]

Happy New Year to you and the fam. Much Health and Wealth for 2024 and beyond.

[@Jessica-kk1cz]

Great overview of some of the advances - thank you! How about the work of Michael Levine’s lab / intercellular communication? Congratulations on the completion of your PhD. 😊

[@andreialcaza]

Happy new year 🎉

[@SlamminGraham]

Congrats on defending!! Now you choose your own path! We need more people working on longevity, aging reversal, and age-related disease! Thank you!!

[@CraigHocker]

Congrats on your successful doctoral defense! 👏🏼 I recently came across João Passos (Mayo Clinic) talk at ARDD 2023 talk and thought that should be bigger news. To actually show that the SASP senescent cells occurs because of leakage of mtDNA and it was possible to remove aging effects by blocking the leakage (dramatically reducing SASP) without killing the senescent cells was quite interesting.

[@richfuller]

Link?

[@rredding]

Links are removed immediately. You can, however, copy/paste the title of the report.... ​@@richfuller

[@daxtonbrown]

Happy New Year! You are the best!

[@mrleenudler]

Congrats! Really hope you keep posting. This topic needs people that take the science seriously!

[@surfreadjumpsleep]

cngrats Dr. Sheekey! I love what you are doing.

[@ArticBlueFox96]

Excellent summary of the year's longevity breakthroughs. I am looking forward to seeing the breakthroughs of the next year. Happy New Years.

[@aagha]

Your videos are awesome! Keep it up!

[@alexmoffett4903]

Congrats on your doctoral achievement! Understanding what a challenge this process can be, combined with my appreciation of the quality and subject matter of your videos, I was inspired to support. I hope you are able to sustain and balance both activities.

[@SilverFan21k]

I wish you continued success on your channel

[@Julian-tf8nj]

Congratulations on your academic career - and thanks for continuing this amazing channel!

[@fatboydim.7037]

Congratulations its great you are doing something you clearly love.😀

[@peterbhagwandeen8359]

Congrats! Dr. Sheekey!

[@seanmchugh6263]

Thanks for 2023- Happy 2024!

[@MegaSnail1]

Congratulations and thank you so much for sharing this important topic. Much good wishes for you in the year ahead.

[@atherum]

Hopefully by the 30s we’ll have discovered immortality

[@anthonyhopper7830]

Great summary of some of the year's biggest biogerontological research-related findings. This is especially useful for laypeople like me (who can't access all of the relevant peer-reviewed papers/reports)!

[@Dr.videofrankenstein]

Congratulations and happy new year!!! ... thanks for sharing this amazing content

[@Celtokee]

Thank you, Sheekey, for an outstanding, concise assemblage, as usual. Regarding taurine, you might be interested that inhibition of the taurine transporter (TauT/SLC6A6) mediates muscle atrophy (Warskulat U, 2004; Baliou S, 2020). One cause of TauT inhibition is nitration of its tyrosine residues by peroxynitrate generated in conditions of nitrative stress (Webster, 2008; Khullar, 2004; Roos, 2004). Also, regarding possible selective advantage of aging, there is the theory that where food is limited for a species, individuals of reproductive age compete for food with those past reproductive age, thus hastening death after reproductive age increases biotic potential of a species. Happy New Year!

[@rebbamf]

Congratulations Dr. Sheekey!

[@BK-dy8jk]

It will be sad to lose you, but I know life changes and decisions have to be made but I enjoyed your channel and dependent on it for information so hope you stay with us for as long as you’re able

[@squamish4244]

You're doing good work for those of us who are 20 years ahead of you and wonder if any of this stuff is going to be ready for us. The clock's ticking for everyone.

[@christopherbrand5360]

Hooray for the successful defense! Also, looking forward to that video which is currently in your editing queue :)

[@georgbrindlinger1008]

HNY, thanks for making these videos

[@leighnash6140]

Congratulations!

[@hankfowler8194]

I believe I will hang about and perhaps have a spot of tea while I enjoy your video.

[@JasonAndrewReid]

Congratulations!!

[@비스트렝스]

Always thank you for the great contents! Happy new year❤ From 🇰🇷

[@Eric_McBrearty]

Great stuff. Very informative.

[@dr.julia-heyakarcic8862]

Happy new year Dr. Sheeky!

[@davidswan482]

Congratulations on your doctorate degree!

[@samhyh8950]

Congrats 🍾🎈🎊🎉

[@peterz53]

Congratulations Dr. S! On astaxanthin, disappointing the ITP used doses orders of magnitude higher than in diet or supplements. Researchers should provide human equivalent doses in their papers to make this clear, and also test realistic doses along side higher doses. Similar for Fisetin in that it appears ITP dose (600 ppm) may have been low compared to what James Kirkland used (20 mg/kg of body weight) or method of delivery (not bolus) not ideal. Again, with fisetin, human equivalent doses should have been given. Simple plasma dilution (Conboy lab 2020 and 2022 papers), a practical intervention, is not getting enough traction as it appears to have many of the benefits as heterochronic parabiosis, not practical as an intervention.

[@StepDub]

I go for a walk when the mood takes me. Seems to work quite well.

[@CameronWright-lw7ut]

As usual, Im late to the party. But Congratulations on your Doctorate Degree!! What an accomplishment!!

[@kx4532]

Happy New Year Doctor!

[@Infamous-El-Guapo]

Loved your singing. Making it more fun

[@ChessMasterNate]

Congrats! Doc.

[@WoodstockG54]

Just what I need, to live longer so I can listen to earth’s death moans.

[@in2caffeine]

Congrats!

[@alwayslearning8365]

Dr. Sheekey I presume? Congratulations on obtaining your doctorate.

[@TheSheekeyScienceShow]

Not completely official, but due to be!

[@scottk1525]

I'm always suspicious of Sinclair's studies in which they claim to "induce aging," and then "reverse" it. Is the repair of artificial damage that they themselves cause really the same as "age reversal?" I highly doubt it. But that's how Sinclair always pitches it. The dude strikes me as kind of a charlatan.

[@DevPythonUnity]

well i am not a fan of sinclair since there are a lot of people telling that working of resveratrol is not confirmed

[@umhi9778]

Are there any studies of him fully "reversing" actual aging?

[@scottk1525]

@@umhi9778 nope

[@BizAutomation4U]

Thanks for putting this together Ms... ahem, I mean Dr Sheekey. I enjoyed the occasional goofy touches (mean that in the most positive sense.. I'm a Pippy Longstocking fan forever lol). If you like constructive critisism, it would be that I'd have loved a conclusion for lay people per section, in some quantitative way that communicates amount of benefit. This satisfies both the deeply technical types and lay people alike, plus .. reaching more audiences is a good way to improve the channel.

[@tadmarshall2739]

Congratulations on your successful thesis defense! Lots of opportunities for you anywhere, but hoping you decide to try the USA for a while.

[@aagha]

Which tablet are you using for handwriting in your videos?

[@XeLYoutube]

thx for timestamp

[@swingyflingex3458]

You should review Michael Greger’s new book How Not To Age

[@patrickmchargue7122]

Big life changes... Good luck with those.

[@markfischer3626]

What supplements do you take? Are there any special foods that you eat to get naturally formed molecules in lieu of those found in supplements that are extracted or synthesized? Right now I'm taking around a hundred different supplements a day. The one that scares me the most that I haven't taken yet is fisetin. According to Rimon of wellness messiah the recommended dosage is 20 mg per KG of body weight one time once every one to three months. Low levels continuously have now effect which is why the experimental results he cited showed no effect. I never heard of anyone dying of eating too many strawberries. Maybe a stomach ache but not serious illness or death. 😊Would you try it yourself? Have you tried it?

[@enigmavariations3809]

What the now effect?

[@jayaybe1]

15:40 Ruddy dinosaurs! 🦕🦖😉

[@susymay7831]

What supplements or other interventions do you take Sheeky?

[@geoffreyhalverson1787]

Thanks for a great show! Now why do we age? Because over population threatens the species and eco system. We need to break with reductionist ideas of individual darwinian selection. Happy New Year!

[@jakjaki5422]

one more you have to know and i found is that senesencce occur because of stem cell deficiency and signals of it propagate to other cells to come to sene and do not apoptosis because there is no there to differentiate raldh1 deficiency as it is the stem cell marker that they express to turn retinal to retinoic to differentiate , beause of this if we use retinoic acid forcefully it will have side effects in long run

[@elliottrubenstein1746]

Good luck.

[@larryc1616]

What about a summary of Spermidine and Ca-AKG?

[@mickmickymick6927]

Congrats on the PhD defense!

[@PaulSchwarzer-ou9sw]

❤❤

[@dilipmehta5471]

Good content . But Rambling communication.

[@shahab4804]

Hi. Your videos are great. But can you please talk slower and more clear? As a non British speaker, many times I find your accent vague. Thanks

[@samuelclemons508]

CDC ? LOL, Negative !

[@dilipmehta5471]

Rambling talk.

[@MillionairesBrainPower-mv9vp]

Perhaps would be easier if you focus better on the subject. Thanks

[@InaMillion9]

You are talking waaaaaay too much before the important stuff, it is annoying to listen sorry

[@jennaharris9272]

Great video and congrats Dr!!