David Sinclair on the Brink of Anti-Aging: Reprogramming Cells for Eternal Youth

[@karl3630]

The most incredible thing is that we are not that far away from reprogramming our cells, and he 's proved it. He's at the cusp of maybe restoring sight to human beings, what an incredible feat. My biggest fear is that there are many people out there who will do whatever they can to jeopardise his work, not because they can do better but out of simple spiteful jealousy! Remember every single human being on this planet will get old one day and suffer everything that goes with it, if we can do something to negate that outcome not only do we profit but all the generations to come. It is far better to prevent these illnesses happening rather than treating them with dangerous drugs, which profit nobody but the pharmaceutical industry.

[@moviesynopsis001]

Bro they have been saying this since the dawn of time, we can't reverse anything. Just accept you're going to die and you will have a much better time on this earth.

[@sergiyriehl543]

​@@moviesynopsis001 bro, немає нічого більш легкого ніж бездіяльність. Люди зроблять безліч помилок, пер ніж станеться чудо. Але воно точно станеться, якщо такі люди як Девід будуть вірити і працювати.

[@rositamegchelenbrink691]

It all begins with sincere forgiveness 🙏🏻

[@marvwinkler8697]

@@moviesynopsis001

[@magicl4088]

@@moviesynopsis001well, yeah but all those times we did Not Know what causes aging, we still dont know exactly but we are so much closer. Aging is Not an imperative, there are animals auch as hydras and Even a kind of Lobster who do not age, in our sense of the word, it will be hard to slow, stop, or even Reverse the process and we areprobably More than a decade away, but it is definetely possible…

[@christinaatkinson6580]

James I love your questions! David keep going, your enthusiasm for this work is fantastic.

[@BrittanyB.-to9ct]

Ok I've been following Dr David Sinclair since 2019 and have been taking NMN since then as well Today is the first podcast I've seen interviewing him since about 2021. As I'm watching this podcast now I swear the information I received stimulated something in me and my body had rushes of tingling sensations. It feels like age reversal or like a power up like in a video game. Maybe our cells understand us and can get excited too. Really I'm not kidding.

[@Cinder222]

How has it been? Have you noticed a reverse in aging?

[@worldcitizen1118]

why are people continuing to post interviews with this grifter, conman david sinclair? ask glaxo about his fraud, if you have doubts......

[@the_best_of_times]

Love this. Your enthusiastic "when?" and "would you do it?" and wouldn't a lab in China be doing this already is a baser line of questioning you wouldn't normally find in most podcasts. Good on David for playing along and not hiding from these questions.

[@adamal-hilali6497]

Love this. James has ability to ask everything you want to know, brilliant

[@pgc6290]

At 5:30 and he is just a small kid/student asking questions. I like that. He is still so young in his brain.

[@worldcitizen1118]

why are people continuing to post interviews with this grifter, conman david sinclair? ask glaxo about his fraud, if you have doubts......

[@pgc6290]

At 34:29 and yes mindset and brain are vary important.

[@tocitim]

David, don't stop...Do the miracle

[@georgiaparaskevopoulou7425]

Keep doing that!!😊

[@tocitim]

@@georgiaparaskevopoulou7425 how are you Georgia?

[@georgiaparaskevopoulou7425]

@@tocitim I am doing well thsnk you!!😊

[@jozette-pierce]

At least help us keep our eyesight. I have lots of work to do. Thanks, David.

[@wideningcarrot6]

@tocitim on the tune mate 😉

[@AndyColeman-e4j]

David Sinclair has been a very very great scientist and his team is exceptional and he is very right about the 3 and not 4 factors, so far they are very much on point as far age reversal goes

[@dannyozuna]

Yes, I'm ready for the upgrade!

[@rositamegchelenbrink691]

So FORGIVE your past 💛

[@pwnfour]

Fantastic interviewer. Asked exactly the questions I've had for a while

[@Rose-vp1sn]

This has been the most informative video thank you

[@trayrene]

Two of my favorites in one room! So good! James you ask the question everyone else is thinking (would David take the OSK??) and I’ve been waiting for this moment since DS came into my conscious awareness! Thank you!

[@ludovicgago]

That was one of best or even the best podcast with David. Besides the book a lot of info was shared here. One big word for both : Thanks . And, keep us posted 😇😜😜

[@TheJamesAltucherShow]

Thank you!

[@chaddy-me-boy8299]

Can we sign up somewhere to get the latest papers David or his group comes out with?

[@joeblow2183]

Great interview. Thank goodness the nmn protocol was held to a minimum

[@tocitim]

David, don't stop doing it...

[@peterm5554]

Great news about clinical trials curing blindness in human eyes starting next year. They are already talking to the FDA and see no show stoppers. This time next year (May 2025) they could be calling for volunteers for the trial. Hopefully once blind people see again the penny will drop and everyone will understand that age reversal is real and more research money will flood in so that we can all become young again as soon as possible

[@louiscomadena3230]

@peterm5554 Hi I'm Louis from Virgina Are you excited To witness the reversing blindness age of the eyesight Next cause hell yeah I am where did you get your information

[@bmilk1177]

appreciated for the gorgeous Host and Dr David Sinclair

[@DrJK-wm9ec]

David Sinclair has lost a little of his pixie dust because of a few missteps. However, there is no denying he is pushing the Longevity space in a new direction…looking at Aging as a disease, the hypothesis that there is of a back-up copy in cells that could be used to reverse aging, and more. I do hope Dr. Sinclair does stay focused on his research and keeps pushing the envelope on Longevity science!

[@aratonit9551]

What missteps are you talking about

[@Preciouspink]

Why does this doctor go on so many different shows? Does this impair the ultimate goal of treating aging?What does he accomplish with all this video attention?

[@GelilaDimetros]

@@Preciouspink scientist

[@SquatFull]

Balderdash that requires credulity to believe.

[@magicl4088]

@@aratonit9551well some of his claims are considered as quackery auch as that he has a treatment so dogs dont age and his earlier work regarding Resveratrol is probably bullshit

[@Kuttanwarrior]

BRILLIANT EYE OPENER!

[@keithmarshalldds511]

Would red light therapy be helpful as viagra for endothelial health? I would think even more so due to its direct effect on mitochondrial function.

[@INDIGE_STUDIO]

Only meat eaters need viagra quit meat and eat plants and boom your young again down low 👌

[@WackyGameEngineer]

Sinclair i bet my Life on you! Keep going :)

[@pgc6290]

At 1:22 and imagine if we could go back to who we were mentally.

[@KLTer-jo9jy]

dear lorde, imagine we'd all be dumb teenagers again. Please, no.

[@DrSomhairle]

@davidsinclair If you look at your chemical cocktail paper, do you know if it’s the primary target of each molecule that is working on the cells or a combination of all their potential actions, would it pay off to do some more targeted molecules for each of the molecules and see if you can administer fewer better molecules. And what are the safety implications of these. Ompounds being combined

[@bitsens]

Would have been good to know what protocol for sildenafil he follows

[@clearlyaudible]

37:00 from 5 down to 2, and now only one small molecule to permanently reset your age ? interesting 🤔

[@bkb2012]

Fabulous!

[@SusanTamas]

Nac and gd11. Any thoughts?

[@daisyh8481]

@user-wl6qk2ud9r NAC amazing take with zinc

[@clearlyaudible]

15:10 good question, my question too

[@KenNelson-ln7iv]

Hi David! 5:24 1. How do you eat olive oil? 2. Do you eat sandwiches? 3. Do you put half & half in your coffee?

[@tudyloco1726]

Question is is where in the body is the control system in the discovery of an upgrade and update of the new control system where is the component is it the brain or is it beyond that cuz now I'm hearing our gut has a lot to do with aging

[@tedchapple5991]

Where is the reference to a published paper showing the documented success of a cloned monkey living out a normal lifespan?

[@gustavopanesso7297]

Thanks

[@jordanong5114]

We need to do more. More progress for the business in the present and future.

[@Irene-qm6wn]

It is really interesting topic. I think apart from all these supplements there are other factors that extent human life. I am living with a 101years old lady. She walks, dresses herself, do her cooking, plays bingo every Friday, Monopoly, rummikub 5x week, She doesn't eat a lot, she knows how to deal with stress. She socialize a lot, She sleeps very well She laugh a lot She doesn't use glasses for sight or to watch the television.

[@dr.labrat-x3z]

The back-up copy is in the protein structure.

[@awestaguetherealtor1520]

We love David Sinckler

[@semaaral2498]

Yess missed him💙🔬🐭

[@edwardbearjames2916]

So then comes the idea could he clone himself? Could you as long as you got along with them still get potential anti-aging help from their blood plasma? Then comes the question of cloning and the rights of the other person and all the others that comes with. How much longer could someone live if they were given younger blood of their own? How many clones of your own could you make?

[@xeniastefanescu507]

What about taking Nitric Oxide or Taurine.,for increasing testosterone?

[@joeblow1748]

Why not ceep pissing in the ocean?

[@robertmccombs8254]

Would senolytics activators effect or possibly remove closed gens? Also David needs to have his right eye looked at, it is becoming unused or lazy eye, possible cure is a patch to the right eye. Additionally, I have a left eye stigmatism and would volunteer if it could possibly affected

[@brosan5404]

43:03 David Sinclair does an age reset live

[@magsharper3268]

Can you recommend a preferred brand?

[@SAMSAM-rw9fc]

If you find a good brand pl lmk btw im taking PartiQuar past 2 months not sure if good or not

[@Ruudjee]

I do not know the molecules he found, however, I do know that partial reprogramming can make cancer more aggressive by turning cancer into cancer stem cells. Cancer detection tests must be way better than now.

[@robertferguson7800]

What is M& N

[@jackwt7340]

The DNA in the cells of a 60-year-old mouse is the same as that of a 1-year-old mouse, but the protein composition is different. When old mouse DNA was transplanted into a cell of a one-year-old mouse, the old DNA came back to life. Is that right?

[@henryjraymondiii961]

What about programmed senesence, the telomeres shorten and it seems to be more than wear. Are we indicating that fundamental lengthening of telomeres has been done in experiments? Otherwise, there seems to be a "clock" that indicates programmed death by a body calendar. An actual time-senesent truly time aged rat may have a body clock that references an aspect of...time...that is not being addressed by artificial ageing tecniques. As scientists and anti-aging proponents, we need to have begun to look at this in a real time manner, because the time it takes to know the proven coucpome of such validative measures-- now THAT could get "expensive" in terms of lost lives. Lets proceed as individuals to try--but we also need this for the future.

[@Aldraz]

Telomeres can be lengthen easily nowdays as far as I know, for example the hyperbaric oxygen therapy does that.. but also some foods and drugs, so that's not an issue.. there are more pillars of aging.. telomeres isn't as important as we thought afaik.

[@jamesmcintyre3456]

David, I am sure you are aware of Dr. Michael Levin PhD from Rutgers and his groundbreaking research on bioelectricity. He is here on KZbin. If he does not get a Nobel prize for his work it will only be due to politics. Is work is so insightful, I think he may well be seen, in the future, as the Einstein of biology ☺️

[@rigwatvchannel4458]

It is interesting and adventure in science Cells are key if programed age can be recet Resuch is possible

[@cgsonic1968]

I have been watching Dr. Sinclair for about 2 years now. Finally about 3 months ago I bought his book, "Lifespan" in Spanish, and gifted it to my dad (77 years old). He read almost the whole book and started talking about NMN. We started taking NMN about 3 weeks ago, since then I've felt more energetic and feel better, my dad is yet to report results (I think it is too soon though since he is taking only 150 mg). We started taking 150 mg but about 3 weeks ago, I doubled it to 300 mg last week and started giving my wife 150 mg (She has rheumatoid arthritis), since then she said she has felt less pain and less stiffness. Keep doing what you are doing Dr. Sinclair, at least in my family it seems to be working....

[@labrenzjasmin85]

fantastic

[@cynthiaaiken2424]

how does joe average get in on a trial?

[@xochiltpfohl930]

Can I work w you ? I admire your topics I am a register nurse w science majors

[@jorn-michaelbartels9386]

Dear David, I am waiting and hoping on your miracle. For my wife’ s and my daughter’ s sake, I wish to get 100.

[@janetmacdonald2823]

Android frozen screen cut me off. I was saying we've had to take the cards dealt by external forces, before. We're shaping our env't with tools like we have for millennia. Only now it's the body we live in. Huge step up. 💯

[@janetmacdonald2823]

A major benefit for our species of extending healthspan is, we'll keep the productivity of exceptionally creative minds. There's a respect for and continued benefit from older people in many cultures. In our culture, there's mainly youth worship, that and the power of money. This is leftover, a vestige from when breeding early and often was required for the species to survive. We're graduating from early primitive needs mostly external to our own best interests, like bulking up species numbers to --- this. Like this interview, the brain using the tools it creates to shape our environment. This is a new game. We've had to take the c

[@vicfarago4091]

left eye appears smaller than right eye

[@punkkauz]

I think I have an idea..

[@ussupplyllc5161]

Or someone who is dying in 6 months should not become young because what if he dies in 3 months? FDA should allow exceptions

[@derlon858]

thats when you realize, the goverment doesnt exist or work nor care about the people, it just protects itself

[@cesarraidi5449]

Hi there I can see that the host is a bit off ,so can you fix the condition call lazy eye ....

[@WILLIAMMALO-kv5gz]

It may be helpful to look at the higher electrical level as in the work done by Dr. Micheal Levin PhD Microbiology. This also may tie in with "Electric Universe theory" to some degree. Thanks to Dr. David Sinclair and James Altucher for this very informative video.

[@marcusiA-immortalistMarcus]

😁😁 I love it

[@johnmessing]

If epigenetics can be indefinitely reset for anti-aging, why has eternal life not yet been achieved?

[@verigumetin4291]

he literally explained it in the video, were you not listening?

[@lawrencelawsen6824]

Do the research as soon as possible it is part of the critical path in statistics, or the shortest possible route. Everything is based on the FDA approval

[@eshaniking4421]

What I would really like to know is how much more effective any of these approaches are at increasing longevity and reversing ageing than a series of simple 72+ hr water fasts.

[@AlexLacorum-hf9ie]

Claiming fasting reverse aging s still inconclusive and does not have scientific backing. If their is already on going trials then it will take a lot of years before we can see it's effectivity in age reversing. David Sinclair works is already taken laboratory experiment so it is more reliable than fasting but still need more time to find out how safe that drug to human

[@BarbaraWiltGerber]

People have been fasting and recorded since biblical times. Way longer than this new experiment. ​@@AlexLacorum-hf9ie

[@eshaniking4421]

@AlexLacorum-hf9ie they can easily do a trial comparing the methods including fasting using their developed criteria for assessing longevity! Why not do it?

[@rositamegchelenbrink691]

It's very simple, you restore your DNA when you completely dissolve the negative mindset with your self-love. This is the inner ascension process, which begins with sincere forgiveness. Due to the negative thinking, the telomeres of a cell can only divide about 60 times and then the cell dies, which is not the intention. The negative mindset is the result of inner fear.

[@rositamegchelenbrink691]

So… in short, ONLY fear makes the unconscious sick and old and dies, leaving the person trapped in the dark reincarnation process. Wake-Up please 🙏🏻💛

[@karinagrippaldi9693]

how come is possible to clon a monkey from a skin cell and you is not possible to make hair to transplant on hair loss cases or find a cure to genetic hair loss ?

[@rosabarrera4216]

Can someone give me his page to buy his supplements please

[@feltonhamilton21]

I believe free radicals should be studied more often because they put out negative waves that can get in the way of signals and charged particles pretty much everything inside the body of a living cell and stop the positive activity between molecules and other particles creativity. Unpaired electrons can carry a negative charge for a long period of time while injecting negative energy and causing confusion between molecules and charged particles and stopping them to not line up with the inner and outer cell structure and work accordingly with the cell inner umbilical cord duplex protein adjustable scaffolding operating system designed to liquefy molecules and deliver them through activities on each contact with the cell inner wall but because there have been damage to the cell internal an external tissue they begin duplication on damaged and dysfunctional tissue, so rather than breaking away into two separate cells the cells clump up into a waste field powerhouse injecting free radical material into the bloodstream and eventually causing damage to other fully developed cells outer surface and enter body. I believe stopping unpaired electrons from doing any type of damage could be much easier than looking for alien resources. I believe it's all about negative and positive charge particles and reducing the wavelength on unpaired electrons and stopping the confusion with a stronger microwave input that can convert into a negative and positive charge and balance the entire waste field of decaying cells so white blood cells can take over and stop free radicals waves interference on the human DNA and from blocking biological digitally coding from positive electrons and molecules and other particles trying to stay charged and keep up with creativity..

[@armankilic]

I guess David is standing up during this video.

[@sindhusindhu131]

Hi sir,do it dont stop it

[@joecool7165]

David, I followed you for a very long time. Your eyes blink a lot now and they just don’t look right. I hope everything’s OK with you have a lot of hope for what you’re doing.

[@SAMSAM-rw9fc]

Wow you are a very good judge I watched this video for a long but didn't notice his eyes after I thought let me read the comments and here you are lol really his eyes are not looking just right IDK what's happening. Btw Im on NMN for 2 months I don't feel any difference but as this is just 2 months I'm continuing Have you started any same kinda supplementary, I would appreciate sharing thanks

[@andrianasotiris6681]

​​@SAMSAM-rw9fc Botox is what's wrong with his face

[@js401]

Try going to a gram and a half of NMN.

[@SAMSAM-rw9fc]

@@js401 Its written on the bottle one capsule a day so I'm following that Can you please answer if you taking any that kinda capsules of NMN if yes what brand? I'm taking "PartiQular"

[@Melungeonpeople]

It could be as simple as a draft in the room.

[@BjJackson-jr8jz]

Time is what causes ageing.no scientest or person can not stop,reverse,or extend time which cause the ageing process in every thing.

[@RogerMimi-yq2ny]

Isn’t There some historical discussion about crick and Watson being first to discover DNA ??

[@Naonicat]

He’s great scientist no doubt about it but in the past he exaggerated some of his theories now most people know that mmm and resveratrol are not the miracle molecules 🤨

[@keithmarshalldds511]

Is it a coincidence that the URL for this podcast have three 4s? Lol

[@MarkShinnick]

Look into Sinclair's financial and claims history: many not happy with his ethics.

[@bjarnetollevsen2163]

Nomen est omen.

[@Preciouspink]

Why does this doctor go on so many different shows? Does this impair the ultimate goal of treating aging?What does he accomplish with all this video attention?

[@SAMSAM-rw9fc]

Good Questions I always was thinking that

[@lumanliu8457]

@@SAMSAM-rw9fcfrom a positive thinking, I think he want to raise his fame and raise money for his business. You can imagine this kind of human trials need a huge amount of money and you know what's more important than the money? People's faith. Now, no one believe aging can be reversed. So no trial will even begin. That's I believe what he wants to change. One thing you can trust is that he is not doing those only for money. Come on, money does not mean too much for people at his position.

[@CarlosElPeruacho]

Research funding is often a popularity contest. More eyes and more interest can lead to more funding and accelerated research.

[@AndroidSon]

How remain joung forever? Just look at this: (I’m 50 years old Japanese man. I show you my secret routine for me keeping my youthfulness)

[@erik_carter_art]

23:57 gave me a heart attack!...

[@matthewcardenas5124]

Rosalind Franklin discovered dna those men just took the credit

[@karinodendaal5277]

Not correct Info Dave. Molly the cloned sheep did not live a normal heathy life. She and all other animals cloned only live half a life span. They don't live a long normal life.

[@brianlebreton7011]

James keeps referring to the DNA being corrupt which is not what David’s theory is. It’s the epigenome that’s not working right. David’s being very politically correct in not correcting him.

[@monaantony9096]

How about just buying a copy of Dr Furhman , Dr Greger , Dr Goldber and Dr Neil Barnard and follow their food guides and we would need no pill n so much research Just eliminate processed food for a start … it’s that simple

[@John-d8p]

Outliving his critics ain't gonna be much of a big deal though since most of those men are really old at this point.

[@DG123z]

Can't wait until they have something you don't have to "believe in" for it to work

[@vickybiagini8623]

You might be waiting for pigs to fly first. Hate to be like that, but it's been decades, and he has nothing, absolutely nothing. He has to keep the gravy train rolling though.

[@DG123z]

@@vickybiagini8623 They have something promising with the three yakanama factors and there are other avenues, such as with Michael Levin's work

[@rg-cb2wd]

We cant even reverse balding lol

[@stephenkern5784]

No but I am 77 with a full head of hair and it is growing out darker.

[@blackpepper8941]

37 very important...

[@paulv7744]

James you do not look 56. Never wouldve guessed.

[@marialancuba1906]

Wat about hair cut 💇‍♂️ for more oxigen on the head !!!!

[@ScaleCrawling]

1. Will you call it the T-Virus? 2. How young will it make Milla Jovovic look?

[@KapowskiGG]

37:00

[@antoniobortoni]

Why people put limits, anything is possible, but the gold rush is here, return to young treatment people will go to another country if illegal , so make it free and public the return to young mix and all, because i want to see all women young again, and at the same age all...

[@ussupplyllc5161]

someone who is blind, should not get a young vision in fear of maybe getting blind? FDA wants safety?

[@dovigliopagnoni3179]

Way you don't talk any More about NMN

[@josselynpierce4099]

I love ur work david sinclair plz study on me

[@techchanx]

This guy is a charlatan, be careful of what he says.

[@blackpepper8941]

Lucky enough to choose Biology as my career ❤, Even AI can't replace my career 🎉

[@pgc6290]

Are you sure about that?

[@gdok6088]

With AlphaFold AI and just recently the release of AlphaFold-3 developed by Demis Hassabis and his team at Google DeepMind based in London, UK 🇬🇧 you will certainly have some amazing and open-source AI to assist in your biology career.

[@DG123z]

"No, i don't".. "okay" 🤦 it was some lady before them though anyway

[@sammyjudeh1117]

Fred Armisan? Is that you?

[@opawillem50]

Is it possible to slow the aging of a beequeen?