Transmembrane Enzyme Linked Receptors | Kinase Linked Receptors | Receptor Pharmacology

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Enzymes- Almost all biological reaction are carried out under the influence of enzymes and this is the reason why enzymes are a very useful target for drug action. Drugs can either increase or decrease the rate of enzymatically mediated reactions. However, in physiological system enzyme activities are in optimum condition and amount.
Receptors are the macromolecule or binding site located on the surface or inside the effector cell that serves to recognize the signal molecule or drug and initiate the response to it, but they don’t have other functions.
The largest number of drug that does not bind directly to the effectors like- Enzyme, Channels, Transporter structural protein, template biomolecule but act through specific regulatory macromolecule or the site on them which bind and interact with the drugs are called “Receptor”
An enzyme-linked receptor, also known as a catalytic receptor, is a transmembrane receptor, where the binding of an extracellular ligand causes enzymatic activity on the intracellular side. Hence a catalytic receptor is an integral membrane protein possessing both enzymatic catalytic and receptor functions.
They have two important domains, an extracellular ligand-binding domain and an intracellular domain, which has a catalytic function; and a single transmembrane helix. The signalling molecule binds to the receptor on the outside of the cell and causes a conformational change on the catalytic function located on the receptor inside the cell.
Enzyme-linked receptors are the receptors for many growth factors, cytokines and hormones and have a major role in the regulation of cell growth, proliferation and differentiation. Mutations in receptor tyrosine kinases are responsible for a wide array of diseases, including cancers, neurodegeneration, achondroplasia and atherosclerosis.
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Good to know that. Thank you for your feedback

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Great. Happy to know that and thank you for your feedback

[@-BhadoriyaMohitSinghN]

Sir your information about anticancer drug is an awesome application of Enzyme linked receptor. I appreciate you as one of the best Pharmacist.

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Simran Khanna My pleasure sir

[@ahemadriaz]

It is quite helpful & easily understandable. Thanks for sharing.

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Thank you

[@ilyaspatel1610]

Thank you so much sir ♥️ and please please make a video on remaining two receptors i.e. JAKSTAT and receptors regulating Gene expression

[@PawanYadav-kh6zi]

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Pawan Yadav My pleasure. Thank you for your feedback

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@@naureennabeel3365 Please watch it - Download Practice Model Question Paper and MCQ & Participate in Online MCQ Test kzbin.info/www/bejne/haizfJ6tgdaFnas

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My pleasure. Thank you for your feedback

[@pharmaboy6762]

Aapka Bahut abhut Dhanyavaad Sir

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My pleasure

[@vinayakpatil1512]

Sir can you please tell me answer that from where that phosphate molecules came for phosphorylation of Jak and stat?

[@owaisahmed3684]

Thanku you soo much respected sir😍

[@vinitasolanki3627]

Sir can you make video on transmembrane JAK-STAT reception process. And thanks a lot👍

[@panchi_agrawal]

tnqsm sir.......for this video. sch m sir aap ki videoss bhut help krti h...tnqsm sirr😊😊

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My pleasure mam. I am so happy that my videos are helping all of you. Please keep supporting.

[@rabeyagowshbash3345]

Thankyou sir for your lecture 🙏

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So nice of you

[@dushyantkukrejafanclub1382]

Sir plz upload the video for transmembrane JAK-STAT binding receptors & for receptors that regulate gene expression . Plz sir try to upload these videos as soon as possible bcz ur videos really helped us a lot 😊😊

[@solutionpharmacy]

We have uploaded other receptors video. And these 2 are similar

[@rashidulbsmmu]

Thanks a lot sir. Nice explanation

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Thank you

[@soumyaagrawal2023]

Thankyou very much sir for this helping video.... 😇

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Welcome

[@jarnaildhindsa4531]

Sir aap se medicine ke bare me sab kuj pta chal raha hai

[@Dr_s_777]

Very very helpful videos for me

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Thank you

[@toshnisinha7640]

Osam video sir I need receptor regulate transcription factors topic video..

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Thank you

[@narendraparihar2494]

Verry nice 👍 thank you sir

[@jarnaildhindsa4531]

Sir atypical antipsychotic depression ka treatment kaise karte hain sir please video vna deo sir bahut jururi hai

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Tq sir,sir ji ye FMGE me bhe Kam aa sakti h kya?? Plz btana muje confusion h

[@adritamallick542]

Sir please upload a video on drug response relationship.

[@rahuldelhi2510]

Sir make video on transmembrane JAK-STAT binding receptor

[@solutionpharmacy]

Rahul Kumar Please have a look to corticosteroid mechanism of action. You will get the same

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Navi Bhatt thank you so much

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Thank you so much for your kind and valuable feedback

[@apshanayesmin1140]

Amazing sir

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Thanks and welcome

[@kanikanegi2602]

Sir pls make video in gpcr signalling pathway

[@idrishansari8184]

Thank you sir....😊

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Welcome

[@pharmacystudy6846]

Sir ,jak state receptor and also nuclear reactor. Where is..?

[@pharmacystudy6846]

Video

[@anjubalkrishnabhandole1095]

Very very useful really.i m also a professor it is really helpful.but sir plz add drug action.how drug binds n give activity.thank u so much.🙏🙏

[@sushilpal3348]

You watch video with focus, Sir also telling the how drug binds and doing response.

[@jarnaildhindsa4531]

Sir please please answer olanzepine ka 5ht1a per kya effect hai presynaptic agonist antagonist or partial agonist

[@solutionpharmacy]

Sorry no idea

[@pharmacythree2928]

Thank you sir 👍

[@dineshgangoda5935]

Thank you sir

[@solutionpharmacy]

Dinesh Gangoda Welcome sir

[@shailjagupta956]

Plz make video on jak stat Pathway

[@alfiyashaikh2472]

Tysm . Sir uh did not upload a video for receptor regulating gene expression?

[@jayshreesil6395]

Sir, in the flow chart it is written "activated kinase". Can u please explain that??🙏

[@solutionpharmacy]

That means functional

[@mayankmehendiratta999]

What is meaning of confirmational change mean in layman language?

[@solutionpharmacy]

Mayank Mehendiratta In simple meaning it is change in structure so that it may produce action. For example key bind with lock to change its stucture and give action. (Open the lock)

[@mayankmehendiratta999]

@@solutionpharmacy thanks for clearing doubt

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Its my pleasure.

[@jarnaildhindsa4531]

Sir recptor par chemicals kitna time bind rehta hai please please sir answer

[@solutionpharmacy]

Till action potential exist. Koi specific time nhi malum

[@jarnaildhindsa4531]

@@solutionpharmacy very big thanks sir

[@kartikgill8453]

Hlo sir , feeling very happy after your lectures..... Sir do we have any notes and videos about jak stat , regulating gene expression and ragulation of receptor , dose response relation ship , drug potency and efficacy.....actully these are in my syllabus and i have to cover these also! Please guide

[@solutionpharmacy]

Thank you. Sorry we dont have notes on thise topics.

[@kartikgill8453]

Ok sir

[@kartikgill8453]

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[@solutionpharmacy]

@@kartikgill8453 Really i ma greatful to you for your valuable support.

[@priyankakachhwaha2261]

Sir enzyme receptor or enzyme linked receptors ek hi topic hai h ya different different hai?

[@solutionpharmacy]

Slight difference hai but occupancy theory same hai

[@priyankakachhwaha2261]

@@solutionpharmacy ok 😊 thank you sir

[@Rahulvarma-hq1cs]

Would you make a video about cology imp topics for exam as per PCI syllabus please

[@solutionpharmacy]

We have already upload important question paper set for all 03 units. Please do find in our channel.

[@moksh895]

Sir , does a cell has all types of receptor present on them?

[@solutionpharmacy]

Moksh not all cell. Presence of receptor is specific

[@rajnilamba3921]

Sir can u help with Jak stat pathway!!!!

[@vishalkashyapvishu3970]

Tqsm

[@Dr_s_777]

Thank you 100much dear sir

[@solutionpharmacy]

Always my pleasure dear. Your satisfaction is very imp for me and solution.

[@syedakiran6027]

Sir i could not found intracellular receptor lecture

[@solutionpharmacy]

Syeda Kiran Actually its not exclusively available. But you may watch alike video under glucocorticoids vidoe

[@MOHITSAINI-ku7hp]

Sir enzyme linked receptor main do pathway hai 1.ip3 pathway 2. Mak pathway Kya wo 4th semester ki pharmacology ke according important nhi hai

[@solutionpharmacy]

MOHIT SAINI IP3 and DAG pthway are inportant

[@MOHITSAINI-ku7hp]

@@solutionpharmacy but sir wo to gpcr main important hai na Enzyme linked receptor main jitna aap ne video main karvaya hai utna hi kar le wo sufficient hoga

[@solutionpharmacy]

MOHIT SAINI yes

[@AnkurKumar-hi9th]

Sir JAK-STAT binding receptors ka video upload kijye

[@solutionpharmacy]

Ankur Kumar ok. Actually uska concept kafi kuch is video se match karta hai isiliye usko abhi skip kia hai. Aage jarur ban jaaega. Thanks for suggestion.

[@AnkurKumar-hi9th]

@@solutionpharmacy Btw thanks sir for uploading all the video..... It really helps a lot

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Thanks❤🌹🙏 sir

[@FarhanKhan-ri6wh]

Sir g protein receptor detail video uploaded nhi hai

[@solutionpharmacy]

Hai uske animation

[@FarhanKhan-ri6wh]

Ji sir

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Vdiya sir ji 👌👌

[@solutionpharmacy]

Thank you

[@mohammadimran-mr1xq]

Tq sir

[@solutionpharmacy]

mohammad imran my pleasure sir

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Sir apke sab lecture sequence me kaise dekhe

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[@shahnawazahmad9165]

Sir plzz Receptor that regulate transcription factors ka video upload kijye

[@solutionpharmacy]

Iske baare me hamne receptor ke 1 part me upload kia hai. Ek baar wo dekh lijiye. Lagega to aur upload kar denge.

[@shahnawazahmad9165]

@@solutionpharmacy ok sir Thnku vry mch

[@asmaaslam2855]

Hlo sir one thing I want to know. How many kinases present in body their tyes and functions

[@vishwanathchaudhary7927]

nice Sir

[@solutionpharmacy]

Thank you

[@talhaazam6085]

Sir g kindly jysy lipincott main chapters haen wesy smjhayein jysy principles k bd aik chapter hai cell wall inhibitors

[@solutionpharmacy]

Sorry lipincott ko nahi parana mujhe. Mujhe cology parana hai.

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@@solutionpharmacy sir lippincot cology ke he book hai hum sb panjab lahor pakistan yhi parhty haen

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Thanks sir for this class I really appreciate and helpfully

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Imran Gayen thank you

[@AYUSHSHARMA-iz6og]

sir please some vdeo upload on biochem and pathology

[@solutionpharmacy]

Sure. After cology and cognosy we will start both of them

[@smitpatkar6553]

Sir JAK-STAT transmembrane receptor will upload as soon as possible Plz sir...

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Sir, plss start medicinal Chemistry video pls sir.

[@solutionpharmacy]

This will start on app. Notes are available for med chem 1

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@@solutionpharmacy when it will start on the App?????? And How much cost of med chem Notes

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Thnkyu sir♥️🙏🇮🇳

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About foaming index

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sir echo problem in video please fix it your sound have echo

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How to de termine vein islet number

[@sanjeevranjan9537]

Thnk u Sir

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Welcome

[@syedakiran6027]

Sir where we can find mcqs of this chapter

[@solutionpharmacy]

Check description box

[@saidabdikarimabukar1105]

Speak english or make english captions so as to avail your knowledge

[@solutionpharmacy]

Please visit our new channel for upcoming lectures in English. Link- kzbin.info

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G protein receptor

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You are a gujarati

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No

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🙏🙏🙏

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thnku sir

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Welcome

[@balkrishnashahi5332]

I am sorry to say that you only tell us what ever written in the book.There is no any concept.So please gives concept.

[@solutionpharmacy]

Sorry sir. I am not that much able to create own concept. I have to explain what is given in book. If book is better please prefer that.

[@fdr.shahid1127]

❤️❤️

[@musikaaffection8570]

Thank you soo much sir ✌️

[@soumyaagrawal2023]

Sir please make video on jak stat pathway

[@durgeshsingh6447]

Thanks 😊 sir...

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My pleasure

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Thank u sir

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My pleasure

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Thank you sir

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Dinesh Choudhary welcome

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Thank you sir

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Thank you sir

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Thanks sir 🙏