Transplant Immunology

[@LucidityAboveStarS]

Thank you for the presentation. I would like to add some points for the Direct Allorecognition: The MHC molecule of the donor is not processed by the recipient APCs and presented to the recipient T cells, that happens in the indirect way. In the direct allorecognition, MHC molecules of the donor APCs present their own antigens to the recipient T cells. Normally, our T cells are trained to recognize only self-MHC molecules, so actually it is a bit odd that in this case they interact with MHC-Antigen complexes from another individual (which is called allorecognition); but they do. A likely explanation could be that the T cell receptors have some intrinsic affinity for MHC molecules, self or foreign. So, it is an example of an cross-reaction in which a T cell that was selected to be self MHC restricted is able to bind structurally similar allogeneic MHC molecules with high enough affinity to permit activation of T cells. (Abbas et al, Cellular and Molecular Immunology- Ninth Edition, page 378) As a summary, somehow the self peptide+MHC complex of the DONOR fits in the RECIPIENT TCR to start an immune reaction.

[@theprincess2972]

Hi Plz anwer I need you

[@khadijaawaisu1624]

i’ve literally been struggling with this topic but finally got it with this video..niceee👌🏾👌🏾

[@timothyhsu9418]

When you say since we don't clone human I know that you must be a scientist.lololol

[@emanuelgrant4335]

Thank you for the video, Dr. Richards. It was great pre-class preparation here at UVA!

[@ThatOneScienceGuy]

The idea of donating an organ creeps me out, even though I know people desperately need them. Part of me thinks that what if consciousness isn't fully stored in the brain, and a very low level piece of my consciousness and carried with my liver or kidneys into the recipients? That wound be weird, wouldn't it?!

[@drSJV]

Thank you! Great explanations, clear to understand 🤍

[@noa3788]

Why HLA typing is required in renal and cardiac transplant while it is not necessary for other solid organ transplant ?

[@drbhanumishra8602]

Awesome presentation Please continue the great work

[@Tennis-3582]

Amazing presentation,, Wow !! My niece is scheduled for lungs transplant tonight ! Hope things will go well .

[@Nanosh_96]

hope he is well now

[@alexgrandizer2185]

Thank you 5 years after this video was published.

[@beatrizpassinho3919]

Thank you so much! That was amazing :)

[@Ravilandge1992]

excellent presentation.You really made it simple for me

[@mohitthakur9919]

Thank you.

[@anilsia1962]

Madam. Thanks for great explanation. Is patient with systemic sclerosis suitable candidate for lung transplant. Are chances of acute failure higher.

[@medicalparasitology3431]

Dear Dr. I am really interested for your presentation, could I have your slide presentation?

[@aditisondhi6102]

How do we have preformed ab for solid organ transplant though we are getting transplant for first time

[@sarahmina1442]

Thank you so much :D Why do we have to look for a previous Hemodyalisis (preexisting Antibodies??) or do you mean transfusion? 27:15

[@maureenrichardsimmunologym9632]

Yes! Transfusion.

[@Peace597]

thank you

[@devonmarshall7507]

Very helpful thank you!!

[@thomas01pd2016]

My f-ing ears bro...