T Cell Activation and Control

Dr. John Looney reviews T cell activation contributors, T cell antigen recognition, and T cell "braking."This webcast is part of an interactive online series designed to bring you, the busy clinician, up to speed with the remarkable advances occurring every day in the field of basic and clinical immunology.
To learn more or to claim CME credit, visit www.ccfcme.org/...
This CME activity was produced by the Cleveland Clinic Foundation Center for Continuing Education and the R.J. Fasenmyer Center for Clinical Immunology.

[@frankieannholmes1892]

So very clear and WONDERFUL ANALOGIES--what better way to show antigen recognition and binding than lovers? And the tides in Nova Scotia representing the ebb and flow of the immune response. And all the incidental references to the diseases that are explained by immune overstimulation or exhaustion. What a brilliant and Renaissance man. I need to view this many more times. THANK YOU for making this available

[@marcelfab1657]

Very well explained. Helped me to study all these modern therapies like PD1 and CTLA Inhibitors. Thanks!

[@romaissach497]

I just needed to link everything together and this lecture helped me with that, very simple and clear, thank you!!

[@chintomendoza]

What an ammazing topic.....This lecture ROCKS!!!

[@calebhaines3794]

Lasers can be used to identify materials that are coorelated with shredding and heating settings on recycling systems.

[@isatousarr7044]

T cell activation and control are essential for maintaining a balanced immune response. Activation requires a combination of signals, including antigen recognition through the T cell receptor, co-stimulatory interactions, and cytokine signaling. This ensures that T cells respond appropriately to pathogens while minimizing unintended immune activation. Regulation is equally critical, with immune checkpoints such as CTLA-4 and PD-1 playing a key role in preventing excessive immune responses. While this helps protect against autoimmunity, it can also be exploited by cancer cells to evade detection. Understanding these mechanisms has led to the development of immunotherapies that target these checkpoints. T cell activation is also linked to autoimmune diseases when dysregulated, highlighting the importance of controlled immune responses. Regulatory T cells (Tregs) help maintain tolerance by suppressing unnecessary activation, ensuring that the immune system does not attack healthy tissues. Long-term immunity relies on the formation of memory T cells, which allow for a faster and stronger response upon re-exposure to a pathogen. This aspect of T cell control is crucial for vaccine development and immune system resilience.

[@prasanthchakrapani8105]

Thank you, wonderful explanation and sharing of knowledge 👏

[@Mr22ogins]

Seriously well put together video. Top notch!

[@doctorrajeevkn3599]

This is a fantastic class. Everything explained. The secret of check point inhibitor in oncology revealed

[@chrisli9685]

OMG, TY for this!!!! It summed up perfectly what I needed to understand!!!

[@chandybundy2667]

Ure so much better at explaining this than my lecturer was. Thank you so much

[@svetlanasoloviova2418]

You save my life tonight, so much thank you

[@rahelnyarko-morrison9354]

Lol

[@kenhayes9718]

Thank you for the time to explain this material so well.

[@GPanos22]

Amazing explanation. Clear and informative!

[@link2442]

I feel that I grasped this better and with ease than the lectures my professor gave through out the whole semester

[@magicuba]

dr. John is a real boss, respect

[@avisekdeyati6505]

Great Talk! Different components of innate and adaptive immunity have been put together in a clear and articulate manner!

[@johnsong7503]

Excellent lecture presentation! Thank you!!

[@zhussipbekmukhatayev7225]

This video helps a lot! Thank you Dr.John Looney

[@zethuandisiwe4188]

A very good explanation but how is a picture of a person indicating HIV

[@gabrielbrill4782]

at 5:05 he mention how t cells get activated in the lymphatics, but a predominant amount of t cells get activated in the thymus and mTECs. I think some treg cells get activated in the periphery such as the lymphatics.

[@arinarakhteenko579]

Awesome summary and nice examples from culture or nature to keep some point in mind thank you!

[@claricecataldi7555]

I need the conctact with this doctor please.

[@Tracertme]

I was delighted to find this video, I am not a doctor or medical student, I am over 60, in a high risk group, according to science, and taught myself everything about these very cells during COVID and active/innate immune systems that I could, and decided not to be vaccinated. I applied science with nature and was only sick for 4 days with omicron BA2. I have never been sick since and continue to build my own health outside traditional medical practices.. I have never been as healthy as I am now, the COVID lockdown period was a blessing for myself, I studied and learned 😅

[@hildavalerolozano7752]

Gracias , me queda la idea de la complejidad del sistema inmune

[@shreineraly1684]

It is primarily explanation but we need to connect that with the clinically associated explanation

[@so-oo6ti]

I am curious about the radioactively contaminated water that Japan is trying to discharge.

[@6789uiop]

Thank you for this.

[@oibal60]

Thanks for this.

[@faithfoi1303]

well done! thanks Dr!

[@jennamore5514]

Very good lecture, thank you !

[@zannatul23]

ayy ;)

[@theequaliser8026]

I wish you could help those with celiac disease surely

[@nope.13]

Excellent! Thank you so much!

[@analasic1823]

Thnk you! Great repetition material!

[@sapnayadav-rc1ym]

thanks a lot sir for explaining it all so nicely....

[@rashmivinayak8377]

Excellent Talk..... Very very clear concepts..!!!

[@AlexanderKubik1993]

Rashmi Vinayak I thought it was very very very clear, not very very clear, didn’t give it enough credit

[@guillaume6373]

Awesome talk

[@tatendagucci3293]

this is really helful

[@spldrstudtom]

Very helpful, thank you very much!

[@becizaistrup2920]

Very detailed and well explained

[@Macroautophagy]

Excellent talk

[@avinashselva9636]

It was a very good lecture. Thank you sir.

[@darkaction123]

beautiful

[@AlexanderKubik1993]

This dude has a stellar mustache though, props to him hahaha

[@jiayuho3459]

Thank you so much for the great lecture!

[@claramarques5606]

amazing

[@mrsoluwaoseunti]

Thank you!

[@thyowen]

great video. really clear and moves really well into what it can mean for future developments. explains why its interesting haha, thanks

[@jaggaiahnaidu4949]

Good lecturer

[@45th_is_47th]

This video really help out a lot

[@jeffreyleikachon1]

Thanks, it helps a lot.

[@김수빈-m6m]

Thanks😊

[@kingpat345]

Nice video

[@limeroundup]

Great explanation!

[@MsAmour2009]

Great job, thank you very much!!

[@caitlinriggs3433]

how do activated T cells know where to go after they have been activated in the lymph node?

[@slehbenhamida3689]

chemokines secreted by dendritics cells lead the way towards the infected tissue.

[@Enes-ld7gk]

by chemokines ofc

[@sivasankarnallapati]

Love it

[@solomondo3490]

How can I download these videos of interest??????? help!!!

[@AlexanderKubik1993]

Solomon Do you go on google and search how! You’re a smart one! (Sarcasm fully intended)

[@evagold5221]

what about infected Mph and DC? Can they make a presentation antigen for T CD8 ? Are there MHC I on DC and Mph or just only MHC II ? Thank you

[@evagold5221]

+Gukan Sakthivel Thank you for answer! Other one thing surprise me: is it really APC have CD4? For what it?

[@evagold5221]

+Eva Gold thank you ! but very often i read about the HIV infects all CD4+ cells =APC !

[@svoidkugan]

+Eva Gold No No CD4 cells are T cell CD8 cells are T cells too both are T cells ! HIV infects T cells!

[@evagold5221]

+kugan svoid Thank you! But why everywhere written about HIV 1 infects Mph by way CD 4 and CCR5?

[@evagold5221]

+Eva Gold This is from Robbins textbook: The requirement for CD4 binding explains the selective tropism of the virus for CD4+ T cells and other CD4+ cells, particularly monocytes/macrophages and dendritic cells. Binding to CD4 is not sufficient for infection, however.

[@richardnevin]

Thanks

[@marymasterman7957]

thank you!

[@toulinma6916]

do activated t-cells PERMANENTLY release Cytokines even though no antigen binds to its T-Cell-receptor???

[@chrisli9685]

No, they don't permanently release cytokines. That is why you have CTLA-4 to down regulate the response along with IL-10 and TGF-beta. It is a HIGHLY regulated system. However, there are times it does go wrong.

[@thesortsakis]

fantastic!

[@drsharafathali4043]

Thankyu very much

[@calebhaines3794]

Activation energy for any and every cell in the body needs to be monitored and controlled to prevent excessive photon and quantum radiation from passing through or onto the body.

[@vivekbhore8558]

Good

[@zakirzak1494]

💗

[@scottslomka240]

Creatine prevents exhaustion

[@davo3299]

chemokines!!

[@yorkshin8901]

Nice talk

[@0sama789]

A great lecture, thank you so much!

[@MsAmour2009]

GREAT JOB! thanks a lot!

[@jiafengxu3126]

thanks

[@vivekbhore8558]

Good