Turning Aspirin into Tylenol

This is a video that I've been meaning to make for a while. I think the idea of converting one drug to another is a pretty cool concept.
About a year ago, I made a series where I chemically converted Aspirin to Tylenol (aka acetaminophen, paracetamol, or APAP). The original series was spread out over several videos and was over 90 minutes long. It has a lot more detail, but it was a much bigger commitment to watch.
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Nile talks about lab safety: • Chemistry is dangerous.
Music in credits (Walker by SORRYSINES): / walker

[@TrueVartoc]

"I was able to convert 200 extra strength aspirins into one really weak tylenol" SUCCESS

[@ItachiMusic]

where did everything else go lol

[@saltmine]

Look at it this way if his yield was super high he might get in trouble with some farma companies ;) but that really depends on the pricing of both painkillers if it would even would be an issue

[@GodlikeIridium]

Yeah it is a success, simply because he did achieve he's goal. And it's pretty cool. And that would be great for chemistry students, either as theoretical exam or as practial lab for 4th semesters.

[@justsomecommentchannel8602]

stonks

[@yigitalpalakoc]

Cant spell success without SUCC so i guess he SUCCed some of it

[@marcusmerrin192]

I'm an old-school chemist (PhD 1987). I love what you do, and it reminds me why I fell in love with chemistry as a teenager! Keep experimenting and teaching!

[@thebassrogue]

That's so cool! I love chemistry but didn't follow the profession... I have fun vicariously thru Nile

[@michaelneal3162]

Dude I am kind jealous of any one who liked chemistry. I technically failed the class. Only because I never did my home work. I got nearly 100% on all my test. It just felt like all I did was balance equations.

[@shauntaebritt6488]

Just curious and out of pure respect, do they use fetal tissue to make tylenol?

[@coop6622]

I love that you two found each other Marcus, this post warmed my heart. ❤️

[@scarcety8133]

@@shauntaebritt6488 no absolutely not

[@bretsutherlandsterriblemem8439]

"Turning one really weak tylenol back into 200 extra strength Aspirin tablets"

[@MrPicklesAndTea]

Imma head out to buy a 30 pack of tylenol so I can have unlimited aspirin.

[@Defhrone]

@@MrPicklesAndTea that's close to how homeopathy works xD

[@ryujinayato1623]

Kage bushin no jutsu!

[@zoeyuroboros5739]

@@ryujinayato1623 what?

[@geostyma]

I just died

[@maol2038]

“Polymerized crap” is the IUPAC name

[@NickiRusin]

underrated comment

[@doorhanger9317]

It's part of the chemical series between "organic side-shit" and "horrible tar"

[@Qsie]

saw this on the diagram and died lmfao

[@sivasubramaniyanrangaraju4730]

Ngl they should changed it to "fibrous elephant shit" for nomenclature Sounds like it has alot more polymers for some reason

[@TheOriginalMaxGForce]

I followed along with your video precisely and I ended up with 42 pounds of crystal methamphetamine. Please advise.

[@Voltnic]

no one else like this comment please (look at the likes)

[@Voltnic]

@@TheOriginalMaxGForce no yes no yes possible nont

[@LANDSHARKK]

Buy a offbeat hat and pick up Pinkman

[@izanagi5136]

Sell it all, repeat, you’re rich now

[@umakariharu8035]

Buy an rv and you're all set.

[@Mx.Cumulonymphus]

"Ah crap I got aspirin, not tylenol" "Don't worry mom, I can work with this"

[@thatonedynamitecuber]

*Makes a very weak tylenol pill* "Mom, I think you're gonna die"

[@themittenkitten_wastakenfromme]

Why the video was recorded:

[@citrus4419]

hahahaha!

[@Xypos]

NileRed: The process is very straight forward Me 26 minutes later: Wait what?

[@loki8061]

@Xypos I'm right there with you

[@chitlitlah]

Well if you couldn't follow the simple 327 steps in the process, I don't know what to tell you.

[@gl1500ctv]

21:36 I thought "he's good... look, there's a Tylenol capsule in the product!" It was his stir bar.

[@BillAnt]

The Tylenol was just a crusting on the stir bar, you'd have to swallow it whole to get any affect. lol

[@gl1500ctv]

@@BillAnt And hope nobody turns a strong magnet in the vicinity of your gut. I'd assume it would continue to stir. Ouch.

[@ethangoldsmith9332]

Hehe

[@joemcroberts9975]

@@gl1500ctv MRI scan after swallowing

[@flamesage0992]

About as big as a real one

[@Gaming_Legend2]

Converting a fresh big mac into a bk wopper

[@Gaming_Legend2]

Samar Nadra the preparation is different, bk here put the meat in a oven that looks like a microwave, and the burger is thicker but have a smaller diameter, and the meat they use if from different type of cows

[@none.892]

Underrated comment.

[@oscargr_]

@@samarnadra problem is... Where to get a *fresh* big Mac.

[@oscargr_]

@@samarnadra Of course I meant that sarcastically. You simply can not use the word fresh for anything in a fast food restaurant. That no country bans food says nothing about it's freshness.

[@oscargr_]

@@samarnadra maybe you re confusing the word cold for fresh... LoL It's true that some additives are allowed in some countries but not in others. "Yellow number 5" if I remember correctly. You will find that sometimes even things like Mars bars are different in different countries. So yeah... They do replace one additive with another to achieve the same 'function'.... But that s still an additive... I would not call it fresh. It's like when they put "fresh milk" on a pack of pasteurised milk, or "fresh juice" on a bottle of reconstructed OJ. I think it's all legal to the letter of the law, but it's not what common sense says 'fresh' means.

[@vickierayhill4637]

I have to admit, I use your videos to fall asleep at night. Your voice is so soothing, calm, clear, and never talk too fast. You could narrate a bus schedule, and I'd buy the audiobook. I listen intently and usually before you're done, I am out like a light. But you are not boring! Thats how I discovered your channel. I actually watch the video again the next day. Thanks for your excellent channel!

[@tia2936]

omg high five bestie 🤺

[@adamwells5396]

I do the same thing! So soothing 😌

[@carlos-db5pg]

I would like if he could speak a little slower cause i'm not a native English speaker.

[@dwaynowilli6822]

@@carlos-db5pg for English, he speaks extremely slow

[@kyoto5463]

@@carlos-db5pg I'm guessing you haven't been listening to English KZbin for a long time, you'll get used to the speed.

[@culgi]

I like to imagine NileRed as an alchemist in a fantasy world. "Today, I will be turning this stone into a bar of iron." or "I had an idea to try to turn a healing potion into a poison."

[@theguythatlikeslegos7708]

Edward Elric vibes

[@johnnye87]

"How to turn a healing concoction into a poison. First, take 200 aspirin." "...OK, then what do I do with them?" "I just told you, *take* them."

[@addyshorhnr3544]

@@johnnye87 oh that shouldn’t have been that funny

[@princessrachelsmith]

I can imagine him, as some sort of bizarro dragon and his hoard is just the bottles and bottles of chemicals

[@princessrachelsmith]

Oh shit new dnd idea Redscaled Dragonborn Alchemist named Nile

[@bernard2735]

Note: The "filler junk" is actually a carefully designed matrix that produces the correct dissolution profile and bio-availability of the tablet, whilst also ensuring proper binding, distribution of active in the matrix, good compression and ejection from the tablet press, etc., all without having a biologically active impact.

[@aethrya]

whatever you say NERD

[@craigstephenson7676]

So really cool filler junk

[@1e1001]

i believe you but that really sounds like advertizing bs lol

[@stargazer7644]

So you’re saying it is filler junk?

[@Lucy-uf6oi]

@@1e1001 the less "advertising" way of putting it is that the matrix is needed in pills so they don't just get eaten up in your stomach acid, and that they dissolve in the correct part of your body to treat whatever issue you're having!

[@zoogoo404]

I watched the original videos a while back. This was far less scattershot and easier to digest.

[@benscott3603]

Of course this is the comment he would like. It reads how he speaks

[@TheExperimentChannel878]

i liked the crystals they looked like needles

[@rosycat4254]

I have no clue what come out of his mouth 99% of the time, but his videos are really addicting to watch

[@RobotHunter1234]

next time someone asks me for a tylenol imma whip out my bottles of aspirin and my chemistry set and make it from scratch just to spite them

[@BillAnt]

At least it will be a fresh batch of Tylenol. xD

[@louisturner8842]

Pretty sure the headache would be gone before you finish

[@ricky107_]

@@louisturner8842 or it get worse because they don't know what's going on

[@arkesh110]

@@ricky107_ **halfway through the reaction** “yeah imma need those aspirins now”

[@FreezeAU]

The “polymerized crap” label in the diagram at 7:44 made me laugh way more than it ought to have 🤣

[@justmehere_]

same lmaoo, the subtle unprofessionalism, I think Nile Blue edited the video

[@ebbeheddle5221]

Same lol

[@PersonaRandomNumbers]

23:12 "So my original prediction of 30% wasn't that far off, I just kind of misplaced the decimal by two spots" LOL

[@purgruv]

Thanks, but I think my headache has gone now…

[@madmike4061]

lmao

[@AmyAnnLand]

Purgruv: Is your profile picture of Chris O'Dowd? If not, you (or the person in your picture) look exactly like him.

[@madelinebitts2766]

@@AmyAnnLand It's pretty obviously Chris O'Dowd with Richard Ayoade's hair poorly photoshopped on and I honestly can't believe you're stupid enough to not immediately realise that. That's hilarious.

[@AmyAnnLand]

@@madelinebitts2766 So you think someone is "stupid" because they don't immediately recognize a random actor? Haha. Okay. As if that's the only determining factor. Forget my degrees and accomplishments; I'm stupid because I'm not immediately certain it's Chris O'Dowd.

[@ClassickXD]

My sister's going to school for chemistry. I always whip out somthing I've learned from these vidoes. Her face is priceless

[@skygalvan1880]

My sister... I aways whip out something... Her face ... Priceless.

[@aSentientPickle]

someone stop this man

[@willyj3321]

I love how passionate he is about chemistry.

[@mheermance]

Only being off by an order of magnitude isn't bad, if you are an astronomer.

[@rogerhamilton8029]

he was off by two orders of magnitude

[@Boskibro]

Why do I feel nerdy for laughing at this joke

[@ObjectsInMotion]

Actual final I took in my cosmology class officially accepted an answer within 3 orders of magnitude as correct.

[@BillAnt]

No problem just move the decimal point over to the left by two, problem solved. xD

[@Mr.LaughingDuck]

Yeah, 2 orders of magnitude, meaning he got

[@RealRuler2112]

Just wanted to say that I shared this with my mother, who used to be a research chemist 40+ years ago; we both really enjoyed it. =)

[@Ehlihr]

just thought you should know, i sent this to my mom who’s a pharmacist, and classically has a video attention span of 2-5 minutes max. that being said she watched the WHOLE thing and loved it!! really great stuff lovin it

[@1323GamerTV]

Can you do converting Advil to morphine next? Asking for a friend

[@slayingdeathgaming5537]

1323GamerTV I’m asking for a friend too also a meth tutorreal would be nice 👍

[@GR-ke3fn]

I'm tryna convert ibuprofen to cocaine

[@projectyardinc4256]

Several people are typing...

[@dislexicdicktionary]

@@projectyardinc4256 agreed

[@disorganizedorg]

I want to see street meth into pseudoephedrine.

[@jeffrendered3564]

That sweet, sweet vacuum filter action!

[@banaan3001]

They're such a bitch to clean though if you have some nasty stuff that's barely soluble in anything.

[@BillAnt]

@banaan3001 < You can always bring out the big guns like acetone, DCM, toluene, xylene, and the rest. ;)

[@louisturner8842]

Rad

[@Kem.840]

banaan3001 said

[@rockabrand7401]

I love these longer videos. They're so satisfying and fun to watch.

[@mariedeflaviis]

Rockabrand The feeling it's sooo fricking mutual !!!!

[@BillAnt]

It's fascinating to watch those beautiful reactions... problem is when you do it at home it just becomes a total mess (crap as NileRed calls it), if you know what I mean. ;D Basically one step gets f-ed up, then the rest is just a waste of time.

[@krashsite2125]

I've seen you before...

[@dannyflo5373]

This is so interesting. I wish I had paid more attention in chemistry

[@Blutwind]

Same but then again in my school the only teacher was a nearly 60 year old witch that was seriously scary (she had mirrored glasses so she could see us students when writtting something on the board) and made chemistry super boring of a subject :/

[@luisp.3788]

@@Blutwind Reminds me of my current chemistry teacher. About 60 year old as well, can't control his anger, and the only thing he gave us to learn so far is texts that are just barely about chemistry that he has turned into these weird concentration practices that are basically just fusing every sentence together and he wants us to write it *perfectly*, and god help those who have a typo that he rates as "stupid". He then lets us write a test, and that's the content of his lessons. He also likes to shout so loud that you can hear it rooms across and he likes to smash objects against furniture (or furniture against furniture) to release anger. I'm glad we never have access to chemicals right now. I wouldn't want to be in a room with him handling corrosive or toxic substances, he'd probably throw it across the room. Oh yeah, he also doesn't like textbooks, so we write down hundreds of pages from his DIY text book (aka incoherent texts as mentioned before). Originally, I was happy I was finally getting chemistry lessons, but I have deep regrets for that wish. Eh, home chemistry is much better anyway.

[@Reivivus]

You only learn this kind of skills in Organic Chemistry class or lab.

[@waharadome]

@@luisp.3788 What the hell, he sounds like a crank

[@luisp.3788]

@@waharadome yep

[@NickC_222]

"Even though I do stuff like this all the time, it still blows my mind that it's possible to systematically build and degrade things on the molecular level." And this is, I think,, probably the very most basic essence of most people's interest in chemistry. It's mine, anyway. Chemistry like this is essentially a kind of microscopic engineering combined with the performance of what feels like microscopic magic tricks, except you perform them for yourself as opposed to the _macroscopic_ card tricks you'd perform for others. Actually doing organic chemistry like this almost feels like you're playing god in a small way, like these things shouldn't be possible and it's incredible that the possibility even exists, let alone that YOU get to just play around with it and have fun with it AND get paid for it, if you're extra lucky.

[@andrewflannery5790]

And this is why I want to study Chemistry when I get to Uni!

[@Raz.C]

@@andrewflannery5790 Best of luck, mate. The only advice I'll offer is to ask you to please, be CERTAIN to attend a university with a good chemistry department. I got into the University of Queensland, which is one of the top 50 universities in the world. My degree (BSc double major in Chem) was both fun and interesting, but above all, the labs were astonishingly well stocked. So we got a LOT of top-shelf experience before ever leaving university.

[@jimcarter6669]

Think I'll just go buy some tylenol.

[@vincevic1062]

Lol

[@jcfnetwork6768]

Lol

[@aveysquarerooted1417]

Lol

[@carrotxo]

Lol

[@ghoststudios3008]

Lol

[@wesleytownsend8214]

Amazing! Since my wife is a chem professor I am really wanting to brush up and retake some chem classes since I have forgotten so much in the 20 years since graduating from college er... maybe longer, since I was way more interested in playing baseball than retaining this info. You my friend are exceptional.

[@hiei248]

This is really cool. As a reference to reality, you created a 210mg rough equivalent of Tylenol? That's wild.

[@RobsMiscellania]

3:48 you should be aware that this is a yield of 94g of a mixture of ASA and salicylic acid. The recrystallization step almost certainly hydrolyzed a substantial amount of your product, not just a few percent. You can confirm this by using the iron (iii) chloride test for phenols. You will obtain a colored adduct with your recrystallized product, confirming the presence of a phenolic hydroxyl group. I know this because I synthesized ASA from salicylic acid and acetic anhydride, and after quenching the reaction mixture and decanting the precipitate, the crude product was recrystallized from boiling water. The melting point was extremely broad, strongly depressed, and was dependent upon the rate of heating. The NMR spectrum was a mess but did demonstrate the aromatic protons around 7.2-7.24ppm, and FTIR showed a broad and intense absorption around 3300/cm, and a sharp, very intense peak around 1710/cm. This is all immaterial, however, since your next step is to hydrolyze any remaining ASA.

[@kotapippen]

What

[@vitamins-and-iron]

thanks to the last sentence, i can summarise as follows: “”

[@TheExperimentChannel878]

the crystals looked cool

[@TheExperimentChannel878]

they were needle shaped

[@ToddWPerry]

Thank God for CVS, if I had a headache and needed to go through all of this for Tylenol I’d have a migraine or a brain tumor before I was finished.

[@josephinegriner2898]

I’m allergic to Tylenol Let me get my tools

[@cyancoyote7366]

Same here, last time I had taken Tylenol I was covered in red rashes from top to toe. Wasn't a fun 2 weeks.

[@joygao4656]

u sure ur not allergic to the red dye in the type or a filler material?

[@cyancoyote7366]

I had an allergy test done for acetaminophen and it was positive, so no.

[@ace-kz9id]

@@joygao4656 if it was the filler material there allergic too they'd likely have issues with more drugs. since atleast to my knowledge the filler is almost always the same, atleast it is for each brand.

[@nerd1000ify]

Do be careful with the phenol. It's quite hazardous: Around a tablespoon on the skin can be fatal, and the burns it causes are painless so you may not notice that you spilled it on yourself until it's too late. Another concern is that trying to wash it from your skin with water tends to just spread it and increase the area of skin that is damaged- you must instead wash it off with glycerol or a solution of polyethylene glycol. I certainly wouldn't handle that stuff without a lab coat on!

[@italydude515]

Thank God you said something man, I think you saved his life

[@threebloodrubies2132]

I very occasionally work with phenol in the lab I work at so this is actually helpful to know, do you know if it has the ability to move through nitrile gloves? Or do nitrile gloves adequately protect you from it?

[@georgeparkins777]

So there's a kind of coffee maker that used to be used a lot more, called a vacuum pot, which is essentially a self-contained vacuum filtering setup for extracting coffee. It's crazy to me how much a vacuum filtering device like the one used here looks like it when the flask is attached. Basically it consists of a flask-like carafe and a filtering bowl that has a long glass tube that goes down into the flask, with a rubber gasket between the two and one of various kinds of filters in the bottom of the bowl. Water bubbles up into the top where it is mixed with coffee, and eventually air bubbles out through the tube too and is not replaced. With the proper timing, you can develop a really good low pressure environment inside the carafe that sucks the water right out of the coffee grounds as the carafe cools. It's especially cool watching water boil below 100 c in the carafe, if you get the pressure low enough.

[@kayjay7585]

I'm totally intrigued and I googled "coffee vacuum pot" and got: "The vacuum pot, also called the syphon, is a beautiful and flashy way to make great coffee. Invented in Germany in the early 19th century, it's a full immersion brewer that also employs a metal or cloth filter, so you end up with a full-bodied and clean cup. " is that the device? There are some new models for purchase for under 100 bucks!

[@georgeparkins777]

@@kayjay7585 Yes. But I use the kind with a glass filter rod. It's hard to explain what that is but essentially it's a glass rod with a bulge in the middle, and that bulge is covered with bumps or burrs. The rod is held down by suction and the bumps make contact with the bottom of the filtering chamber, forming a coarse filter that allows quite a lot of liquid to flow past it but not medium-grind coffee. The cheap models have a reputation for being fragile. Mine are both 1950's and more resilient. I plan to give them to my children if I ever have any.

[@apodis4900]

Ive learned more about chemistry from your channel than I did from seven years at school with a shitty teacher. Thanks man.

[@AdasiekkkTrzeci]

Great video. Here's a couple of points that could be useful for improving the method: (1) I've seen some sources suggest that deprotonation of salicylic acid aids decarboxylation due to the competition for the proton. This should also stop the esterification as the carboxylate is not electrophilic. (2) Before nitration, protect the phenol with either acetic anhydride or (acetic acid + HCl + boil). Do the nitration using c. sulfuric acid as the solvent, and 1.1 equivalents of NaNO3, at -5 degrees Celsius (ice/brine bath), then hydrolyse. It adds two steps; however, this will lead to a selective mononitration to p-nitrophenyl acetate. Also means you avoid forming nasty di(-) and trinitrated products, which will be explosive. Work it up by pouring it onto ice and water and filter in vacuo. The crystals you get out will be almost exclusively p-nitrophenyl acetate. (3) The decomposition of p-aminophenol is due to oxidation/polymerisation in light, but it actually amounts to very little (if you check by NMR etc), so long as you keep it out of solvent. Recryst. from water is the usual way of purification, but I found that toluene works well too (if you can get your hands on it). (4) Recryst for p-aminophenol should be easier than for paracetamol. Source: my own research lab experience

[@kenriven5237]

Neat! Whenever I want to turn my aspirin into tylenol, I just pour some mor into the tylenol bottle. But you're method is much more impressive. Keep up the good work.

[@nickheyer]

When I want to convert my aspirin to tylenol, I just bring my receipt back to CVS and they swap it out.

[@tombombadil9622]

I personally hated chemistry in school but this is just so interesting that i regret paying so little attention to it in school. Thank you !!!

[@Draco301293]

You are awesome Nile! I'm so happy that you are succeeding with KZbin!!

[@NileRed]

Thanks!

[@professorxgaming2070]

Your channel has sparked a great intrest in Chemistry with my children and I. Seeing how things connect when you find pathways to connect them. Absolutely brilliant

[@spiritworker903]

The art of turning 200 aspirins into 1/2 tylenol :) For real now, I have a love for chemistry and your videos are pure candy. The right equipment properly used, apt explanations pleasantly delivered, good quality camera, camera work and cuts makes it a joy to watch. My average patience for youtube vids is about 7 minutes, yours watch like professional documentaries. Your videos are excellent fodder for chemistry students. What I find particularly elegant and alchemistic is that your subseqjuent videos keep transforming molecules made in earlier installments, highlighting the dance of functional groups that is applied chemistry. Every molecule can be an end point, starting point and intermediate. A pleasure.

[@lolroflpmsl]

And this is why I do inorganic chemistry... :P QUANTITATIVE YIELDS!

[@vornamenachname6300]

I watched the orignal series like 2 or 3 times , but one video covering the basic reactions is pretty nice as well. I think you should do this always: a while after ther series combine it into an video

[@mariedeflaviis]

Finley Franke YAAAAS PLEASE !!!!

[@BillAnt]

Twas the night before Christmas, when all through the *house* Not a creature was stirring, not even a *mouse* Yet one thing was stirring, twas NileRed's low yield Tylenol *crumbs* Ha-ha-ha

[@dislexicdicktionary]

Damn ouch 😂

[@citizenclown]

Man, I love your videos. I have always loved chemistry and physics, and ironically, i dropped out of chemistry just due to my attention to 3D CAD/CAM and physics and now photography, and just not able to dedicate the correct amount of time to chemistry that it deserves. Thanks for all you do. I really enjoy seeing your work.

[@Daniel-tl6hx]

I feel like regardless of how much you love Chemistry, the clean up sometimes makes it feel like it isnt worth it

[@brendanbush2174]

17:30 That flask looks so pretty with all those greens!

[@HexCopper]

I'm taking Orgo 2 at university right now and we are basically learning different reactions and mechanism. I'm now re-watching all your organic synthesis to see how much I can recognize. This honestly is amazing to me being able to come back and thinking how and why you came up with your reaction pathway or possible side products.

[@josistachelbeere]

your videos are really calming for me somehow. And i learn a bunch about my favorite kind of science along the wayy so perfect combination. Thank you for doing these videos! :) they help a lt especially now

[@verainsardana]

im studying organic chemistry its fun to watch things happen instead of cramming reaction :P

[@Smashy360]

Your channel has definitely reinvigorated my interest in chemistry. Thanks!

[@Angel_Billy4-30-23]

Hey, I'm fairly new to your channel but I fell in love with your content. You make some pretty awesome videos and I genuinely enjoy watching them. I also appreciate how, for someone like me who doesn't really understand the science behind the experiments that you do, you explain every step of what's going on so everyone can follow along with what you're doing and that's great because otherwise I would not be interested and wouldn't really know what was going on in your videos. Thank you for explaining the science of your experiments for people like me. I am interested in what you are doing but I don't really know the chemistry behind them so for you to explain it for us, keeps me interested and I always learn something new from watching you. I love your channel and your content and you genuinely help me to not only appreciate science but help me to like it and keep my attention and I actually really enjoy what I'm watching, so thank you.

[@nikik1326]

Reminded me of my chem labs. Loved watching and guessing your next steps without stressing for any upcoming exams lol

[@johnperalessyahoo]

As much as i hated chem in school, i love watching your videos.

[@apinchofkatie]

as a pharmacy student, i loved this video. it's so cool seeing the structure change.

[@dexter2392]

Really cool. A video of full chemical synthesis will all the steps and difficulties described. Thank you, as a person who's very interested in that.

[@Xenon3.6.9]

That's one is the one of most lovely project, NILE RED.

[@Gorboror]

24:41 Why I watch your videos, even though, a lot of the times, I don't understand it.

[@brendanbassett2525]

next video: "turning Pseudoephedrine into crystal meth"

[@mikehibbett3301]

Fair play to you with so many steps involved!

[@pedrobg97]

Wow, that NMR it's amazing

[@tabletopjam4894]

I think you should do the Caffeine as a single video, no matter how long it is, I think it’s nice to not have to deal with the wait time for slow internet(which I have half of the time)

[@TrabberShir]

Request: If you are going to do a long and complicated synthesis chain like this for caffeine, but don't want to do a lot of your normal high production value videos, could you make a B channel where you upload lower production value deeper dive videos for each step as you go? You are probably correct that a summary like this is of more interest to most of your viewers, but the 90+ minutes of your original series seemed to have a lot more reflection on what went wrong where and how you might want to do it different or why you did it the way you did, which is very useful and/or interesting information for some of us.

[@timehunter9467]

This was seriously fascinating, I’m amazed by how things are converted.

[@wheremakeysat]

This takes me back to organic chem lab. Love your content, keep it up!

[@hikiwi]

Would you make a series of Flavor and Odor making videos? Love your channel!

[@NileRed]

I plan to

[@hikiwi]

Amazing! Thanks for the great work

[@TheGayestPersononYouTube]

Seconded! I’d be definitely interested to learn some general tips for esterification especially ones that don’t use the alcohol also as the solvent.

[@thewolfin]

Ingredients: aroma Wow so descriptive

[@lordpinochetuttp3819]

He has, Pyradine, Cadaverine, Trimethylamine, Skatole

[@TrabberShir]

Outside of north america Tylenol is more commonly recognized than acetaminophen. Having grown up in Texas, I default to the generic name and over the last year I have needed to purchase it in Mannheim Germany, Cork Ireland, and Santiago Chile. In all 3 cases the word "acetaminophen" was not recognized but the word "Tylenol" was recognized when I asked where to find it (although in Santiago that was likely a result of Tylenol having a more standardized pronunciation globally).

[@invencible33]

You should had tried with paracetamol, it is more likely to be called that way.

[@TrabberShir]

Thanks, next time I need some will try that.

[@mariedeflaviis]

Well at least in Venezuela , we ask for acetaminophen or paracetamol. Tylenol is also found but it's not as common as the other two.

[@zockertwins]

In Germany I have only ever heard of paracetamol

[@daveprice5911]

Trabber Shir Yeah, usually paracetamol is most recognised

[@orellaminx3530]

Watching a video like this makes me want one long ass video of you just cleaning all your glass after a project.

[@johnnyw8482]

This was interesting to watch. I graduate in May with a B.S. in Chemical Engineering, and my senior project is designing an acetaminophen plant. I didn’t end up getting phenol as a raw material but I know people who did.

[@_Backpack_]

this is how I'll get ahead on my Chem class. no joke, I love these videos.

[@darrellbeets7758]

goddamn this gave me a headache, can i have that paracetamol

[@dr.v645]

That was very fun, thank you kindly!

[@PrehistoricPineapple]

no disrespect; i love your videos. this one in particular though i’ve been putting on to fall asleep every night for the last week. it knocks me out like 3 minutes in every time. i like to think that eventually i will learn something.

[@colorgreen8728]

Bro made a aspirin potion 2:25

[@senjiroanimations7284]

Splash potion of Pain Relief

[@jort93z]

I've made aspirin before, or ASA to be precise. At some lab. ended up being pretty high purity. Couldn't take it back home though, but was about 10 grams yield or so.

[@johnpossum556]

I could collect more than that in a nature walk at my local park.

[@demoniack81]

If you're talking about willow bark, that contains salicylic acid only, not acetylsalicylic.

[@jort93z]

yup. demoniack is right. You can make ASA from salicylic acid, but you'll have to also add Acetic anhydride plus some catalyst. ASA is superior and i don't think theres any ASA found in nature(not to my knowledge anyway).

[@johnpossum556]

If its a pain reliever and I were using it for that function then why would I care about the details? I know it works, I've used it.

[@FriedEgg101]

You pop out to collect willow bark when you have a headache?

[@owenjacobs6353]

Just had a mental breakdown check. Just wanna let you know, your voice is very comforting to me. i dunno why, but it is.

[@pyrotas]

The purple tint of the p-aminophenol solution violently brought back memories of me developing with Rodinal and the color change of the spent solution

[@jackscully7986]

7:43 "polymerized crap" lmao

[@tomahan044]

I never knew aspirin is not the same as paracetamol. In The Netherlands we often use the words interchangeably meaning the same thing, which is probably paracetamol.

[@NileRed]

hmm interesting. Yeah, definitely not the same thing. If they were, this video would have been way shorter :p

[@demoniack81]

Here in Italy tylenol is known as Tachipirina, while Aspirin is, well, Aspirina. They're definitely not the same drug, although in a pinch they can be used somewhat interchangeably as they both have antipyretic and antiinflammatory properties.

[@yatagarasu1495]

propably because people are just like "does someone have an aspirin", meaning they have a headache, so someone hands them a paracetamol pill, which does the same job

[@thewolfin]

Also aspirin is relatively safe for hangovers but paracetamol definitely not.

[@josephmorneau4339]

Tylenol is not in the NSAID category of drugs and does not have anti-inflammatory properties. Just an FYI.

[@sombrashibe]

As someone who takes migraines medications that has APAP in them, this was a fascinating watch! Thank you 💖

[@asbjrnyoung-groener1646]

No idea what I was watching, but super excited to see that you did it.

[@matthewgraci3509]

19:27 he turned grape soda into ginger ale

[@1stPCFerret]

Fascinating! Although, if I get a headache, I'll just take the Aspirin. 😁

[@Jmjholden]

I love the subtle Nile-ism in these videos

[@Patrick-ry5ct]

Cool Video. It set me back in the Time when i do synthesis.

[@yingxiawei821]

7:43 “polymerized crap”

[@thelivingend127]

I'm curious about your cleaning process. How do you clean everything?

[@hoaithunguyen4473]

Look for his other chanel, NileBlue. He post clean up vids there.

[@bryanstellfox8521]

I'd like to see what kind of yield you would have if you just started with pure phenol. Great video, I always enjoy your stuff!

[@AA-gl1dr]

You just made a bunch of chemistry concepts click for me. Fantastic video.

[@nicholi8933]

This was great. The nitration step is terrible. Still gives me nightmares from my old classes.

[@azmah8730]

i also got ptsd from my old classes

[@BillAnt]

Yeah that step was total crap, but he did mange to clean it up with activated carbon. ;D

[@shiryo_]

Sometimes I wander how fast I would die from drinking some of the things you show in your videos

[@liv97497]

But some of the things look so appealing haha

[@shiryo_]

@@liv97497 ikr some of them have those pretty colors and look like they have great texture I wish they weren't deadly

[@BuckcreekTV]

I love this video!! I know its extra work but by any chance in future videos could you show all the steps taking place in a reaction such as the push of electrons? I'm taking Organic chem now and would love to use your videos as a way to better understand the subject matter!!

[@bellabear653]

Kids today are so lucky to have your videos and teachers especially in high school should take advantage of this to inspire young minds.

[@xXTehnXX]

could you have kept it as an ester instead of a phenol when you added the no2 group so the ortho position would be sterically hindered so the reaction further favored no2 addition at the para end?

[@user-zr8bo5le5p]

For my next trick I'm going to boil water and turn it into ice.

[@saltmine]

Your conclusion at the end I couldn't agree more with I think this is super interesting I wouldn't try doing anything what you do outside of a lab with a professional supervisor. But your videos give a great insight into chemistry wich sadly my school didn't give... Ikr neither physics.... Thanks science for KZbinrs like yourself so that I at least can enjoy some chemistry online

[@Chrissy4605]

Wow, I hope you didn't get a headache from this project!!! I love listening to your voice!!! Purple Chrissy