I am sorry for the loss of your 33 yo patient to Covid 19 Dr. Griffin. Thank you for another very informative podcast.
@wolpumba40993 ай бұрын
*Summary* *RSV Vaccination (**0:00**)* - CDC revised RSV vaccination recommendations for adults 60 and older. - Recommends vaccination for everyone aged 75 and older. - Recommends vaccination for individuals 60-74 with specific chronic medical conditions (e.g., heart or lung disease) or living in nursing homes. - Recommends against routine vaccination for those 60-74 without risk factors. - No recommendation yet for individuals aged 50-59. - Durability of protein-based RSV vaccines (GSK, Pfizer) appears better than mRNA-based vaccines at this time. *SARS-CoV-2 (**8:08**)* - COVID-19 cases and hospitalizations are rising in Puerto Rico. - Study highlights different infection responses: (9:58) - Abortive: Detectable immune response but no positive PCR or symptoms. - Transient: Positive PCR but only one detection over time. - Sustained: At least two detectable PCR results over time. - Moderate coffee consumption may reduce COVID-19 severity. (14:28) - Cannabis and tobacco use associated with increased risk of hospitalization and ICU admission. (15:08) - XBB booster effective against hospitalization and ED visits, but older vaccines show no significant protection after one year. (16:51) [unclear if this is because these are mRNA vaccines and if classical protein-based vaccines would protect longer] - Paxlovid may benefit hospitalized patients even if started after five days of symptoms. (23:41) - Fecal microbiota transplantation shows promise for treating insomnia in long COVID patients. (26:45) - Three main long COVID symptom clusters identified: sensory, fatigue/cognitive, and breathing/exercise intolerance. (30:47) *General Recommendations (**32:08**)* - Continue to follow CDC guidelines for COVID-19 prevention. - Get vaccinated and boosted as recommended. - Consider the potential benefits of early treatment with Paxlovid if you test positive. - Support organizations like Floating Doctors by donating to their fundraiser (parasiteborders.com). i used gemini 1.5 pro to summarize the transcript
@misterk70403 ай бұрын
Well done.👍
@peony2863 ай бұрын
Dear Daniel and Vincent, thank you very much for another informative and intellectual scientific talk! This week I feel so interested in fecal transplant and insomnia.
@JW4REnvironment3 ай бұрын
Kurt Vonnegut really showed a remarkable dry wit in his writings like Slaughterhouse Five. Thanks to Daniel for mentioning this excellent author, and many thanks for his continuing insights into Covid 19 and other infectious diseases. I truly appreciate Daniel’s taking his valuable time to bring his expertise to the public through these podcasts. I tell all my friends about Paxlovid’s benefits thanks to TWIV! Now I will probably get the Novavax before traveling in a couple of weeks…
@Logotic3 ай бұрын
Kurt Vonnegut was uniquely brilliant. Each one of his sentences evokes a whole world.
@gayluinstra13963 ай бұрын
Whenever I hear about someone young getting hospitalized or dying of covid it makes me very sad and scared for young people. I’m sorry you lost a patient to covid.
@DavidDavisL3 ай бұрын
Thank you for the insights regarding potential differences between mRNA and protein based vaccine durability. I will be more strongly considering the Novavax booster this fall for a number of reasons, and look forward to your analysis of future research in this area.
@WillNewcomb3 ай бұрын
Returning to China this week after 4 weeks in UK upset my routine and i forgot about the Clinical Update! What a nice surprise!!! I noted I was one of only two masked on a full flight of 250 passengers. With KP.2/3 incidence rising I felt it was too risky since it was 11 hr flight and a study showed that flights of > 6 hrs increases risk of infection 25x!!!
@redhen6893 ай бұрын
I flew from London to NY yesterday. I guess I should have worn a mask…. We’ll see.
@patriciahoke47223 ай бұрын
Puerto Rico - not to be hyperbolic, but lots of young people are leaving or have left, leaving a lot of older and sicker people with decaying infrastructure behind.
@tleighb3 ай бұрын
I look forward to this every week! Thanks for the info!
@nevets4ever43 ай бұрын
Another fine and informative episode - thank you both. And - I could only imagine the TV advertisement campaigns for "crapsules."
@GothikBeerTV2 ай бұрын
Weed-vaper here! Dr. Griffin, I love your wall! It's precisely what I want in my house.
@DudeFun-yi7nu3 ай бұрын
Thank you so much, I hope TWiV will survive the end of democracy
@marg7163 ай бұрын
Lol while also 😢
@dougmicheals60373 ай бұрын
I dont think you know what democracy is.
@marg7163 ай бұрын
Thank you again ya’ll. 🎉🎉🎉
@4everyoung243 ай бұрын
“Smokin’ on the weed.” “Crapsules” What a show!!! 😂😂😂😂😂😂😂
@Logotic3 ай бұрын
"Swallowing Crapsules to cure your anxiety and insomnia" sounds exactly like a Kurt Vonnegut line...
@riok62343 ай бұрын
It sounds like we still have much to learn about mRNA technology.
@donnamunro20903 ай бұрын
Vincent looks super cool and young in the t-shirt and black jacket!
@Logotic3 ай бұрын
He does. I wish we could see what was on the t-shirt.
@jonetyson3 ай бұрын
I would hesitate to judge mRNA's platform based on V1 of their RSV vaccine: Could they have just picked too low a dose? Too bad Vincent didn't say what reasons that immunologist at the Karolenska had for suspecting protein vaccines were more durable the mRNA. I'm also curious to know how such reasoning applies to Moderna's individual neoantigen therapy (aka cancer vaccine) for Melanoma, although that vaccine is given with many boosters and the phase 2 data going out 3 years showed a durable effect, both in recurrence free survival and distal metastatsis free survival.
@yru4353 ай бұрын
Thank you so much for sane science talk.
@paulam39873 ай бұрын
Thanks for covering the FMT research. My impression of this area is that the transplant evokes positive responses in the short term but the benefits don't persist. I don't recall the time dimension of the study period described by Dr. G., but there wasn't a long term followup evaluation. Since the FMT is generally not an ongoing treatment (eg., multiple doses over time), long-term follow-up will be key.
@alijawad20423 ай бұрын
That was very good.Thank you very much
@Ramiiam3 ай бұрын
Is the implication that the localized immune response in the transiently infected individuals prevented a systemic infection?
@terrydoyle11413 ай бұрын
Well done, guys! I'd like to know how much weed was smoked for this 1.8x increased hospitalization odds. Please, Vincent, you rightly want quantification of all science claims. Me too in this case.
@frogsong1003 ай бұрын
Bravo, as usual. 🎉🎉🎉
@Rene-uz3eb3 ай бұрын
Puerto Rico probably enjoyed a bit of island isolation with the travel restrictions so for many it's the first exposure to covid now.
@brendanmay95853 ай бұрын
Unlikely this late in the pandemic.
@wednesdayschild36273 ай бұрын
Wouldn't they always have less exposure because it is an island.
@katiehettinger78573 ай бұрын
Population density on the island and older members of the community returning to participating in social gatherings may also account for the increase.
@AnnetteKapple3 ай бұрын
I was vaccinated against COVID in October and came down with COVID 5 days ago. I'm thinking my immunity wore off. This has kicked my butt the last 5 days. The cough is causing muscle pain. I'm hoping my cough gets better by the 10th day.
@gymjoedude3 ай бұрын
Remember vaccines didn't prevent infection, they reduce severe disease and hospitalization. Antibodies go up after immunization then go down, but your t cells remember the vaccine and flight it.
@laurier33483 ай бұрын
Annette, you need a Booster.
@danielasuncion99913 ай бұрын
Annette: Sounds like you had been exposed to an ENORMOUS amount of COVID-19 germ. I heard of a study where volunteers who were currently suffering from Covid, had their virus output measured. It was noticed that the volunteer who breathed out the most virus, gave off A MILLION TIMES more virus, than the volunteer who gave off the least amount of COVID-19 virus.
@danielasuncion99913 ай бұрын
Before the pandemic, I had a flu like infection that resulted in a cough EVERY waking minute. After I was on the mend, I was sent for chest X-ray, because I felt like I had cracked a rib!
@laurier33483 ай бұрын
@@danielasuncion9991 Was it H7N9 ?
@leonjohansson65423 ай бұрын
Dr. Daniel Griffin is looking trim and tan. Lost some weight?
@suekoi38853 ай бұрын
I’m confused. My limited understanding is that a protein based vaccine is the traditional way vaccines have been developed. Why was a new mRNA Covid vaccine developed instead of just going with the protein based? Is it because mRNA vaccine can be modified quicker to match a current variant? Would it be ironic that a protein based Covid vaccine is better because it lasts longer?
@KiwikimNZ3 ай бұрын
The mRNA vaccine is modified genetic material from the covid virus, this causes the body to make the appropriate antibodies. Protien vaccination is using a protein that is mimicing the covid virus, triggering the body to produce antibodies, they do not contain any genetic material,this type of vaccine is the same as traditional vaccines we had been using for many years. From what Incan gather the protein one gets a better immune response, less side effects, mRNA is reactogenic, so you may expect fatigue, muscle pain, joint pain, headache maybe some nausea, vomiting, maybe a little fever and myocardidtisis. I think they are hoping this will have linnger lasting immunity, confusing I know!
@christinaduffy66183 ай бұрын
Is there a current protein based vaccine??This MRNA info is kind of scary
@KiwikimNZ3 ай бұрын
Yes Hep B and HPV etc which have been around firvseveral decades.
@redhen6893 ай бұрын
I had the Novavax COVID vaccine in October. I have COVID now.
@marklemont37353 ай бұрын
8 months later. Sorry you have covid. May you fully recover soon.
@westonhuffman79083 ай бұрын
Well, I wanna get a fecal microbiota transplant.
@judithparker46083 ай бұрын
Such as Scurvy or Rickets ??
@AnnetteKapple3 ай бұрын
I didn't pursue getting Paxlovid because a friend said she felt worse on it. Don't know if unpleasant side effects are common?
@OldOneTooth3 ай бұрын
It's common for symptoms to get worse in the 2nd week of the disease if I recall right. The first time I got it, it was so mild at first then the symptoms of disease hit me hard. No paxlovid back then. It's best to get antivirals early rather than later if I recall the general advice right. Later once the virus is cleared it's more calming your immune system down. So if your friend got worse under paxlovid it might simply have been the natural disease progression. It also may not have been as bad as it could have been without it.
@brendanmay95853 ай бұрын
@@OldOneToothyes, but let's also not pretend that there are no side effects. Particular GI issues are common with paxlovid. But, it reduces chance of serious disease and probably also long COVID/sequelae
@JW4REnvironment3 ай бұрын
I only had a small funny taste from Paxlovid but my symptoms improved a lot in only a day or so. I will definitely get Paxlovid again if I get another case of covid 19! I would ask my doctor to give it to you if I were you!😊
@OldOneTooth3 ай бұрын
@@brendanmay9585 why we look at studies rather than individual cases to decide effectiveness are side effects.
@katiehettinger78573 ай бұрын
Isn't the real question are you willing to chance hospitalization and death or face the possibility of a few unpleasant side effects?
@chinupduck48493 ай бұрын
@19:29 and so it begins
@laurier33483 ай бұрын
Your 33 yo patient died because he was not vaccinated.
@terranceoliver69843 ай бұрын
I don't trust these guys.
@JW4REnvironment3 ай бұрын
I really trust Dr. Griffin, who donates his really expert time to this! He was very accurately a big booster of Paxlovid and continues to explain how extremely effective and helpful it is. Even though he doesn’t make any money off of Paxlovid…it just helps his patients as it really helped me through 2 cases of Covid 19!
@JW4REnvironment3 ай бұрын
I trust them! Dr. Griffin donates his valuable time to help us listeners out. He is totally right about Paxlovid. It helped me tremendously through 2 cases of Covid 19!
@suesaxton30583 ай бұрын
Why don't you trust these guys ???
@katiehettinger78573 ай бұрын
No one made you listen to them. They are reporting the latest science published on subjects that could be a life or death issue for you. This program is talking about illnesses that are emerging, the inform will change as scientists and doctors used new medications and better understand how diseases effects our bodies.