TWiV 695: COVID-19 clinical update #41 with Dr. Daniel Griffin

Daniel Griffin provides his weekly clinical report on COVID-19, including thoughts on the first immunizations with Pfizer mRNA vaccine, the anticipated EUA for the Moderna vaccine, whether the vaccine prevents infection, not just disease, monoclonal antibody therapy, and much more.
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[@cars941]

RN on the frontlines here. Just got my first dose of the Pfizer vaccine today! Woohoo!

[@IMSiegfried]

Yes!!! Congrats!

[@pedroferreira4134]

Thanks Daniel, and thanks Vincent for having Daniel about. It really is a pleasant channel to watch. All of it.

[@lh5108]

Dr. Griffin is my favorite doctor. He alway brings us some new front line stories.

[@janehale4402]

In one brief half hour Dr Griffin has told me all I need to know about the vaccines ,how reassuring it is to listen to a professional give us the facts and advice.An example of duty of care ,so obviously missing when our politicians obfuscate, boast and fail to give us guidance or facts. From Britain.

[@calvaryassemblyofgodsouthi8046]

We need to remember all the patients that Dr Griffin and other front line heroes treat and ultimately lose to this dreadful disease. Those in their teens and thirties. Praying for you Dr Griffin. We so appreciate all that you do! You to Vinnie😉

[@zedgarden]

It’s so sad to hear a doctor describing what he and his colleagues go through every day at work, seeing people under their care dying from the results of catching this virus, and yet there are millions of people out there, some of them my acquaintances saying this is hoax and that it is not worse than a flu. It is mind boggling.

[@stephaniesmith6643]

Just goes to show how willing some people are to deny reality.

[@IMSiegfried]

@@stephaniesmith6643 Denial is an excellent coping mechanism but very unfortunate when it's used during a pandemic. :-/

[@intomd3730]

@@IMSiegfried Covid-19 should be treated home under careful medical care. Being hospitalized is often the result of failure to treat patients timely at the first sign of symptoms, which can develop into the inflammatory diseases, especially the weakest patients.

[@therombaro]

6:55 - Story of the Gentlemen from Nigeria 10:00 OTC Covid test 13:38 Vitamin D and Ivermectin... well,... dammit 14:03 - Vaccines 15:49 - Moderna vaccine immunological data, T-Cells, etc 18:56 - Choosing definitions for Infection, disease, severe disease 19:35 - Infection, described 20:26 - Disease, described 20:46 - Severe disease, described 21:15 - Transmission study at college campuses. 21:58 - 67% Percentage prevention of asymptomatic transmission / infection. 23:05 - Which vaccine is better? Pfizer or Moderna? 24:00 - Pregnancy and Breast feeding 25:16 - Autoimmune disease concerns 26:05 - Distribution concerns, 6M doses of Moderna, 3M doses of Pfizer 26:33 - Pfizer allergic reactions 27:25 - Recommendation of observation after vaccine administration. 27:40 - The two-shot system, excess vaccine doses 30:04 - Incubation period 31:21 - Period of detectable viral replication: Passive vaccination / monoclonal antibodies. 65k doses are distributed every week, not all of them are getting used. Check out “Eli Lilly” website for more info 33:27 - REINFECTION, article Gupta et al 35:25 - Early inflammatory phase, steroid usage. 35:55 - Secondary infection phase 36:35 - Tail phase, long-haul Covid 37:37 - Post-vaccine infection, shedding, long-hauling 38:56 - Can someone have the vaccine after receiving monoclonal antibodies? 39:52 - Recommendations for post-infection vaccines.

[@JeeJubee]

13:38. I second your comment

[@jonathantrautman]

Daniel Griffin has to be the first person I've heard actually say something about postponing Christmas or SOMETHING everyone takes it as a foregone conclusion that we'll just have another disaster

[@davodkhalafkhany6868]

thanks again team #TWIV for the latest updates

[@liberty4347]

Ivermectin would have saved your patient s What's wrong with you! Pharma profits over health 💰💰💰💰⛑️ Where do your pay cks come from? Association of American Physicians and Surgeons!!!! Their patients are not dying?

[@JeeJubee]

Exactly why the public has such little faith in “science” which is SO unfortunate. But when these docs keep showing their faces, saying “tisk, tisk, my patient is dying” and remdesivir or steroids is all they get on their death beds, the rest of us have to fend for ourselves. Ivermectin is still missing from the conversation.

[@operalove7221]

Vincent and Daniel - thank you both for these brilliant updates. They are really appreciated and the information is helpful in lots of ways.

[@0scartheCat]

Yes my wife fainted when she had a Yellow Fever shot before going to Nigeria... and when I was 5 in 1968 i flew to USA from England, I was actually given a Small pox jab which I understand protected me for decades ...

[@paulhorne8882]

Thanks Daniel and Vincent

[@brentpalmer9530]

Thank you for being here for us; a beacon of information in a storm misinformation.

[@philoneill9865]

Another excellent informative presentation by Dr. Griffin.

[@jmer9126]

You guys are the best! Thanks so much for sharing your knowledge and for all you do.

[@Polkadotpup]

Thank you. Personally I put myself on hard lockdown 3 weeks ago just based on the lack of holiday self control the population demonstrates. Hopefully the scientists will be able to reach between the ears of the government for public messaging, but realistically we are probably headed over the cliff. See everyone on the other side.

[@fedegufedegu]

Thank you so much.

[@earthangel2524]

Dr. Griffin said he might talk about IVERMECTIN. But he doesn't Rx it. PLEASE, VINCENT, invite a primary-care DOC WITH EXPERIENCE helping people stay of out hospital with AGGRESSIVE EARLY OUTPATIENT TREATMENT with Ivermectin or any of the other successful protocols.

[@RussCR5187]

I asked my primary care physician to review the ivermectin paper written by the FLCCC group, which I provided to him. He did and agreed that the scientific evidence is compelling. He has promised to prescribe it for me should I test positive for covid. He stopped short of prescribing it ahead of time for prophylaxis.

[@earthangel2524]

​@kban When TWIV's classy hosts respectfully interview solid Ivermectin sources, we'll hopefully be spared "trolling" ad hominems from the peanut gallery.

[@earthangel2524]

@@RussCR5187 Good for you and your doc. I had a similar experience.

[@sengsational]

@kban the early in-vivo dose calculation was insane. That's not what clinicians are doing. They're using the same dose as for parasites and GETTING RESULTS!

[@JeeJubee]

kban. not true!

[@Polkadotpup]

Thanks to everyone involved in producing these videos. They are the best and most reliable on the web. I was reading about the new variant of CoVid that is currently in England. Have any of you heard about it jumping the pond? Does anyone on TWIV want to comment or discuss the variant. Thanks to all.

[@jessegee179]

Yes agree, would like to hear twiv discuss this. From UK.

[@christopherrobinson7541]

I have not done much research so far, but the senior health officials in the UK (Chris Whitty, etc) have said that a mutation has resulted in a variant of the virus has occurred, including changes to N501Y, which is part of the RBD of the spike protein, which has increased transmissibility by 70%. My interpretation is that this means that R0 has increased from 2.5 to 4.25, which has huge implications and pushes herd immunity over 75%. It also means that light mitigation measures will not work and that hard lock-down will be necessary. It also has an impact on vaccination, not necessarily on the effectiveness of the vaccine, but on the uptake required for herd immunity.

[@ovrjoyd]

We need cheap at home rapid testing. Imagine how many cases were missed. not to mention sequencing different strains.

[@earthangel2524]

Michel Mina just said (on Lex Fridman's podcast) this can only happen via executive order. Let's write Trump and Biden. My Kumbiya Holiday dream is for Don and Joe to sign this jointly TODAY!

[@andrewtowell6074]

I'm not sure what's happening in the USA but here in the UK all nurses are tested twice a week with home tests, similar to how a pregnancy test works.

[@ovrjoyd]

@@andrewtowell6074 We don't have an affordable lateral flow assy home test available yet. Only to has a EUA and is by a prescription only. The other option is not yer available and is NOT cheap!

[@marcschreitmuller997]

I‘m 47 with some allergies and despite I know how a strong allergic reaction feels - can‘t wait to get the SarsCovid-19 vax. But I‘m Swiss, so I must wait. Meanwhile our neighbors one after the other get infected...

[@rraborn]

Thank You for these clinical presentations

[@unluckypuppy13]

"just one wife by the way " 😂

[@dixonpinfold2582]

What about immunity conferred by infection? In discussion of vaccination rates and herd immunity, it seems to have been forgotten. In the US, confirmed infections stand at 18.7 million, or 5.6% of the population. Undiagnosed infections have in recent months been presumed to be four to ten times confirmed ones. This would mean that, assuming a modest multiple of four, total infections have reached 28%. Isn't the US then at least a third of the way to herd immunity already? Why would anyone suppose that anything near 100% vaccination will be required, or even 80%? And infections aren't standing still. They are rapidly rising. At 200k newly confirmed infections a day, that's another 9% of the population a month, including undiagnosed and asymptomatic infections. By the end of February, then, on present trends, 28% grows to 49%. How can a 49% incidence of infection not matter? I don't get it. Professor Racaniello? Dr. Griffin? Hello?

[@ToddHoff]

After allergy shots they always make you wait 30 minutes before leaving.

[@lilylevental2808]

Thank you. This broadcast is beneficial to all that in the process of making informed decision in regards to COVID19 prevention, treatment and vaccination. Few friends, nurses, already got the vaccine. I can't wait to be vaccinated

[@ghogsten]

Hellooooooo everyone!

[@kennyw871]

Given the sparsity of vaccine, do you think it's reasonable for people that were infected receive vaccination after the most vulnerable do, assuming of course, these people have some protection that lasts for months?

[@dorasmith7875]

My doctor told me very few doses came to Austin and the one hospital that is giving hte infusions is only giving two a day, when I told him I keep hearing on the news that people don't seem very sick when they first come down with it and it isn't getting used.

[@t.c.s.7724]

Please review CYCLOSPORINE for use in covid. I saw an interesting pilot study using cyclosporine in tandem with steroids. Interesting that some elements of allograft rejection similar to covid pathology, i.e. Coagulation, compliment, cytokines, endothelial damage, etc.

[@barbarahenninger6642]

Dr Been reviews all the new studies in detail. kzbin.info

[@earthangel2524]

@@barbarahenninger6642 Dr. Been is so great! Vincent, PLEASE invite him on the show to talk about AGGRESSIVE HOME TREATMENT FOR EARLY COVID.

[@JeeJubee]

Vincent must be afraid Dr Been might mention IVERMECTIN.

[@jaromevanwells808]

My mum in a nursing home in Boston got the covid in April she is 95 with dementia. She had mild symptoms. Two weeks ago she was reinfected recovered but is in hospice as her dementia has accelerated and she is but a zombie refusing to eat or drink.

[@cky5573]

Prayers for your mum and for you

[@rubiesrred7042]

So sorry fir your Mom. Sounds like she is a fighter!

[@jaromevanwells808]

@@rubiesrred7042 Thanks for your kind words. It's amazing she survived two covid infections. I have been doing some reading and oddly the ninety years olds often show mild symptoms. The vaccines will at least for six months at a shot protect from severe consequences from the virus. It will not protect from getting covid. It may be vaccine shots will be every six months for those who want them for many years to come. It is a nightmare descend upon us as a species. Scientists have warned and waited for this in our species. Please stay to plot, be brave, refrain from the need or want to live life as before. Let the Holiday's go without gathering. Wish all well. Very, Very, Very Well!

[@samanthanewton1340]

What about the nurse fainting on live tv?

[@christopherrobinson7541]

The sight of her small pay cheque has that effect on some people.

[@ovrjoyd]

At 11 months I am in a tough situation. No one believes me!

[@annoloki]

Don't waste your effort on them; when somebody doesn't want to do their job, there's no point trying to convince them to, best you'll get is they do a bad job, they're no good to you. Just keep trying different docs until you speak to one who you don't have to fight to convince. Reach out to others on social media etc, there will be groups of people sharing experiences and support, see if you can find anyone local who has had a good experience with a doc they can recommend. I don't know if there's anything they can actually do yet, but as it could take a while finding someone useful, is good to get started so you have someone who will help when they can. Also, keep an eye out (online) for any trials or research studies who are looking for people like you; it's the only way any answers can be found. Um... maybe some magnesium supplements, our populations are becoming increasingly magnesium deficient as it disappears from our soil, and the less magnesium you have, the slower the rate you can burn sugars for fuel, leading to the obesity and diabetes we see in our populations, making it a root cause of covid co-morbidities. I've no reason to believe it's linked to post-COVID syndrome, but it is a hurdle to having any energy that no one needs at the best of times. Most people would want to aim in the 200-400mg/day range, but I don't know anything about you, so don't assume this is good advice for you specifically. I'd say to do your own research, and it is always good practice, but don't expect your average doctor to know about the magnesium problem, it seems almost completely unknown. Good luck!

[@rubiesrred7042]

@ovrjoyd Please take some time to go through the ivermectin studies. Lots of research ongoing for treating longhaulers. Good luck in your healing. c19ivermectin.com/ mobile.twitter.com/CovidAnalysis

[@ovrjoyd]

@@rubiesrred7042 THE PROBLEM IS WE ARE NOT ALLOWED TO USE THE HIGH DOSES THAT WERE EFFECTIVE IN INDIA. Sorry, noit yelling, just hit caps.

[@IMSiegfried]

@@ovrjoyd Who's not allowing you to? Some people are under the impression that the FDA does not allow when this is not true at all but rather it is the doctor's discretion. You need a doctor who thinks outside of the box. I have such a doctor and the only reason I found him was through him specializing in HRT for women (HRT is but one example for doctors who typically (but not always) think outside the box) and he also sees patients who just need a regular MD for other health issues. Any drug that is not outright banned by the FDA and Ivermectin is not may be used off label with different dosing, in the exact same way millions of drugs are used off label by doctors all of the time! yourappointment in hopes that they will read them before you see your doctor. Do still bring another set of copies of the studies to your appointment just in case and try to go over them with your doctor as to why you want the higher dosage. That said, hopefully you will find a doctor who has already read the studies and knows that it takes a higher dose to be effective. Navigating the western medical health care system is difficult at best- I know from over 2 decades of dealing with it myself. If at all possible you would do well to have a patient advocate with you to assist in your healing journey. Hope that helps and please don't hesitate to ask if you have any other questions related to medical care in the US.

[@shuetwong7077]

If I had Covid already and the blood test shows that I have antibodies, do I need to get the Vaccine?

[@annoloki]

Antibodies may disappear within a few months. The vaccine would likely have a stronger effect if it is had when antibody levels are lower... the vaccine makes cells produce spike like proteins, which blood test is probably looking for antibodies to... lots of antibodies would just neutralise the spike proteins quickly, using up those antibodies, but stopping the immune system from finding so much to react to. Personally, I'd give antibodies at least a chance to lower first, so, not get the vaccine within a couple months of infection, unless I was at higher risk of serious disease, in which case, I wouldn't pay too much attention to a youtube comment that is just guessing :-)

[@rubiesrred7042]

I agree with Annoloki, for now you can wait to get the vaccine and help push others ahead of the line who have not been infected and successfully cleared it like you have. MRNA vaccines are for protection from disease severity (90-100%) and perhaps with a good ability to block asymptomatic disease (67%) as the Dr Griffin presented. As reinfections are still somewhat rare (a second infection with a phylogenetically distinct version of C-19 from your first infection) then consider if you are high risk for exposure ( lifestyle or work - work around a lot of people or travelers) then as your antibody titres go down, go for the jab.

[@rasmasyean]

In principle, the vaccine should simulate a "strong virus" without actually causing the bio damage of a real one. Your body will thus adapt to fight it. So if you had a really mild case, you might not have a strong memory. I mean, look at the hardest hit area like NYC. Such a large second wave with much lower blip in deaths. Despite what they say about "reinfections with proof via genetically different virus exhibiting mutation over months in the wild", as of now I'm personally taking the stance that they are wrong that reinfection is rare. Practically, no one logs all that stuff like that. To ME, it looks like a brunt of the second wave there is reinfection of asymptomatics. gothamist.com/news/coronavirus-statistics-tracking-epidemic-new-york Note that the average endemic coronavirus memory is 12 months. I'm sure in that study, they didn't even include "endemic coronavirus asymptomatics". I mean, how would you have even found them? Furthermore, many still believe disease severity many be related to dosage. They jury is still out even though there's no "proof" here either via some paper. There's a mink study in another TWIV that says the minks aren't effected by higher dosage, but as we all know to beware by now..."mice lie and monkeys exaggerate, but minks are different?". lol

[@debbietaylor4107]

I just had a conversation yesterday with someone who says he won’t take the covid vaccine because it has “aborted fetus cells and mercury in it” 🙄 Can someone tell me how much of this has any merit? I’d love to have a better response than “I’ll have to go look into that” next time I talk to him. He seems more concerned with the anti choice stance of his church (on abortion) than he does about getting covid again. He was infected in April with a mild case.

[@RussCR5187]

I don't know about other vaccines, but I believe the mRNA vaccines just consist of the lipid nanoparticles mixed into a simple saline solution.

[@debbietaylor4107]

@@originalkk882 thanks!

[@debbietaylor4107]

@@RussCR5187 thanks!

[@justhare]

There are no adjuvants in the mRNA vaccines. Adjuvants are where you would find the traditional “evils” that anti-vaxxers have traditionally been concerned with (Mercury, Thimerasol, formaldehyde ect.)

[@rubiesrred7042]

Dr Been discussion on Fetal Tissue and vaccine production. @OriginalKK is correct - this is an anti-vacs misinformation trope but please listen to this for yourself. kzbin.info/www/bejne/aYXRaGWte5KNqcU

[@stephaniesmith6643]

What good is a home CoV-2 test in isolation. It will happen outside of a medical context, and outside of public health surveillance monitoring and recommendations. Does not seem helpful.

[@IMSiegfried]

Not if hooked up to bluetooth that is being used as you suggested.

[@eliermaxwell5910]

What happens if you get the same vaccine more than once

[@christopherrobinson7541]

You make a small contribution to the increase in the stock value of the company who supplies the vaccine and get a slightly sore arm.

[@eliermaxwell5910]

@@christopherrobinson7541 lol

[@JeeJubee]

Puts off Ivermectin? WHY???

[@patriciahoke4722]

There are not many American doctors who make it all the way to a lot of youtube views who will espouse Ivermectin. It is a drug that is widely available and used in the developing world, and is touted by some high profile foreign doctors, but American doctors remain skeptical and some go so far as to call it dog medicine (which it - also - is.) Personally, I have no idea.

[@HotelPapa100]

Ivermectin has had some positive results in vitro. In concentrations that you will never achieve with approved dosages. It is not an unproblematic drug and can have severe side effects.

[@JeeJubee]

@@HotelPapa100 Check out the nearly 100 studies that beg to differ.

[@intomd3730]

@@HotelPapa100 ivermectin is certainly not the only one.

[@jessd956]

You’re saying that if you have not had a previous severe reaction to a vaccine, that you should get it. However, the nurse in Alaska who experienced life-threatening anaphylaxis in response to the Covid vaccine had no prior history of allergies…

[@jessd956]

Also, what about patients with mast cell disorders. Like Mast Cell Activation Syndrome and Systemic Mastocytosis? I would assume that they would automatically receive a medical exemption for to their predisposition to idiopathic anaphylactic events?

[@krissto22]

What about people that haven’t had any previous vaccines except for the ones in their childhood?

[@peterkapusi5882]

I dont like this guy. Talking Ivermectin if we reach some number of views..? Isn’t your job to help save lives of people? Oh I forgot you do not get paid to do that...

[@JeeJubee]

He sounds like Freaking Trump! “Ohhh, my RATINGS!”. Ignores saving lives. How quaint.

[@Aloneagainofcourse]

I'm so happy Pence and his wife got vaccinated...... NOT......🙄