TWiV 858: The vax of life with John Mascola

[@MrOzzyCam]

Thanks Vincent and TWiV team for another episode!

[@GadZookz]

Mr. O’Cam, You must behave! 😃

[@_c_y_p_3]

This was another ⭐️ episode. John Mascola was one of those recent best of TWIV episodes. I know I say every show is the best but to hear his story, I sorta feel he coulda been on for longer because you only touched the surface of most of the topics mentioned. As always, much love from Sweden.

[@zinnialady5153]

I enjoy each of you for different reasons. Brianne I enjoy your insights and how you are always thinking and questioning. You love when you can pick someone’s brain I’ve noticed. You love learning something new.

[@lesfaby8997]

TIMESTAMPS 03:34 Guest biography 09:30 Vaccine research center info 12:54 VRC works on what vaccines 17:30 Status of HIV vaccine development Links for this episode 20:27 Accelerated COVID-19 vaccine development 23:20 Why mRNA vaccine focus 24:25 How development was sped up 26:07 VRC role in operation warpspeed 29:23 Warpspeed vaccine candidates 32:50 Goal vaccine in a year 33:19 Common standards for vaccine trials 36:40 2 Protein vaccines may come out 37:42 how to handle variants 41:31 protection against all symptomatic disease less than 50 pct after 6 months while serious disease protection persists 44:01 vaccines designed to avoid serious disease 45:30 monitoring adverse events 47:22 Can we increase pct vaccinated 48:59 US Seropositivity rate 49:50 Lessons for the future 50:53 what is needed for other viruses 51:49 unanswered virologic or immunologic gaps 54:30 surge capacity plan 57:55 flu vaccines 58:33 RSV vaccines 1:02:18 panel summary 1:03:27 Letters 1:03:30 Paula deer 1:07:22 Sue Ellen trusts TWiV guests more than others 1:10:19 Saskia omicron spread by immune evasion 1:12:20 Stephen preschooler vaccine trials 1:16:05 J.P. Rosalyn Franklin grave 1:17:47 antigen tests question 1:28:49 Anthony General Lees 1:30:02 Damien TWiT humans can't create life 1:33:06 Alex non virus comments 1:33:48 Vaccine Townhall Audio Timestamps by Jolene Thanks 1:34:00 Weekly Picks 1:34:02 Brianne How Sesame Street is Handling the Pandemic 1:35:52 Rich Zamboni: How it works 1:39:00 Alan How lightning starts 1:40:52 Vincent Buon-A-Petitti Listener Picks 1:43:21 Meika Wordle

[@Peter_S_]

As always, thank you Les! Highly appreciated.

[@showinghandlesisawful]

Thank you

[@luisfernando-mm3jt]

Love all you do thanks for the wisdom

[@beproudskeptic1522]

Thank you, please keep doing this, I so enjoy it. I have learned so much.

[@westfield90]

What an absolutely interesting brilliant show with a very articulate guest and great questions from the twiv team.

[@clippybrokentooth1305]

Looking forward to watching 👍🏼

[@luisfernando-mm3jt]

Brianne is Allways always laughing... Love her... And the others to😊😊

[@simontemplar404]

Amazing episode. This story would make a great "science" movie.

[@monicamolloy5105]

Thank you all. That was very helpful, informative and fascinating. R/ Monica.

[@TB-ck1jr]

I think our family ran into a bad batch of PCR. My husband started with symptoms on Sunday and tested positive at home twice. The next day, I had a sore throat. I tested positive at home that night. My son's nose was starting to run a little too. Tuesday morning, I took myself and the kids for PCRs. My husband went on his own in the afternoon. On Friday (husband still symptomatic, I'm still symptomatic, son more symptomatic, and daughter had started) we got our PCRs back. Husband was positive, but the 3 of us that tested in the morning came back negative. I tested myself and the kids again at home and we were all positive. Took the kids to get PCRs again on Saturday and me on Monday. All three now positive. I'd assume that we tested too early the first time except for the fact that I tested positive at home the day before the PCR. 🤷‍♀️

[@bid6413]

Great to get an inside look. Thanks.

[@bid6413]

Very interested in anything related to the “long-haulers” issue. Thank you for everything.

[@ScotHarkins]

I have an in-law now 20 months into severe long-COVID that came on after a severe two-week illness (not hospitalized). But without a positive clinical test they do not qualify for one of the nearby long-COVID clinics...nobody could get tested on Kansas City at that time (March/April 2020). It feels like long-haulers need to ban together, but that it incredibly difficult while living with the ongoing post-acute sequele issues. These people are getting screwed out of disability and proper care and therapy.

[@ghaclord]

@@ScotHarkins the struggle is horrible. My adult daughter in the same situation. So disabled she can’t work and activities of daily living are challenging.

[@emerraldx]

another point on inherently trusting TWiV guests when encountered on other sources, any professional not too busy to communicate with the public and wise enough to accept an invite from the TWIV team deserves my attention, not to mention I am sure Vincent is rather particular with his guest selection which immediately gives their words more credibility in my eyes

[@jenniferwinsor7740]

I'm watching this episode waiting to lose power with the January 29th snowstorm. We're in the potential jackpot snowfall amount in Plymouth County, MA. Enjoying the behind the scenes information of the covid 19 vaccines and operation warp speed.

[@Gieza-Brake-Pahl]

This was really interesting! A couple of requests 1) as a sailor I would appreciate if you would add the wind speed and direction to your weather reports 2) as a diabetic overweight older guy I am trying to lose weight to reduce my comorbidities should I catch Covid, I would therefore appreciate if you would stop mentioning food, especially Italian food.

[@cynthialeech2507]

Listen to TWIV as a podcast while walking. The time and pounds fly!

[@christopherrobinson7541]

@@cynthialeech2507 Opening your wallet on a windy day is not to be recommended.

[@susanryan622]

On youtube there is no boundary between pics. And as a very low-level participant this was a great, great “epitope”!

[@fanfreluchefanfreluche1246]

Thank you all of TWIV for yet another most interesting and informative podcast…I’ve never been disappointed on the contrary…we learn and get entertained…your podcasts have almost become addictive…Weather here in Gaspesie…rigorous winter….

[@JimK0QJC]

Sorry an off topic question: is the lighting in the incubator florescent? Maybe an explanation for the green tint on the video form the incubator.

[@lesfaby8997]

@James Lauridson Vincent has LED lights that are color adjustable. He chose the color because of his shirt color.

[@dkmj]

Go Brianne!

[@Paulus8765]

Brianne, like

[@Artbyevelyn]

What are your thoughts on the new NeocoV found a day ago in China by scientist

[@TechnoLawyer]

I agree we need to stop looking at case numbers. My wife, kids, kids and myself (all vaxxed) all had covid recently. It was a cold circa 2019, take some dayquill and you're fine. If it weren't for the positive rapid tests and the current times, I wouldn't have thought twice about it. Cases like we had are irrelevant, and that is so very many people right now. Unless the concern is a run on dayquill? 😆

[@moniquedewyk6341]

A lot of the stuff that is reported about numbers of cases is reported just to scare people into getting a vaccine, staying home, wearing a mask and social distancing. Two year after all this started that does not seem to have worked.

[@annaraj7958]

Can you explain why I get severe allergic reaction( anaphalysis) for the Pheifer vaccination? Since i was vacinated I have problem with liver and skin and swollen my arm etc

[@alandun27]

Listener pick - Kudos to Brianne! also for that smile . . .🙂. . . never stops . . .

[@alandun27]

@@TonyFisherPuzzles STATEMENT - This is not at all what I meant. I LOVE HER SMILE which is CLEARLY not fake but intrinsic to her open and kind and generous nature! Sheesh!

[@skepticalbadger]

@@TonyFisherPuzzles Pathetic comment. You should be ashamed.

[@bcase5328]

Unfortunately those under 65 years old, don't remember what diseases can do. They grew up in the age of vaccinations, and take the protection for granted. So, they fear side affects more than disease. With monitoring, how about fill out our knowledge of human immunity, microbiology, virology, and ecological systems on the excuse of readying for space colonies/stations.

[@randmorf]

Yes 'The Atlantic' Magazine. Went to their website to check out the latest news and came across the article "The Case Against Masks at School -- Districts should rethink imposing on millions of children an intervention that provides little discernible benefit". I did not read further as in my book masks are effective not only against all variants of Covid-19, but also just about every other respiratory disease. So, be aware that publications recommended on TWIV (around 1:35:08) also can contain articles written by the opposition.

[@etc6615]

“Mantra” ??? Such empathy! How do you hope to influence if this is how you talk?

[@ScotHarkins]

I'm really trying to find _anything_ about safety in a crowded canoe (dragon boat) with 20 paddlers out for 1-2 hours getting a great workout. We require paddlers be fully vaxxed + boosted, but unmasked only inches away from a bench mate and a couple of feet from people ahead and behind. No cases yet in several months, but holy cow with Omicron we paused for the peak and will resume in February.

[@ScotHarkins]

...and the health department says "rowing is safe". We are way way way closer together than rowers. UGH!!!

[@Starclimber]

I commend you for your prudence.

[@skepticalbadger]

In that setting you are VERY well ventilated, but of course it's an infection risk. Fully vaxed you are at low risk of serious disease. Do you want to avoid your sport forever to prevent getting infected? I doubt it. Just get on with your life; I say this with all good wishes.

[@GadZookz]

There is only one way for scientists to create life and that is the old fashion way; no degree required. 🙂

[@ScotHarkins]

I'm so tickled to hear someone mention TWiT (Leo Laporte) on TWiV. Yes, TWiT might have ventured into fantasy. Maybe someday...in the future...the far future.

[@GadZookz]

Any offspring, naturally conceived at the Incubator, should receive a complete scholarship to study virology at a world class university.

[@ianlight2141]

The protein virus also good globally !

[@charlestongren2860]

107

[@charlestongren2860]

Lightning. Creation of live exp.

[@Starclimber]

@@charlestongren2860 Congrats on the primordially soupy comment.

[@walterredfield9379]

Why is the girl laughing all the time?