USMLE STEP 1: PHARMACOLOGY (VIDEO 1) THE BASICS

[@RandyNeilMD]

ERROR in my words at 7:50 mark. I meant to say "ORAL" has LOW C(max), HIGH T(Max), but I said Anesthetic... This was my error... Please make sure you catch this.

[@drsindhuchandra]

Got it. Can u do the rest of the concepts also soon please. I find them very helpful. 😊. Im grateful and hungry for more ( u guessed right - have my exam in September!)

[@nihaarshrestha]

Thank u Dr Neil. Please add this comment on the video description as well.

[@soumyadip4637]

thank u but i think AUC FOR IV route greater than AUC FOR oral route of a drug (bioavailability concept)

[@umerkhan7545]

Hello: can you please upload the laminated notes so we can benefit from them .They are amzaing

[@rameazzam]

please biochemistry videos

[@kribagasbas3298]

As my way of saying 'Thank you', I did not skip the ads. 😊 Thank you soooo much!

[@RandyNeilMD]

Krizzamer, No worries... I'm glad you found the videos helpful.

[@adeelsajid995]

I love how you not only teach concepts, but also how to think and reason through questions. Excellent approach!

[@RandyNeilMD]

Glad it was helpful.

[@Soriyou3]

This is insanely good. These are concepts that are easily overlooked by medical students because it's not covered in First Aid or any other board resources. Thank you Dr. Neil.

[@RandyNeilMD]

Glad it was helpful.

[@mohdrizwan7996]

This is by far the best gen pharm video I've come across, you make things very simple, Dr Randy. Forever indebted to you for being an angel for all of us

[@RandyNeilMD]

Glad it was helpful

[@chetanreddycds]

Dr Neil your videos are like passive diffusion thank you for making concepts easier :)

[@RandyNeilMD]

Chetan, Always appreciative of your comments... Thank you.

[@agh6452]

Wow 🤩 I can say NO professors can teach the way you have the talents 👏👏👏👏💐💐🙏🙏👍👍 thank you sooooooo very much!!!! The way you are drilling in to the high yield; that leads me to the right direction of learning. Much appreciation thank you again 🙏🙏💐💐 I am listening many times and learning every single word!!

[@RandyNeilMD]

A GH, Trust me when I say... this was a cumulation of someone who had to start from scratch and learn everything the hard way... Most of my stuff is from others who are smarter than me... I am glad it is helpful. Thank you for your comment.

[@bigmon9187]

Got my pharmacology exam monday, this is extremely well taught thank you so much.

[@sohniya7681]

You are the definition of a blessing sir. Thank you so much!

[@RandyNeilMD]

RC, Thank you for taking time to comment... glad it was helpful.

[@rameazzam]

I just want to thank you. I passed my step 1 exam. And i remebered you so much at the time of the exam. Your videos helped a lot. Best wishes for you

[@RandyNeilMD]

Absolute Perfection. Enjoy the moment... Then ATTACK STEP 2... CONGRATULATIONS!!

[@rameazzam]

@@RandyNeilMD i took step 2 before step 1 and passed it also :) and your videos helped a lot also in step 2 especially the biostatistics

[@alitariq5581]

Thank GOD some one is teaching right on point

[@RandyNeilMD]

Ali, Thank you for taking time to leave a comment. I appreciate your words.

[@celloivan]

Where has this channel been all my life!?? terrific

[@RandyNeilMD]

Thank you Ivan.

[@dailydoseofmedicinee]

The two main areas of pharmacology are pharmacodynamics and pharmacokinetics. Pharmacodynamics studies the effects of a drug on biological systems, and pharmacokinetics studies the effects of biological systems on a drug.

[@RandyNeilMD]

No worries... we will cover both... Just starting from scratch.... Hope it is helpful.

[@nagraar6099]

Very very very well stated . You did a great job one of the best explanations I've seen ! Better then kaplan , and even boards and beyond.

[@RandyNeilMD]

Thank you for taking time to comment and the kind words.

[@princessz5087]

Thank you very much for the basic pharmacology video. It’s such a great reviewing source by going through those questions. Love the format.

[@RandyNeilMD]

Princess, Thank you for the feedback... Sometimes, "old school" makes it more real... I do appreciate your comment.

[@amiraalmahdi3383]

Thanks so much. I finally feel that I am getting some topics that were intentionally ignored...

[@RandyNeilMD]

Glad it is helpful.

[@AM-lu3vu]

This was so helpful! I've been having trouble with Pharm - not able to find a good resource for understanding these concepts and I've struck gold with this video. Thank you Dr. Randy!

[@kamyathakkar1287]

THE BEST explanations I've seen! 😍😍

[@RandyNeilMD]

K T, Thank you for the comment.

[@mohammedabdulkadir5250]

promise made , promise kept..thank u doctor

[@RandyNeilMD]

Mohammed, You are welcome...

[@genesisnnodim2171]

Thank you so much. Pls more of the pharmacology videos. God bless u more for making these topics easy

[@RandyNeilMD]

Genesis, Thank you for comment... As long as you tell me they are useful, I'll keep doing them...

[@jg8198]

Thank you Dr, Neil, I love your thought process thru these questions.

[@RandyNeilMD]

Thank you for the comment... Glad it was helpful.

[@il3354]

I wish I could like this video a thousand times. Thank you from the bottom of my heart!

[@RandyNeilMD]

Thank you for the kind comment

[@noshabzaheer]

I have only seen a couple of videos and there's not a video that wasn't helpful Thank you so much ❤️ I love these videos where you go straight back to the basics My basics are pretty weak and I'm trying to strengthen them

[@RandyNeilMD]

Appreciate the comment. Glad videos have been helpful.

[@Drfauzanosman68]

God bless this Dr . . You make medicine easy Bro. I would love you as my tutor. Thanks

[@RandyNeilMD]

Fauzan, Thank you for the kind words...and taking time to comment.

[@agh6452]

YOU ARE the BEST👏👏🙏🙏!!!!

[@RandyNeilMD]

A GH, Thank you. You are always kind with your comment.

[@shreyakhatri1205]

I watch every single video of yours and they're crisp and drills everything into my mind! I was hoping you could make some videos more on biochemistry section of metabolism for step 1. Thanks!

[@RandyNeilMD]

Shreya, Thank you for the feedback and glad it is helpful. I do plan to do some Biochemistry... It's actually not too bad. Let me finish out the pharm first...

[@shreyakhatri1205]

@@RandyNeilMD will follow through your pharmacology first ! That's also a really important section and most of the times I don't pay attention /really know what my weak areas are! Now the topics that you covered were my weak areas and I missed them so big thankyou!

[@DRSHRABONIDEY]

Thank you so much doc for making tough things so palatable,life saver. Always hungry for more🍀

[@RandyNeilMD]

Shraboni, Thank you for the comment. Glad it was helpful.

[@bhamininarayan5848]

Hello sir I'm ur new subscriber thank u so much sir for this type vedio it's very helpful, I'm in 4th yr med school i'm started usmle step 1...prepration I think ur phrama vedio lecture is very helpful thank you so much sir🙏🙏love nd huge respect 4 u from 🇮🇳🇮🇳🇮🇳🇮🇳🇮🇳India

[@RandyNeilMD]

KEEP STUDYING HARD!!!

[@paramjitsingh8388]

This one best explanation video I watched

[@RandyNeilMD]

Glad you found it helpful!

[@ryanh.nguyenmd5357]

Excellent, Doctor.Thank you so much

[@RandyNeilMD]

You are MOST welcome Ryan...

[@grethelturino2553]

The best teacher so far, Thanks a lotttttt

[@RandyNeilMD]

Thank you Grethel for the kind comment.

[@hazazihazazi4204]

thank you Dr. Randy

[@RandyNeilMD]

Hazazi, You are most welcome.

[@Knstar5566]

Dr. Nail you nail it again, thank you so much.

[@RandyNeilMD]

Thank you Musawair. Glad the video was helpful. Keep studying HARD!!

[@drhoneybee973]

Doc u d BEST😎always on point, making concepts clear,toughest of tough gets easy by the end of each vid...thanku dr.neil........if possible could u plz touch CARDIO & NEURO...wil b of great help!!!

[@RandyNeilMD]

Dr. Shreya, Thank you for the comment and feedback. Always appreciated.

[@ShahrulIslam-d5k]

wah!!!!! thats amaizing. thanks a lot sir.

[@RandyNeilMD]

You are most welcome.

[@Lishawarrior2014]

thanks so much sir , this videos are really very very helpful to review the chapter and for real exam . You covered most of the high yield topics through questions.. Thanks so so much sir ! we are so lucky to have you amid us .

[@RandyNeilMD]

Taz, Thank you for taking the time to comment. It reassuring that the material is helpful. Keep studying HARD!!

[@joliechoi4312]

You are always the best at explaining things ❤️❤️

[@RandyNeilMD]

Thank you Jolie. You are very kind.

[@xaaboopinkly]

Huge thanks sir! Your videos are incredibly informative!

[@RandyNeilMD]

Xaaboo, Thank you for commenting.

[@rajagopal277]

hey doc..im happy u started doing Pharma vids..waiting for the anaesthesia basics! thanks

[@RandyNeilMD]

Raj, I'm not sure how deep I will go into that... (Throughout this, keep in mind...I am in Psychiatry)... I'll try my best, but I may stay at the 10,000 ft level... let me see what question we can create.

[@rajagopal277]

Randy Neil, MD 👍🏻👍🏻

[@mohamedlehachi2351]

Good video With good details!!

[@RandyNeilMD]

Mohamed, Thank you for commenting. Glad it was helpful.

[@stellaszeto1]

Thank you so much for these videos! For the first question in this video, would you mind elaborating on why IV administration wouldn't have the shortest Tmax? I understand inhaled anesthetics are "closer" to the arteries but IV does not require absorption whereas inhaled anesthetics would depend on the blood solubility and MAC of the specific inhaled anesthetic administered. Thank you!

[@JooAnnna]

I WAS ABOUT COMING TO ASKED THAT BUT IT DONED ON ME THAT IV WILL HAVE TO GO TO THE HEART, THEN LUNGS, THEN BACK TO THE HEART BEFORE REACHING THE ARTERY.

[@deepakhiremath6171]

It should be IV route unless it is a continuous infusion. IV route has no absorption and Cmax reaches almost as soon as drug is injected. Inhaled anesthetics take a little bit longer than IV

[@ashv117]

your awesome. This video was so helpful. Thank you!

[@RandyNeilMD]

You are most welcome Ashish

[@mashthekashmj4337]

excellent video

[@RandyNeilMD]

Thank you

[@aliotako1647]

Thank you doctor❤

[@RandyNeilMD]

You are welcome.

[@tejasviniv6902]

Awesome video

[@RandyNeilMD]

Thank you Tej. Much appreciated

[@nourinchowdhury1301]

Helpful indeed, keep it up 😇

[@RandyNeilMD]

Nourin, Thank you for the feedback...

[@NatashaR1212]

I wish I had you in my medical school 🥺

[@RandyNeilMD]

Better late than never... :)

[@HanJo328]

wow, well explained

[@RandyNeilMD]

Thanks Hannah.

[@mishalshahab4913]

The best 👏

[@RandyNeilMD]

Mish, Thank you for the comment.

[@MedManiac1]

Thanks sir. you r a blessing to students. ❤️

[@RandyNeilMD]

You are most welcome. Glad it was helpful.

[@thirstycrow10]

Nicely explained 👌🏼

[@RandyNeilMD]

Afaq, Thank you

[@Michelle-fn5nc]

Thank you for another amazing video!!!

[@RandyNeilMD]

Michelle, You are most welcome...

[@okemearomek4558]

Made this look so easy 😳

[@RandyNeilMD]

PERFECT.

[@sangayongmu2962]

Terrific!

[@RandyNeilMD]

Thank you Sangay...

[@pharmacistnazish3095]

Thanks

[@RandyNeilMD]

You are most welcome.

[@AdrianaNanette]

This is great thank you!!!

[@RandyNeilMD]

Glad it was helpful!

[@obie6997]

great work!

[@RandyNeilMD]

Obinna, Thank you for the feedback. Much appreciated.

[@1janitra]

Thank you so much 👑✨

[@RandyNeilMD]

Afshan, You are most welcome.

[@archubas]

You are the best.. dr

[@RandyNeilMD]

Thank you Archana

[@rozareimbayeva4620]

Thank you 👍👍👍

[@RandyNeilMD]

You are most welcome.

[@rozbes1229]

great😎

[@RandyNeilMD]

Thank you

[@riyaaggarwal7824]

Thank you !

[@RandyNeilMD]

Riya, You are most welcome...

[@iyahvictory7494]

Sir you a life saver

[@RandyNeilMD]

Humbled Iyah

[@AnnaXystros]

Hi Dr Neil, thanks for these videos! Super Helpful!!!! Could you explain the difference between primary and secondary active transport? Does 2ndary AT use ATP? How would you know the difference then between Facilitated Diffusion and Secondary Active transport?

[@AbhishekSingh-fm4ff]

Sir...why have stopped making videos....plzz continue making them .

[@RandyNeilMD]

Jus a short break... no worries. We will be back

[@mahnoorshah3110]

Hi dr. Neil! In the last question, how would the curve be for a drug that depends on ATP for transport?

[@mahsahajizadeh2880]

thank you so much

[@RandyNeilMD]

Mahsa, You are welcome. Glad it was helpful.

[@meowmeowone8479]

(Oliver Twist voice) ''Please, sir, may I have some more please?''

[@RandyNeilMD]

MMO, I always appreciate your comments...

[@nihalthapa6593]

For the second question- how do you know that the 20mOsm cap is referring to saturating carrier proteins used in facilitated diffusion and not equilibrating the concentration gradient for something like simple diffusion?

[@drownedingames488]

Because we have a drug that inhibits transportation

[@michaeldob2153]

@@drownedingames488 Sorry but the drug does not inhibt the transport.

[@mane6377]

Very helpful 😊

[@RandyNeilMD]

Mane, Thank you for the comment.

[@mhissytipsy]

Thank you for all the videos... please can you make videos on ecg reading and xrays as well.. Thank you

[@RandyNeilMD]

I wish I were that smart...

[@omamaraltaher4182]

Thank you so much😍😍

[@RandyNeilMD]

Om, You are most welcome.

[@sablegs]

Thank you so much sir for making every concept crystal clear.You are the best. Sir plz if possible do a video on genetics basics.

[@RandyNeilMD]

Gautami, Thank you for the comment... The GENETCIS is there... Hope it is helpful

[@sablegs]

@@RandyNeilMD will check it out immediately.thank you sir.

[@fortheloveofmedicine4634]

Do you have those notes available yet? I am an MS1. Loved these videos, please share the quick sheets. Thank you.

[@RandyNeilMD]

I'm working on getting a new website thats updated...

[@rashedhejaze1290]

Thank you Dr.Randy , do you have those notes available yet ?

[@OShawna23]

Hi Dr.Neil Can you please make a video about half life calculations ?🙏🏾

[@kellyenciso8090]

Thanks!

[@RandyNeilMD]

Thank you Kelly. Very kind of you.

[@youmnahashem679]

Dr Neil to the rescue

[@RandyNeilMD]

To Infinity and beyond..

[@Saad-ir5bq]

Could you please example for the last example why can’t it be C? The amount of ATP could also limit transport right ? It could be both B and C?

[@OkanVKILIC]

Dr. Neil first of all thank you for videos. As far as I know rabeprazole (PPI) inhibits H-K ATPase. How does it inhibit Na-K ATPase? Digoxin and oubain inhibit Na-K ATPase. I think there is a mistake. Please Correct me if I'm wrong.

[@RandyNeilMD]

Off hand... I do not know.

[@danielbohn]

👏🏻 👏🏻 👏🏻

[@kiranmoparthi5190]

Please upload the laminated notes i have my exam in 75 days and it will be helpful to review in between. Full support from INDIA ❤️🧨

[@RandyNeilMD]

Kiran, The notes have been my Achilles... I have to rely upon someone else to upload correctly. You can email [e-mail] and I'll try and attach the file.

[@somibenam9280]

dear Dr.Randy, Where are these pdfs? I wanna have them but I couldn't find them

[@Drfauzanosman68]

Please what is your website?because i would really like to make use of your laminated notes. Thanks

[@RandyNeilMD]

Fauzan, It's coming no worries... Coastalmdlive.com... not quite ready yet.

[@antoniomontesgtz5224]

Dr. Neil great videos, but i need your notes for pharmacology, please 😭

[@umaumz9270]

at 7:52 Anesthetics, Cmax is High and Tmax is Low. Right?

[@perseveranceinprincess]

i think that was a mistake by him

[@RandyNeilMD]

UMA, Thank you for catching that... I pointed to ORAL and then wrote Anesthetic... I hope people also catch this... Thank you.

[@umaumz9270]

@@RandyNeilMD Am glad I could be of any help. Thank you, Sir.

[@umerkhan7545]

Hello: can you please upload the laminated notes so we can benefit from them .They are amzaing

[@mukta81]

Oh my god, you just saved me.

[@RandyNeilMD]

PERFECT

[@tasneemkhalil6950]

thankssss

[@RandyNeilMD]

Welcommmmee

[@AN-hx6oh]

Thank you Dr. Neil for your work! Amazing explanations, very simple and helpful! P.S.: Where can I find pharmacology PDF files? Thank you.

[@RandyNeilMD]

I'm working on a new website... It will have everything...

[@AN-hx6oh]

@@RandyNeilMD thank you

[@danishwaqar3537]

Great videos sir and well explained.Thankyou..what is your website

[@RandyNeilMD]

Danish, Thank you for commenting. I will put a copy of website up in description... It may take some time for the notes to be there...

[@alveena9769]

Between passive and and facilitated, wouldn't passive also stop at a certain point when there's no more concentration gradient?

[@shahbazali-jn2rc]

Hello Sir thank you so much 😊. Sir can you please make vedios on substance abuse. Like downers, uppers and hallucinants. Thanks 👍

[@RandyNeilMD]

I'll take a look...

[@97onsi]

Thanks a lot Dr. Randy i learned a lot from your videos' can you please tell me from where can i download your pdf notes.

[@RandyNeilMD]

Onsi, the pharm file was too big for the website. You can email at [e-mail] and I'll try and send...

[@user-vh5hy4mo1j]

SO HELPFUL! they didnt even teach this to us in med school. Thank you!

[@RandyNeilMD]

Glad it was helpful for you...

[@mr.k8251]

Thank you dr I downloaded the pdf

[@RandyNeilMD]

PERFECT.

[@biancadestro2110]

can i ask you where I can find the pdf?

[@manuelgoncalves4937]

What about syrup. How does the PK affect it?

[@mignonnebebe6702]

Could it not be passive diffusion when the concentration gradient has been eliminated?

[@ahmedsakr5355]

Plz could you make a video about general pharma equations ( t1/2, loading dose , maintenance dose , Vd) I really find them confusing and my exam is soon

[@RandyNeilMD]

Ahmed, Those weren't my favorite either... but we can cover... It will all be in order from how I had it written in notes. I didnt have too many (or any that I recall) calculating questions on exam...mostly concept questions based on formulas...

[@ahmedsakr5355]

@@RandyNeilMD thank you so much

[@Mohamed_Yousif2298]

Are pdf notes available yet?

[@RandyNeilMD]

you can email me and I will try and send. NEW Website still in creation... randy.neil8 @ gmail.com

[@vevenaneathna]

eh some of the inhaled barbiturates have multiple volumes of distribution and their time to c max can be measured in hours since they take forever to partition into neural tissue/across BBB. vs an IV bolus of diacetyl morphine. pharmacology in medschool makes no sense to me, just memorizing a bunch of short hand rules that have more exceptions than applications. this is coming from someone who used to be a pharmacist. I guess you are breathing out inhaled anesthetics pretty quickly so some of them dont get to very high concentration and therefore their time to c max is pretty early.... but in general there is no real way to know for sure given how vague the usmle questions are. and i guess iv infusion is slower than iv bolus but thats not clear to me in the question. owell.