TWiN 46: Neuronal activity promotes glioma progression

TWiN explains research showing that interaction between glioma cells and neurons in the brain shares mechanistic features with synaptic plasticity that contributes to memory and learning in the healthy brain.
Show notes at www.microbe.tv/twin/twin-046/
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[@Renatus_Eruditus]

_Timestamps by René Suarez_ 1:22 Paper - Glioma Synapses Recruit Mechanisms of Adaptive Plasticity Brain cancer research and synaptic connections between neurons and glioma cells 6:51 Brain plasticity and glioma progression 16:14 Brain tumor development and BDNF's role in glioma proliferation 22:09 BDNF's role in glial cell synaptic plasticity 28:04 Glioma cell synapses and their impact on proliferation 37:27 Glioma development and potential therapeutic targets 44:40 Neuroscience and psychedelics _Audio timestamps by Jolene_

[@tonaruch8623]

Thanks for answering my question

[@sueyoung2115]

I am learning much from your podcasts! I am somewhat hearing impaired and I would be so grateful if you could enable captions for the videos. Thank you for your work and sharing!

[@fernie5128]

Hi, If you go to the description section just below the video and open up the "more" section you will see that there are accompanying notes with a hyperlink to them. Perhaps this will help for videos without captioning. Another viewer and fan of microbe tv.

[@sueyoung2115]

Hmmmm, yes, thank you.

[@RTew021]

Always view Twin after its release, but I was hoping you would say something about other kinds of cancers and their interactions with adjacent tissues, whether depolarization or some receptor activity analogous to what was described for neurons and glioma cells might be a factor in how rapidly non-neural malignancies proliferate. Or whether the capacity to invade normal tissues or even the metastasis tendency might have electrical features similar to what according to this paper drives the aggressiveness of gliomas (including the positive feedback system that Tim recognized).

[@3dtimelapses450]

Interesting