VIRUS SIMULATOR 2020 (Part 1/4)

PART 2: • Virus Simulator (Part ...
I meant to say "brunt", not "blunt", at 10:54. Oops!
Music:
"Evo" by DemiPixel
/ demipixel
"Childhood Memories of Winter" from: Music4YourVids.co.uk

[@alex_black776]

All fun and games until carykh’s new character is a red dot

[@sentient_water]

First: evolved d o r i t o Now: R E D D O T

[@Revilatan]

A red cute dot.

[@usernameusername4037]

Broke: Black Woke: *C H A R C O A L C O L O U R E D*

[@gingeh1]

Hotel: Trivago

[@mhesus]

Horses: In the back

[@TheElvisnator]

Actually Woke: The N-Word colour

[@Marci124]

I'm guessing it wasn't 000000.

[@markifi]

wait does KZbin demonetise your video if you say 'black'?

[@asdunlavey]

Five parts? That means viruses are more complex than special relativity.

[@ray-without-organs]

Jack Dunlavey hey early fellow

[@arandompig3997]

yes, it's a very known fact that viruses are harder to understand than special relativity

[@oscard4801]

Biologically, the viruses aren't classified, because their complexity is really high.

[@juhotuho10]

cells are actually stupidly complex mechanisms

[@kindoflame]

The mathematics of special relativity never gets much harder than trig, so it this really so hard to believe.

[@Loweren]

Hi Cary, Biology grad student here! That's an interesting model (though at first I was thinking you've got plant or fungi cells because they had cell walls instead of cell membranes like animal cells do). I'm curious how you will use it to simulate viral spread, and maybe some other processes like necrosis or tumor formation! Speaking about telomeres, while it's true that they are an important factor in aging, their role are a bit more complicated that that of caps on the ends of shoelaces. Telomeres indeed shorten with each cell division, but the rates of cell division in the organism are not uniform - skin and gut cells divide much faster than brain cells, for example. In addition, telomeres are still present even in older organisms, and some species like mice have much longer telomeres than us, but they live shorter. What also matters here is epigenetic regulation in the nucleus - telomeres serve as an anchor to the inner surface of cell nucleus, and as they degrade, this anchoring slips, leading to mis-regulation of expression of other genes because of positional effects. Aging is largely still a mystery to biology, with dozens of competing hypotheses battling it out on the fields of academic journals. Personally, my opinion is that the hierarchy of repair processes repairing each other degrades over time starting from the top, but I won't get into much detail here. Hopefully your simulations would shed a light on this issue!

[@SimplyAnExistence]

Rowen Loweren I have a question about that. I know you obviously won’t have an answer due to the mysteries already unanswered as well as me asking a question that delves into that, so I’m mostly asking for your thoughts on it. What would happen if the telomeres were always perfectly replicated, keeping the original amount that was there before, rather than being chipped away, and unable to regenerate fast enough?

[@Loweren]

@@SimplyAnExistence First of all, cancer rates would be higher, because shortening of telomeres is one of the factors that keeps cancer from growing too much. Cancer cells happen to have mutations enabling high telomerase activity, because malignant cells that don't have high telomerase activity don't become a tumor. Otherwise, if we, let's say, find a way to prevent all cancers from occurring, then the cells would still deteriorate over time from such factors as DNA degradation, epigenetic drift, production of free radicals in mitochondria, stem cell exhaustion, accumulation of protein aggregates. So I would expect aging to not change much, especially in slower-dividing tissues.

[@SimplyAnExistence]

Rowen Loweren Alright. That’s nice to know xd

[@plasmoxxie8275]

Thats deep

[@menooNFT]

wow interesting and i understood that! *clicks on show more* nvm imma head out

[@TheElvisnator]

CaryKH: *_You guys were so disappointed that I didn't make a KH joke last time_* Also CaryKH: *_*Doesn't make a KH joke*_*

[@oscard4801]

Exactly, and that's how it works xD

[@GalexiDude]

CaryKidHelper

[@aaronstephen3058]

Cary Kreate Hepatitis

[@aureavita8653]

Cary Kills Hitler

[@brandonchan5387]

Cary Karen's Husband

[@connorm3436]

10:45 I would say the damage to the codons is more analogous to the accumulation of spontaneous and environmental (e.g. chemical or ionising radiation) damage which the cell has numerous processes to rectify. Telomeres are more to protect against the damage that results from cell replication (which it doesn’t appear that your simulated cells are doing) and their degradation is more related to cell senescence, where a cell has reached the end of its cell line. Active genes are more prone to spontaneous and environmental damage as they have to be more exposed (free from histone proteins) for the DNA enzymes to access them, but as a result they aren’t as shielded from damage.

[@georginho36]

Connor M ye same

[@Marci124]

One process to name drop would be methylation.

[@carykh]

yeah that's a good point, about how my cells don't reproduce. I recall from somewhere that human cells can only divide ~60 times before their telomeres are all used up. Since my cells never divide, they would be safe from that kind of damage! However, perhaps the DNA enzymes you mentioned are more analogous, since the enzymes accessing the genes is somewhat similar to my "interpreter" reading each new codon.

[@ron9365]

we got big brainer here

[@ionarevamp]

@@carykh Additionally, certain factors like supplements, diet, and most importantly cardio exercise increases endogenous production of telomeres. I'm not sure how in-depth you plan to go with you simulator, but that might be an interesting detail to take into account

[@Cooliokid956]

In this universe: normal business In THAT universe: DIGEST HAND REPAIR WASTE REPAIR FOOD DIGEST WALL REMOVE WALL DIGEST WASTE

[@ashleybyrd2015]

I fear to know what creatures would come out of such a chaotic world, if at all.

[@Green-vw5vr]

WRITE WASTE

[@BoibbleicecubebfdiMrexist]

MOVE HAND WASTE

[@BoibbleicecubebfdiMrexist]

Also i don’t think digest hand is possible, as “hand” is not a 2nd option. MOVE HAND FOOD

[@Cooliokid956]

Boibble ice cube bfdi Mr. exist yes i noticed how it worked after i did this

[@absolutelyrandom4978]

just a highschool student but from what i know, telomeres are the end of the chromosome. each time a cell divides, it gets shorter and shorter until it disappears and the cell can't replicate anymore. this is one reason as to why we age. when we're born, the telomeres at the ends of our chomosomes are pretty long but the more out cells replicate, the shorter they get.

[@juliengrijalva8606]

Every time replication happens, the ends of DNA are lost. Telomeres are DNA that don't mean anything, so it's okay for them to get lost. When they run out, cells can still replicate but important DNA is lost every time.

[@ValkyrieSirena]

If human beings able to replicate the telomeres then human beings will be immortal

[@solstice_enigma]

Rest in peace, KH jokes because of Cary's out of ideas... Or make an AI that will make a KH jokes for you!

[@oscard4801]

Upcoming video: Hi I'm CaryKnockingHelp (literally)

[@oscard4801]

A really good idea, a KH Phrase Generator AI.

[@GalexiDude]

CaryKirbyHiiiii

[@OctoBirb8Claws]

I made something for that! perchance.org/znylij5zzt#edit

[@flowrling]

@@OctoBirb8Claws I got "Cary Ketchup Holder"

[@Owen_loves_Butters]

Who else is just repeatedly watching the first 2 episodes while you wait for part 3 to come out?

[@knuti27]

Me

[@weirdernow]

Carykh: Releasing the virus is the best part! Scientist and doctors: So you have chosen, virus.

[@kaninchengaming-inactive-6529]

-God on his visit to Wuhan, 2019

[@MaksKCS]

@@axye1024 Probably because he's a 9 year old trying to make jokes

[@kaninchengaming-inactive-6529]

@@MaksKCS at least he's older than you.

[@weirdernow]

I don't care I have an IQ of 131 and I am older than a 9 year old, but younger than an 13 year old.

[@weirdernow]

@@MaksKCS how old are you? I am a 10 year old physics scientist and also web developer. Not boring physics that goes in TV for less than 131 IQ people to enjoy, like, level Einstein science.

[@Lanausse]

CaryKH of the video bc Cary doesn’t need to always make a KH joke: CaryKillerHuman

[@flowrling]

I like that. :)

[@PL9050]

Kinda like "Cary Kills Hitler" and "Cary Katches Human" mixed.

[@therainbowknight]

I like that. :)

[@S3rial85]

Carykh in part 4: "Anyway i decided to redo this part and recode that part so now it is better but we will have to start from the beginning, see you next week"

[@chopseh]

You know it’s gonna be a good carykh video when he has the evolution simulator bgm playing

[@coffee_candy_]

"insert how early i was related comment" "insert meta virus intro story"

[@sql64]

Original

[@movedhahaha6431]

I swear cary gives us the best content we never asked for

[@2half1whole46]

Nobody: No one: TWOWers when they get eliminated: 8:03

[@wakanakamulan2152]

Nobody: Ziltch: No Girls: No Boys: Not even you: Not even Nobody: Not even a cell: Not not: Not even "Nobody:": Not even : key: Nope: It's nobody: You guessed it, It's nobody: Yeah Nobody: Nobody party time: Well technically it's nobody: Yeah Nobody: Nobody even scrolled down this far ): : When you put a : next to a ): it combines making the : not look like a :: I don't even know what to say anymore: Is anyone even here?: Why are you still here? Just to suffer?: Well guess what, the punch line is coming soon so keep scrolling: You're almost there: So close: SOOOOOO CLOSE: YOU ALMOST GOT IT: JUST 1 MORE: No one: A cell when their wall is broken, or a cell when they break their own wall: Lol I forgot the timestamp, lol xd lmao get rekt n00b lol

[@erik19borgnia]

I thought the same!! I miss TWOW :(

[@circumplex9552]

@@wakanakamulan2152 why

[@MilkyGees]

@@wakanakamulan2152 lol ok

[@wakanakamulan2152]

@@circumplex9552 I was bored

[@akoaykilalamo]

We will get through this guys. Belief is a powerful thing

[@jan-lukas]

Java has a compiler and an interpreter, this way you can compile code and use it on every computer

[@revimfadli4666]

Java's like a weird hybrid indeed, where you compile programs into bytecodes that are faster to 'interpret' by JVMs

[@MatthewChenIsAwesome]

My biology side is cringing as my computer science side is overflowing with awe. Thanks for the great work, Cary!

[@rover8066]

What font are you using in processing? I've grown fond of it

[@dragon_pi]

no, you have grewn FONT of it

[@StefanReich]

@@dragon_pi Oooouch

[@carykh]

It's an ever-so-slightly modified version of "Interstate Condensed"! fonts.adobe.com/fonts/interstate Curious why it's called "Interstate"? The US government uses the non-condensed version of it on highway signs

[@Architector_4]

@@carykh What are the modifications? I've grown fond of them

[@monad_tcp]

2:54 Java is interpreted, all languages are interpreted by the CPU in the final case, that's how Turing Machines work, you can't escape that (except by hardware synthesis)

[@ObeyBunny]

I must have missed your name pun, so I'll call you "Cary Kovid-Harrower." Also, I'm jealous of your giant sexy brain! When you end up causing the technological singularity, be sure to upload your consciousness so we can copy and paste your personality into an army of androids.

[@flowrling]

"Giant sexy brain"?

[@abrasmage]

@@flowrling _yes_

[@ashleybyrd2015]

_Backs away, slowly._

[@ktosnieznany5543]

Yes, the memories of evolution simulators are coming back! Great video ^^

[@MigattenoBlakae]

Colorblind here: NEVER DO RED AND BROWN PLEASE😫

[@minecraftspiderman3584]

i just love how viruses and microscopic bacteria slowly travel across our bodys and infect us within days

[@finminder2928]

I love that you can change the simulation, while inside the simulation (without having to restart)

[@anlu2]

Molecular biologist PhD here. Codons are something else. The things you describe are more akin to genes. And instead of telomeres protecting codons from degradation a better analogy would be DNA repair repairing the genes. A gene is a stretch of DNA information. A codon is a three-letter stretch of DNA/RNA information that is translated into a single amino acid. Several amino acids make up a protein. That's why all genes come in multiple of three DNA/RNA letters. You see then how a single codon is not enough to encode a full gene. Typical genes are comprised of around 200 codons, which are 600 DNA/RNA letters (aka. nucleotides.). There are 4 different nucleotides (ATGC), therefore 4*4*4=64 different codon variations possible. However, we only use 20 different amino acids to make proteins, so many codons code for the same amino acid, one code for gene start, and ~3 for gene stop. There are some but surprisingly little variation of what codons code for across all living organisms, indicating a common origin for life. en.wikipedia.org/wiki/DNA_codon_table

[@deimuader]

Biochemistry PhD here :) That was a clear and concise answer, liked it.

[@anlu2]

@@deimuader thanks colleague :)

[@justjames4]

You're so smart! Though don't you get demonetized for saying the virus's name?

[@secretgames1906]

No; KZbin allows it now (it says it on the KZbin Creator Studio)

[@slimegamerseven]

Wow. When that one cell died, it gave me TWOW vibes because of the background music. I miss twow.

[@AlexanderPrussak]

*cary voiceover:* it took 3-4 days *cary in editing:* I was such a naughty lying boy as voiceover cary, I should admit that it actually took exactly 5 days

[@bigziti_osc]

8:04 I had flashbacks to TWOW. What fun 4 episodes I had with you. (RidgeRR4)

[@neurotrophy3788]

Hey Carykh! A huge fan here. I am not sure how the final simulation will look like, but I would suggest renaming the food particles to oxygen or fresh air, as the virus affects the oxygen levels and decreases them when it attacks. Also I wonder how it would work if you made the air/food particles come from and waste particles get excreted by special groups of cells that represent the lung/intestine and kidneys, respectively. As in our body, special cells group to make a special functions because they "interpret" special "codons" to make that function possible, so maybe you could do that, as I can't make much sense of your grouping of the cells (maybe it is only to provide distance for diffusion?). Ah and btw, renaming "codons" to "genes" is more accurate

[@Max-nc4gz]

Release the rest NOW, you just teased us too much ^^

[@electra_]

The fact you can combine unintended genome actions and stuff to make "Remove Wall" for example reminds me of Baba is You.

[@Qoride]

*Global Pandemic Killing Millions...* carykh: Time to make a simulator

[@baumeisterjack9281]

I like this idea of simulating cells in a body like this, i'm stoked for the next episodes. And regarding Telomeres: Telomeres are needed for cell division because every time your DNA is replicated small bits at the end go missing. If the the Telomeres are too short because of too much DNA replication, the cell dies (programmed cell death). Damage from UV light is repaired by DNA polymerase (dont know which one exactly from the back of my head right now) (it's a protein).

[@deimuader]

Well, DNA damage can be pretty diverse leading to different repair mechanisms and proteins involved. In humans, DNA polymerase δ and ε are mostly used for proof reading and repair, but there are usually many other proteins needed.

[@cheukmng9863]

carykh: covid-19 youtube: *DEMONITIZED*

[@LegoEddy]

I feel that this series might become my favorite series since evolution simulator

[@circumplex9552]

NOBODY: This very intelligent cell: REMOVE WALL

[@enzoqueijao]

I thought this was gonna be a biochem video. If it was, you would definetely be a complete genious lmao

[@jimmy4716]

2:48 umm ackshually java classes are compiled into something called java bytecode which is then interpreted by the JVM (java virtual machine) into the machine language architecture that the JVM runs on, so really java is interpreted just like python, but with extra steps. inb4 isn't that what normal compiling is? no, the difference is that java compiles into an intermediary language for the JVM to interpret which is why you can run java bytecode on any cpu architecture that has a JVM built for it. compiled languages like C compile the source code directly into native machine code that the cpu will then directly understand without an interpreter. For the code to run on different cpu architectures, a compiler needs to compile into the target cpu's architecture and have separate builds for each architecture. This is why software often has a 32 bit (x86) version, and a 64 bit (x86_64 or amd64) version.

[@Architector_4]

I mean if you want to get skeptical on this, CPU's instruction interpreter - the part that figures the length of each instruction, its parameters, and what is supposed to do - _interprets_ the incoming machine code into the individual instructions on the fly.

[@c14n_]

Human cells don't have a cell wall, they only have a cell membrane. Bacteria, archaea and plant cells have cell walls though. Also, most viruses including coronavirus (ones that aren't retroviruses) don't take over your dna. The viral rna never enters the nucleus even, instead it gets translated in the cytoplasm as mrna by ribosomes. Good video regardless - just wanted to share my thoughts.

[@zxcvbnmproductions5022]

I don’t want TWOW 24A, I want Algotriconthalon.

[@AcoriSage]

YESSSSSS I've missed these kinds of videos from you!!

[@jurakarok3343]

In that universe cell deaths produce the sound of a glass chime breaking. Science has yet to explain this phenomenon.

[@fdagpigj]

making this into a multipart series is just evil

[@s0lati]

That whole entire time I was trying to click on the taskbar.

[@MadamLava094]

Hey, this is a really cool idea! I know you're known as the "haha funny neural network go brrrr" guy, but I would love to see more ideas like this. Keep it up! (Ps, whats it coded in?)

[@TheBrettN]

Where’s my TWOW!? You promised us this. Don’t lie to us for the 5th straight time.

[@Ayfri]

Hi, I have a seeious question : Why don't you use Intellij IDE ? With GitHub Student Pack you can get free license, and via the files of Processing, you can use Processing into an Empty Jqva Project (or Gradle), and Intellij is like the god of Java IDEs, it helps you a LOT, with autocompletion, documentation, Finding duplicates, creating with one button Getters and Setters, generating Constructors, auto importing things, generating overloading methods with default value in one button etc Many many things are included in this IDE, it really speed up things and helps you read your code with fully customizable themes, customizable coding styles, a lot of plugins that makes many many things, it's really worth of it !

[@leandersmainchannel4493]

I'm so inspired by this cell structure that I am going to program a 2D robot that paints and mixes colored balls!

[@jamdonut]

it looks really cool lol, it's fun to see stuff you havent seen before

[@Maazin5]

Your creativity and ability to develop these ideas so quickly is so impressive

[@pendragon7600]

bruh nice. Gotta love that 2am on monday post I love this s*hit (censored for the children)

[@Daro-Wolfe]

pendragon except you left all the letters there 🤣

[@EtanMarlin]

9:23 And the cell DIES, Bruh oof 😂

[@ray-without-organs]

Etan Marlin how tf are you commenting about a scene 9 mins foward when the vids only 2 mins old??????

[@EtanMarlin]

@@ray-without-organs you recently changed you're profile picture

[@riotorres7389]

Bruh how

[@grugspro]

Something I've wanted to see from infection simulators is post_mortem infection, where the can travel from a dead body to a living one when not treated properly

[@kindoflame]

Judging by dead cells generate a whole bunch of waste, I think he is probably going to do something like this.

[@kevinshen9391]

Fascinating Simulation, please continue this!

[@GothBb666]

I want to try and make it a full system, like, just as you mentioned, there are extra planes. One plane has a heart, which controlls the rate at which particles move, another one has a kidney or a liver which eliminates waste, and another one has a brain, which just tells cells how to move or something

[@sammortlokk]

This is such a detailed simulation and we've only seen one part. I'm really looking forward to this series!

[@leonardosanchezaguirre2459]

Cary: Develops a new, original simulator KZbin: Agario it is!

[@tcookiem]

"Maybe in later parts I'll actually release the virus" Yeah it would be interesting to see how your creation fares in the real world

[@dragonymous3509]

When he’s looking at the cell at (6, 9). Nice.

[@mashmachine4087]

Im so excited for a new "evolution simulator" style series! Those were really fun!

[@ironici]

It sounds pretty fun to write your own instructions and see how long your cell will last

[@LePenguia]

Digest the Cell Wall.

[@o-manthehuman7867]

Cary: says covid 19 KZbin: Hippity Hoppity Your Revenue Is My Property

[@theajayyy]

KZbin does not take the revenue. When demonetized, they get zero dollars too and it does hurt their revenue.

[@webbraham2768]

He’s right. The first Big Mac is so much better than the eighteenth

[@kesaya3806]

Congrats on 8k on the disc!

[@matieking]

Just a tip, animal cells actually do not have cell walls! Only a cell membrane

[@artemius8442]

In this video, Cary can really... MAKE U GO crazy by NOT making a KH joke! :P

[@styxnstones98]

wait so now i have to wait to watch this ugh i would watch a 3 hours video about this

[@quimlast7180]

The model is very non-biological but I'm excited to see what it ends up looking like anyway.

[@gringusgaming]

THE LIFE SIMULATOR VIDS ARE BACK!!! YES!!!

[@itsvicdev]

stickman with fat yellow head makes plague inc in a nutshell

[@midnight5023]

Cary, you forgot to do a carykh pun again

[@HexCopper]

I’m looking forward to seeing the rest of this series Reminds me of a platapus cell game I played back in sophomore year. Really interesting and in depth with hints to reality

[@kindoflame]

I remember that too! Great game that was incredibly accurate to real life.

[@7of475]

"If there's some biologist out there, feel free to correct me." Well, I can confirm that there IS a biologist out there. I'm not a biologist, but hey, rules are rules. A Telomere isn't actually the correct thing you said, it's actually a a brand of spaghetti.

[@loganrocks-wd3gu]

Omg evolution simulator 2 electric boogaloo much hype!!!!!

[@osmo2384]

Animal cells don't have a cell wall, only a cell membrane.

[@bitterlemonboy]

Finally someone that actually attended middle school on youtube

[@osmo2384]

@@bitterlemonboy actually I'm British so there is no middle school, just a primary school then high school then college then university.

[@valantisalatsas7249]

imagine if cary ends up helping finding a cure

[@oscard4801]

Comments: CaryKH doesn't made a KH joke. Upcoming video: Hi I'm CaryKnockingHelp (literally)

[@GalexiDude]

Cary Kant I go a few videos without Having to make a KH joke

[@allesman]

Part 1... of 5! (yay)

[@raddiecat6528]

if u miss your cary joke here's one cary KitKat hunger

[@AuroraVeil_]

Cary you uploaded this at 2 am go to sleep

[@thatotherandrew_]

This... is impressive. Good job with Processing!

[@hellmaestroosu792]

Looks like a dope tower defense game. I like it.

[@-ism8153]

6:09 Thank you for choosing to show us cell (6,9). KZbin is in your debt.

[@StandardName562]

Where is part 2 Cary? I miss you

[@lucakollmer]

sorry cary, im studying cell biology and your simulation is nowhere near close to reality but thats never the point! great video bro

[@cringium]

This series is gonna be good

[@onecommunistboi]

What happened to the series? Why is this unlisted? :(

[@tommykelly6840]

Great idea and love your videos! But the only issue with this simulation is that a virus like SARS-COV-2 does not affect the DNA. It simply hijacks ribosomes with RNA. A virus would have to reverse transcribe in to the cells DNA

[@Number_055]

Man, you just got done being laughed at for using pygame, and now you're outing yourself as using Processing too. Good work. (And more sincerely, good video)

[@WmLatin]

Great so far, can't wait to see all of it!

[@wallywutsizface6346]

You should adapt this simulator to an evolution simulator for the cells instead of with viruses

[@TheKirbyGamer713]

Came here cuz of the looks, stayed because of the complexity.

[@fotoschopro1230]

Coronaviruses are Riboviria, not Retroviruses, which means that they don't actually change the cells DNA. Instead they just directly use proteins in the cell to replicate their own proteins and genetic code. Just wanted to point that out.

[@mcstrayy]

Animals don't have cell walls. They only have a cell membrane.

[@hpsmash77]

I never expected Cary to murder innocent cells trying so hard to survive