Ozempic is a game-changer. Here’s how it works.

This diabetes drug could be the future of weight management.
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Ozempic, a medication developed to manage type 2 diabetes, has been in the news a lot lately because of one of its signature side effects: drastic weight loss. Both Ozempic and Wegovy, Ozempic’s counterpart approved specifically for weight loss by the FDA, are brand names of a drug called semaglutide. Semaglutide is one of several drugs that mimics a crucial digestive hormone called glucagon-like peptide 1, or GLP-1. It amplifies a process our bodies perform naturally.
GLP-1 is released in our intestines when we eat, and there are receptors for the hormone in cells all over the body. In the pancreas, GLP-1 promotes the production of insulin and suppresses the production of glucagon. This helps insulin-resistant bodies, like those with type 2 diabetes or obesity, manage blood sugar levels. In the stomach, GLP-1 slows gastric emptying, extending the feeling of being full. In the brain, GLP-1 suppresses appetite, which also promotes satiety and curbs hunger, so we eat less.
In late 2022, a rush to use Ozempic off-label for weight loss, likely prompted by its sudden rise in popularity in social media, led to a shortage of the drug for people who need it. But more drugs like semaglutide are currently in the process of being approved by the FDA to be prescribed for weight loss, likely signaling an end to the shortage and a promising new generation of medical treatment of obesity.
Further reading:
Mila Clarke's KZbin channel: / thehangrywoman
The New Obesity Breakthrough Drugs, by Eric Topol
erictopol.subs...
The Discovery and Development of Liraglutide and Semaglutide, by Lotte Bjerre Knudsen and Jesper Lau
www.frontiersi...
The pregnancy risks of Ozempic and Wegovy need more attention, Julia Belluz writes for Vox. Read more here: bit.ly/41znHCv
Note: The headline on this piece has been updated.
Previous headline: The game-changing weight loss drug, explained
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[@Vox]

There's a lot about Ozempic we didn't have time to get into in this video, including more about medical discrimination around obesity and more context around recent drug shortages. This article from our website, written by Julia Belluz, provides more info: www.vox.com/science-and-health/23584679/ozempic-wegovy-semaglutide-weight-loss-obesity

[@aprilmason1616]

Will you do an in depth video as well? It is so important for the public to have all the correct information. If I could I would love to help, but I study still and live else where. Im just so passionate about food and health related topics and got super excited for the video haha Okay bye 👋

[@NadirAgha]

*including more about it's side effects, long term effects, indications, contra-indications, and how necessary it is to use it only if a doctor prescribes it.

[@mysisterisafoodie]

Honestly this is a topic where there is just a lot of unnecessary outrage. There isn’t enough supply for the current demand. They should just make more. Done. Whoever wants to buy it, if they can afford it, should be able to. If not, lobby your insurance companies to do better. Better yet, why don’t you elect officials who will give y’all public healthcare? And whoever needs to prescribed it should be able to. I don’t hear anyone complaining about milk, because growing children need to drink it. There’s enough for recreational milk drinking and for children to drink it too.

[@gwenstacyspidercat4294]

You "didn't have time to get into?" My siblings in christ, you decided the parameters of the video. The medical discrimination and context around drug shortages should not be considered secondary content, bc most ppl watching this are never going to read your article...

[@CristinaNoujaim]

Why doesn't this video (or your article) cover the studies that show that weight is gained back and more statistically by those who *stop* taking ozempic? Or the long term effects on the body?

[@Vonononie]

“Maybe you’ve heard the jingle” no, because medication isn’t advertised in my country!

[@petar4onachev]

Bless your country! I am tired of seeing medical adds everyday, where are you from?

[@StellaMariaGiulia]

Same

[@jessealexander9074]

Its only legal in the U.S to advertise medications

[@shana736]

@@jessealexander9074 Direct to consumer advertising for medical and pharmaceutical drugs is only legal in two countries which are the US and New Zealand

[@Vonononie]

@@petar4onachev UK but I don’t think prescription medication is allowed to be advertised anywhere in Europe. Over the counter stuff, like basic painkillers and cold remedies, are allowed to be advertised but they aren’t heavily pushed. I can’t see a reason why medicine should be advertised, isn’t it given based on medical need not because you want it?

[@ericshaker9377]

You guys should really bring on a credentialed source like a doctor or pharmacist for videos like this

[@tumblingrosesstudio]

Good idea

[@firstprinciplesinvestor3464]

right, like they used some random lady off youtube as their primary source

[@dominicrincker8280]

It felt like an ad

[@allisonjoydahlen569]

I agree!

[@phinsup402]

More like a passive aggressive sales pitch, shame on you Vox.... bring in a medical expert (scientist) next time.

[@angelina-po7hq]

As someone who works in a pharmacy, I have seen how this hurts many patients who need this medication to control their diabetes. For almost 3 months straight we could barely receive this drug to dispense due to the unexpected increase in demand. I completely understand the want to lose weight and ozempic does help with this, but people with diabetes need medications like these to live their lives.

[@steventhan93]

Are you saying T2D relies on this med to stay alive? Because that's not true at all, this med is FDA-approved in 2017, and T2D predates that by a long shot

[@tdawg719]

Ditto

[@Bassen97]

@@davidbjordan people w diabetes need it. People who are obese can stop eating junk food and start eating healthy and less and exercise. Not that hard

[@stevethepocket]

@@davidbjordan So really the solution is to just ban processed food.

[@jaguarrior]

@@stevethepocket banning processed food, would not do anything to make my diabetes better. Mine is caused by PCOS, a metabolic disease

[@rosethompson1983]

I used to be 280 pounds, going blind due to a rare obesity complication called Intercranial Hypertension, but was able to take Ozempic for just 4 months and for the first time in my life felt full. I’ve kept up the initial weight loss and so far lost 80 pounds. Without this medication, I believe without a doubt I would be blind in my left eye by now.

[@MsSarcasticity]

The reason why you cannot feel full is most likely due to eating carbohydrates which cause hunger hormones to increase. Completely remove carbohydrate sources and increase saturated fats from animal sources like butter or beef tallow. You'll feel a lot fuller on less food without without shooting yourself up.

[@kidsdomath1330]

@@user-kr6jg6qb7l Ad.

[@andreasamardzija1496]

I am not obese but I do have issues with binge eating and never feeling full, so I can't imagine how amazing it must have felt to be satieted. I'm so glad you've reached a healthier weight and saved you eye and possibly life.

[@cat-.-]

Intercranial hypertension? so you have hypertension between your two skulls?

[@ItsDanny91]

I also have this condition. Im 200 pounds so im at the point where its causing headaches and ear ringing. My optic nerves used to be swollen which i was told leads to the blindness

[@TheHangryWoman]

Mila here! Thanks to everyone for your supportive comments and Vox for letting me share my experience. When I started Ozempic for diabetes management, few people talked about the effects, so I decided to document my progress. I'm so grateful that it has made diabetes management easier for me but disheartened that vanity weight loss has made it out of reach for patients who need it. Jimmy Kimmel even made a joke about it at the Oscars - that's what I meant by vanity weight loss and trivializing the medication. I hope this is a good solution for people living with diabetes and obesity, but even more so, that the long-term effects don't cause additional health challenges. That remains to be seen, and I'll be documenting it for as long as I need it (or can afford it or access it).

[@katiemoreno3013]

@@crazyprophet3276?? She literally has T1 diabetes??

[@FutureCommentary1]

Thanks for putting yourself out there so that people can have concrete examples. I struggle with weight myself. Very hard. Glad you are getting help both for diabetes and for weight management.

[@KunalM-ec3pm]

Wish you great health 🤗

[@drizztcat1]

I'm glad you told your story! As a fellow diabetic who has had success with Semaglutide, it's good to see the message getting out about the drug, even if it means occasional limited availability. I'm now on Mounjaro, and I've had even better luck with it, with fewer side effects.

[@Vox]

It was so great talking with you Mila, thank you for sharing your experience and perspective on this story with us! -Coleman

[@TammyJerkChicken]

I’ve been trying to lose weight after my dad ended up in the hospital due to diabetes, I had been hearing that ozempic from this is a quick fix to life long commitment but in the end the hype is causing a shortage for the people like my dad, who’s still here only thanks to his able to have access to these meds. I really hope that the supply issues improve but also doesn’t become out of reach due to expense too.

[@toasted_.coconut]

Their lives matter, too.

[@hjewkes]

The good news is that production has ramped up massively over the past 6 months, so I would expect the shortages to get a lot better soon (NovoNordisk is on record as saying late march)

[@laurenconrad1799]

I feel you so much. I’m in the exact same scenario. Ozempic is a lifelong commitment and not a quick fix. The side effects are no joke. But it truly can help people whose genetics make it harder to lose weight than a person born with a faster metabolism. ❤️

[@I_WANT_MY_SLAW]

They can make tons. They an unlimited supply. Its just the healthcare system is very corrupt.

[@zjsz4954]

A drug is a drug how you use it is irrelevant. The problem is the labels we attach to drugs being a “weight loss drug” or a “diabetes drug”

[@averycoolgal]

I've heard A LOT that challenges Ozempic as "safe". I'm a little wary of how we grazed over Mila's heart palpitations... I understand many drugs have side effects and for those living with diabetes, Ozempic really is a game changer BUT as we see it presented more and more as a weight management tool, I just worry about how positively it's framed in this video. I'm not gonna lie, this feels like an Ozempic promotion to me :(

[@basmalawessam2488]

Yes! I expected them to go a little over the heart palpitations part, which sounds super dangerous to me. I think people need to wait until Ozempic is properly examined to be deemed safe for people using it for weight loss specifically.

[@theuscivicsnerd7070]

The severity of heart palpitations and the frequency of them we'd need to look at. Heart palpitations from this doesn't surprise me but it's not a horrible side effect.

[@Dan-uh9sg]

Heart palpitations are a common side effect of many medications. They also tend to be caused by medications that cause dehydration. GLP-1 agonists typically have a diuretic effect AND reduce thirst (as a side effect of increasing the feeling of fullness). Properly hydrating and getting electrolytes is a good first step to try in that case. With these medications, it's important to be proactive about hydration and frequently sip liquids. She likely had a conversation about it with her healthcare provider and decided on steps to ensure that it does not become an issue before she started using Ozempic again.

[@jonathanodude6660]

keep in mind you take it once weekly. if its constant palpitations id be more worried. many people get worse symptoms from coffee.

[@MsCorpora]

I agree! Calling it a game changer in the title is way too encouraging!

[@ayarel01]

Vox, I’m disappointed that the abuse of this drug by Hollywood and influencers for a “quick-fix” to weight loss wasn’t emphasized as much as it should be. I have a family member that is dependent on it to stay healthy, yet shortages are making it difficult for them to obtain and afford it. And what about the long-term side effects for those just wanting to drop weight quickly? This video should have been a lot more cautionary.

[@monkeylordofdoom14]

I was thinking the exact same thing!!

[@justduro1527]

I dont think the drug has been around for long enough to see long term side effects

[@thundercaaat]

100% AGREE!

[@narnigrin]

@@justduro1527 The long-term/longer-term effects that have already been observed, afaik, are basically that if you use this drug to lose weight and then go off it when you've reached your target weight, you tend to very quickly gain all of the weight back. Which means that if this is a magic "get thin quick" drug, it's a get thin quick drug you'll have to keep taking for the rest of your life.

[@laurenconrad1799]

I think this was the best explanatory video about what’s going on inside the body that I’ve ever seen. They could always do a part 2 to address the Hollywood issue. It’s tough to tackle everything in 7 minutes.

[@OrianaZ5]

I was diagnosed type 2 on October '22 with an aic of 7.2 and I weighed 240 lbs. I was started on Mounjaro and lost twenty pounds over two months. Due to insurance not covering anymore I was switched over to ozempic and although the weight loss is slower my recent aic as of March 10 is now 5.6! I needed help with controlling my hunger and cravings and this definitely helped with that. Yes you still have to eat right and exercise to really see the benefits. As of today I'm 203 lbs (slow but steady). Ozempic and other drugs like it have made a huge difference.

[@shaanchaudhry5719]

If you don’t mind me asking what is your age and height? Did ozempic put your diabetes in remission or is it still something that is always there?

[@OrianaZ5]

​@@shaanchaudhry5719 Hey so for reference I was 38 years old when I started and 5'5". Now im 39 with my last aic of 5.3 and weigh 155lb. Doctor said diabetes is in remission. Hope that helps and good kuck!

[@liz2Alonso]

Are you no longer diabetic?

[@BigDaddyWeightLossJourneys]

I lost 75 pounds on ozempic in 12 weeks!! I love it and I am a big guy with a type 2 diabetic this has been a life-saving game changer!!!!!

[@joeytheestallion]

I know you commented this 7 months ago, but how are you doing now? How much did you lose, and how quick? I'm in the process of getting Ozempic for weight loss myself

[@Fleetstreetbestone]

@@joeytheestalliondo not get this evil drug

[@michellecrawbuck1198]

Did you have any side affects

[@moya_moyz5471]

@@joeytheestallion I wanna know too. I’m abt to start this after my sleeve got reverse

[@StopGodIs]

What strength did you take ??

[@8antipode9]

I have type 2 diabetes but I am far from obese, and my doctor put me on Ozempic for a while. It did a good job with what it's supposed to do, but I HAD to stop. I was felt nauseated CONSTANTLY and I finally decided that life on Ozempic wasn't worth it. Those side effects are just too much.

[@kontrop6339]

try intermittent fasting

[@SomeDudeQC]

​@@kontrop6339is that good for diabetes?

[@bria1660]

I stopped because my kidney functions were impacted ... also the side effects for me were horrible.

[@inuhundchien6041]

The nausea make you not eat thus get skinnier

[@starlett08]

Injecting it in your thigh instead of abdomen helps or eliminates the nausea.

[@somerandomfella]

In Australia diabetics are missing out on this medication due to the weight loss crowd creating shortages.

[@zXPeterz14]

Imagine being so lazy that you would rather take a diabetic’s medication instead of eat less and move more

[@stuartclifton4764]

@@zXPeterz14 this could be something useful to me, as I have an extreme sweating/overheating condition where even low levels of physical exercise can lead me to pass out :( struggled with it since I was around 13 and I'm now 26, not insanely overweight but this could help me massively!

[@noname-zp1yh]

​@@zXPeterz14 if it was that easy they would have already done it.

[@PhilfreezeCH]

@@zXPeterz14 did you watch the video? You still need to do that, semaglutide just makes it easier through things like supressing appetite and so on. It helps you to eat less.

[@Kamikazeesouled]

@@stuartclifton4764 then just eat less.

[@sarahm4669]

In Canada they're not allowed to advertise the specific use of medications or use jingles, so we get a lot of extremely vague "[drug name]: ask your doctor" commercials and I never knew what Ozempic was used for

[@jessicasadler3460]

Semaglutide has been a game changer for me, currently I am down 71 pounds and almost to my goal with 34 pounds to go! I have tried for years to loose weight but struggled. With being able to loose weight I have more energy to exercise.

[@JazzParrott]

Ik you commented this awhile ago, but how fast did you see results with the semaglutide?

[@royw-g3120]

In case people are wondering why the natural GLP-1 molecule has been changed, it is because in the body it has a very short half-life, to be used as a medication it would need to be in a permanently attached pump device, impractical and expensive. Hence longer acting forms were developed that resist DPP-IV the enzyme that breaks it down.

[@gilessteve]

I was. Thank you.

[@smalltv459]

@@gilesstevesame 😂

[@Jerguu]

I want to point out that this drug has been a game changer for several people I know in terms of weight loss. It's not just a few pounds - we're talking about 40-50 pounds on someone who used to be 200-210 pounds. It's a life changing amount that suddenly takes a lot of load off your body.

[@nicholsonfile]

Stimulants work that way as well.

[@windwhisprz]

Exactly and when people lose weight they feel better about themselves and then they are motivated to take care of themselves better and eat healthy because they finally see results. Losing 10 pounds can kick start someone into making other lifestyle changes for the better.

[@C1azed]

​@@windwhisprzstatistical 95% of peopl gain the weight back within a year of stoping the meds, drugs can't change bad habits

[@peter.gorski]

And they rebound when they stop using it.

[@Jerguu]

Maybe - maybe not. We don’t understand enough about obesity to know. It’s between the patient and their doctor. The more likely situation is they taper back down to a maintenance dose.

[@SilkCrown]

Weight loss is not a trivial or superficial desire, it is a medical need that can drastically improve people's lives and save lives. We should not be pitting T2D against obesity, we should be asking for additional production of this drug.

[@Tonixxy]

Only smart comment here

[@Divinia93]

@celery eating healthy has so many layers to it, what is deemed as healthy could possibly not be America has to unlearn and relearn so much

[@Tonixxy]

@celery7810 obesity is a disease

[@amberblaylock1973]

This! Also, addressing obesity could help to keep people from getting T2 Diabetes in the first place. Blows my mind that people don’t understand that.

[@Sara3346]

@celery7810 and obesity is a disease.

[@supersri2832]

Who are here after avacado nikokado transformation

[@Mmastrikes205]

🖐️

[@JUNiOR-fy2ni]

Me

[@dipeshmalla4157]

orlins life matters

[@bria1660]

I was prescribed Ozempic for diabetes 2. I loved it because I no longer had to take 3 pills a day. The side effects for me were horrible ..stomach pains, gas, diarrhea, constant burping, heartburn ..but I did lose 15 pounds in 2 months. My Doctor took me off medication because it also had negative impact on my kidney functions. The downside was as soon as I stopped using the medication, my food cravings came back and I gained all the weight back within 4 weeks.

[@allisonscanlan4144]

Most people who move to europe lose weight and it stays off

[@JR-90]

Maybe if you changed your eating habits, this wouldn’t have happened. It doesn’t matter if you take something like this and lose weight, if you’re gonna keep eating junk food afterwards.

[@bria1660]

@@JR-90 No, I try to eat healthy and only eat junk food occasionally. Whenever I would try to eat, I would frequently get nauseous. Foods I love did not taste or even smell the same. I found myself taking a few bites and then throwing away my food. Also, I found that I could not eat anything late at night. I could not drink alcohol or soft drinks or I would pay for it for about 4 hours with constant burping and gas. For me, Ozempic was not a pleasant experience and I do not miss it.

[@supergg07]

I have been taking Ozempic for a while I’m over the side effects and I have lost 50 pounds. I am at a standstill though with the weight loss but that’s OK for now. I have chronic kidney disease and it has never did anything to hurt my kidneys in fact with that, and my pill I take, my kidney functions have been going up

[@bria1660]

@@supergg07 Good to hear you are having positive experience. Continued good luck. I will say when I stopped taking Ozempic, my appetite came back with a vengeance along with the weight gain. Just curious but did your doctor say you will need to continue taking this medication to retain the weight loss?

[@dixxixio]

Back here because of Nick Avocado 😂

[@JacobCarlson]

Thank you for choosing to focus on how this drug is SOO lifechanging for those living with diabetes and obesity. That's really important and not enough are spreading that message.

[@felipeallegro9683]

I struggled with my weight most of my adult life and finally had an solution with the Gastric Bypass. It’s important to understand obesity has a physical and mental aspect, so being in therapy for almost 4 years as well. So many people change one addiction to another or worse don’t follow all medical protocols and end up sometimes in a worse shape.

[@livelongandprospermary8796]

I havent gained anything back since stopping wegovy (same med as ozempic, different dose). I went from 212-185. That was late 2021-early 2022. I have fluctuated a little, losing some and gaining a little back but ive been holding close to that 185 or so. I havent made any changes either, since i weighed my heaviest. Like im eating the same i did at 212 and its been almost a year off the meds. Weird that back then i was just climbing and climbing on the scale with the same exact diet that is allowing me to maintain a much lower weight. Idk 🤷‍♀️

[@FlabbyTabby]

IMO gastric bypass is a bad idea. Main reason people have trouble losing weight is because almost all of them don't know the real science behind it (hint: insulin is the key). Or because of medical conditions. It should be a last option. Surgery in general is risky.

[@FatNebraskaMom]

Straight up true. 100%

[@azca.]

Did you first trying eating in a calorie deficit or attempt to exercise at least 30 minutes a day? No one ever talks about working out and goes straight to weight loss meds

[@laurenconrad1799]

@@FlabbyTabby Sounds like the opinion of someone who isn’t a doctor.

[@salmay4266]

This sounds too good to be true, and when you take into consideration the long history of pharmaceutical companies' predation on the most vulnerable, the whole thing makes me very skeptical.

[@patriciacsapo]

This video sounds like an ad

[@rcs3681]

It definitely is considering all the side effects it comes with. Nausea, digestive issues.

[@CarSVernon]

yyyyep

[@yaeli_i_guess]

you're right. i worked in a pharmacy and the pharmacist told me exactly this- nothing good is ever without a 'catch'

[@sarachaya]

Yeah they forgot to mention that ozempic created thyroid tumours on rodents

[@sarwat.qamar96]

My mom uses Ozempic weekly for type 2 diabetes that she's had for almost 30 years now and we live in Pakistan, so it's great to hear this drug is FDA-approved, and to be able to just learn more about my mom's symptoms and how the drug works.....Thanks Vox!

[@stejannaone4141]

FDA has lost its credibility with the Opioid menace - both with Oxycontin and Fentanyl.

[@JR-90]

Question: how do you get this without prescription?

[@ranaka007]

@@JR-90 in a lot of South Asian countries, we can get most of the medicine off the counter, without a prescription ✌️😬

[@LunaLi-d1d]

You thought about get it from abroad ?Because of exchange rate,cheaper price.

[@unofficial1065]

I CANNOT be the only one here after niko avocado 😭

[@Yorithegrt]

im here for him toooo

[@alexandraalbertz1442]

I am at the 9 months mark now on compound semiglutide (Ozempic but not name brand) and I lost 44 pounds so far. From a BMI of 35 to a BMI of 28 so far. Still going strong ahead. I can move so much easier now and work out 4 days a week. I wish everybody the best in their journey to complete health

[@gilbertodemelo]

Here in Brazil quite often you meet upper class women who make use of Ozempic. Many doctors will prescribe it just for aesthetics, not for health reasons.

[@rafinha7081]

E eu achando que esse remédio não existia aqui.

[@JL_Lux]

Weight loss is health reasons 😊

[@gilbertodemelo]

@JL-xf2zh upper class people in Brazil are already a lot thinner than average

[@JR-90]

@@gilbertodemeloIs it easier to get your hands in this medication in Brazil?

[@vir_rm]

@@JL_Lux It strongly depends. For obese people, probably. For people with no complications, it's an unnecessarily risky choice.

[@officiallyawesome8585]

At least their commercial is catchy 😂

[@Johnsonsvideos]

I hate that people have to watch commercials. I would pay anything to never see another ad in my life

[@Utsav_Viradiya]

@@Johnsonsvideos "anything"? - Then pay one million dollars now!

[@benjaminreyes3624]

@@Johnsonsvideosyou can pay for an ad free option for KZbin

[@monsterinthedark6519]

My Dad uses this product for diabetes management and it has really helped him. After 2 interviews with the VA I will be taking my first dose next week. I look forward to the help it will give me.

[@poppingmolly8867]

I am glad for the positive effects it has for people with diabetes. For someone who struggles with PCOS, it sounds like these drugs could be helpful for that community as well

[@LillibitOfHere]

I've been struggling to lose weight my entire adult life. Even when I was counting out 1700 calories a day, full time breast feeding a baby, and cycling hard an hour a day on the road weight was still very slow to come off. The entire older generation of my family is diabetic, I'd be thrilled to take this before becoming diabetic as a preventative.

[@rubia12gilable]

That’s why I’m on it. I’m insulin resistant because of the PCOS. I haven’t necessarily lost a lot of weight but I am fuller quicker and my sugars have been better.

[@cherylferrer6916]

I just got diagnosed with pcos and insulin resistant as well. I hope my specialist may help me with what I’m going through. Thank you for this video

[@triceyb1363]

I have PCOS, and it has helped tremendously. I'm at least 30 lbs down in about 5 or 6 months.

[@sattineez]

I really wish for it 😢 as a person who has it+hashimoto it could be a great tool

[@kymberdusmythe930]

I have found that it also helps with cravings. I'm very glad it exists.

[@iwearleatherjackets1]

Let's be cautious. New miracle drugs come out all the time and then 10 years later, there's a class action lawsuit.

[@puppppppies]

Yup. I'm willing to bet 50 bucks that this is gonna be the next phen-fen

[@nilnil7325]

Thank you for having some sense! This drug doesn't have sufficient long-term data to show it is safe in the long run. The hype that is being created around it is due to marketing and people need to take a step back and look at this whole situation with a healthy dose of skepticism.

[@wolfsbane1991]

This drug has been used for YEARS for diabetes. It's not new, and it's not a miracle drug. It's literally been on the market for decades. Stop spreading misinformation.

[@holistichealthhacksinfo]

Why aren't more people realizing this. This comment should have 5,000 likes. Let's revisit this in 2 years and see how all these people are doing. I was borderline type 2 diabetic until I changed my lifestyle. Now there is no diabetes in sight. Wake up! These "quick fixes" will always have side effects and yo yo weight loss/gain is terrible for your health. Learn to get to the root of the problem!

[@WEPNewsEntertainment]

Actually this is not true

[@HachBoxe]

That's amazing to see innovations from side-effects.

[@aprilmason1616]

It is! It think thats why we can use one drug for a variety of diseases

[@laurenconrad1799]

I agree. ❤

[@icomment4692]

Listerine

[@SomeDudeQC]

​@@icomment4692glycerine

[@crazydee8]

Pcos women also are seeing great improvements with this medication however alberta blue cross wont pay for it because of the weight loss craze.

[@immortalkombat9289]

Ozepmic stock boutta go up

[@Maxtee77]

Video did a good job explaining the MOA. Just note that this requires a prescription from a doctor because of some contraindications associated with use. Not a panacea for good health, it will reduce your weight but you also have to improve lifestyle.

[@accidentalinfluencer]

I literally came here after Nikocado redemption arc video’s, cause idk what ozempic is, and a lot of comments say he’s using ozempic to lose weight that fast, here I am learning something new everyday 😲 P.S im not accusing him of for using ozempic or not, tbh i do not care at all, probably just slightly happy for Nikocado lose weight 😂

[@soulqueen3819]

I'm amazed it really does work, I been on it for a month and lost 12 pounds already

[@bluejay8836]

Love that we heard from a KZbinr and not an Endocrinologist 😑

[@johnd.7606]

I remember trying this, losing ten pounds because my doctor gave me a simple dose for a month, and then hearing my insurance refused to cover it. It's $1,100 a month without insurance.

[@itspossible2015]

I'd do it. Think of it as spending $300 for a gym membership over 3 months - except with a near guaranteed outcome within a month!

[@SolSister10596]

Ah. So it’s a choice between this or my rent. I’m going to choose my rent.

[@hicknopunk]

Metformin is really good to make you have nausea and generally not want to eat. Cheap too. Heck, talk to diabetics, many will throw the hated nausea pills at you.

[@tralalalalallala]

My father (67 yo, kidney and liver transplanted) is also diabetic, and one doctor made him take ozempic rather than regular insulin. He almost rejected the kidney because of that, vomiting every day, no strength at all, could not drink any liquids.

[@merrymachiavelli2041]

The larger-scale implications of this drug (and future superior drugs like it, which are currently in development) could be _massive_ . We are on track for a majority of the worlds population being overweight or obese. All the focus on individuals (either to shame them or celebrate/affirm them) distracts from the fact that this has massive public health implications, which we're dealing with on top of an aging population. The fact is, at a population level, recommending diet and exercise is not an effective strategy. Heath experts have been doing it for decades, and the public health problem is still getting worse. So we need to either radically reform the food industry or our lifestyles (which also won't realistically happen, at least to the extent it would have to), or try to come up with some other method of addressing the fact we aren't biologically wired to live the lifestyles we have. Honestly, this is the most hopeful I've been about actually addressing obesity at scale.

[@salioneradam]

​@Zaydan Alfariz even Europe doesn't have rules strict enough. We have problems with obesity too. Industry needs to change globally to stop selling calorie-dense addictive foods.

[@sizzurpr7608]

Exactly

[@tomashgrey2211]

Yeah, let's shift the responsibility for our health to a magical pills. Let's get hooked on em. Genius solution 👌

[@brickmack]

Most functioning adults don't have these problems. Its not as though everyone under 500 pounds is chaining themselves to a radiator to keep themselves from compulsively eating a whole donut shop, they just... don't have a desire to eat that much. Maybe the correct question, as for drug use, is "why does such a large chunk of the population have such miserable empty lives that eating themselves to death is their only coping mechanism?"

[@LafemmebearMusic]

@@tomashgrey2211 that’s not what was said here or in the video but I also hear the validity in your points hyperbolic nature. We definitely shouldn’t be putting our dates in the hands of pharma. AND there’s a real issue that isn’t being solved so this could be a step towards a solution but certainly not the whole solution by a long shot.

[@lauracrawford8723]

Ozempic really IS A GAME CHANGER. im serious for anyone who struggles with the food issues it actually changed my life, not only did i stop eating a ton of unhealthy food, it made me NOT EVEN WANT the food i desperately craved before, like big time. It’s a fantastic addition to a good diet/lifestyle, it may not be the right decision for everyone, i knew one person where it made them gain weight, but for me and everyone else i know who went on it, it really changed everything. I couldn’t recommend this more.

[@gregh988]

It really does make everything easier. Quick advice, inject into your thigh to minimize any nausea, and make sure to drink more water than you usually do.

[@chubi143]

DOES IT HURTS MORE?

[@ScytheNoire]

If almost all people who are obese are at risk of diabetes, then perhaps it would be good to prescribe drugs like Wegovy or Ozempic that can help as a preventative medicine to help obese people lose weight.

[@hicknopunk]

Metformin

[@madyalvarez428]

Even outside of just diabetes management and weight loss, ozempic and other similar injections (like Saxenda) are really great for PCOS since it’s functionally like being pre-diabetic!!! Saxenda was just approved by the FDA for use in patients with PCOS, and I have a feeling that Ozempic will be next.

[@samanthablevins8009]

Eating healthy does NOT prevent PCOS! Get educated before you comment to the world on stuff you don't know about

[@XhumpersX]

@@samanthablevins8009 You're not wrong there, but you're also incorrect for saying that PCOS is NOT caused by obesity. The two are strongly correlated, but there haven't been any studies that definitively show if PCOS causes obesity, or if obesity can cause or exacerbate the PCOS cyst growth in the first place. The latter would certainly explain the massive rise in PCOS alongside the similarly massive rise in obesity over the past 30 years.

[@samanthablevins8009]

@Afterglow Beats there are many women out there that have pcos and are otherwise healthy and are not obese. I do believe eating healthy helps with every aspect. I just don't want someone speaking out of what seems to be hatred for obese people.

[@hicknopunk]

As a T1D I am telling you not to play with drugs as dangerous as insulin. Just don't. There are better, more obscure meds to make you lose weight. Just limit yourself to 70 to 100g of carbs a day.

[@jujusmom1508]

I have lost 110lbs in 12 months and it has changed my life.

[@nyc1655]

Just got this today I’m 285lbs and diabetic

[@Djjdkfjfkfn]

Any side effects?

[@phillipteems6617]

Feeling better is a side effect of losing 110lb. Good for you!

[@loyaldogpublishingllc915]

Congrats!!!!🎉❤

[@chakalaka3960]

And now?

[@anaajibicho]

Tried this. Terrible Gastro symptoms that led to panic disorders. Gutted (pun intended) my immune system. Still dealing with side effects two months later. No free ride.

[@RebelleFlo]

So sorry to hear that. I hope you’re on the road to recovery ❤️‍🩹. Would you mind expanding on what happened to you? I’m thinking of taking it so would be grateful to hear about firsthand experiences. I wish you all the best 😘

[@hicknopunk]

Metformin is a great nausea pill

[@marsyplays3s248]

i need this for my insulin resisstance and i hope it helps with that and my weight

[@Isaisaisa2001]

An ad for a prescription medication with a catchy jingle is probably the most dystopian thing I've ever seen. It's the kind of thing you see on a Black Mirror episode.

[@charlienelson2002]

A friend is on it, and the results are phenomenal. It works.

[@etherealessence159]

Yes it does. People say so many negative things about it. I've had good results in many different ways.

[@aeonsolo]

I trust your channel and the production value is great. But this one feels off. There is a gap in balance of pro and con. A bit like advertisement. As someone unfamiliar with the subject I might not grasp the full picture here, but that's just the way I felt watching/listening.

[@canopus8012]

I'm obese and have bad knees and take Semaglutide shot #7 tomorrow, have so far lost 9% of my starting weight, no extra exercise and not dieting at all, i simply feel full all the time, nauseous 2 or 3 times per day everyday but it only last a half hour or so, loose bowel movements almost everyday, i can only afford the next pen as I'm paying full price, but that should be enough to see me to a 12% weight loss - thus will be no longer be technically obese.....Semaglutide is an amazing drug.

[@walterdaems57]

Give it 5 years and the ‘miracle drug’ will turn out to be a nightmare

[@ForestGirlTeresa]

The video doesn’t mention the more serious side effects of Ozempic, such as thyroid tumours, but the overview is good. I am a candidate for Bariatric surgery, and I am about to start my prescription of Ozempic. I will just be sure to monitor myself closely for side effects. I tried a trial round of Saxenda (liraglutide) but couldn’t afford to stay on it as insurance doesn’t cover it. Ozempic is a viable alternative and has the advantage of it being a weekly injection instead of a daily one.

[@lyndiskenny-howell1323]

good luck to you as you start your ozempic journey! i recommend having either a zofran prescription or gravol/dramamine on hand, as the nausea in the beginning can be very unpleasant. make sure you drink a lot of water, it reduces your appetite but you also don't really feel thirsty. it's super super important to drink water, (stay hydrated) so don't forget! This medicine has been a life changer for me. i hope you will get to enjoy the same experience as i and many others have had. take care!

[@vish452]

It's a repeating Patten , happened many times in history . This kind of drugs get popular very quickly with only temporary effects ,but cause unknow side effects which are mostly long term or permanent .

[@edkwon]

Will be interesting to see what kind of long term side effects manifest once this is widely used for application of weight loss

[@inuhundchien6041]

Yup, you can't stop this the same way you can't stop injecting insulin if you are diabetic, IF you don't change your lifestyle. So for diabetics this is good they just change from one medication to another. For others they are just adding more expenses. I do think it's still good for the initial weight loss but certainly at the same time going to therapy, go to cooking class or enroll in gym to become a 'skinny' person intrinsically.

[@edkwon]

@@user-kr6jg6qb7l I'm referring more to unexpected adverse side effects with prolonged use, not the expected effects from stopping use

[@princevalium25]

I was prescribed an antipsychotic a few years ago for severe depression and it made me gain 80 pounds and gave me prediabetes. I cant seem to lose any weight or improve my insulin resistance. Doc recommended Ozempic of Mounjaro but its nearly impossible to get it right now

[@jaguarrior]

Rybelsus is the pill form of ozempic and is a lot easier to get than the injectors. That's what I'm on for my diabetes because none of my pharmacies can get ozempic at all

[@letsgetiton99]

came from nikocado, seen ozempic comments, now im here

[@ILoveLenin]

Love ozempic. Where has it been all my life?!!❤

[@PirateOfTheNorth]

Ozempic was in the news in my country recently because of a shortage

[@FOJO27]

Which country? Just asking since it seems to be in short supply everywhere. (Was assuming you're in the US or Canada)

[@adwaitgoku27]

Where's the advertisement disclaimer?

[@jmemixx]

How long can you take it is there a limit?

[@curtisaitken7027]

I look at it this way. I was borderline diabetic. I went to my doctor and asked for it for weight loss. He gave it to me. I’m two shots in. First was 0.25, second last night was 0.50. I had no side effects week 1. I am feeling a little nauseous today. If this is day 1 week 2 and this is the worse it gets and I lose weight…hopefully my stomach shrinks and I make better habits…I’ll stop taking it when I reach 10 lbs less than my goal weight. I’ll stand on a scale every day and make adjustments accordingly. Also I am on a low carb diet. What can go wrong. I might as well give it a go.

[@lindseyhiccups]

Diabetics NEED that medicine!

[@SuperHero-dq4jc]

One should wonder why we have a weight problem in the first place. What is it in food, portions, sugars, etc. ?

[@EmilyJelassi]

When my endocrinologist prescribed ozempic to help me with my type 1 diabetes, I was told that there’s a shortage because non-diabetics are taking it for weight loss. While I’m glad that there’s finally something for that, I’m also furious that the medicine isn’t being prioritized for diabetics first! Anything that can help prevent diabetes burnout and at the same time help me lose weight is unbelievably helpful. The idea that this medication is being trivialized into being “just a weight loss drug” is infuriating!!!

[@scottanos9981]

The type 2 diabetics literally got their disease from obesity, the same disease the obese people are trying to treat with ozempic. Diabetics do not have the moral high ground on this.

[@jessijoweb]

I was thinking about this too, but if we can cure obesity in people before it becomes diabetes at all, it feels like a win.

[@kjkj4725]

A lot of obese people have pre-diabetes. You can’t blame them for trying to stop developing the actual diabetes.

[@royw-g3120]

Unless you are overweight Ozempic is not licensed for type 1 diabetes. Your doctor can prescribe it off- license but he should have made that really clear to you at the time.

[@PrettyLipsCo]

Hi, I am a 47yr old mom of 8 and currently pre-diabetic. I started keto over a month ago and started walking about 6days a week. So far I have successfully dropped from 222 to 208 since Oct 2023. Hearing all the news about ozempic makes me want to try for myself. Sounds so tempting but I'm afraid because I've heard you can't ever stop taking it once you start. Idk what to do.😢

[@ortizbryan27]

From what this is saying, would a high protein diet be the best diet for weight loss and diabetes management.

[@RebelLeaderSolari]

I tried this for my Type 2 diabetes and I was SO SICK on even the lowest dose. If you have IBS, pelvic floor dysfunction, lack of a gallbladder or any other gut struggles, please DO NOT take this if you can help it. They say the side effects go away after a few months, but they don't. This drug permanently worsened my other health conditions and despite my own research suggesting this was not the drug for me and lengthy conversations with my doctor, Ozempic was pushed and my concerns ignored, and I regret letting it happen.

[@jerrymartinez2528]

On my first week trial run 4 days in noticed getting full with less food ,side effects aren't to bad , my sugar levels have got way better 100-135 average I'm ready to continue this road

[@eazzymode]

Maybe healthy food shouldn't be so expensive in comparison to junk food in USA?

[@aturchomicz821]

Least Dystopian Capitalism knock on effect;

[@FOJO27]

In Canada too 😕

[@pramitpratimdas8198]

Because healthy food is socialism!

[@ElMANCHILD]

I understand I’m not a doctor, but as someone who has loved working out since I was 15, I’ve experienced all kinds of transformations-from looking like a ‘burnt marshmallow’ to being in fantastic shape, to looking more average, and even being ‘jacked and juicy.’ Now, at this stage of my life, my focus is more on maintaining an aesthetically pleasing physique, while also staying physically ready should the need arise. The point is, through all these phases, I’ve seen firsthand how the body adapts and changes with age, exercise, and diet. For people who are making significant lifestyle changes, especially later in life, a medication like Ozempic can be a great tool in that journey. It’s all about finding what works best for your body at different stages.

[@TwoTwoFourSix]

You know what else helps with secreting more GLP1, eating more protein.

[@brocky69]

Feels close enough to an advertisement, I wonder if the manufacturer was somehow generous with vox, not like a payment for services or anything like that, more like a donation?

[@MLouah-gp9ef]

I love when Vox puts on its faux scientist glasses and pretends to know anything about nutrition. 😅

[@dryvonne1999]

Great way of keeping people on medications for life, big pharma loves this.

[@healthyinformation]

yep

[@tylerpadgett70]

@vox: "Caution with the rivals the effects of metabolic bariatric surgery" minute 4:45. Expected short-term weight loss following bariatric surgery Operative procedure :: Excess weight loss (percent) Gastric bypass :: 60 to 85 Adjustable gastric band :: 45 to 55 Sleeve gastrectomy :: 55 to 80

[@lenamasverat]

Ozempic is expensive. It’s about $1000 a month out of pocket, only a few insurances cover it completely.

[@humancat2434]

Despite the few caveats at the end, it still felt like video was trying to sell me on a new weightloss drug

[@wombatofmassdestruction1044]

What happened to diet and exercise?

[@georgiawidgeon7710]

I found this very interesting. I am currently using Ozempic that my doctor put me on. It is doing what it's supposed to do for me.

[@joshh.3870]

Ya bro she’s not running 🧢

[@laustudie]

Nice i am buying me some, this makes weight loss so much easier :] Will probably use half the dose though. This makes life so much easier for everyone, really a miracle drug it seems.

[@danielgardonia5473]

Has an added benefit of reducing your overall alcohol consumption. Before Wegovy I abused alcohol and just 3 weeks in my use is a fraction of what it used to be.

[@tumblingrosesstudio]

❤

[@jaydehy]

My mom and her friend recently got on it. I was soooo skeptical… but It actually really works, her appetite has gone down and she’s lost weight (she works out three times a week, and does cardio every day, but hasn’t changed her diet even though her portion sizes decreased). She lost 10 pounds in a month

[@Ardante11]

I’ve got a roommate that’s got only a month’s worth. I told him he should start exercising to speed up the weight loss because Diabetics need those drugs more. He’s been trying to get more but I dont think it’s needed if he simply starts working out.

[@Megadextrious]

I got diagnosed with thyroid cancer in 2020 and subsequently got a thyroidectomy. My endocrinologist said it would now be nearly impossible for me to lose any weight, so he prescribed ozempic to help me get my bmi down. Super weird I keep seeing videos and news articles about it now…. I hope it works 🤞🏻 😅

[@jeffrowisdabest]

I've changed my diet drastically. I went from 300 to 282 and then couldn't lose the weight no matter what I did. I'm 6'3" and should be around 220. I just started Ozempic today.

[@pizzaparty-r1c]

It works. Worth every penny and benefits outweigh the side effects, if any.

[@yelrishorena8621]

Hi I any update

[@jeffrowisdabest]

@@yelrishorena8621 A little over a month in, I'm down about 15 pounds. Seem to have hit another wall, though. We'll see. I'm still happy with the progress.

[@younglalaofficial]

I way 154 and i feel like my stomach is to big. Should I use it?​and should i change the way I eat?@@jeffrowisdabest

[@JennAyBaybAyy]

Do they give this to people without diabetes? Thanks. ❤

[@BD-or5yh]

I blame big pharma for purposely keeping supplies low while knowing demand is so high. I get it’s economics 101 but it leads to patients prescribed being shamed.

[@anniej1580]

Thanks for the informative & positive video! I wish you the best! 🌻

[@windwhisprz]

I don't understand how she stopped taking it due to heart palpitations but then went back on it again. So what changed? Was it the dose or something else?

[@aprilmason1616]

Could be a combination of factors, really depends on the individual

[@nikribble]

I'm sure she has videos regarding this, but I wish they would have mentioned it in this video

[@theprinceofawesomeness]

my dad is Diabetic and he's been using Ozempic for years now. (note: i live in the EU)

[@LunaLi-d1d]

Have you considered importing it from abroad?

[@teresabenson3385]

4:32 Was the placebo also "paired with an adjusted diet and exercise?"

[@jackoneill1336]

There is no way this is healthy long term for non-diabetics

[@kiattim2100]

it isn't. It also isn't great for diabetic's people for long term either.

[@notapplicable1483]

Man, I really think this video misses an important point. While it can help you lose the weight, once you get off it the weight really wants to come back. It’s still mainly up to large life style changes to prevent the weight from coming back. I fear that more and more people are going to become dependent on this for keeping the weight off & won’t be able to get off with out weight gain. Of course this is great news for the drug manufacturers but poor for the normal person that uses it.

[@therealshard]

I truly hope it's long term safe because (speaking as a 100% non expert) my understanding is that the human body is a complex system and one small change can lead to a cascading of multiple effects. I hope the listed side effects are as far as they go! :)

[@headaqe1708]

I thought Canada and USA was the same as a kid cause we spoke the same language pretty much. But when I went to Texas for the first time as an adult recently…. The amount of ads for pharmacy and legal industry was INTENSE looool I never noticed how little is pushed in your face in Canada compared to the states. It’s still advertised here, just not like that 😂

[@Nju1]

I wish they creates some medicide that treats insuline resistance. Like something that made all the cells in our body more insuline sensitive.