Alzheimer's and the Brain

Vsauce is proud to announce our support for Alzheimer's Association’s #TheLongestDay now and throughout June during Alzheimer’s & Brain Awareness month. Visit www.alz.org/Vsauce to join us!
More good links:
www.alz.org/facts/
Alzheimer’s disease facts and figures [PDF]: www.alz.org/documents_custom/2...
Basics of Alzheimer’s disease. “What it is and what you can do” [PDF] www.alz.org/national/documents...
What is Dementia? www.alz.org/what-is-dementia.asp
Alzheimer’s disease:
www.alz.org/research/science/a...
www.nia.nih.gov/alzheimers/pu...
en.wikipedia.org/wiki/Alzheim...
compare causes of death: vizhub.healthdata.org/gbd-comp...
Solar system movement around galactic center: / 735788050316288004
brain facts: www.brainscape.com/blog/2012/...
cortex thickness: www.pnas.org/content/97/20/110...
more on cortex:
wilson.med.harvard.edu/nb204/M...
www.alzforum.org/news/research...
APP:
www.bioscience.org/2012/v17/a...
ghr.nlm.nih.gov/gene/APP#loca...
pdb101.rcsb.org/motm/79
VIDEOS: how proteins are formed from DNA
• From DNA to protein - 3D
• Video
Memory:
en.wikipedia.org/wiki/Long-te...
en.wikipedia.org/wiki/Neurona...
en.wikipedia.org/wiki/Memory
/ why_cant_i_list_every_...
Video of real human brain: • The Unfixed Brain
The Alzheimer's Project (HBO): www.nia.nih.gov/alzheimers/al...
I highly recommend this: www.imdb.com/title/tt2371383/
Down syndrome:
www.cdc.gov/ncbddd/birthdefect...
www.nia.nih.gov/alzheimers/pu...
Alzheimer's disease risk-factors: www.researchgate.net/publicat...
wiki images:
en.wikipedia.org/wiki/Electri...
en.wikipedia.org/wiki/Masterm...
en.wikipedia.org/wiki/Book#/m...
en.wikipedia.org/wiki/VHS#/me...
commons.wikimedia.org/wiki/Fi...
gullible

[@beactivebehappy9894]

"The human brain is the most complex structure ever in the universe." - Human Brain

[@Kaledrone]

*Insert Obama medaling Obama meme*

[@gabrielangelorvalmores8212]

Kaledrone /\ lmao

[@toocooltododrugspencil1691]

Lol

[@NickVanCash]

It's self proclaimed lol

[@thetruerekkermum3310]

"yes." - Human Brain

[@Denisoiu-ts4ck]

"Now im scared of my own brain" - My Brain

[@cicadarin7325]

XDDD

[@animationspace8550]

You are your brain. It is all that makes you you.

[@kakyoindonut3213]

@@animationspace8550 jokes on you, I watched vsauce tutorial video of what my body can do without brain

[@Elli_s5672]

our brains*

[@tryme3930]

I just laughed when i saw this. Then i was like did I laugh because my brain saw a brain joke or was it me?

[@0odalisca0]

The biggest mystery ever is Terminal lucidity, when an Alzheimer patient (with destroyed brain) suddenly turns back completely lucid, adequate, with full memory, like fully normal person, shortly before the death.

[@thechrononaut1]

@@thepwrtank18 Sure, you wouldn't want to see your loved ones, or hear your favorite song, read your favorite book. No, no. You'd want to make sure people know how to log into your Google account. Doubt it.

[@butter_nubbs63]

There is even a more rare version of that call paradoxical Lucidity in which it just happens randomly, some people breakdown over the stress of knowing whats happening to them and how they will just forget again

[@DontYouDareToCallMePolisz]

Memory isn't really fully remembered, it's about Stage 2-3 remember-ance

[@tolvajtamas8567]

Man with Alzheimer forgets he has Alzheimer, remembers everything. *task failed successfully*

[@weedboyjjofficial6350]

reminds me of end-of-life-rallying in those near death without alzheimer's. people who are right before death, who are previously in very poor condition, suddenly gain a bout of energy and begin to move around and talk to loved ones again. strange stuff.

[@noob19087]

My grandmother, who does not have Alzheimers, got sick and was temporarily sent to recover at a home for Alzheimers patients. It was honestly the grimmest place I've ever been, like actually from a horror movie. The people were like zombies, just sitting there quietly staring at the tv, like passengers on a plane. One lady started going "help... help..." while staring at me, and another one was walking back and forth the corridor (for my whole 1½ hour visit) singing about how she wants to die. Aside from the nurses chatting in their break room and my grandmother, those were the only words I heard on the whole visit.

[@josmamatotaldrama]

Alzheimer's is like seriously torturous, there should be assisted suicide hotlines for it or something, or maybe something you agree to like being an organ donor that says you'd like to be assisted in suicide if it happens

[@beast_boy6822]

@@josmamatotaldrama I would really like to write a will that if somehow I develop symptoms for alzheimers, I would like to have that assisted suicide option

[@featofclay2295]

@@josmamatotaldramaEuthanasia should be legal worldwide. No one chooses to come into this existence, therefore everyone should be at liberty to exit it whenever they wish, especially if they are severely impaired of body and or mind.

[@butanikuminecraft]

It should only be legal when someone has a terrible disease with no cure, otherwise it would be just outright suicide @@featofclay2295

[@maple494]

"Everytime someone dies, a library goes to ashes" -Someone I saw in the KZbin comments once.

[@sanatoriumnugget6598]

I dont get it

[@John_F_Kennedy79]

@@sanatoriumnugget6598 someone correct me if I’m wrong, but I believe the library is meant to represent the metaphysical manifestation of ourselves, our brain being the library itself, and the thoughts and memories being the books. Once we die, this entire library is just... gone. Disappears, it goes to ashes. Just like we do, we will all dissimilate and return to the earth, sublimating our physical entity to face whatever larger cosmic cognizance awaits us upon death.

[@sleepyangel3775]

@@John_F_Kennedy79 Very well said

[@johnscarce792]

@@John_F_Kennedy79 wow.

[@georgia8865]

I've heard that quote with different, more self explainitory phrasing: "A dying man is like a library on fire." But your way is more poetic, I think.

[@mememan9061]

All the newest comments can be divided into two categories 1.Everywhere At The End of Time reference 2.among us

[@crimsononaut_in_space]

Yeah basically sad album and a game that drove people insane

[@fairyeater]

both of you suck equally

[@mememan9061]

@@fairyeater ?

[@mememan9061]

@@crimsononaut_in_space lol more than a sad album

[@ViiiEmerald]

AMOGUS

[@ineedzemedic5810]

Listening to a brain explain the brain to our brains feels like inception

[@krabman2889]

When I saw the title I was like “one is a genius, the other’s insane”

[@artistadam50]

I was just thinking this lmao, the brain is giving itself so much credit

[@Zigby_]

I first watched this when it came out, I was in the 10th grade. 6 years later and I'm applying for a MSc, & then hopefully a PhD, in Neuroscience. Thank you Michael :)

[@Stratahoovius]

Go get it!

[@DrApocalyptus]

What's your area of research? :)

[@festerma5076]

gl bro :)

[@Zigby_]

@@DrApocalyptus Not sure yet, I'm applying first for a 1 to 2 yr MSc starting Sept 2024 before going for the PhD. Currently I am researching the neurophysiological significance of Lactate/Lactic acid as the capstone project to my undergrad but I have dozens of future ideas, some of the most intriguing to me include: - Examining the roles of exercise metabolites and myokines in relation to exercise induced neuroprotection - Examining changes in neurochemistry with substance abuse, and how substance abuse contributes to neurodegeneration - Study of Depression as a neurodegenerative disease - How Traumatic brain injuries in early childhood influence subsequent brain development and neuroplasticity, especially in comparison to TBIs which occur in adulthood - Studying Neurodivergences: Differences in brain structure & neurochemical profile, and the development of Alzheimer's disease in neurodivergent populations as opposed to within "normal" brains. - Studying the combined effects of habitual exercise and learning/puzzle solving tasks performed in sequence on the progression of a neurodegenerative disease or in reducing prevalence of neurodegenerative onset.

[@zerotwo7319]

Just figure out how neurons decide to make connections. Long connections. How do they decide to link up?

[@rsbullygta]

Alzheimers is my biggest fear. Such a scary thought to think you might forget everything you know now someday.

[@Liftedpeace61]

Smoke weed, it's been proven it stops it from developing.

[@raymcdonalds5209]

Proof?

[@AGoldSoldier]

+Liftedpeace61 your source? And what about the lung cancer that is "proven" it causes

[@joshuasnowden4491]

+A Gold Soldier are you a ducking idiot, that's what vaping it is for

[@r3d0c]

Quote: THC is protective, removes intraneuronal Aβ and completely eliminates the elevated eicosanoid production in induced MC65 cells. www.nature.com/articles/npjamd201612

[@bethkerr5658]

Alzheimer’s is terrifying and so sad. You lose the person before they even die.

[@this_is_based]

You’re at 100 likes now

[@pipemong]

GodlyMemeBoi 151 thanks mate

[@quintfl]

I can't imagine my parents not knowing who I am. It's probably the worst way to lose someone.

[@fruitypeebils]

with alzheimers you have to say goodbye twice. first you say goodbye to a friend, then you have to say goodbye to a stranger

[@bethkerr5658]

JOHN JOHN you will one day when you lose everything because of a disease.

[@fatcatfroggie]

1:38 "Among Us" -Michael Stevens

[@RoboPlaysYT]

A-

[@nen4965]

Thanks

[@mr.duckie._.]

oldest among us

[@Cordonguy]

it's like forgetting a memory you were thinking about, you remember thinking it was cool, and you refuse to forget to, but then when you try to think too hard, that cool Idea of your just fades..away.

[@Biipo-ct9os]

Then it gets to a point of forgetting forgetting

[@boxofbugs2292]

My great grandfather developed Alzheimers, and he recorded a video for himself to remember everyone. It was an hour long video of him 10 years before assuring himself that his family will take care of him till he dies. Sometimes, he would get very scared of us, but we'd give him the video and just smile. Rest in peace, Great granddad. You will live infinitely through our memories

[@expertcontributor8464]

That is a truly brilliant suggestion that I will, without doubt, employ with my Grandmother and Grandfather; the latter who is on memantine and doing reasonably well considering, but my Nan, who refuses to take it because of the initial side effects it causes, is fast deteriorating...like her mother before her. Eventually she won’t remember, which is where your advice comes into play, Thank you, and withouit question of course - I am so sorry fo your loss. Potentially, with a joint effort at least, we can support each other, and make this dreadful experience far lless terrible that iit already is for us.

[@jtarantula3390]

SpxceWaves that made me sad

[@Shadow77999]

Smart move by himself lol

[@nickkohlmann]

@Rodrigo Rearden We all do.

[@vinnybyrne09]

It would be cool if you shared that video.

[@imfogg9048]

I like how my brain is learning about it's self.

[@leoterss]

the power of the brain, and the horror of losing it to a disease

[@kiwikiwi2483]

My brain convinced me to watch an video about a disease related to a brain, video in which I'm learning about my brain.

[@jainamhandleisntavavailable]

Yes

[@shinyprisma6085]

Brain-ception

[@jainamhandleisntavavailable]

@@johnsonjack4611 you still have Alzheimers ,you commented this 2 times

[@tennisracket166]

1:38 Make it stop, MAKE IT STOP🔥🔥

[@manwhoismissingtwotoenails4811]

😨

[@Xihrzah]

i bet you laugh when you hear the "fart" word too, like any 8yo child!

[@fisherhq7778]

My great grandma recently passed due to Alzheimers. She was a beautiful caring woman and every moment I shared with her felt special, we lived only a block away from her and my great grandpa's house, we got to see them a lot due to this. But. Once my grandpa died, my great grandma's alzheimers got worse. I live in a new state now so when we got to see her after those years of being apart. (Last time I saw her was during my great grandpa's funeral. ) she looked so out of it. As if she was confused on how to even live... she looked so weak, so much more skinny then the last I saw her. She kept talking about my great grandpa and how she was thinking of him, I think she knew he was gone but it seemed as though she didnt... Turns out she forgot how to even drink water cause of her alzheimers, she didn't know she was dehydrated which made her have a stroke. After that... the children of my great grandma decided it was time for her. So she was put in one of those places where you're set peacefully to sleep and die. They make it so it's not painful, and so they go out without any more pain. I know my great grandma was gone but I knew it was her still even when she looked so gone. When we finally got to her funeral from our state and I got to see her resting peacefully I couldn't stop bawling my eyes out. I missed her, but I know this was the best for her. I know she's happy up with my grandpa but letting go has been so hard to face with someone you love dearly.

[@logman5evr]

Of course this is recommended to me after Everywhere At The End of Time

[@TheManInTheComments]

Lolol I just though it was epic and didn’t know what this stuff was

[@monomate]

@@TheManInTheComments You thought Alzheimer's was "epic"?

[@TheManInTheComments]

@@monomate yes

[@bogmires]

@@TheManInTheComments its a horrible experience i wouldnt even wish on my worst enemy.

[@TheManInTheComments]

@@bogmires i mean it depends on what my enemy would have done. and don't be trying to change MY personal opinion on it because you dont have the same one

[@rhettwilkerson1828]

When I was a little kid I thought Alzheimer’s was called Old timers

[@emilymiller5045]

Same. I thought the name was a pun

[@smorrow]

Eggcorn

[@stephanieaugustine3044]

i thought it was called all timers

[@cowafungus8104]

That's probably because old timers used to call it that, some still do

[@howiemandel85]

Same

[@andrediego6131]

"If the brain was simple enough that we could understand it, we would be too simple to understand it"

[@lulu4882]

my friend's mom just died from freakishly early onset alzheimers, in her early 50s i think. it sounds like one of the most horrifying and heartbreaking ways to die. it's sometimes genetic and matrilineal, so i'm really hoping my friend doesn't develop it, at least at such an early age. such a tragic loss. i lost my mom years ago as well but i still can't imagine what it was like, living with her in those last years as it got worse, knowing there's not really any effective treatments to slow it down much or reverse the effects. i suppose all we can do is raise awareness and support research with whatever means we have. everyone struggling with this awful disease and those who love them have my sympathy.

[@nbaclutchhoops1589]

It’s actually incredible how this guy sets up topics and transitions into them

[@MiamiVice.]

Content creators like Michael are an invaluable resource to us all. I wish these guys were on the news every night, mentioned in songs, making cameos on TV, etc, instead of the trashy mainstream entertainment stuff we're surrounded by.

[@theheffleyshow4686]

9:58 lmao A PP

[@theheffleyshow4686]

Sorry

[@nbaclutchhoops1589]

MrBlueD3V1L imo Luke is a great coach because all the players and the front office loves him and even when the kings season was basically over he had them playing their hearts out for meaningless games which turned into a hot streak and got them close to the playoffs and tied for 9 seed

[@WorldLie]

"This guy".....dude...its vsauce

[@Ryb0jo]

This disease is scary. Imagine forgetting everything in your life that defines you as a person. That just leaves you lifeless and dead.

[@haroldinho9930]

Its like someone sucked out your soul and leaves you like a lifeless husk,and then kills you

[@ziril3972]

Oh gee

[@NikoBaza]

It's not scary just for the person, for all people that surrounds them too

[@topnotch3232]

Ryb0jo dang, both lifeless AND dead?

[@litchtheshinigami8936]

a shell of a former person. it still moves and breathes but like a puppet on a string can't do anything for it'self

[@isaiahrosner3780]

Sometimes it feels like it’d be impossible to have dementia/Alzheimer’s. Certainly I’d notice if I couldn’t remember stuff, right? Then I remember my dreams, and how I almost never notice I’m dreaming. Scary stuff.

[@capecon]

A very scary thought for sure

[@RealValkor]

I am making a presentation about dementia and this is so helpful, I am glad I managed to stumble by this video again after so long haha.

[@maija_]

Good luck 🤞🍀

[@Frognade]

You graduated yet

[@kreeper803]

post-awareness stage 6 is without a description

[@restfulflames9855]

Everywhere at the end of time...

[@ahmed4363]

I saw this exact same comment two times. Which has the exact same reply

[@restfulflames9855]

@@ahmed4363 you've forgotten.

[@ariestheram5693]

P. t. a www a rn dp i on

[@leoterss]

@@restfulflames9855 shit you got your profile pic changed and everything. fuck. definitely hit hard on me too as my grandpa has it

[@chrisj197438]

I was in a Alzheimer’s unit of a nursing home performing maintenance and had to go into a patients room. On the Wall was a frame holding a picture of the man during WWII. He had many medals and a plaque inside stated that he was in the first wave of men to hit the beaches in Normandy. He survived all that hell lived his life. Alzheimer’s left this man an 80 pound shell of himself laying in a bed wearing a diaper and holding a teddy bear. I hope a cure is found because this is what awaits anyone with this disease.

[@morganwilson3020]

Chump Johnson my great grandfather was also among the very first wave of men to storm the beaches of normady and he also developed alzheimers before he passed

[@generichuman2044]

@@morganwilson3020 Alzheimers is terrible. My grandmother developed it towards the end of her life. One day I was visiting her and was sat in her living room. She turned to me and started screaming at me to leave. This is the same woman I had had visited almost every day for 14 years. Yet all of a sudden she didn't know who I was. It is incredibly scary

[@anhhuynhkimnguyen6793]

My grandfather fought in a war and he was paralyzed on his right side, later on he developed Alzheimer’s and he was stuck on a bed, being cared for by people he doesn’t remember. Now that’s scary.

[@madisonbrooks5793]

Pretty sure he deserves a teddy bear if he lived through wwii

[@madisonbrooks5793]

Teddy bears are nice dude

[@rufusgreenleaf2466]

An elderly guy goes to my gym, i see him like once a week or sometimes once a month and he always talks about a seizure he had which has made him have anxiety about being outside. He talks about it to me everytime he sees me and also says "I'm pushing on though, you've got to these days" in which i agree........I've known him for about 5 years yet he never remembers me 😔. I always just smile and make him feel comfortable.

[@Breadstockimage]

Imagine living a life of 80 years just for it to be like you haven't lived a single day in the end. Sounds terrifying as hell.

[@isko1032]

Alzheimer's disease is when you realize *It's* *just* *a* *burning* *memory.*

[@peewee139]

@@farted5842 damn, no need to be rude. just let ‘em be

[@invertedcarcal6871]

*sobs*

[@tess4518]

And it’s the scariest at *the end* when your *place in the world fades away*

[@concernedthanos6725]

*s t o p p l e a s e I d o n t n e e d t o r e m b e r t h a t*

[@masicbemester]

@@tess4518 *softly* Don't

[@MOBISHELEVEN]

WHAT 2 VIDEOS IN A MONTH, HOLY SHIT

[@MOBISHELEVEN]

or rather in a months time, but you see my point

[@DragonvalePost]

Ikr

[@samueleli2740]

i think its because national geographic fired him XD. JK

[@darkwolfx2037]

+Samuel Reyes wait he worked for them ?? but i didn't see him in that channel :(

[@Retterime]

He probably worked on both of them, switching between the two on working on the videos.

[@tylercraddock5537]

1:38 i know its been said a ton already

[@whynot9616]

My grandma passed in 2018 from Alzheimer’s. And she was 85, my mom is older, and she’s 66. Ever since my grandma passed that’s all that been in her mind is, weather or not she’ll get it. The past two years she asked me if I wanted to go to Spain then Greece. So I said yes, I want to know that if she gets diagnosed in like 20 years that, I can look back and not regret going to that trip, or regret that conversation. I spend time with her, not so that she has someone to talk to, but so I can feel better about know I enjoyed the most I could with my mom.

[@user-iq7mk3gb9w]

Breaking news : Man with Alzheimer's forgot he had Alzheimer's, remember everything. Edit : Oh crap I did not remember writing this comment.

[@matchalatte9612]

I used the stones to destroy the stones

[@helenbunnehmummeh5154]

If only that were true.

[@myusername3689]

@@helenbunnehmummeh5154 If only it was that easy

[@joseislanio8910]

So he ended up remember he had Alzheimer's as well, forgetting everything once again

[@satriadicky3732]

If someone who has alzheimer remember everything. Then death is near

[@perkisy4608]

"bro guys he said among us laugh" and "every where at the end of time" is the jist of all these comments.

[@litapita3500]

Among us is the gayest game

[@fatchins9126]

@@litapita3500 sus

[@cultist1368]

@@fatchins9126 amogus

[@cultist1368]

@@litapita3500 yeah played it like 3 years ago not that bad but now its just cancer atleasts its dying out i think

[@spacekid9680]

But remember... someday even this video will be Just a burning memory...

[@z794hfbw8I]

1:38 caught me off guard so much lmao

[@eamsh-0z201]

1:37 I can never hear it the same ever again...

[@bunnyventi]

AMONG US

[@spphicore]

What if you Wanted to go to heaven But god said: *post-awareness stage 6 is without description*

[@billrobertjoe]

t e ar tak r

[@nivdexbram]

Oh no

[@accursedbear3795]

Why did you have to remind me of that, that was one of the most depressing 6 hours of my life

[@FlovecadMe]

Oh no-

[@hisdudeness4537]

I will listen to that album while tripping on shrooms. I will confront death itself.

[@4ortKnox]

Ik I'm not the only one who would love to just sit and have a conversation with this dude for hours

[@4ortKnox]

👍

[@CrazehhTacozz]

same but he might make my brain explode

[@ryanthompson9156]

These videos make me feel smart because I can understand them.

[@phillynch4971]

he demands you wear a shirt though

[@Shmagalag]

I bet you have nothing interesting to say.

[@sonarcha1711]

1:37 GET OUT OF MY HEAD GET OUT OF MY HEAD GET OUT OF MY HEAD

[@vannhantran547]

My Grandpa got Alzheimer at the age of 75, he still lived quiet well until hit 89. I miss him alot. Idk if i can get Alzheimer one day but hoping me will beat it

[@unusuallyasian4070]

“The oldest among us” oh no.

[@pratheekbhat6595]

⛽📮

[@Lecotatuta]

@@pratheekbhat6595 kzbin.info/www/bejne/emXGe5l5orOcrbM

[@jamsya493]

🈷️

[@mandogandrobociguy1974]

🧧

[@peppers9968]

🟥🟥🟥 🟦🟦🟥 🟥 🟥🟥🟥 🟥 🟥 🟥

[@marcelaoo]

1:37 I CAN’T EVEN WATCH A GODDAMN VSAUCE VIDEO IN PEACE ANYMORE, PLEASE MAKE IT STOP

[@raimarafiq6853]

PLEASE JUST END THE PAIN GET THE FUCK OUT OF MY HEAD

[@wafflelink4806]

STOP IT! ITS CORRUPTING EVERYTHING

[@focalpoint._]

get out of my head get out of my head get out of my head get out of my head get out of my head get out of my head get out of my head get out of my head get out of my head get out of my head get out of my head get out of my head gET OUT OF MY HEAD GET OUT OF MY HEAD GET OUT OF MY HEAD GET OUT OF MY HEAD *_GET OUT OF MY HEAD GET OUT OF MY HEAD GET OUT OF MY HEAD GET OUT OF MY HEAD GET OUT OF MY HEAD!!!!!!!_*

[@shuichisaihara2043]

the oldest *amogus*

[@lewis9s]

ඞ

[@theplant4046]

My heart nearly fell off when I saw this clip 2:09 I thought my new phone screen broken or something 🤣

[@Aaron_Mullins]

My grandpa just got diagnosed with Alzheimer's and I found this very informative. He acts like a confused child a lot so I have been taking care of him and helping him go shopping and stuff. I dread the day that he forgets who I am or needs to be placed in a facility that can watch him 24/7.

[@justinh6651]

I would hate it if Michael got Alzheimers when he's older

[@standupyak]

Well he has his YT channel to look back on

[@landencarr5443]

that would be the literally most cruel irony in the world

[@landencarr5443]

@@standupyak hed probably forget his password before he could use his youtube channel to remember. and even then he only gets to remember the end product and not the process it took. he might end up humming along to the music as the voice that used to be his own distorts and stops making sense. sorry that hit a sad note for me lol

[@ADVxxxxx]

I feel like anyone would hate anyone getting Alzheimer’s

[@sivvinod3187]

@@landencarr5443 just stay logged on

[@yesman1231]

It's incredible that i have an organ in my body that wonders what itself tastes like.

[@Mustikkakeitto4]

U r ur brain

[@dreadthefeds]

+Misgu are you?

[@whatsinaname7289]

😂😂😂😂😂

[@nikie110]

Are you not?

[@_GatoradeMeBitch]

I know, my gallbladder thinks that all the time But i too have an actual organ, brain, which awknowledges that gallbladder infact is bitter.

[@pee_sauna]

To be completely honest, this video is what started my road to neurology! Thanks vsauce

[@JeffHoliday]

My mother is entering final stage Alzheimer's as we speak. I watched my grandfather waste away from it, now her. It's terrifying not only to see her lose herself every day, but to see the support structure for me and my father wash away as people don't know how to help and can't handle it. Please, if you know someone suffering? Don't run from their disease. Be their friend, even if they can't remember you being there. Those who maintain their care often feel so alone and helpless. Knowing they aren't alone is the greatest gift in the world you can give. Thanks for this video Vsauce.

[@tvstompitharder]

Thank you for your comment.

[@havefun2334]

Wow. Even if they lose the ability to remember who someone is, they will never forget who their son/daughter is deep down in their hearts and brain.

[@alexlam24]

Donate to research or try to find ways to help speed up research

[@thatguyonyoutube807]

I'm so sorry you have to go through this, I can't imagine how hard it must be.

[@chris1krr801]

my grandmother has alzhimers and 100% REFUSES to accept there's anything wrong with her and will not see a doctor as well as cancels any appointments we make for a doctor to come to the house to see her. she's even had relapses of when her ex husband use to beat her and says that it's my current grandfather that does it.

[@puroboludeo1]

*Wants to talk about the brain and Alzheimer's* *Begins talking about a clock and the movement of the milky way* Classic Vsauce

[@realbland]

"Can we get back to politics" * Proceeds to talk about physics *

[@Silver-jd6xi]

Well, gotta build a foundation before you do the house.

[@gamerro3610]

*gy*

[@yoshifan0312]

Ich bin schwarz Only Vsauce can so seamlessly transition between those topics.

[@element1192]

Kiwifruit Vsauce: No first I have to build a sculpture of Danny DeVito out of play-doh

[@depressiongaming3741]

4:44 cool my brain has depression to

[@Ellipsis115]

8:16 REALLY good example, thank you! I'm using this more in the past year

[@think_of_a_storyboard3635]

"Things associated with a reduced risk of Alzheimers disease include:" - Physical activity - A heart healthy diet - learning a second language later in life - Being social, frequently interacting with people - Protecting your head - And intellectual activities like - Crossword puzzles - Playing instruments - Reading - Board games - Education Well, I guess I'm fucked then.

[@creamer-1837]

Im with you

[@hoodieman25k]

aaaaaaaaaaaaaaaaaa pain

[@SideReverse]

You are educating yourself by watching Vsauce.

[@klm9440]

Among sus

[@jiminsmxgicshop]

samee

[@mariossoultates]

"Post-awareness stage 6 is without description"

[@lambsauce4273]

"Post-awarenes- uh what was it again?"

[@TheExperienceYT]

@@lambsauce4273 ______________________

[@nestoons4539]

Someone already made this comment

[@zedlz]

@@nestoons4539 they did i don't remember

[@danicarakic2270]

i like your pfp

[@AudiRSAvant]

Out of every disease that existed, I still think that this one is the most terrifying and grueling one ever

[@The_Loopr]

1:37 HE DID THE THING!!!

[@realkarfixer8208]

My grandfather died of Alzheimer's, His oldest son Died of Alzheimer's, My father, aged 80 is in the advanced stages of Alzheimer's. Just yesterday I received the letter from his Geriatric Dr. "[dad's name] does not have the mental capacity to manage his personal, financial, and medical care." I've watched him decline over the last 10 years, falling rapidly over the last year and a half. The worst is yet to come.

[@norukamo]

forgetting yourself is a terrible thing. stay strong.

[@cowboydoggo6168]

Now you need to continue the family legacy

[@stirby8089]

@@cowboydoggo6168 w h a t 😳

[@Minecraftdude28]

It's not an easy thing, but care for him to the best of your ability and cherish every little moment you have left.

[@leepicrandomaa]

@@cowboydoggo6168 in what way exactly ???

[@aydenfragoso2701]

Vsauce stop uploading KZbin red videos. We miss you

[@trevorrogers95]

Dude, there has not been a betrayal as great as Vsauce leaving us for youtube red since Anakin chopped off Mace Windu's hand and pledged himself to Darth Sidious.

[@Denden-kj3rn]

His yt Premium videos are really good but yeah it does suck that he doesn't upload on this channel

[@Jonathan-bu7iv]

Who the fuck actually has youtube red? I bet it's as barren as the sahara desert.

[@RandomNullpointer]

Problem with YT Red is that it's not available in many parts of the world. It sucks to feel like knowledge is only allowed for certain kinds of citizens.

[@mikumikuareka]

@@RandomNullpointer yep, true. I had to download Mind Field series from torrent even when I'm ready to pay for this content simply because I had no another option.

[@HunterVibez]

I loved this video. It's terrifying. My grandma had Alzheimers and her final days she forgot how to breathe

[@kawru_kun6846]

If you're watching this after 7 years or even later then you just witnessed Vsauce before drugs

[@rvymvn]

The next Vsauce video better be 2 hours long

[@sergeiivanovichmosin6409]

no please I can only cum so much

[@jemmaiemma4889]

Ur profile picture fits ur comment so well I'm dying😂😂

[@rvymvn]

Isn't it nice when we all work together

[@Youniversou1]

Elijah Elliott-Ebanks it wasnt

[@monteh4604]

Elijah Elliott-Ebanks have no life

[@zeapsin186]

When he said "among us" I wanted to drive a railroad spike through my skull Edit: this was an unintentional reference to Phineas Gage

[@syntheticvocalist-p472]

Same.

[@PunishedKrab]

sus

[@packosand3287]

One time i had a mental breakdown because of amogus i cried, laugh and all sorts of emotions after that i adapted to amogus

[@user-fs6cp4iv7s]

Phineas gage moment

[@frozenpeanutbutter7035]

That’s a bit Sussy of you

[@keekeekakakookoo]

this is very interesting, i especially love it when you add thought provoking words to make us really think deeper of our reality.

[@ferretyluv]

You might have to redo this video since the whole amyloid plaque hypothesis was based on falsified data.

[@JSL-ym6nv]

I agree he should redo this video with new info.

[@thedaddyfish4808]

Next could you explain the science of your uploading schedule ;)

[@nacho1461]

lmfao

[@travislc2013]

Jesus Christ, savage

[@WickedGaming005]

Damn rip vsauce

[@UrbanLetsPlay]

This comment should be nominated for a prize.

[@ramuk1127]

*prize

[@ashtonbutler2082]

When my grandfather got Alzheimer’s and dementia, whenever he looked in a mirror he talked to his reflection thinking it was his brother. I hope when I’m in my 70s and 80s there will be a cure.

[@sammytheusername6818]

the disease can also start in ur 90s and 100s

[@joeblow7008]

my grandmother thought that i was her brother. it was less painful to play along.

[@andreiluca8310]

I dont want that cause I wont just loose my mind but I also will become a pain for the others. They will remeber me in my current state who uses logic whenever I have to solve any problem and cry seeing me again who says stupid things and cant remeber his own name.

[@matteobarahona5095]

my grandfather calls my dad Alfredo. his name isn't alfredo

[@roadkill5727]

@@andreiluca8310 if I ever got diagnosed, I'd make a plan to commit suicide. I think that dying while still being me would be the least painful thing to do for both my loved ones and my own final moments. Alzheimer's is a terrifying and painful experience for all involved especially the victim so I would refuse to allow it to happen to me

[@mariomaniac581]

6:20 Probably stupid question coming up: If that car moves exactly as fast as you think, how would you control it? If the brain can't process it faster than that car moves, how do you make timed decisions like turning or slowing down?

[@basantatamang2249]

We also have subconscious reaction that take over while the brain is processing the information it partially takes over, it's kinda like instinct. But that car is only going in straight line on track bro if you drove that in a high way with heavy traffic at that speed or higher... RIP you can't react on time nor is it Realistic that you can stop or take sharp turns at such speed.

[@Reiskan_paskat_videot]

Well, your hand or foot doesn’t move more than 1-5km/h relative to your head, eyes or brain. If you were to be moving at 430km/h and there is a wall, you’d see it and be concious of it from many miles on a straight road, so you’d stop the car. It’s just the question of when dare you take the foot off the gas. And no, you can’t turn at that speed, you’d crash… badly. Then there is reaction time, if you were to drive at that speed and a wall spawned with in a 100m out of nowhere no warning, you’d crash even at 70mph, you’d hit the wall because of reaction time, you wouldn’t start to break until 1 second after the wall suddenly appeared and in one second there is a lot of distance at 70. Mind you, breaking takes tens of meters of distance. You wouldn’t survive those sudden moments in a Bugatti at 430 even a mile wouldn’t be enough to be a safe distance.

[@mariomaniac581]

@@basantatamang2249 Yeah that makes sense

[@chickenskink1]

I'm a freshman psychology major and it was very exciting to even recognize the very basics in this video! It still taught me a lot of new things. The dean of my faculty, Prof. Dr. Nikolai Axmacher, and his team are currently researching a possible link between differences in spatial navigation and later development of Alzheimer's and a certain gene that's known to increase the risk. Unfortunately I wasn't picked as a participant for the lab study due to my history of mental illness. I'm still excited to see the published results. Interestingly, the ethics committee decided that the scientists are not allowed to tell participants whether they possess an increased risk of developing Alzheimer's. Personally, I agree with their decision.

[@petuniasevan]

My mother started showing overt signs of Alzheimer's last year (2021). She stopped using her computer, started missing credit card payments, and was starting to have trouble navigating (she got lost going home from my house, a route she'd driven for 10 years). She was very intelligent, so was able to compensate for many deficits, hiding them by such tricks as evasiveness and changing the subject. But she was starting to repeat the same exact stories, questions, and commentaries to me every time I visited. I realized that she had no memory of what was discussed on a previous visit, so I got an appointment with her family doctor. He tested her cognitive functions and told me that she definitely was showing symptoms of Alzheimer's Disease. Well, I let her stay in her independent living apartment as long as I could, but when she was found one cold April evening (it was right at freezing) wandering the streets and sitting in the road confused, I had to act. I had her sent to the hospital for observation and more cognitive testing. She was definitely getting a lot worse and acted erratically. It took a month but I got her into a facility that cares for Alzheimer's patients, with secured doors so wandering residents don't get out. They are doing a good job monitoring her but I think that the disease has accelerated its progress in the last three months and her confusion has gotten to where she doesn't recognize me. She thinks I'm a co-worker from three decades ago. Anyhow, I suppose this is just venting as I'm the only one of her three children who is in location and ability to deal with this. I'm just thankful that I can talk to my aunt (her sister) by phone or text anytime I need to. Say "I love you" to your loved ones who might be developing Alzheimer's. Say it every day. They might not remember who you are, but they remember love.

[@themindboggler8055]

I feel so sorry for you. The fear that either of my parents will have Alzheimers at some point towards the end of their life causes me to feel so depressed. it's caused me to stop taking my family for granted and I've started to show a lot more care and am trying to be around and help them as much as possible. I've even tried to subtly pass this on to my friends but they dont seem to understand. I can't possibly imagine how you feel right now, all I hope is that you are able to spend as much time with your loved ones as you can. Take care.

[@wren_.]

@@themindboggler8055 if you are concerned, tell your family to get scanned as regularly as they can (if you have the money and resources). Alzheimer’s can be stopped if you catch it early enough, but the moment you start showing symptoms your mind is already mush.

[@fizzybossyt8675]

@@wren_. I'm not sure about Alzheimer's but doesn't scanning too often for a certain condition lead to higher chances of a false positive?

[@crunchy__boy]

I cant tell you what to do or how should you help your mother but i wish you and your mother the best luck and im sorry for you my grandmother had a tumor in her brain and she could not recognize me or my mother sadly she passed away i hope your mother will get better.

[@apenasapa]

Dear god, im so sorry for you, i know this is an random commenter talking to you but, please power through it man, i truly from my heart think that this shouldn't be happening not only to her, but you too, you and your mother are such troopers and my sincerest love and support for you and your mother won't change as long as i remember, hope you two are going well rn..as well as you can be at least... Hey, thanks for sticking by this message, i guess I'm kinda of an softie when the case is Alzheimer's , it is truly my worst fear.

[@Demonetization_Symbol]

Developing a neurodegenerative disease is my greatest fear.

[@lewisybf]

same here man

[@5erase]

I will always leave myself an out just in case, early stages of dementia and I am taking myself out on my own terms.

[@lewisybf]

@@5erase same I’m morbidly came to the decision that hanging myself or suicide in any form is 100% easier then forgetting existence slowly, id rather just get it over with at some point and I believe it’s justified at that point. There are plenty of people that have agreed upon this point and there are people who have acted upon these terms.

[@jimmio3727]

@@lewisybf You know the real problem? You won't know that you're forgetting your existence unless someone else tells you so. The human brain can say suicide is the answer, but the human brain also says must-survive; the latter wins when the brain is going.

[@Demonetization_Symbol]

@@lewisybf I didn't know people acted on plans for suicide in case of a neurodegenerative disease.

[@huntermushero9362]

Dementia is the scariest but most fascinating thing to witness. I’ve been working in nursing homes since I was 16 years old so I have seen it unfold in many different ways. I’ve seen so much tragedy but also I’ve seen some of the most beautiful aspects of humanity in this line of work.

[@Lousfw]

I would rather die before I get dementia, dementia is a terrible way to go.

[@NotAPolarBearXD]

"the oldest a m o n g u s"

[@someordinarydude8813]

Just came here after listening to Everywhere at the end of time.

[@CaJoel]

Same. That album really changed me

[@adyrebecca9001]

I'm watching this while listening to it right now haha

[@taritangeo4948]

That kind of art that leaves permanent footprint in you. Unless, of course, you develop Alzheimers yourself.

[@nickanthropocene6502]

After several attempts I managed to listen to an hour and 40 minutes of it before I was unable to listen to any more. I learned that real fear is ugly and highly discomforting, not edgy or romantic.

[@chocopie1165]

I finally finished it tonight. It’s without description

[@43615]

the brain also named itself.

[@pessimistkai5569]

well i can decide to name it shit

[@MAXIMUM646]

The brains gonna need you all to stop

[@alexp5569]

@@pessimistkai5569 naming your brain shit means naming yourself shit

[@Summer_Xia]

Unfortunately he can't understand himself well

[@elehtinhalil871]

hackingpro No one brain named all brains

[@40watt53]

Losing your memories is the single most terrifying thing to me. You'll live a full life full of people and events and places and by the end it's like you lived for no time at all.

[@austinwthompson45]

1:38 got me dead, I still have Amogus.

[@WeldonWen]

"Learning a second language later in life" Reason to learn Japanese: -Watch anime without subtitle- Protect myself from suffering Alzheimer's

[@calvindejong4566]

i had a feeling that SOMEone would comment this. bravo sir.

[@__julia___749]

I know 5 languages so I guess that might help?

[@__julia___749]

@Annie Leonhart oh no

[@__julia___749]

But not Japanese, mostly languages with Roman roots...

[@IvanTube0]

@@__julia___749 howd you learn japanese? i would like to learn since i only speak 2 languages

[@crazy_killa-818]

My grandmother has Alzheimer’s, she hit me today because she forgot who I was. Horrible thing Alzheimer’s is.

[@DrAdityaReddy]

:-(

[@nguyenhoanglong420]

@Aura Darkskipper no ARE WE OKAY :)

[@emmanandoca8591]

God I know. My grandma keeps calling me at night to let me know that there’s a strange man in bed next to her and she wants me to come get him to leave, not realizing it’s her husband she’s been married to for almost 70 years.

[@516sahithi2]

@@emmanandoca8591 God... That's terrifying

[@trentweems4374]

@@emmanandoca8591 That's horrible:( My grandmother had Alzheimers and she went from smiling and talking softly and sweetly to requiring at least 10 seconds to respond to anything you would say. She could no longer walk, barely could talk, and she could barely eat/drink; often resulting in being dehydrated. Her entire being became nothing more than a newborn child without emotion. A shell

[@RodPrimata]

1:37 HE SAID THE THING

[@DylanZeee]

Why did i know that he was going to say among us before i clicked the timestamp

[@unoriginalclips9923]

When imposter is sus

[@lucidmlem]

1:38 GET OUT OF MY HEAD

[@micklenier6152]

"1:38 1:38 1:38"

[@fjordfish3363]

my grandfather was an actual enthusiast for all the things you say would help to combat alzheimer's. he loved crossword puzzles, he had a diet specifically geared towards being good for the heart, and so on... unfortunately, he still got alzheimer's. :(

[@mariammontaser7843]

I'm so sorry for your grandpa :"( , but he still had a slow progression right?

[@wasifzakwan8722]

Shows you how you almost have no control over your fate.

[@ahmedshakil405]

Things are uncertain. Beyond controllable.

[@wasifzakwan8722]

@@ahmedshakil405 True.

[@MagnumLoadedTractor]

Did he had a accident or did something involving copper?

[@joebodynobody764]

I watched my grandfather sink into the abyss of Alzheimer's. To watch the strong man he was, eventually end up shriveled up in the fetal position when he died, saddens and scares me. I'm sad it happened to him, scared it could happen to my mother, scared it could happen to my sister's or myself. That disease takes everything from its victims. Life, memories, dignity.

[@kaiden2319]

Turd Ferguson III ok this is epic

[@Chinaball-fx7gi]

@@kaiden2319 how? i know this could be a joke but how?

[@Chinaball-fx7gi]

@Sahyun Silvermoon I guess that is true

[@fellowinternetuser2301]

@ZayD wtf?

[@mifhadi]

@@kaiden2319 liverpool fans of course

[@molamincharge]

Rewatching these videos, where in the past I was just entertained by them, but now, a nursing student, is facisnating. More pausing and consideration has proved that training your BRAIN WITH THINGS THAT ARE INTRESTING AND STUDYING THEM IS IMPORTANT

[@FlipeFlop]

1:38- AMONGUS (click 3 dots to learn why) so i needed a break from the existential dread about dementia , i keep seeing youtube videos about it, stuff like EATEOT (everywhere at the end of time) and i posted this to keep me okay.

[@honeybeeami2654]

If I ever get diagnosed, I’ll beg my family and friends to help me end my life before it gets severe. I’d rather die as myself than become trapped in my own body without my mind

[@dragonlordsaviour7005]

hope it doesn't get to that stage.

[@unknownguyindo4356]

That's if the other disease doesn't get you first. Sometimes old people died because a sickness like a heavy flu more often than Alzheimer.

[@justint.2858]

I'd do a 360 no scope off the Eifel Tower, if I'm gonna die it's gonna be pretty sick.

[@Vileplume87]

Same it will be easier on every one knowing that I died with my experiences

[@ovnimoss]

I completely agree

[@Gumby518]

Is it fair to call Vsauce the 21st century Bill Nye the science guy?

[@caedmonwalz6011]

It would be a crime if we didnt

[@300joker]

He's Michael from Vsauce. He is a brand of his own.

[@Gumby518]

The Joker I'm well aware. But all of the Vsauce channels together are unique yet the same; quirky and informative.

[@anyonesguess1569]

Definitely

[@tylershelton6048]

NO, Bill Nye is a farce, Michael is actually informative and subjective.

[@OPowl-wi3pv]

Micheal saying Among Us: 1:37

[@DanTheManm]

1:38 truly an among us moment

[@joshuav9005]

My grandparents grew up in England and moved to New Zealand in 1971 and now my grandad has Alzheimer’s, he has no clue what he did 5 minutes ago but can talk about their childhood in Liverpool effortlessly.

[@erikho6936]

Our brains are weird

[@Krektonix]

No way. I'm 14 I moved to NZ at 7, August 2012. We lived in Blackpool. What's your last name? Mine is Needham. My grandma has Alzheimer's

[@haroldinho9930]

My grandma has bad dementia,can’t remember my name,keeps asking the same question every 10 seconds and thinks her long dead husband(20 years)is still alive,she also thinks it’s 1984

[@Krektonix]

@@haroldinho9930 wow, that's the same with our grandma. She forgot how to eat and with me being across the world I have no idea what she's like. She has care and stuff, but idk if she's got tubes to eat or anything. Apparently she waves to herself in the mirror. When my mom went back to England 2 years ago she couldn't remember my mom. But she said "you love me, don't you?" I will never forget it.

[@ethan7252]

Krektonix My grandma died of that disease, apperently she forgot to wait for cars to cross the road and...

[@adrake1]

So I guess we didn't have to wait until 2017 for a new Vsauce video...nice

[@KK-fe8tu]

XD

[@pelliqw6633]

Can you plz help me reach 1M subs for no apparent reason actually I'll make longer vidz tnx

[@hennepun6992]

I was expecting that too

[@billybandabull5573]

lol

[@Speedswiper]

No.

[@mentalillness1574]

This is one of my fav vsauce videos

[@deynarenae127]

My step grandpa had dementia, and passed away this past January, I hated seeing him slowly lose memories, and small bits of his personality, the disease itself is very horrific..

[@justanotheridiot8108]

I feel like this video only shows in your recommendations after you watch Everywhere At The End of Time or when you haven’t finished it. Like that 6 and a half hour album is the key to unlock this video.

[@guysimreallyary1223]

Yes I agree

[@toxic_shr00m]

It's not a song, it's an album

[@justanotheridiot8108]

@@toxic_shr00m I realise that mistake now. I’ll go edit my comment. Thanks for pointing that out :)

[@toxic_shr00m]

@@justanotheridiot8108 No problem, thank you for understanding.

[@Guest-lq6vt]

Thats actually a super cool thought lol

[@monzerfaisal3673]

1:26 You know shit's about to get real when the Vsauce Music starts!

[@monzerfaisal3673]

#Vsauce #Science #Music

[@HerveyShmervy]

+monzer faisal you don't really have to put any hashtags in KZbin comments

[@hann3sses200]

#but #you #still #can

[@monzerfaisal3673]

Hann3s ses Ok i'm sorry

[@HerveyShmervy]

What have i done

[@thehalfgrain]

1:38

[@Dev1n0871]

I know my humor is dead when I laughed as he said “the oldest among us”

[@christinegrunert168]

So we are all just a floating tofuu of memories

[@WolfyRed]

111th like!

[@Jayden.productions]

ew no!that would mean our brains would be food!😝

[@thegreatestshenfan6484]

yep

[@sonodietrodithe4iltuoincub848]

@@Jayden.productions and this is why zombies likes brain

[@crotchet6439]

Yeah more or less

[@hezekiah8765]

Everybody gangsta till youre hella old and Its Just A Burning Memory starts quietly playing in the background

[@youraveragefloridaboy519]

We don't have many days

[@amayurubashaka3608]

Some of the songs keep playing in my head and I, ironically can't forget it. It always makes me anxious throughout the day.

[@lambsauce4273]

That would be an empty bliss beyond this world.

[@sbirkkk]

Bro don't make me remember

[@myalt3019]

Heartaches, heartaches My loving you meant only heartaches Your kiss was such a sacred thing to me I can't believe it's just a burning memory Heartaches, heartaches What does it matter how my heart breaks I should be happy with someone new But my heartaches for you Heartaches, heartaches My loving you meant only heartaches Your kiss was such a sacred thing to me I can't believe it's just a burning memory Heartaches, heartaches What does it matter how my heart breaks I should be happy with someone new ... Who are you?

[@Hatshadow-mu4mw]

This is actually a really wonderful and informative video. The explanation has been done really well. Thank you Vsauce.

[@raginginsanity3718]

My grand father who recently passed away showed signs of Alzheimer’s. He would freeze in the kitchen and claim he didn’t remember were the bathroom was and stuff. Though it never fully developed during his life it’s still a very intense situation. My aunt with Down syndrome has also been on a downhill. She sees people in her closet, and she has said there’s this girl in the basement like yelling up at her and being mean.

[@HebaruSan]

"Hey Vsauce, Michael here." Does Michael think our name is Vsauce?

[@Fedico7000]

I actually was wondering at the beginning of the video if he’s just gotten so used to saying that intro that he’s logically phrased it like that in his head.

[@GunnzzNRoses]

its like Hey, Vsauce Michael here. not hey vsauce, michael here.

[@cxrseofspadez]

Yeah, I thought the same too! I still don't know why ÓwÒ'

[@leomessi80012]

@@cxrseofspadez seeing someone use "owo" unironically damages my brain

[@HebaruSan]

@Haramguez Then shouldn't we be the ones uploading videos to this channel?