Weekly Research Updates for April 27, 2024

00:00 Introduction and the usual bad Dad Joke
00:32 Relationship of socioeconomic status, childhood asthma, and risk of ADHD in preschool children
04:13 Pelvic floor pain in male adults with and without ADHD
07:46 Female orgasmic disorder in female adults with ADHD
10:05 Paraphilic sexual fantasies in adults with ADHD
13:56 Transcranial pulse stimulation as a treatment for teens with ADHD - a pilot study (TPS uses ultra-high frequency sound pulses to stimulate the brain; but it can also involve magnetic or electric impulse stimulation as well)
Research Discussed in the Video
Associations between symptoms of attention-deficit hyperactivity disorder, socioeconomic status and asthma in children
M Omura, S Cortese, M Bailhache, MC Navarro… - npj Mental Health Research, 2024
www.nature.com/articles/s4418...
MP75-08 ATTENTION DEFICIT HYPERACTIVITY DISORDER IS ASSOCIATED WITH DEVELOPMENT OF PELVIC PAIN SYNDROMES IN ADULT MEN
TC Crisostomo-Wynne, S Holt, M Hehemann - The Journal of Urology, 2024
www.auajournals.org/doi/pdf/1...
The relationship between female orgasmic disorder, attention-deficit/hyperactivity disorder, and depression in Dominican women
R Alarcon-Rodriguez, R García-Álvarez… - The Journal of Sexual …, 2024
academic.oup.com/jsm/advance-...
Paraphilic fantasies and behavior in attention deficit/hyperactivity disorder and their association with hypersexuality
D Turner, P Gregório Hertz, L Biedermann, S Barra… - International Journal of …, 2024
www.nature.com/articles/s4144...
Efficacy and safety of transcranial pulse stimulation in young adolescents with attention-deficit/hyperactivity disorder: a pilot, randomized, double-blind, sham …
T Cheung, BK Yee, BK Chau, JYT Lam, TKH Fong… - Frontiers in Neurology
www.frontiersin.org/journals/...
Research Not Discussed in the Video
Attention-deficit/hyperactivity disorder and dopamine receptor D4 (DRD4) exon 3 variable number of tandem repeats (VNTR) 2-repeat allele
L Baum, CC Lee, R Ye, Y Zhong, SF Hung, CP Tang… - Annals of human genetics
A systematic review of the beneficial effects of prebiotics, probiotics, and synbiotics on ADHD
P Allahyari, SA Torki, BA Kavkani, Z Mahmoudi… - Neuropsychopharmacology …
Major clinical implications of adequate nutrition in children and adolescents with attention-deficit/hyperactivity disorder: a concise systematic review
MS Rocha, LL de Aquino, G de Oliveira Gonçalves… - International Journal of …, 2024
Plasma fatty acids and attention deficit hyperactivity disorder: a Mendelian randomization investigation
K Zhou, Q Zhang, Z Yuan, Y Yan, Q Zhao, J Wang - Frontiers in Psychiatry
… therapy versus physical exercise to prevent co-occurring depression in adolescents and young adults with attention-deficit/hyperactivity disorder: a multicentre, three …
JS Mayer, L Kohlhas, J Stermann, J Medda, GA Brandt… - European Archives of …, 2024
Motor proficiency of persons with attention deficit hyperactivity disorder or autism spectrum disorder diagnosed in adulthood
C Otterstedt, LMJ Strömsten, J Sandlund… - Disability and Rehabilitation, 2024
Sleep and internalizing problems in primary school children with attention-deficit hyperactivity disorder
HY Dong, CY Miao, Y Xue, Y Zhang, L Shan, FY Jia… - Pediatric Research, 2024
Comparison of Opioid Use Disorder Patients with and without Problematic Internet Use in Terms of Impulsivity and Attention Deficit Hyperactivity Disorder
NB Bal, BY Örnek - Revista brasileira de psiquiatria (Sao Paulo, Brazil …
Positive distance learning perception, personal resources, and loneliness among higher education students with ADHD and/or SLD
A Sharabi, O Shelach Inbar - Learning Disabilities Research & Practice, 2024
Detection and Classification of ADHD Using Deep Learning Based on EEG Signals
X Liu - Highlights in Science, Engineering and Technology, 2024
The Self Referent Effect in Attention Deficit Hyperactivity Disorder
Z Ahmed, S Cunningham, S Rhodes, A Gow… - British Journal of …, 2024
Alpha Event-Related Decreases During Encoding in Adults with ADHD-An Investigation of Sustained Attention and Working Memory Processes
R Freichel, N Zink, FY Chang, JD Vera, H Truong… - Behavioural Brain Research, 2024
The impact of transcranial direct current stimulation on attention bias modification in children with ADHD
V Nejati, R Estaji - Journal of Neural Transmission, 2024
0176 fMRI Neural Activation During Working Memory After 5-Nights of Sleep Restriction in Adolescents with ADHD Traits
V Dionisos, S Moyles, G Mason, T Christiansen… - Sleep, 2024
Language and reading in attention‐deficit/hyperactivity disorder and comorbid attention‐deficit/hyperactivity disorder+ developmental language disorder
KMA Parks, JO Cardy, MF Joanisse - JCPP Advances, 2024

[@publius9350]

"Sex!" - Russell Barkley, retired neuropsychological clinical professor with noted expertise in ADHD and an affinity for dad jokes.

[@thecavephilosopher4074]

These videos always cheer me up - educational not only on the papers but also on scientific literacy, plus dad jokes! What more could one want!

[@tracygelder]

I’m 53 and have just been diagnosed with severe ADHD. I’m here because you were recommended to me. You’ve no idea how much your information is helping, not just me, but also the people around me! Fascinating! Really interesting 👌 Thank you so, SO much 🙏😘 (I only wish I’d been diagnosed decades ago 😩 lol 😆) x

[@JimmieHammel]

I have ADHD, was diagnosed as an adult, but had all the symptoms from first grade, and i developed asthma as an adult. Asthma runs in my family, but my parents have a "psychological issues are all laziness" mindset, so the only one with any diagnosis is my father. He was diagnosed with seasonal affective disorder (which i also have) which he was diagnosed with while he was trying to quit smoking at age 45. Edit: but I do remember hearing when I was diagnosed with ADHD that both asthma and allergies were more common in people with ADHD. I also know that whenever I have to take a course of Prednisone for a bad bout of asthma, my ADHD symptoms decrease and my energy levels improve dramatically.

[@matreaus]

Dr Barkley, have thought about making a video about what were the most significant changes in your approach to ADHD based on new knowledge and research in the last 10 years? I've watched a lot of your videos from 10-15 years back (like CADDAC lecture), and they are brilliant, but I was wondering if there are some concepts that since then you changed your perspective on, because of new research and experience.

[@publius9350]

I agree this would be a great idea. I have often seen people comparing his ten year old video to someone they prefer in the current year and are upset about some matter overlooked. So many advances have occurred in a few years, which is actually the main issue in ADHD treatment and the main reason I enjoy his weekly research review.

[@pattyw9543]

😂 90 degrees

[@RudrashisPoddar]

Hello Dr Barkley , Could you please do a video on relevant studies and the research community's take on impaired working memory in the context of ADHD? I have always been cognizant of my incredibly limited working memory, but now as PhD student I feel it's effect more profoundly than ever before, having gotten diagnosed as an adult.For me, it's like no matter how much you know about something or prepare ,when it comes to showtime or explaining concepts , the words JUST escape you .This also happens consistently in social interactions a lot. I have been a huge beneficiary of your content.

[@UnePaquerette]

Hi ! About the first 2 studies, and what they made me think of (as a non scientist ADHD adult) : *1. [**0:32**-**4:12**] Asthma in children, social status & ADHD :* We have a bunch of old houses in France, and construction work/renovations are expensive. A lot of flats or houses are unlendable because they do not check the health obligations etc. Sadly, a lot of structures end up empty for these reasons. • Asbestos was used A LOT in construction during the 2nd half of the XXth century too, when it was more about building fast than healthy (especially from the 60s i'd say?). Big chunks of the country had to be Re-built post WW2 (destroyed or quarantined areas, and post-colonial remigrations, mostly). • If you are middle class, you'll likely be renting your place, and not have the money to move to a newer one (for big cities, that implies staying in social housing when you're eligible, thus in what usually is soviet-like building blocks). •If you own your land, you'd need a lot of money to renovate, and a (potential) new home to live in the meantime, which increases even higher what you'd own to the bank. Those are some correlations to increased risks of asthma in the global population already (+ pollution). Now if we add: • ADHD adults being most likely to struggle with their stable money (long term vision, spontaneity, unfinished projects, lower paying jobs, health issues...) • Genetics • Lower paying jobs in France's big cities being in suburbs, or poorer parts of towns and thus concentrated together (+ old polluting cars...) • The increasing loss of medical practitioners nationwide (including the government closing smaller hospitals, ER permanences...) • Trauma transmission ⇒ To summarize my view on that : Since ADHD children are more likely than non ADHD children to live and grow in poorer, more stressful and less healthy environments, of course they'd be likely to look like they have more asthma ? Especially since asthma can be a psychosomatic symptom of distress for children (as bellyaches, eczema or "restless behaviour" can be too). I'm no scientist though, and may very possibly be missing stuff, but it seems logical ? *2. [**4:13**-**7:45**] Pelvic floor pain in men with ADHD :* Could there be a link with hypermobility? I'm stopping the super long text here, have a good day everyone, and go drink water ! ❁

[@nyarparablepsis872]

I feel like the paper with the paraphilias + ADHD topic was missing out big on looking into backgrounds like trauma or, god beware, sexological topics (when did the paraphilia form, why, etc).

[@wonderwend1]

You can correlate owning a kettle with adhd for heaven's sake!

[@jsonbourne9799]

Remember that correlation does not imply causation, so even if there were a statistically significant correlation between ADHD symptoms and kettle ownership, it wouldn't be clear if ADHD causes increased desire for kettles, or if having a kettle might somehow increase the risk of developing ADHD 🤣

[@przemek193]

Hi Dr Barkley rly nice reaserch about low economic status and astma. Around year of 3 i get astma, my parent dont know why, noone in my family have it. Family Doctor say that around year of 2 i have couple of alergies who poorly treated thats why it convert in astma around year 3. Low economical status in my family give me and my sister a lot of stress. Parents have many argue, we have many PTSD from this and toxic parenting. My life was rly low standard, later in life i begin to have stronger adhd symptoms when i get a lot stress from work and i dont know whats is wrong with me, 2 years ago i go to psychiatrist and i get diagnosed with very high accuracy i begun to take medication and work on symptoms. Now im 31, diagnosed at 29. My life is better than any before, my whole family dont know i have adhd, i tell tham and they see only excuse. Its funny because after that 2 years, everyone see that my adhd was not excuse simply because i become a lot more focused, organized person etc. Your videos is game changer. Sorry for my english is not me national language. A lot love for you Dr Barkley and this chanel community ❤

[@obgfoster]

ADHD parents can create toxic environments for kids, and may live in areas with lots of pollution, which can cause asthma. Nobody in my family thinks any of us is odd because we all have ADHD!

[@drgillykahn]

That’s shocking with the SES study.. how do you conduct longitudinal research without controlling for time 1 or ADHD in the parents? 🤦🏻‍♀️

[@courtneyriley185]

Very cool 👍🏻

[@quenyasansel]

Huh. I have both asthma and an orgasmic disorder, and I come from a lower socioeconomic family. This was a particularly interesting week for me. Thank you Russell, for bringing these to us! I have been searching high and low for any studies relating to my specific sexual disorder, and I have found none. This video is a gift indeed!

[@nancysdsk]

Thank you you Dr. Barkley

[@andymellor9056]

As a European who measures temperatures in Celcius, I'm avoiding corners.

[@jsonbourne9799]

For our American friends, 90°C is 194°F! 🌡

[@ematise]

Thank you!

[@themobbit9061]

I wonder if they screened the women with orgasmic disorder for history of sexual trauma.

[@quintonrichards4805]

Dr. Barkley, do you have any comments regarding enlisting in the military when doing so requires 1 - 2 years off all ADHD medication? Additionally, do you have any insights that could benifit a soldier with ADHD during times of high stress and chaos, or in the quiet before the battle? Thank you for your life of constant contribution to the ADHD community. You are such a valuable resource and the world is better for your work and commitment.

[@james_subosits]

The adrenaline you would experience actually helps calm your brain down - people with ADHD typically do well in jobs like that actually. Remember that the majority of the military nowadays doesn't even step close to the front lines though.

[@BBWahoo]

I had asthma as a kid. That's so interesting, it went away when I got older, and my family seemed to involve our pet chihuahua in making it go away, but I'm not sure how true that would be. Thanks for the research! I appreciate you.

[@alanberkeley7282]

According to page 65 on Tom DeWeese's book Tell me I was wrong , Russell Barkley said "Once convinced of an ADHD diagnosis there is no compelling reason for that person to avoid Ritalin". If you did indeed say that, do you stick by it?

[@Millennial_Manc]

Dear Dr Barkley… is there anything pharmacologically to be done about drug tolerance to stimulants? I initially had an almost complete remission of symptoms but for less than 2wk. Memantine revived the effect for a week which is my only clue. Praximexole, bupropion, lisdexamphetamine and methylphenidate all had a short but profound benefit, and if I break for a couple of months, I get a couple of days on restarting. I suspect I’m beyond the scope of what 2024 treatment can do for ADHD… there’s not much written on overcoming treatment resistance that I’ve found.

[@jsonbourne9799]

I don't have a solution for you sorry, but FWIW, it could be worth trying the other things that help with symptoms, while the medication is working. I find it much easier to meditate while the medication is working for example.

[@Millennial_Manc]

@@jsonbourne9799 I’m getting very little benefit from it. It worked perfectly for over a week when I started it but very little effect since then. Something to do with calcium ions destroying receptors I think.

[@user-cm4je5iq9k]

Dr Russell , may I know your opinion about using Modafinil for ADHD ? I've heard that many psychiatrists are currently prescribing it off label and I'm very excited to know your opinion about it

[@Steuben1978]

Are there studies with guyausa tea for treatment of Adhd? Iam using it to self medicate and my work related concentration problems are mostly gone.

[@LukeSnywalker523]

I have ADHD and have had asthma since I was a kid, fascinating to see that there's a possible relationship

[@publius9350]

They have known about the relationship for a long time, this is just a recent study. The president of the ADHD coaches association, Tamara Rosier, had an issue at the National Academies workshop which I witnessed and was like, that's what we are going through, why are researchers blind?

[@Drnonstop]

Me hearing adding items (externalizations) to the act: hmm, quite interesting, brainy! science! Me hearing the corpses… animals… ITEMS!!!-part: gulp uhoh (I learned absolutely nothing about rushing to conclusions which was stated a lot.) (Also the last part I thought it was one of those kinectic head scalp massages aka scalp orgasm toys)

[@iliyanovslounge]

I have asthma so this is interesting… me and my dad love the dad joke by the way :)

[@publius9350]

It has been known for a long long time. There has just been low expectations for seeing the connections in the medical field.

[@MeinVideoStudio]

90 °C 💩 that is Sauna Level Hot

[@courtneyriley185]

😂 11:44 glad i dont have this part of ADHD . Id probably end it all.

[@courtneyriley185]

My crazy was wanting to do it in the public with my husband when we got married hahaha

[@saraacayan5291]

Dr. Russel, do you know any psychiatrist in Canada who is familiar with your ? Im on stimulants, and I feel like I need a dose adjustment/ change of med but i cant find anyone who takes me seriously. The last psychiatrist I spoke to told me if i really had adhd i wouldnt need a dose increase. Im not even at MRD for dexedrine and he thinks im abusing stimulants cause he knows i have a upcoming exam. I was diagnosed less than a year ago, and it was so liberating to know, all the challenges I have faced for the past 37 yrs were caused by adhd and not because im lazy or not smart but now im just being looked as stimulant abuser and its heart breaking. I dont have access to the doctor who did my initial assessment. ☹️

[@kidwolfman]

Everybody processes(metabolizes) these meds differently so, besides the fact that these doctors are treating you horribly, that sucks. You can get a DNA test and they will give you a list of medications and how you would most likely process those meds. For instance- I process adderall very fast because I produce more of a certain enzyme than others. So although adderall works, I have to take much more than the typical person who takes it every day. I hope that makes sense, best of luck.

[@Drnonstop]

Try reading on your governments website, try mail universities neurosci-department. Mail mail mail!! Mail everybody! I’m still looking for one in another country and you got to know what your rights are as a patient, as a citizen and as a dysfunctial being. I haven’t found a stimulant that works either, I have turned my life around to eat, sleep, exercise better. Slow but surely less panic attacks, more realizing that even If I can’t be helped, I will not be helped by others enough that my life will be optimal - I gotta do that myself. I’m sorry to hear the treatment and the harsh judgement from others, it happens too much. You could have a look at Barkleys stages of grief / denial with ADHD. Eye opening.

[@saraacayan5291]

Thank you. I will look into it. Some doctors spend so many years in med school and post graduate school and once they are qualified they are too tired to apply their learnings to their clinical practice!

[@russellbarkleyphd2023]

See if Umesh Jain, MD is still in practice in Toronto. Also check the caddra.ca website.

[@ematise]

😅90°

[@Patricia-vd9xh]

😂😂 90

[@daddyslittlehurl]

Thanks! Wish more people would do these research summaries geared to a non-academic crowd

[@wonderwend1]

... and explain just how ridiculous some of the research is.

[@daddyslittlehurl]

@@wonderwend1 oh yeah for sure. It's a great public service

[@truth-hurts3089]

Parental ADHD = smoking. Smoking = asthma

[@obgfoster]

Ciggies & coffee got me through college! Coincidentally, both my parents were smokers. ... and I have asthma.

[@jsonbourne9799]

Good point. Perhaps SES of the parents might be correlated with poorer air quality also.

[@drrodopszin]

At least our sex life is a bit more interesting!

[@Drnonstop]

I’m wondering about the subjects in the study by the way. If you’re having a healthy sex life, don’t make a big deal of it, maybe prude - would this be a less interesting study to enter? Could the subjects maybe exaggerate as some sort of coping mechanism? Are they maybe porn addicts that have no encounters but claim they do? Would past traumatic experiences in addition with therapist sessions affect the results? Stay safe out there, no means no and it’s a tango, not a breakdance.

[@toiletthinker8693]

No place to warm up in the Oval Office

[@ivana61681]

🤣🤣🤣

[@nowie4007]

😂😂😂