Chromosome and Kinetochore (2014) Drew Berry wehi.tv

[@fishflavoredicecream]

This is simply one of the best videos on KZbin. Educational, scary as fuck but funny as hell. The way they animated kinesin and dynein walking along the MT was cute and comical

[@did_i_ask_btchDO_i_look_i_care]

🙂even I used to get scared in childhood bt now I sleep with skeletons😂

[@FBWUniverseMode]

This is hard to believe, it's mind blowing that all of this is happening right now and in high speed and THAT ITS ACTUALLY HAPPENING!

[@RaviGarlapati]

And that it's happening in each and every tiny part of ourselves..... With no intention or involvement of ours

[@kijuubi]

@@RaviGarlapati wtong the frequencies determine it, which are we.

[@sea5205]

God is good

[@يزيدخرمي-ق2ل]

This is the creation of our great creator, he is Allah (God)

[@Ranjan_Mohanty]

@@يزيدخرمي-ق2ل your allah is a bitch who you fuck 5 times a day, now go back to fucking.

[@namthainam]

WOW! WOW! WOW! Thank you for making this in-depth knowledge accessible to someone without a biochem degree!

[@darkstatehk]

Because of your videos, my son took a keen interest in biology at high school. Thank you for posting such amazing educational works.

[@jagathperera5287]

Wow...animations and sound effects are amazing....

[@paulferry7791]

What's amazing isn't how quickly this seemingly takes place but rather at the perspective of molecular motion through the myriad of interactions time transport for us and how slowly. It's not moving fast so much as we are moving so much slower in comparison.

[@viperhc]

I also really enjoy these animations, so incredibly fascinating & amazing as to what happens in each of our trillions of cells.

[@blueblimp]

The first part reminds me of Neo waking up from the matrix in The Matrix. Great stuff.

[@thomasbeatty9496]

The best example of cell mitosis I have ever seen. Absolutely great for someone interested in Genetics. Thank you.

[@brianjones483]

Whenever I watch these videos I'm always amazed by the fact that, if you subscribe to a strictly mechanical view of the universe, this is what you get when hydrogen gas gravitationally collapses. The universe is a complexity engine. Life is a creative dissipation of the big bang's initial energy.

[@leejohnson262]

imagine watching this high

[@usualdosage7287]

It changed my life

[@mkultramarine1692]

equally as crazy

[@johngraham1407]

Freaked me out😵😂

[@JasonCunliffe]

Just watch it & you will get high !!

[@ZodiKeesh]

Me rn and I just 😳🤯

[@AuroraEAustralis]

I love the sound. I love how everything looks robotic Micro world in us

[@pilotavery]

Biology is just nano robotics...

[@kijuubi]

@@pilotavery how is it only robotic, i think it has a consciousenes. If u think u are just a machine, then u failed to understand your true being outside of this world.

[@pilotavery]

@@kijuubi each of these individual proteins are not conscious. They are molecular machines that have a very very precise output. Very consistent as well and the same Gene always encodes for the same protein which always has the same behavior. Someday we are going to figure out how to make a computer conscious, since we already understand how neurons interact with each other, however that doesn't mean that it's not a machine. Each individual piece is still predictable, the consciousness is emergent behavior

[@kijuubi]

@@pilotavery be quiet human i cannot stand your bs stuff anymore, beleieve what u want and shatter in your ignorance. you already live ina consciouse computer, to be precise ina a fractal consciouseness but imprisoned in your own fractal hence your replicatable and reverted processes, u wont find nothing out there.

[@pilotavery]

@@kijuubi do you understand how protein folding works? Google was able to solve this and it only is solvable because individual proteins behave as molecular machines. We've even synthesized custom proteins that behave exactly as designed. A computer is just a machine but it can perform complex calculations because of the emergency behavior happens when you stick them together in certain patterns. proteins by themselves are not conscious, just like individual brain cells are not conscious.

[@ksurovov]

2 cancer cells disliked this video

[@KaushikBoruah]

just to let you know the cancer is increasing one cell a year

[@oleksiilapenko4968]

we have a small tumor here, it's 12

[@chinnuliya]

It's 16 Now....

[@naimishkeswani7923]

Now 18

[@hackart8973]

20 canser

[@robertohvargas]

Les quedo bien chingon.! Si Watson y Crick presenciaran este video en su epoca, seguro se vienen y se cagan al mismo tiempo 😂. La precision al conservar las proporciones y dimensiones en la animacion 3D, es lo que le da el toque de presenciar algo que ningun humano habia visto antes, y que al mismo tiempo sucede miles de millones de veces cada segundo de nuestras vidas. Este video es un trabajo Magistral sin duda! Felicidades!

[@AB-if8pd]

This is totally awesome and unbelievable. I'm in a state of awe...😮😮😮😮

[@anamfatema7584]

Subhanallah what a creativity and complicated it is Allah subhana wa talla make it mashallah Best vedio and explained excellent awesome bro

[@Ranjan_Mohanty]

allah didn't do shit, now go and fuck allah.

[@NeuralAcademy]

AMAZING VISUALS!!!

[@thatnerdguy5541]

Thanks for this explanation!

[@inthefade]

I love these animations

[@cjhepburn7406]

Simulations...from what I understand.

[@gumnaampkgroup1057]

kzbin.info/www/bejne/fmjPpKmpmL1qqMk

[@Gelatinocyte2]

@@cjhepburn7406 It's only partially simulated, the rest is/has to be animated by the team - because they're trying to show the mechanism of something that, in reality, is naturally stochastic.

[@Novak2611]

Mind blowing !!!

[@ЄлизаветаХарькова]

That’s the scariest educational video I have ever seen

[@DaLokNessMonster]

Really helped my understanding thanks so much!!

[@Byggarebobo]

Cool video, but keep in mind that this is not how it really looks or works. For instance the force driving the separation of the chromosomes is generated by microtubule and mediated by a ring like structure that wraps around the microtubules, called the dam1 complex, this complex is attached to the huge kinetochore complex. Neither is really visualized here and there is much more structures and machinery that is yet unknown participating in this process.

[@quinxx12]

The ring complex is not the only force. The chromosomes are also pushed from both sides by Kinesine-motors.

[@Byggarebobo]

The ring complex is not generating the force, the force is generated by hydrolysis of gtp by beta tubulin and stored as structural strain in the microtubule lattice until microtubule begins to depolymerize. During depolymerization the proto filaments curve outwards which makes the ringstructures slide up along the microtubules. But yeah there are probably motor proteins involved as well

[@Thomaaasooo]

very interesting, but they did not "forget" Dam1 in this animation. Dam1 only exists in fungi and there are no Dam1 homologs in mammals...

[@williamwheatley1852]

I'm quite glad I saw your message as I was starting to think where the kinectochores had come from, if their waiting for the signal that everything is in the right place and tension is correct then where are they stationed beforehand. You give me reason to believe there's a place for that which may not have been built in this animation.

[@unnitamahato1579]

Structures are very detailed. Very good video.

[@alaaalsamany7520]

سبحان الله Amazing vidio and clear explaination

[@Ranjan_Mohanty]

Fuck allah!

[@huijieyuan4649]

I love your BGM, it's very interesting!!!

[@bikrammajhi7278]

Wahhh!!!!OOOh Amazing video. Thank you guys.

[@flygirlzaz]

This is an incredible video. Wow.

[@orsonkaart1853]

Incredible video's, easy to follow and great to watch !

[@alexacarenati]

mindblowing....

[@赵雪冰-i8z]

Life is so amazing!

[@larina4211]

is the part of the microtubule next to the kinetochore is the + or - extremity

[@dylanboye05]

amazing and trippy video

[@lorisperfetto6021]

I've seen molecules WALK

[@suraiyaaktermeghla1325]

Really Mindblowing😳😱😱

[@monuvermagymlife8347]

Very nice video sir

[@Majintel]

are the blue things in 3:37 also kinesins? and what is their role??

[@DaLokNessMonster]

This is so beautiful

[@PacificCircle1]

Good evidence for evolution. Millions of molecules in billions of cells in million of organisms equals many chances for error, i.e., mutations.

[@FairyRat]

It's really amazing what the law of large numbers is capable of given our universe.

[@PacificCircle1]

FairyRat Trillions of rolls of the dice will eventually result in many things. Given a nation of millions of people with inventive attitudes, they are likely to invent cars, computers and Moon shoot rockets.

[@crisjones7923]

I can't tell if you are serious or trolling...

[@Gelatinocyte2]

@@crisjones7923 wdym?

[@Hatsunemiku58077]

Omg this was so informative thank you

[@tanishqroyal2184]

Mind blowing concept and animation👌

[@simonewalter8020]

Great. Thanks a lot 🌷

[@gewargisgeorgios8186]

Fascinating stuff

[@sadiasarki2021]

Amazing 🌼

[@clinicalpharmacy3]

plz tell me : is the microtubule binds to the kinetochore it self or to the motor proteins ?

[@khadejaalom1954]

I think the microtubule first come to the kinetochores and then both of them work as a magnet

[@mariamzayed91]

OMG Awesome vedio!!!! Thank u very much!!!!💙💙💙

[@joshuamangerel4722]

cool video but what's with those weird sound effects lol

[@michael18276]

the sound effects are the best part.

[@wisdom9195]

Broooo, I'm high as fuck and this just blew my mind.

[@dannyali7305]

So what's the smallest thing in brain?

[@yeamsalvacion4324]

You

[@moonchild4u]

Best video

[@khadejaalom1954]

Well my question is does the kinetochore disattach themselves or the microtubule pull the kinetochore? And does the divided kinetochores have the same amount of molecules at each of them?

[@Curtainstag_e]

What is your major? And which year at college?

[@Gelatinocyte2]

For the first question: the microtubules pull the kinetichores apart. As for the second one: that's a bit of a silly question to ask; it's a bit complicated and oddly specific metric to try to measure/answer, that's like asking how many sleeping blind people are there in a skyscraper.

[@smitheesaha6678]

are chromosome found in every cell?

[@isuckharderthanlife5413]

Only cells that have a nucleus. Red blood cells for example have no nucleus, therefore no chromosomes.

[@Gelatinocyte2]

It's also important to note that prokaryotes also have chromosomes, just that most of them are circular and are unlike the chromosomes of eukaryotes.

[@Millmar]

Gorgeous 🧬❤❤❤

[@amritam4737]

Just Thank you 🙂🙂

[@XxBongZilaxX]

So there's something here?

[@immrainberry8658]

Very helpful, thank u

[@peacepeace8164]

Thanks

[@aayushphadte]

Satisfying video 💚🤤

[@genicadelara5243]

This is the best!

[@antagonizingusername]

athiests be like "yup, this just built itself in a pool of warm rocks"

[@GuardianSoulkeeper]

Nope.

[@Gelatinocyte2]

No atheist ever actually says or believes that. What a very dumb strawman. Nice try.

[@subhamkarmakar3320]

Next level 🔥🔥

[@avishaksingha671]

Really helpful thanks..

[@ലൊട്ട്ലൊടുക്ക്]

Superb ❤️❤️

[@brekhnakhan5183]

Very nice

[@Dunya202]

very helpful. thanks.

[@ayeshafazal391]

Fantabuluous

[@KkT-i3i]

Good

[@shahnawaz007]

Iam watching this video I just says OH MY GOD 🙄

[@jacobogle8784]

Amazing

[@Василий-т2ч8ь]

Все больше склоняюсь к тому,что Вселенная как и Человек- Бесконечны!

[@doodelay]

I think I've been dumbfounded

[@aaaaaaaaaaaaaaaaaaa790]

This is terrifying.

[@zahranouri7577]

very niccccceee

[@goosecouple]

Most of this is based on imagination. The electron microscope doesn't have such a strong resolving power.

[@Gelatinocyte2]

We use x-ray diffraction and NMR to capture the structures of these molecules, not electron microscopes. Electron microscopes only give us the rough/general shape or outline of large macromolecular complexes.

[@chrisvinu]

congratulation

[@sadiasarki2021]

Love it

[@bultaco2222]

omg brilliant

[@higginswallop5009]

Is this a prank or is it real?

[@alhaeri1]

great

[@monuvermagymlife8347]

Aur banaiye video

[@ranaaydn8989]

that was amazing!!!

[@junaid8707]

Allah has made cells so complex

[@browseforsports7275]

Subhan ALLAH

[@Ranjan_Mohanty]

allah needs a good fuck !

[@Hyumanity]

Fucking beautiful!!!

[@deadchannel4275]

3:40 walking chemicals

[@cjhepburn7406]

I don't know if they're figurative of literal representations. Imagine if that's their actual anatomy. Lol!

[@gumnaampkgroup1057]

kzbin.info/www/bejne/fmjPpKmpmL1qqMk

[@munazzasadaf7132]

The only 46!!!in one cell

[@afifayousaf2466]

2:01 diphallia?

[@charlizecramer117]

definitely could've gone without the sound affects.

[@gopikrishnamanaidu1130]

wow wow wow iiittt iiss aawweessoommee super i love but it was like boiling an omelete

[@Muhammad-Ateeb.S]

Insane

[@toheed_zafar381]

Never saw this tyoe of video

[@inserthere6387]

wow

[@sakubashiba3610]

can we please somehow create an O chromosome ?????? you take the O you split it you get o o then it gets larger to O O.... this X and Y is so inneficient....in theory a O chromosome dna sequeice can be build right? wth dude why is the body so dumb... making x and y when O is 1000% better no end cell death or cell aging.... jeeeeez and i thought the body is smart.... also can someone theoryse what would and O chromosome species be ????

[@Gelatinocyte2]

Circular chromosomes do exist but they're only found in most bacteria and archaea. Also, the X and Y chromosomes aren't literally referring to their shapes; all chromosomes are sausage shaped, but they come in pairs and are bonded together in the middle, hence the "X" shape.

[@afafmkimel4885]

سبحان الله ❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤

[@elmoudenabdelmouhsine9035]

لا اله الا الله العظيم سبحاااانه عما يشركون.

[@red8527]

What the fuck did I just watch???

[@mimizdani8194]

سبحان الله

[@betteru7676]

This vdo is hilarious...

[@kaanugurlu5251]

jesus fucking christ this is sp00ky

[@Yasmeentea]

+kaan uğurlu I know. It was fucking scary in a weird way.

[@rajadcruz1919]

kaan uğurlu mind ur language

[@wvhillbilly1909]

There's just no way this could happen by chance--it's far too complex. Only God could design something like this.

[@blurryimage4585]

Of course it couldn´t happen by chance. That´s why we use evolution to explain it, or God to avoid the explanation.

[@faithwhatevers4165]

"I don't understand something outside my knowledge base, THEREFORE GOD!" -every idiot ever

[@rowanvanderven6967]

+lenka z evolution is based on random variation = dumb luck

[@blurryimage4585]

Dutch Guitar If it was = it would be. But it´s not. It´s only you exposing ignorance again and again. Boring.

[@rowanvanderven6967]

random variation and natural selection can not explain the extreme complexity in the cell. Or the fact that we have heart, lungs, nervous system, muscles, organs etc. We have 100.000.000.000.000 cells in our body and we can't even explain 1.

[@larina4211]

is the part of the microtubule next to the kinetochore is the + or - extremity