What are light chains, how are light chains reported, and why?

[@elwaposv]

This answers exactly my question, my Lambda was abnormal now on treatment seems to be in range even a bit lower than range, my ratio has gone up, thats what i was worried about. Very useful and informative video. Thank you.

[@HTUMyeloma]

Glad you found it helpful!

[@marandabest8947]

My Lt Chains were normal and my ratio was high but this video was extremely helpful. Thank you!

[@Cactikeeperr]

Did they say why they thought that was?

[@arthurmabeejr8752]

This is an excellent explanation about "Light Chains", the only thing I'd like to see is an explanation on why doctors prolong diagnosing Multiply Myeloma when they know the short and, long term complications that arise. This includes organ failure, diabetes due to primary cause, bone pain, fractures ect., If a patient has symptoms of the disease and, impaired red blood cells and other labs that show or point to the disease. I see some PCP's have this information in thier hands refusing to send someone to a hemotologist because they think it's OK to prolong the diagnosis. I hate to say it but, I'm one of these patients: my hypercalcemia is still not under control, my red blood cells are impaired, I have constant bone pain- mostly in my spine, I have severe bone fragments missing in my spine, I'm under weight with kidney problems, my blood pressure goes up and down like a yo-yo, my Dexa-Scan show bone loss in these area and in my hips, I had to have half of my thyroid surgically removed. I'm 62 years old male with a severe deviation of my test levels, the doctors are giving me Alohendrate 70mg per week for bone loss. My endocrinologist says my PTH is normal, sometimes my T-3 is too low as he kept me on the same dosage of Synthroid 75mcg for over 3 years. Is there an answer for my problem? I'd like to get my health on track since I'm very active, I lift weights 3 times a week, and split my cardio 2 to 3 times a week? Help, please?

[@ElephantsRock19]

I'm not a doctor but a patient with some of the same issues. I highly suggest you go to a Myeloma specialist for a second opinion. Also, check out the Multiple Myeloma Research Foundation, create an account, and contact their helpline, they're a great organization to help and can point you in the right direction. The same goes for Health Tree Foundation, and International Myeloma Foundation. Best wishes to you!🙏

[@dom38732]

perfect explanation, ty!

[@betzib8021]

I have mgus w kappa lambda ratio rising. But m spike is lower. What does that mean?

[@EL-yi6df]

How to you feel? If I may, what were and are currently the numbers? Best wishes.

[@yogamon]

The reason the ratio is all over the place for when, for example kappa is 200 mg/L and lambda is 3 mg/L is from freelite’s defect of the gap effect causing wildly inaccurate results for the uninvolved light chain. Values below 6 for lambda and 3 for kappa should just be reported

[@EL-yi6df]

I got Kappa 105 and the ration 8.85. I'd appreciate if you could relate to these values and the freelite challenges. I mean, shall I repeat the test? Best wishes.

[@aboobackermk]

Hi.what it means 1 in 100 dilution value for serum free light chain lambda(greater than 165mg/l)

[@yogamon]

That is abnormally high lambda flc value

[@msocr3215]

Kappa light chains at time of MM diagnosis was 264. kappa/lambda ratio was 54.10.

[@EL-yi6df]

How do you feel? If I may, what was the treatment you were given? Best wishes.

[@chocolate82467]

Thank you for this. I have a question. My kappa is 12.81 mg/dL, lambda is 3.58 mg/dL & ratio is 3.58. Should I be concerned with these numbers?

[@HTUMyeloma]

Talk with your myeloma specialist for questions like these. They will be able to give you a more accurate answer.

[@unpopularopinionedpariah6102]

My kappa is 22.43 mg/L and Lamda 1.66 We're opposites? 😆😓

[@unpopularopinionedpariah6102]

My kappa is 22.43 mg/L and Lamda 1.66 its the weekend and i got to wait for doctor to call 😓 What's a lot of kappa? 100? im only 3 points over 😥

[@HTUMyeloma]

Hi! Please send us an email to [e-mail] and our team will help you!

[@unpopularopinionedpariah6102]

@@HTUMyeloma Cant you just tell me that these numbers dont necessarily mean plasma cell cancer :\ or cancer in general :\ Im only 39...still waiting on more blood tests... doctor sending blood tests to special places i think.. i figured since he hasnt contacted me yet... its not that bad or we still dont know... or im low on the priority list cuz its not that bad...

[@unpopularopinionedpariah6102]

@@HTUMyeloma is my kappa ratio 22.43/1.66? so im over 100?!

[@Littlerockjw]

​@@unpopularopinionedpariah6102how are you now?

[@michelleharvey272]

My kappa free light chain is 104.94 . My lambda free light chain is 12.31 . My ratio is 8.525. Can anyone advise me what it means please.thankyou in advance please

[@HTUMyeloma]

Hi, thanks for reaching out! Our team with medical background might be able to help with your question. They can help you understand lab results, genetics, and other questions you might have about multiple myeloma. As a friendly reminder, keep in mind that they cannot provide medical advice. Please send an email to [e-mail] with your questions and our team will be happy to help you. You can mention that we sent you from KZbin.

[@keertipatil4357]

After diagnosis of plasmacytoma still my kappa lambda ratio is 24.25

[@ankushpandey5127]

My kappa is 3000 and lambda is normal and ratio is 635.....???

[@HTUMyeloma]

Hi, thank you for reaching out! Could you please share an email address with me? Our team can send you an email with resources related. Thanks

[@Littlerockjw]

How are you now?

[@manjitsohi8609]

If kappa in your serum 20 and lambda normal and normal kappa and lambda ratio

[@ilonaspichka3216]

Please tell me what it is?

[@harisqureshi2144]

It is normal?

[@rathikadikshit9142]

Can kappa light chains and kappa/lambda ratio increase in chronic inflammatory conditions and/or infection ?

[@douglasanderson5516]

One of my results is noted as chronic inflammation. What does that mean? I have an unonown/undetermined sharp pain in my sides by my lower rib cage that causes me to shout out in pain especially when I try to get out of bed. CT scans, MRIs, PET scans reveal nothing. Could this be from this supposedly chronic inflammation.

[@rathikadikshit9142]

@@douglasanderson5516 Do you have elevated kappas and ratio ?

[@douglasanderson5516]

@@rathikadikshit9142 I had Alpha-1 Globulin increase that appears to be polyclonal, suggesting a chronic inflammatory response. That was the notation from my blood work.

[@yogamon]

@@douglasanderson5516 you mean elevated IgA?

[@douglasanderson5516]

@@yogamon no, I don't think so. I transcribed the note attached to the results. ALPHA-1 Globulin.