What is a biased agonist in Pharmacology and how does it work?

Biased agonism is an important concept in pharmacology that has implications for drug discovery and development. It has opened up new possibilities for designing drugs that can fine tune cellular responses to better match the desired therapeutic outcome. Biased agonists act at G-protein coupled receptors (GPCRs) to preferentially stimulate one of two possible signalling pathways: 1) G-protein dependent signalling or 2) beta-arrestin dependent signalling. Understanding how drugs interact with G-protein coupled receptors is important, because they represent the targets of around a quarter of all modern therapeutic drugs. This video explains what a biased agonist is, how it activates GPCRs and the consequences of receptor activation. Examples of agonists with bias for either the G-protein or beta-arrestin pathways are given and the consequences of the bias explained.

[@javadkeyhan6383]

Very informative yet in a plain way thanks alot ❤

[@professorGpharm]

My pleasure 😊

[@simi3275]

very important video, thank you!

[@professorGpharm]

Glad you think so!

[@Fabian-ci4cb]

Thank you that was wonderful! Subscribed :)

[@professorGpharm]

Thanks for the sub! Pleased you liked it.