What Is Triple Negative Breast Cancer ? with Dr Liz O'Riordan

What Is Triple Negative Breast Cancer ? with Dr Liz O'Riordan
Triple Negative Breast Cancer can be really scary. If you've just been diagnosed, you might have been frightened by some of the information you've found online. I'm Dr Liz O'Riordan, a breast surgeon with breast cancer, and in this video I'm going to gently explain what Triple Negative Breast Cancer is, how it's treated, and as a bonus at the end I'll talk about the new treatments for TNBC if it comes back in the future
Financial Disclosure www.sunshineuk.org/doctor/1179...
Website - liz.oriordan.co.uk/
Author ‘Under The Knife’ and ‘The Complete Guide to Breast Cancer’
Podcast Host - Don’t Ignore The Elephant
Instagram @oriordanliz
Twitter @Liz_ORiordan
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[@claireneilson2441]

I was diagnosed with tnbc in June 2020 , I’d just turned 50 . I had lumpectomy , followed by 4 rounds of chemo - docetaxel and cyclophosphamide…. Then a month of radiotherapy, including 4 boosters at the end of. Such a scary type of breast cancer . Thank you for such an interesting video , wishing you good health

[@user-ry9xr7os7z]

I am a recently retired male NP, and my wife is near retirement from her career as an OR RN. Our oldest daughter, an elementary school principal, developed triple -ve invasive ductal CA two years ago. She had surgery, chemo, and radiation therapy. She is back to work and doing well. As a NP I diagnosed several women with breast CA, as well as cervical disease. I continue to research literature about triple -ve disease, and are encouraged by health care colleagues who share their personal experience with breast CA. Your expertise and personal experience is so important to share with patients and families who are going through this process. I will follow your progress and look forward to learning more about this disease. You have my best regards and respect for your work. Take care and know that there are many who will benefit from your journey. Take good care of yourself.

[@kiminsley1728]

I have been diagnosed with triple negative breast cancer this week. I am so scared.

[@zaferaksit2009]

Thank you for so vividly explaning TNBC. One of the few times IHC paves the way to the right treatment options.

[@RocStone]

My mother was just diagnosed with Triple Negative and we're praying and trying to stay strong, thank you for the information.

[@auaticamazon]

Thank you. I had adenoid cystic carcinoma of breast with a local recurrance 20 years later which was excised from reconstructed breast. Triple neg. Diagnosed at 36 now in my 60s

[@akikou5550]

Thank you for taking the time to share these important information for us whoa are diagnosed with breast cancer. It’s a scary, overwhelming, and filled with emotions. Equipped with the necessary information makes it less scary.

[@wendaoosterbroek1162]

It's nearly three years since I was diagnosed with TNBC. My treatment plan was chemotherapy, lumpectomy, radiation therapy and carboplatin. My tumour turned out to be chemo resistant so my chemo was stopped and I was rushed in for a mastectomy. Thankfully it was localised. I continued with the rest of my treatment plan. I also had two reconstructive surgeries and need to have one more as the result was not satisfactory. I am a recently subscriber and so happy I came across your channel, your information is invaluable thank you.

[@DrLizORiordan]

Thank you for sharing this with us. I'm glad that you've found my videos useful x

[@judybee6698]

@DrLizORiordan how would one know if their cancer is resistant to the chemo? I wasn't diagnosed triple negative until after the cancer was removed. Why should I now receive chemo for something that may not exist, and may be chemo resistant.

[@ASH-T786]

If you don't mind me asking how did you know your tumour was chemo resistant Can we ask our oncologist to do scan while doing chemo sessions?

[@wendaoosterbroek1162]

@@ASH-T786 After my first round of chemo, I had an examination and a scan, my tumour had nearly doubled in size. Oncology decided to proceed with my 2nd course but it was still increasing. I could feel and see the changes it was happening so fast. Therefore I was told my tumour wasn't responding to chemo (chemo resistant). The 2nd course was stopped immediately and I had a mastectomy.

[@destro1989]

This is incredible content Dr Liz.

[@DrLizORiordan]

thanks

[@louiseniriain]

I had tnbc August 23 All chemos and surgury. Achieved PCR 20 rounds of radiotherapy. Taken off immunotherapy due to ill effects

[@saraquiney3887]

Thank you Dr. I was first diagnosed with Her2 positive, when through all the treatment, surgery, docitaxel, EC and then phesgo (herceptin injections). I thought I was ok and starting to live my life but then a few months later discovered a lump under my collar major bone, it was triple negative, PD1 negative, had lumpectomy, they could remove all the tumour as was near blood vessels. I had chemo, carboplatin and paclitaxel. On pet ct, it showed I was responding well, then another follow up, it showed I had progression. My world shattered there, my oncologist recommended trodelvy as my cancer was in chest wall, axilla. I didn’t want any more chemo so hubby and I decided on radiotherapy. Oncologist mentioned that radiotherapy will not get rid of the cancer. I didn’t care as I wanted to have a family holiday. I did radiotherapy. I had ct snd showed stable, had a pet ct after a month and it showed complete metabolic response. I was so shocked. Oncologist said it’s good news. You are NEAD. I now have a scan end of October, I am nervous but keeping positive. I am not sure if my fasting helped. Sorry for the long comments.

[@DrLizORiordan]

Thank you for sharing this with me. I'll keep my fingers crossed for you x

[@saraquiney3887]

Could you please explain to me NED and NEAD. Does this mean I still have cancer cells but they are dormant as I am NEAD. Thank you.

[@ASH-T786]

Good luck I am currently having chemo for her2 positive breast cancer 4/6 done Hate the side effects with passion 😢😢 icing on top picked covid from my last chemo session

[@saraquiney3887]

I know it’s not easy but you are nearly there. All the best.

[@ASH-T786]

​@@saraquiney3887❤

[@geraldinehorgan8994]

Sincere thanks …. Take good care of yourself as well 🙏😊

[@DrLizORiordan]

Thank you! You too!

[@karentzv3061]

Thank you! I learn so much from you and am becoming a better RN because of you.

[@DrLizORiordan]

You are so welcome!

[@138galaxia]

I have learned a lot about breast cancer thanks to your videos and my wife's oncologist. Now I can understand and help my wife more and also share the information with more women than I know Thank you. I always have you in my prayers. You are making the Difference in our lives!

[@DrLizORiordan]

Thank you so much for your lovely message. I'm glad I can help

[@ASH-T786]

Same here I learnt so much from you Dr Liz thank you Always praying for your good health

[@koleathaholman2861]

Thank you.

[@DrLizORiordan]

You're welcome!

[@barbaramcmahon1065]

Hello and thank you for your clear explanation! It's really helpful. If I may, I have the Ki67 of 90% and did not CPR after the chemo treatment. Got about 3mm lump of cancer cells left over in my left breast. From your experience, is there a big chance of having a metastasis soon enough? I'm 43. Thank you in advance. Warm greetings from Poland. Basia 😊

[@danielleharris8663]

Thank you Dr I would be really grateful for an in-depth video for Inflammatory Breast Cancer please. I am HER2 and Er positive I had Neo-adjuvant chemo Carboplatin and Docetaxel and Phesgo injections but only had a partial response. Had masectomy and radiotherapy and now I have just started Kadcyla as high risk of it coming back

[@DrLizORiordan]

I. I've done a short talking about IBC and I've got a video coming in the next couple of months.

[@user-hs6gt1qi9q]

Thank you so much your videos are very good! I hope you are feeling ok now ? I am TNBC had 14 months treatment 6 months chemo x2 surgeries and then 6 months oral chemo ( as the IV chemo only shrunk my breast tumour by a third) and during this time 12 months of IV Keytruda ( Penbro ), and 3 weeks of radiation !- my first surgery showed 2 dots had spread into my sentinel nodes so they re operated again and did an axillary clearance which was clear but of course that was the worst op to recover from - can you do a pod cast on that - the risk of Lymphodema, cording, aching arm due to nerves being cut ? I also only had a lumpectomy as BRCA gene negative but scared maybe I should have had a double mastectomy ? Guess I could still ?

[@alin9022]

Thanks a lot Dr. O Riordan. This was a detailed description of management of Tripple negative test cancer with BRCA 2 receptor positive 0please clarify: 1) is Neo Adjuvant chemo therapy before breast cancer surgery beneficial? And does it work by debunking the tumor and h hence making surgery easier? 2) Which chemotherapeutic agents are generally chosen for neoadjuvant chemotherapy in tripple receptor negative breast cancer. 3) In a patient with BRCA 2 receptor and tripple receptor negative would mastectomy be a better option than breast preserving lumpectomy? 4) in a patient with tripple negative and BRCA 2 positive - is bilateral prophylactic mastectomy an advisable approach to prevent a recurrence? .

[@noreenkhawaja4613]

BRCA1 positive here. Diagnosed at 40 with a 2.9cm tumour. Margins were clear. Negative nodes. Had PCR after lumpectomy followed by radiotherapy and double mastectomy with reconstruction. Did try Olaparib last year however my bloods were always down and it made me quite poorly. Is it worth trying Olaparib again a year later? Many thanks

[@Leslie-AnnHoult]

Thank you so much for this - I’ve completed my active treatment for TNBC a year ago & am now on zoledronic acid for 3 years. My question regards my daughter & 2 granddaughters as I’m 69 years old& therefore wasn’t given the Brach gene test. As I don’t fit the first 2 criteria for TNBC does this mean my daughter & granddaughters should be tested/monitored? My daughter is 42 & granddaughters 12 & 10. Many thanks

[@shinl1348]

Thank you for posting this. I haven’t through red devil and then taxol. There is still something there on the MRI and I have surgery this week. I am stage IB but my KI 67 score is 70-80%. I am reading that I still have a high chance of recurrence even if I experience pCR, is that true? I am scared, appreciate any information you can share.

[@hellenakamei3561]

Hello doc its good to learn more about tnbc from your vedeos. I was also diagnosed just recently from tnbc DCIS grade 2 and may i know more about ki67 labelling index as it was mention in my biopsy report it was high=87%

[@DrLizORiordan]

High Ki67 means that your cancer cells are growing more quickly and it's being used in some places to decide whether to give chemo

[@elizabethjones7698]

Thank you so much for your video. I have TNBC in my right breast and weak ER+ in my left 20% ER+. Dr advised I was being treated as if both were TNBC. I have been using ovestin cream, with my left being weak ER+? Is this ok? 6:01 PS writing this from my hospital bed following bilateral mastectomy yesterday and feeling great.

[@DrLizORiordan]

Great to hear you're feeling good after your surgery. I can't give personal medical advice about HRT I'm afraid

[@govindagovindaji4662]

1:43 More clarification needed here. Since Triple Neg 'also' doesn't have the Her2 receptor, how did Triple Neg 'get discovered at the same time Her 2 was~? Or do you mean that any 'left over' type cancer (one that does not even respond to Her 2 receptor drugs) is considered Triple Negative? I do understand the part about the receptors. I simply do not understand how 'it didn't exist' until the "trials were over". Do you mean, labs and doctors were simply unaware of it as a distinguishable cancer?

[@raheenarajab4487]

Hi Dr thank You for Your information I have been treated TNBC in India now I m undergoing immunotherapy only I m an Indian citizen now I to come to UK under dependant Visa tier am I eligible for Immunotherapy under NHS and is there availability of injection and can I get it on time ie 21 day cycle

[@sdha5865]

Hi Liz, thanks for your informative videos. Please can you do another one on triple positive breast Ca? X

[@DrLizORiordan]

i'll add it to my list

[@sdha5865]

@@DrLizORiordan Thank you so much❤️

[@stewartsantiago8939]

5 yrs ago my wife was diagnosed with er/pr positive breast CA. Now had recurrence to tnbc. How is that possible?

[@annaloph]

Make also a vid on ER+ PR+ Her2- case thanks be well truly Dr. Liz 🌎🩺💖🙏

[@DrLizORiordan]

Great suggestion!

[@annaloph]

@@DrLizORiordan 💖💖💖🌹🤗

[@QueenSpicyMama]

@@DrLizORiordan also ER- /PR + Her 2-

[@judybee6698]

So, I have been diagnosed with TNBC but did not receive the diagnosis until after lumpectomy and lymphnode surgery. Biopsy acquired 4 samples and at that time was reported as weak er+, pr-, her2-. After surgery it was reclassified as triple negative. So, I did not have neoadjuvant chemo. Tumor was 6mm, nodes negative, clear margins. If all cancer is gone and never traveled to lymph nodes, why do I need chemo?

[@mariavaldez1947]

Hi I have a similar situation as you and wonder the same thing. I’ve only done one round of chemo.

[@coolgirlsuchi]

Hello doctor, what is the use of achieving PCR after neoadjuvant chemo? And if we achieve will it reduce the reoccurrence for grade 2 and stage 2 tnbc

[@DrLizORiordan]

If you get a PCR then trials have shown your risk of getting a recurrence in the future is much smaller than someone who didn't get a PCR

[@elizabethgribben4320]

My beautiful niece was only 34 when she died of tnb

[@amara1954]

I was just diagnosed. Most terrifying word in the English language: malignant.

[@DrLizORiordan]

Sending you a hug x

[@ASH-T786]

🙏🙏 praying for you We know what you are going though 4 months ago I was diagnosed the emotions still feels like the day I was told I have it

[@coolgirlsuchi]

Can i know the differenent type of TNBC which are slow growing and in which way they are differnt Doctor

[@DrLizORiordan]

We can't tell that from looking at them under the microscope I'm afraid, There's no real way of knowing whether anyone's TNBC is fast or slow growing in the beginning

[@louisereinhart1149]

Very helpful. Yes, TNBC is very scary.

[@user-hs6gt1qi9q]

Is it safe to use ovestin cream vaginally after being treated for TNBC please ? My GP said it was safe but I want to be sure ?

[@DrLizORiordan]

Yes it is

[@Khensani_Mbekwa]

Was first diagnosed in 2019 at 25years old. Had chemo, lumpectomy,reduction and radiation on my right breast. Recently was diagnosed with the same on the left. The tumor is growing to quickly, currently having chemo and pembro(2 doses so far)...the tumor is growing still,skin is changing and tumor is soft around the skin...battling the thought of mastectomy before finishing chemo as I fear the lump will burst. What is your opinion on my next step?

[@DrLizORiordan]

Your oncologist may decide to halt chemo so you can have surgery and then go back on it again

[@fenlandwildlifeclips]

I'd be really grateful for an in-depth DCIS video, especially re high grade, extensive DCIS. How common is it? What happens if an invasive element is found? What are the risks? I have 140 mm micro calcifications with DCIS. It's in every milk duct. I have been trying to get some clarity on what might happen if an invasive element IS found. I've not come across anyone with anywhere near as much as me. I've been told the likelihood of an invasive element being found is low, but I think it's higher than I've been led to believe...I'm also starting to think my personal situation is uncommon. I'm 44 by the way.

[@DrLizORiordan]

Hi. I''ll add those questions to the things I cover when I do DCIS. The larger the area of DCIS, the more likely it is that there will be a small invasive element, as we know DCIS does become invasive breast cancer if it's not treated. But we cannot give personal odds of you having cancer with DCIS

[@fenlandwildlifeclips]

@DrLizORiordan I understand that, but the local clinic has been saying it's UNLIKELY I'll have an invasive section. They've also told me off for watching KZbin videos! However, I've had to fill in the gaps myself. They are reluctant to discuss hypothetical scenarios, but being autistic means I don't cope well with unknowns. Now that I know there is a very real possibility of ongoing treatment, I can mentally prepare myself. It's a case of hoping for the best but preparing for the worse. BTW all the best with your treatment.

[@leslieisaacs3080]

Diagnosed TNBC W/Ki67=60%, grade 3 but the imaging didn’t provide enough to know stage? Is this common?

[@DrLizORiordan]

Stage is a combination of nodal invovlement, tumour size and receptors so imaging alone can't tell you that

[@unlockyourwellbeing2448]

Thanks for your videos about breast cancer - very useful. I was diagnosed with TNBC this year. You don't mention in your video the Keynote 522 protocol which I believe should be used for TNBC - which fortunately for me includes Immunotherapy from the beginning of treatment, having been cleared by NICE late last year? I have completed the chemotherapy regime and because it (and immuno) were so effective only needed a lumpectomy and 3 lymph nodes removing, so avoided mastectomy or even double mastectomy. Hoping to get PCR when results come back. Radiotherapy to follow. Don't know my BRCA status as it seems the service is very behind - my appointment is late October, this all started in February!!! If there is something there it may require further surgery. From my readings there is also something called Capecitabine which many people are prescribed if there is any residual cancer cells? I'm not sure if your video needs to be updated to include these 2 things? (Keynote 522 and Cape) Many thanks for your calm and informative videos.

[@sheetalshetty7381]

How are you now?

[@anne-mariegawen8022]

@@sheetalshetty7381 All good thank you - clear of cancer. Just feel about 10 years older in terms of aches and pains

[@jaxpot07]

I've heard that, after TNBC, if you have two years "cancer free" it is recommended you take HRT....Liz, what is your take on this? Hope you are feeling ok in yourself whilst helping the rest of us xx

[@DrLizORiordan]

Breast cancer tends to come back in the first 2-3 years or 10-20 years later. Although TNBC doesn't have ER receptors so HRT should be safe, if it does come back it can mutate to develop ER receptors so there's a risk that HRT could stimulate mutated cancer cells to grow

[@user-hs6gt1qi9q]

I read in a “ Living with triple negative breast cancer” book that it said “avoid coffee as can increase reoccurrence risk only for TNBC but not hormone positive cancers” is this correct should I have decaffeinated coffee / teas ?

[@DrLizORiordan]

I’m not aware of any research proving that

[@sadaf4356]

I diagnosed triple negative breast cancer patients 3 m ago my chemo is complete I take medicine my question is you just tell me after chemo n medicine you tell me my survivel time my pet scan is clear

[@cassieoz1702]

Oh, I'm so sick of being an anomaly. My ER+/HER neg lobular cell carcinoma has devolved and is now triple negative (my skull metastasis was excised)

[@DrLizORiordan]

Oh I’m so so sorry.