What Most People Don’t Know About Bupropion/Wellbutrin and Anxiety

There is a common misconception in mental health treatment that Bupropion tends to worsen anxiety symptoms in patients with depression. This causes many doctors to avoid using the medication for the treatment of depression. However, no one ever bothers to ask where this concept comes from and what does the evidence really say about worsening anxiety when using bupropion. The topic of today’s video is bupropion and anxiety
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Disclaimer: This is not medical advice, and the information is provided for educational purposes only. Please consult your doctor for any specific medical questions. All content is created for informational purposes only. The Content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider. If you think you have a medical emergency, call your doctor, go to the emergency department, or call 911. We do not endorse any specific treatment, tests, or procedures. Reliance on this information is solely at your own risk.

[@Leodefrance59]

I have anxiety depression, a diagnosis of ADHD and i was a drug abuser and smoker and it helps me with all of that. I quit alcohol, drugs and vape in 2 or 3 month after the first bupropion pill. I'm so happy with it and i live normally now, go outside every day. Can study again because of focus and will search for a job soon. Lifesaver for me.

[@kimd8659]

I was given Wellbutrin in rehab (along with anti depressant, anti anxiety, and mood stabilizer) to help with my cravings to meth. I’m now 21 months sober and so grateful for this medication!

[@ST-fl5fy]

What was the anti anxiety lexapro?

[@jam9297]

Yikes man. And what happens when you get off of all that stuff? What is that stuff doing to your brain? I'd rather still be an alcoholic than on a cocktail of psych meds. At least alcohol I know I can taper myself off and be fine as long as I get to 60 days. Those psych meds might f you up for a long time

[@Unanythang]

Congratulations. Stay with it

[@Unanythang]

​@@jam9297sounds like the alcoholism talking buddy

[@ciggeslifts]

@@jam9297lol what kind of comment is this hahah, go drink yourself to sleep bud 😂😂😂😂😂😂

[@olganovikova1537]

Helped my Depersonalization/Derealization, paranoias and anxiety waaaaay more than lexapro.

[@RationalNon-conformist]

The brain can heal with good food.. also, getting a full thyroid panel done and making sure hormones are doing well.

[@kl0n0pin]

I take Wellbutrin for 2 and a half years and it it great for my anxiety, very mild depression and some ADHD symptoms (not diagnosed with adhd). For the last 6 months im taking it with 10mg Paxil just because i wanted to quit clonazepam which i was taking for 2 years (0.5/day). I found it to be very good for helping me to start do things without overthinking it, even if it is going to places and doing things that would cause me anxiety before. So, YES. MUCH less overthinking (anxiety symptom), social anxiety and it somehow helps me to be more autosugestible. For example, if i find myself overthinking, I just have more "power" to dismiss it by telling to myself that it doesnt matter and continue with LIFE!

[@sevginvatansever2920]

Did it boost your libido?

[@kl0n0pin]

@@sevginvatansever2920 I have always had pretty high libido (i'm 30 now). Didn't notice any difference when introducing wellbutrin and even paxil. Only thing related to sexual part that i noticed is slightly longer and stronger orgasms if I have sex during first 5-6 hours after taking my daily wellbutrin 150 xr dose at around 10AM.

[@MissDoreen]

Thank you for your vulnerability about your anxiety. I have been prescribed buspirone for severe anxiety. I took it and it made my anxiety symptoms worse. I had to immediately stop I’m also on clonazepam for severe anxiety. I have been down the whole antidepressant, antianxiety antidepressive medication road you name it I’ve been on it. In my experience . I have found that if you have to add another antidepressant medication to the one you’re on. It’s telling me that the original prescribed antidepressant is not working. Plus over many years, you can start to develop ticks and un voluntary movement and body motions. I’m going to stick with my clonazepam taken once daily It works well for my anxiety. I also know that it is highly addictive, which is why I don’t over use, or smash up and snort it! 😊 I wish you well, and I am happy that the BuSpar buspirone is working for you. BTW, BuSpar was discontinued 10 years ago. Which is why it’s called abuse from now… 🤔 sending you lots of love, prayers and positive thoughts! And so it is🙏🏽💜

[@kl0n0pin]

@@MissDoreen I was never taking Buspar (buspirone) as it is not available in the EU. Maybe you confused it with buPROPion (Wellbutrin)...which im taking now. Since november im taking 300mg XR but without Paxil. I quit Paxil cold turkey(with my doctors permission )when i was upping wellbutrin from 150 to 300 with zero "withdrawal" symptoms. Other than Wellbutrin, the only medication i take is diazepam 5mg as needed (usualy not more than 2-3 times per month when i have presentations in front of the class on uni.

[@mstenson4]

Sounds like what I need!

[@zanescents3986]

Thank you for this video! I’ve been prescribed but haven’t started it yet. This gave me a lot of reassurance!

[@Michelle-bl8sz]

As a CNP these videos are so helpful. Thank you!

[@aminatakamara8262]

Thank you doc! This is very informative

[@EX0DlSS]

I take buspirone for anxiety and Wellbutrin for depression. I’m sure the combination doesn’t help everyone but for me it works and I’m thankful for the regularity that these medications bring.

[@ShrinksInSneakers]

It's always good to hear real life examples of people having success with treatment. I appreciate you sharing, if you haven't subscribed to the channel please do and spread the word

[@nichill7474]

I thought bupropion and Wellbutrin were the same thing, one generic version and the other name brand but both have the same ingredients.

[@shannasharp9124]

Same! I just posted basically the same comment

[@ryanarcher9881]

​@@nichill7474 buspirone as in buspar

[@jimmonade]

@@nichill7474buspirone not bupropion

[@gmarie9507]

Thank you, Dr Rossi! These videos are so helpful.

[@ShrinksInSneakers]

No problem, I'm happy to help

[@__alec__]

Hey Dr Rossi, love your channel thanks for the great informative content. I was wondering if you would consider making a video about combining Stimulants with Antidepressants / approaches to treating ADHD with anxiety/depression comorbidity. Thanks! 🙏

[@homelessrobot]

I have a pet theory that one source of anxiety is the nicotine receptor antagonism in people who use tobacco. I was prescribed buproprion XL for ADHD and i notice that after every dosage change, my ADHD symptoms worstened, well beyond baseline without buproprion. Like, getting really mad and being super hyperactive. I eventually figured out that it was because it was completely shutting me off from nicotine when i changed dosages, so I was going through withdrawal without even knowing it. I will tell you, knowing that you are going through withdrawal is much more manageable than not, because you can correctly attribute symptoms, and if you are unaware (or the symptoms are disconnected from the cessation of tobacco use), your brain leads you in some strange directions looking for relief. Self soothing body movements, insomnia, emotional outbursts, muscle tension, racing thoughts, paranoia, and general restlessness. I felt like i was losing my mind. I had similar results trying to quit smoking with chantix several years ago and had to stop taking it, and eventually somehow I connected the dots.

[@dexcoon]

Wellbutrin gave me facial ticks, a short temper, restlessness, and horrible anxiety. I really think it can make anxiety worse in certain people.

[@IAmLegend9291]

It can , but I think the point of this video is that the risk is the same as SSRIs

[@rebekahjoy7921]

@@IAmLegend9291no.

[@HeyYaHo-co3dn]

We're you only taking welbutrin or taking other meds also?

[@wread1982]

It raised my blood pressure extremely high and made me extremely angry but I loved everything else about it, quit for those two reasons

[@caitlinrios2030]

What did u end up taking instead if anything? Then what happened? I’m having the same thing

[@aeriumsoft]

id love a more indepth video on naltrexone, think you have talked about it before but for example low dose naltrexone, off label usages (ive heard autism and all kinds of addiction, not just opioids), and discussing the research around and effectivity of Contrave as it currently starts, cheers

[@elamarjordan]

BRILLIANT! EXACTLY RIGHT!

[@ShrinksInSneakers]

Happy to help bring this information to the public, thanks for watching

[@ashleybrown4450]

Thank you for sharing this. I’ve learned that Bupropion does tend to make me feel more stimulated, which in turn can make me anxious. However, I found that if I keep a regular mild cardio routine (walk, run, or dance 3x/wk), everything feels nicely balanced. If that makes any sense.

[@evelynwaugh4053]

I can't cite the study, unfortunately, as it's in the dim past, but I have read one where regular exercise was found as effective as antidepressants in lifting mood. I used to run and lift weights, so I am aware of the effects of endorphins on mood and can well believe it. Exercise is one of the positive routines that helps lead to an upward spiral.

[@VICARI0S]

Great video as always. I am curious how effective it is for smoking cessation and as adjunctive therapy for someone who's already on psychostimulants for ADHD?

[@user-kj9ul9wm8i]

Starting this in 2 days for GAD. It’s funny, cuz I’m anxious about taking medication for my anxiety. But from what I’ve gathered in the video and the comments, I guess you won’t really know if it’s for you or not until you try it. Thanks for the evidence based approach in all your videos. We’ll see if this is for me or not.

[@ekhlaas]

This is where I am. I am having anxiety about taking it (or any other medication, specifically antidepressants. Never tried them before and worried about how I will feel on them).

[@jonmb93]

did it work for u?

[@edie4321]

I hope you didn't take medication for your anxiety. It devastates your life. It may work for a little while, it is best to learn to deal with it naturally. Have you tried natures route. Get out in some. It works amazingly.

[@NorthCountry84]

But the literature says otherwise! Jk. I’m not a fan of when docs get boxed in by “what the literature says” and dismiss what a host of patients report to the contrary.

[@IAmLegend9291]

Updates ?

[@thelastrebelshow1627]

Bupropion can cause stressful situations to be more intense unless you remind yourself when you start feeling more stressed than the situation dictates that it’s largely the bupropion. At least for me that’s the way it’s worked and obviously I can only speak for myself.

[@AMM-1817]

I feel like I’m dealing with that now. It’s like an endless cycle. Wellbutrin really worked for me in the beginning but I’ve begun to notice a change in myself. Short fuse, easily annoyed, and my thoughts seem to always be racing. Has not been enjoyable, to say the least. 🫨

[@kembm]

Thank you!!!

[@erikbudrow1255]

Good stuff. The only thing I didn't like was that you said "Nobody wants to gain weight." If you're a hard-gaining string bean like I was for most of my life and you're trying to bulk up you want every edge you can to put on weight.

[@wread1982]

Wellbutrin made me gain 15 pounds

[@ThomasAgain]

Thx for the video

[@agaragar21]

Helps waking up and getting going with my day with ADHD

[@thelostbookofjohn]

I’ve been on Bupropion (300mg) for three weeks now to treat both depression and GAD. Let me tell you that the first two weeks were about as close to hell as I think I’ve ever been. Insomnia and constant anxiety (buzzing in my sternum, shaky hands, etc). However, about four days ago all of the anxiety completely melted away and I’m only waking up once in the middle of the night as opposed to six or seven times in weeks 1 and 2. The depression is a little more pronounced now but even that is weakening. I expect (if I keep on this trajectory) that next week will bring a lot more stabilization overall. This medication is exactly what I needed and I almost gave up if not for some really good Reddit reviews telling me to STICK WITH IT for a while longer. I’m glad I did. I feel much, much less anxiety than I ever have before. Thanks for an encouraging video, doc!

[@sevginvatansever2920]

Did it boost libido?

[@cosmolove]

@@sevginvatansever2920it did for me. Strattera totally killed it, Bupropion brought it back.Also waking up rock hard each day like a teenager. 150Xl for 2 months, now on 300xl. i hope it works out for me because this alone has helped my life and possibly saved my marriage!

[@sevginvatansever2920]

@@cosmolove did you see any side effect

[@cosmolove]

@@sevginvatansever2920 yeah a headache day 1, nausea day 1,2,3 and at 300xl I started getting very irratable and short-fused with caffeine. when i stopped the caffeine i felt fine again. ah yes and with the 300 I've felt suuuuper tired and almost like being high the first 3 weeks, now it is getting stable barely at close to 1 month. overall it has helped tremendously with major depression disorder, a little with adhd symptoms, and helped general anxiety disorder quite a bit

[@sevginvatansever2920]

@@cosmolove do you still use strattera? Because maybe you stopped to use strattera, your libido has been increased.

[@marieb9961]

Thanks 😊 I like u I understand your explanation

[@blairkerr7911]

Dr. nice video dispelling activation of anxiety taking Wellbutrin.What would your starting dose be for someone with G.A.D senior adult?

[@blondebomber-qo2uy]

My anxiety did get worse during my wellbutrin therapy but i stayed on it because it almost 100% cured my depression. I'd definitely rate my experience as pretty high even though i eventually had to switch off of it due to the anxiety increase. But thats just my experience!

[@gillmahoney4742]

This is from tweny years personal experience. I dropped,taking all antideps ans i proved wasnt on about wuicide all the time and crying, but been really bad without too

[@GoFartherPodcast]

I know they often pair Zoloft with Wellbutrin, because it can help with anxiety

[@blondebomber-qo2uy]

@@GoFartherPodcast Interesting, maybe I'll bring that up with my doctor because I loved the Wellbutrin just could not tolerate the side effects!! Thank you for the tip 🥰

[@GoFartherPodcast]

@@blondebomber-qo2uy you’re welcome; it might be worthwhile, or it may not be worth it (Zoloft has side effects for some people ), but maybe it could help Best of luck!

[@alvaradom27]

Thanks for explaining Bupropion side effects. I just picked up my script and have some added fears after reading the side effects. Still trying to decide whether to take this medicine.

[@ShrinksInSneakers]

No problem, I'm happy to help

[@louishenrich6306]

Great video Doc, I have been on venlafaxin and had some weight gain and also reduced libido, and a lot of sleepiness, thats why I got aderall to counter atack that.. I quit all that a year and a half ago, now with a lot of anxiety im gonna start with Bupropion, will share my experience here after 2 month of usage

[@frozencoke1]

any updates?? from someone considering taking it

[@jimmonade]

How did it go

[@smollgar]

Wish I could find a psychiatrist like you :(

[@sherrytabor4843]

I took Wellbutrin for about 6 months. In the 5th month I experienced very heightened anxiety, as well as increased heart rate and arrhythmias. I am in the process of weaning myself off this with my doctors approval. It did help with the depression so I am slightly disappointed to quit taking it, but the anxiety episodes were frightening and it was getting to where I just had a low-grade anxiety all day long. The anxiety was too debilitating to continue. I appreciate your information, but, for me, I couldn’t continue.

[@medini2]

Wonder if at some point your dose increased or you switched from to an extended release Wellbutrin?

[@RationalNon-conformist]

You can find healing without meditation, try carnivore.

[@rebekahjoy7921]

SAME

[@Yasen1791]

Thanks 🙏

[@user-dz3qp3hm3f]

Hello Doc, I want to provide my experience and also the research I've done so far to at least open you up to the idea that some people do experience heightened anxiety when taking this med, and more than just the initiation period. I first tried this med as a freshman in college when I had my first major depressive experience. It did benefit me at that time, but I came off it after about 9 months. Throughout my college experience, I developed a high level of anxiety and was diagnosed with both GAD and panic disorder. I then went back on Wellbutrin and developed intense anxiety, like someone was throwing gas on the fire, much worse than any time I have started an SSRI. So, I'm now in my late 20s and know that for me, other than that first time I used it to treat major depression before the start of my anxiety disorder, I have always experienced heightened anxiety from it. It is an NDRI with a structure similar to amphetamine. I understand those fact are only so helpful in answering the question of whether or not it increases anxiety. But, I have also had psychiatrists who are very experienced and also value the scientific literature tell me that there is reason to believe those with high baseline anxiety don't do as well with Wellbutrin. So, yes it offers many advantages, but I hope you at least consider the experience of people like me and know that studies don't always capture the many phenotypes of anxiety/depressive disorders.

[@dmcsunshine1]

Wellbutrin was BAD for me.

[@charleswomack2166]

Have you tried exercise? I was diagnosed with PTSD after I had an anxiety attack that I swore was a heart attack! I went to the ER because I honestly thought it was a heart attack. Then I started doing push-ups and other calisthenics, along with running and. Bike riding. It really helped me.

[@siyuanzheng9700]

Until what weeks did you find that your anxiety was worsen because of bupropion?

[@ginalyn7834]

I’m not a doctor but my son had the same experience went off asap

[@scottsinger7110]

If you take Wellbutrin and also have anxiety do not go up to 300mg. I take 150mg of Wellbutrin and I have GAD. I also just started Buspar a week ago, and I take propranolol 60mg ER every day and take Klonopin 1 MG as needed. Works pretty good, but I do want to get off all the meds and just exercise and eat healthy, but I'm glad none of the meds have really any side effects.

[@stevio8865]

I've gotten Bupropion as my first antidepressant for depression. I'm not diagnosed with anxiety disorder, but it gave me so much anxiety. I even got psychotic. My doctor called it nihilistic delusion, where I felt like nothing makes sense anymore, not even existence itself. It was like my whole believe system about the world and my existence changed within a few days to this psychotic depressed and anxious state in which everything felt completely pointless. I obviously stopped taking it (after about four weeks) and it took me months to "forget" how I was feeling during these few weeks. I also did get sexual side effects. I didn't feel my orgasm anymore. Never had that with any ssri/ssri medication.

[@phoenixmoon9116]

My God I wanted to love it. It started working with depression, focus, food intake, even energy. With that being said I also turned into Zemus’ HATRED!! I was so ANGRY! How can I not be depressed but still feel so filled with rage? I even started hating myself!

[@rebekahjoy7921]

SAME!!!

[@rebekahjoy7921]

SAME!!!

[@PlexiumGames]

Can you do a video about MAOIs? I think they are very underrated and useful in some situations.

[@DennisBolanos]

Yes, that would be good.

[@whatdoyoulivefor735]

Bupropion worsened my anxiety AT FIRST. Once I adjusted to it, my anxiety was completely soothed. The first several weeks were difficult but I’m glad I stuck it out!

[@camellia8625]

From my experience taking Bupropion for ten plus years followed by not being able to take it these past 6 months due to supply issues at present B actually helps me in terms of sex drive. I have GAD in addition to Bipolar2 and have not had any increase in anxiety with B.

[@sevginvatansever2920]

Does it boost libido?

[@natalyo.4278]

I had mixed clinical depression with GAD for 2 yrs, and wellbutrin helped tremendously with both! also suffer with social anxiety, it hasn't affected it- not better not worse

[@jdssurf]

i hope it works for me, lexapro has me shut down

[@Dustin_Quick_Holy_Smokes]

I love this med! I had so much fatigue With depression it nearly crippled me. I have my energy back!

[@MissDoreen]

Hi Dr., I am just a first time listener. Thank you for all of your information. But I’d like to know why would one have to add an anti-anxiety medication to the current anti-medication? I feel that if you have to add another antidepressant medication to the one you’re already on. It tells me that it’s not helping with depression. I have been on many SSRIs anti-depressant medication‘s. You name it I’ve been on it. I was prescribed buspirone. Because the FDA discontinued Buse bar and made the generic form. I think I’m just going to stick with yoga and meditation and positive thinking and healthy eating. Thank you for your wisdom and expertise. Have a blessed holiday season..🙏🏽💜

[@GrannyGooseOnYouTube]

I do find Wellbutrin to be somewhat effective, but only for the first few weeks. Then it tapers off, and I feel like I'm back to Baseline with my adhd. My dosage has been increased, but the effectiveness is still short-lived. Despite being prescribed Ritalin in another county, I moved here only to have it taken away, and replaced with the wellbutrin. My current psychiatrist seems to have moral objections to prescribing stimulants. It's doing me a disfavor, because I cannot get the medication that's most effective for me. I understand she's the doctor, but I'm the human being with the adhd. I'm looking for a second opinion currently.

[@JesusSaves77799]

I had depression and anxiety and was prescribed Wellbutrin with my SSRI. I felt absolutely horrible on it. It made my anxiety go through the roof!

[@Xraycrayon]

Wellbutrin helped my anxiety and depression way more than any ssri I’ve taken. Didn’t cause sexual dis function like ssris did and helped me loose weight.

[@DaneKelly-qj2ft]

Did you experience hair loss? I’ve heard many say that this is a side effect

[@shannasharp9124]

I have depression and anxiety. I take buspirone for anxiety and bupropion for depression and it’s the perfect combination to make me feel comfortable and at peace.

[@EricMobley1]

I take this combo too! Never felt better ❤

[@shannasharp9124]

@@EricMobley1 same!

[@bsbrum]

My son was taking Bupropion XL for 8 days and killed himself. Of course he was 22 and the attending primary care provider who prescribed it apparently had no clue about the FDA warnings not to prescribe it to anyone under 25 since 2005.

[@ShrinksInSneakers]

This is tragic and a difficult situation anyone who practices psychiatry long enough would face. What I can say about the FDA warning is that it's something to educate the patient about but not a complete contraindication to prescribing medications. Many child and adolescent psychiatrists prescribe antidepressants on a daily basis to children under the age of 25. Depression is a possibly modifiable risk factor and the big issue is was the black box warning discussed. I appreciate the comment sorry for your loss

[@bsbrum]

He was suffering from a traumatic brain injury, and was also told to stop drinking. In the documentation I’ve read about prescribing Bupropion, head injury patients and secession of alcohol are both significant contra-indicators. Add his age. Also received no psychological counseling before prescribing this med, on the first visit too. I am shocked that primary care providers are allowed to prescribe drugs like this, and there are virtually no protocols for mental health that would push for counseling first. He also answered no to all suicide screening questions on the day it was given to him. He showed signs of mild depression, and was dead 8 days later.

[@darthdebby]

I am so sorry for your loss. My heart goes out to you and your son.

[@vadim.watchme]

He didn't wait the first two weeks for the side effects to go away.

[@rebekahjoy7921]

@@vadim.watchmeare you kidding me?? You are just a terrible person for this comment. No words. I feel sorry for anyone who’s in your life. Worst comment I’ve ever read.

[@jenniferchamberlain1393]

I'm on 20mg lexapro and dr added 150xl Wellbutrin. I'm someone who is scared of side effects of medicines. So I'm in my first week and I haven't feel any real "energy" just brain fog and dizzier. But today I'm drinking water more and trying to constantly eat to see if maybe that could be causing that. Any comment on Wellbutrin and lexapro together?

[@cloviscareca]

I had bupropion for weight loss and it sucked; my blood pressure went to 14x9, anxiety went to the roof. I used this drug for a year, then tapped it and after tapping it out, I noticed how much this drug had worsened my anxiety; my blood pressure went down to 11x7.

[@Pleasedontbealarmed]

Very interesting, thank you! Is Bupropion also a good first-line choice for depression and pain comorbidity?

[@Pavel1560]

I have depression, anxiety disorder and nasty lower back pain, I'm on bupropion 150mg/d and pregabalin 225mg/d and this combo works great both for my mental health and chronic pain. But I think it depends which kind of pain you have.

[@ericadams5019]

Im 50 now and have had ocd, adhd, anxiety, depression and autism. I dont know if its good or bad but I've internally shouted at the internal voice I had so much that I no longer have a internal voice or dialogue. :shrug BTw, I am on 450mg of Bupropn HCL, 30mg Buspirone and 25mg Hydroxyz hcl. I think they helped...

[@InstrumentalArcanum]

I have a question. I just started topiramate. The question I have is. I take lamotragine I find it helps a great deal but when I go higher dose I get really bad headaches /migraines . When taking topiramate .I also found in reference to topiramate low libido is a side effect 😢😮😢 Is this true ? Does it cause low libido in men ?😢 I'm really sad about this.

[@deniserichards8441]

Hi, I really enjoyed your video. I would love to try Bupropion but concerned because I have hypertension. What is your experience with risks of it increasing my BP and I tend to get headache’s from tension. Will it help relieve the tension and tense muscles in back and neck? Thank you 😊

[@wread1982]

I had to get off of Wellbutrin cause my blood pressure was 150/86 and at the doctor it would go 180/110 and it also made me snappy mad at my family, BP way down now off of it

[@cuteflygon]

Recently decided to try it again after first taking it years ago. Took Luvox which made me tired but seems to help with sleep, Zoloft which I am currently on has way too many side effects. I rmb wellbutrin at least dint give me insane side effects and I rmb I was feeling pretty decent when I was on it. Stopped cuz I still had stigma towards medication then

[@bostoncharm1]

What do you think of Bupropion as an add on to 10 mg Lexapro? how much added on is too much? I have take Lexapro for severe anxiety and panic attacks. it has helped a lot. but I developed MDD after menopause. (I check my VIT D and thyroid on the regular. I do have to take VIt D suppliments frequently to keep it up). I only take 75mg bupropion now. in the morning and the lexapro in the afternoon. My docs want me to take more bupropion because it doesn't help the depression enough. I was afraid to because of the myths you mentioned. and thought the side effects may be worse mixed the lexapro. I don't want to get more anxious or not be able to sleep or feel jittery. I have been diagnosed with ADHD inatentive type, cyclothymia , anxiety and panic attacks.

[@beeathome1064]

I really liked taking buproprion, but it seemed to worsen my PMDD symtoms and anxiety recently when they added Prozac with it for PMDD. I’m wondering if there is a better combo for that? The buproprion helped my adhd symptoms :(

[@Einsd619]

I’m on it for PMDD and it’s been a life saver. Significantly decreased my anxiety the bad week before my cycle. I cannot take an SSRI. That turns me into a monster.

[@rhymesgalore81]

Just started 150 mg of Wellbutrin with 20 mg of Cymbalta in the morning today. We'll see!

[@toddwilliams4493]

I took Wellbutrin for two weeks... I was locked and it felt great... it did keep me up at night though ... unfortunately, I suffered a panic attack and stopped taking it cold turkey... eight weeks later my head is still not right! Suffering from Severe anxiety... maybe I should have stuck with it!!

[@robertceliberti7175]

I took Buproprion years ago. It didn't help me but it can help a lot of people. With a lot of meds I'm sensitive.

[@ShrinksInSneakers]

I keep it around as a first line option because the side effect profile is much better than SSRI and SNRIs. Like all things in medicine it's about finding the right treatment and matching it to the correct individual. I appreciate the comment

[@TheCoolOwen]

Would like to get back on Buproprion again. What about Auvelity (dextromethorphan/bupropion)? Asked doctor and he didn’t even know about it.

[@jamescalifornia2964]

Interesting that Wellbutrin is often used with an SSRI ...

[@leslieball533]

Long story short, Zoloft was great, but I couldn’t take it in helpful doses for various reasons. Bupropion takes care of all except my irritation and rage. Just 25m of Zoloft added to my bupropion took care of the problem.

[@nikkirox69]

I’m supposed to start this medication Monday. To help quit smoking and also I have anxiety and apparently depression but I’m not sad. Anyways, my anxiety tells me not to take it but I need help quitting smoking so I’ll let you all know how it goes for me!! ❤

[@ShrinksInSneakers]

thanks for watching and commenting, best of luck with treatment keep me posted

[@la.4971]

hey! how did it go? hope you're doing well

[@melissachadwick5717]

What if you had an unknown seizure disorder as a child that resolved as you grew up?

[@user-nq2zn9tw2g]

Does it help for anhedonia? Caused by depression?

[@nichill7474]

Bupropion works well for me. My doctor and I decided to take a week off to see how other positive changes in my health will make up for the need for it. But after a week i notice the lack of motivation and low energy coming back again. I wished there was an actual cure but im good keeping bupropion as an option until i find something else.

[@miguelsalabert7824]

Hi Doc! I'm from Brazil and I watch all your videos. Thank you so much, these have been very helpful to me. I have some questions. What do you think about taking Wellbutrin XL (300mg) with buspar (30mg)? Can Buspar help with anxiety and increase sexual desire in this combination?

[@bmitidieri]

Olá Miguel, Dr. Rossi não cobriu sua pergunta no vídeo, mas posso te esclarecer um pouco.... A bupropiona tem um dos melhores perfis de efeito colateral no questão da disfunção sexual quando se trata do tratamento de condições psiquiátricas(citadas depressão maior e TAG), já a buspirona nem tanto; Ambas foram usadas no TRIAL Star-D que ele mostrou, mas foram usadas em combinação com o citalopram, não as duas em associação. Em relação a sua pergunta: Depende da causa e do curso da disfunção do desejo sexual, mas eu pessoalmente não vejo essa combinação ser usada com esse intuito.

[@blktegs]

What are your thoughts on wellbutrin as an add on for 20mg lexapro. In ocd

[@Corleone007]

I have clean quite strong GAD, with very little or even no typical symptoms of depression, Buproprion makes me sleepy at the beginning when combined with SSRI :) while SSRI alone does not make me sleepy :D Those drugs are tricky, but there is one (uncertain) thing wich may happen when you take mild stimulants having anxiety. Of course in that case primary drug might be an SSRI, like Zoloft (but not in all cases). Sertraline always should be first choice as it it affects less hormones due to weak dopamine reuptake inhibitory. It is believed that too much serotonin over dopamine increases prolactine and some other hormones. When it comes to buproprion....Yes at the beginning it may increase your anxiety, but what about noradrenaline receptors downregulation after a time? that might be one of the positive pathway in reducing anxiety. It's kind of rebound effect as well. When you take benzodiazepines for a short period when addiction not happen, then rebound anxiety appears, as when you take downer then you stop it, you expect rebound effect. So maybe when you take mild safe stimulant the opposite thing take place :) I wonder if drinking coffee which would be unpleasent for anxious agitated people can downregulate receptors over time and when you stop drkinking it you would be calmer and sleepy :) Maybe it's all about receptors, when too little serotonine or dopamine (prolonged bad mood and stress affect that level and other negative compesatory reactions happen), the receptors become upregulated which is why you easily get anxious (especially when you take a pill which may be a bit stimulating) , when is proper amount of the neurotransmitters or even too much, if you take drugs which inhibits reuptake process, then receptors start to downregulate which makes you more stable or even a bit blunt if the effect is too strong. It is plasticity of brain. Of course this is very simplified it's much more tricky , complicated. Downregulation process sometimes is not good :) This is one of the reason you may feel the drug does not work as good as earlier over time and you must increase dosage. When you start drug and you do not feel too much adverse reactions (benzos should be added for first weeks when too much anxiety exists) you feel very good, even a bit euphoric. You wish to be like that for longer time, but compesatory reactions (downregulation and others) reduce that effect :) tricky thing....Additionally I believe that anxiety connected with hyper stuff, like hyperactivation, overreaction, too much negative energy which affect sleeping, may happen more often in people who were a bit hyper since they born... so I wonder if that mild hyper + anxiety is negative synergic effect and buproprion in that case may help as overtime it might reduce that small part of ADHD (many people may have very mild kind of ADHD that in normal circumstances are not treated with any stimulant)

[@sashaflip7450]

I just got off Wellbutrin because it made my anxiety worse. I was having anxiety attacks and racing thoughts. Felt better like a week after stopping it.

[@IAmLegend9291]

I have a mild depression with dysthymia, along with generalised anxiety with panic attacks. Doctor didn’t prescribe SSRIs because they made me worse in the past and also sexual disfunction. He said this could make me worse , he gave me Ativan for anxiety. I’m afraid to start the Wellbutrin my anxiety is already bad . Advices ?

[@sarahwind5206]

My son developed seizures shortly after taking this med and they have continued ever since.

[@cosmicenigmarevealed]

Thank you for the info, I will not be giving this to my child.

[@MinPer7]

That’s my biggest fear I am do paranoid at that possibility. I live alone so don’t know what to do

[@Laxexp]

Can Wellbutrin be bad for the liver? My Comprehensive Metabolic Panel Blood work came back high on both AST 51 and ALT 82. I have been on Wellbutrin for about 30 days.

[@wread1982]

Bad for your kidneys if it raises your blood pressure

[@highspeedhayden]

So longer pumps, easy bulk, & less noise in my head. Sign me up

[@robreynoso2848]

This pill has helped me feel motivated, which kills the depression. Libido is the highest in years, has caused a lil bit more anxiety but the positive feeling you get will combat the anxiety. Pill isnt for eveyone.

[@mindyh830]

I love Wellbutrin ❤

[@clericregnor]

It was great, except it stopped my gut. I used it for about a year, but would sometimes wake up with symptoms of intestinal blockage, like dry heaves. Anecdotally, it seemed to have a positive effect on sexual function even for those without PE. Is it okay to use miralax everyday, in order to tolerate otherwise beneficial meds?

[@sugarraynay4153]

I’ve only been on less than 2 weeks., I feel chipper and giggles more

[@aaronheryford3507]

Wellbutrin is good to me. And so is Effexor.

[@roselereau6981]

I am worried about developing tinnitus.

[@Jay_Pride]

Everyone is different, just sharing my experience; I might be out of the norm.. but I took Wellbutrin for 1 year @ 300mg XL tabs in the morning and largely noticed zero change in my mental health and actually gained more weight during this time. I think for me, if it improved any happiness triggers = wanting to eat more. Secondly, I think it enhanced my already panicky feeling and made them worse at times. It also seemed to worsen my ability to focus and thus my performance at work has worsened. I started with 150mg for the first month and didn't notice any changes, therefore leading to 300mg. I tried 450mg here and there and only noticed I was more panicky on those days. I went straight off Wellbutrin cold turkey, noticed zero side effects in doing so and largely feel the same as when I was on 300mg. I initially went on Wellbutrin for what I felt was depressive effects after a long term relation breakup and not at any point during the first 6 months did it help me feel better about the situation, I think time was the healer there, not the Wellbutrin unfortunately. I was hoping in the least that it would curb my appetite but that didn't happen, not even close.

[@ShrinksInSneakers]

It's always a mixed bag, it's always good to hear about real world experiences with treatment

[@iamthefiremanjj]

What are the most common meds given for anhedonia and dpdr symptoms ?

[@janisjansons5707]

I like Wellbutrion for Energy and Motivation butt for me if NET is increased i start tu forget how to talk.Kinda start to forget names.

[@jamesmclean1977]

Please help!! Im in Scotland and my psychiatrist prescribed my bupropion fir the past 8years or so..as id tried everything fir my major depressive disorder and nothing came close to being of use.bupropion was a life changer until in January this year we heard it had been discontinued .all i can find on this os that December 2022 GSK said they stopped manufacturing due ti the presence of Nitosamine impurities that were foumd and potential for causing cancer.so im unable to get it anywhere in Britain.this medication allows me to get out of bed and function each day with nearly no side effects other than occasional slight nausea. Please help with any info you have on when or if it will become available again?? As nothing else i can try that works in a similar way to bupropion. PLEASE PLEASE HELP !! 🙏Kind regards James

[@Thinkbeforeyoutype]

Wellbutrin gave me really bad anxiety and within a day or two of taking it, I started getting the urge to/started smoking weed again after quitting for 5 weeks easily with no temptation.

[@thijsjong]

Welbutrin increased my libido. It sometimes could go up to 3 times a day and I am 52. My libido went back to the level of 25 year old. I had to tone down my sexual activity as it was eating up my time and was getting rediculous. I got busy with other thing taking my mind of what my johnsson wanted.

[@AaaAaa-im5hq]

What is your dose for Wellotrin?

[@mikegrise353]

It did worsen anxiety for me but I also take Zoloft so it was minimal. Bupropion is anxiety prone for people that are sensitive to stimulants (like me) because it acts on dopamine (why they say it’s activating)

[@mikegrise353]

You can try and rationalize all you want with medical examples but it’s the truth. You compared citalopram with bupropion. Citalopram is the most sedating of all of them, even more than Lexapro because of the histamine affects. Have you taken any of these medications? I feel like you wouldn’t have the opinion bupropion is first line unless with an SSRI if you had. Literature is crap unless backed by anecdotal proof

[@CrepitusRex]

I take Bupropion and the only thing that sets off my anxiety is that fact that you continuously keep looking to your right while talking!

[@luciamixon8119]

Interesting. I was prescribed this and changed my mind after one or two pills. It probably had not done anything yet. Glad I didn't continue. I've been managing. I sure don't need anything to increase anxiety or weight gain.

[@bostoncharm1]

it doesn't cause weight gain. does the opposit

[@Corleone007]

What is maximum proper dose fo sertraline when combined with buproprion? as they share at least one of the isozyme of CYP450 (not strong inhibition)

[@spoonbillyerd]

im terrified to get on it because of the risk of tinnitus and hair loss. what do you think of this?

[@JohnnyScumbagg]

Wellbutrin gave me absolutely terrible anxiety, restless, can’t sit still, makes me make weird faces and noises. No thanks. Getting tf off it.

[@MissDoreen]

Well, Buterin, buspirone or BuSpar. I was prescribed buspirone for severe anxiety. Buse bar was taken off the market about 10 or 12 years ago. And now they have the generic form buspirone. I have been on many anti-depressants throughout my lifetime. And in my experience, if you have to add another anti-depressant to the original antidepressant. This just makes me to believe that it’s not helping anxiety or depression. When they discontinue a certain medication and they make a generic one, hast to wonder if it’s very effective.🤔 I appreciate all of your information. But you have to be very careful with taking antidepressants and anti-anxiety medication’s. They can cause unwanted facial body movements that are uncontrollable. I’d rather just do yoga and meditation 🙏🏽☺️

[@TAY-570]

Did the symptoms go away?

[@markdelk8328]

Same here!

[@amyl8450]

Same! I also gained weight super fast!

[@JesusSaves77799]

Same! I tried it years ago with my SSRI for past anxiety and depression and it made me feel awful and like a nervous wreck!

[@user-bk3qi4tf4n]

I take Buterin I’m restless and cannot sit still and I have racing thoughts and my anxiety is worse, but I overthink on it

[@minepolz320]

YAAY!

[@brittanyguerra602]

My dad took this medicine after taking Fluoxetine which was working well. He wanted the added benefit of quitting smoking. He killed himself within two weeks without warning after the switch. He was 55. Be careful

[@straightflush6095]

I don't know, I think Bupropion is a terrible choice for anxiety. It's because of it's mechanism of action. The noradrenaline reuptake causes a rise in blood pressure and heart rate which are strongly associated with anxiety and/ or panic attacks. Noradrenaline is known to stimulate the amygdala instead of reducing it's activity like benzodiazepines or even SSRI do. Anxiety disorders are often associated with (temporarily) higher pulse and blood pressure, so I think this medication is making anxiety worse in anxiety provoking situations. But that's just my opinion and experience

[@dallas44forlife65]

If someone is experiencing both anxiety and depression I usually start with Zoloft or lexapro … if the anxiety improves but the depression lingers I will add 75mg of Wellbutrin in the AM ( not the XL) … if they still have anxiety ( which tends to be more debilitating) I’ll switch the initial SSRI to an SNRI ( I like cymbalta better bc it’s not as dose dependent as Effexor) … if the patient is over 55 I will use Trintellix … if the depression is causing sleep and appetite issues I’ll add some low dose mirtazapine … if the anxiety remits but Wellbutrin doesn’t help the apathy and mild anhedonia I’ll add low dose Ritalin

[@ginzo666]

@@dallas44forlife65 Is that long acting Ritalin? If you add Ritalin, do you stop the bupropion? I'm on 60 mg duloxetine and 150 mg bupropion XL. Still some apathy/anhedonia, but like 75% improved. Looking to get all the way there with a minimum of side effects. Thnx in advance.

[@wread1982]

It raised my blood pressure so much I had to stop it

[@cloviscareca]

​@@wread1982same

[@cloviscareca]

I agree. Buproprion raised my blood pressure, plus made my anxiety 10 times worse

[@justinwise3467]

I take 300mg Ext Rl once a day, I've taken it for the past few months...I feel like my social anxiety has gotten better but overall I dunno. Gives me killer dry mouth though

[@bethanysobraske9781]

In every video, there is mention of avoiding it for people with eating disorders, but no one says WHY. Can you explain?

[@Thinkbeforeyoutype]

Probably because if you have anorexia or bulimia, the Wellbutrin's appetite suppressing/enlarging behaviors would either taper your hunger, leading to even more unhealthy weight loss or cause weight gain, which could be, potentially, a mental catastrophe for them.

[@TFGcine]

I’ve been on these meds for four months now. The side effects the first two weeks were hell but now I feel great. I’m glad I did not follow the horror stories online. These meds work differently for everyone. You won’t know until you take them. Avoid drinking too much though because it can cause you agitation the next day.

[@ChuukeseStink]

🤔Intial side effects for me was increase anxiety and erectile dysfunction. Anxiety went away in less than a week. I didnt get my sex drive back till the 4th week.

[@donatospoony]

It’s prescribed , and covered by my insurance , but micro dosing is better.