Why Losing Weight is Difficult with Type 2 Diabetes | Dr. Dan Obesity Expert

Diabetes and Weight Loss: Why Does Type 2 Diabetes Makes Weight Loss So Challenging?
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Today, we’re exploring why losing weight is so challenging for people with type 2 diabetes. Despite new medications like Zepbound, weight management remains tough for those with this condition. Interestingly, losing weight can help manage diabetes, but diabetes itself makes it harder.
In the SURMOUNT-1 and SURMOUNT-2 trials, participants received either tirzepatide or a placebo over 72 weeks, aiming for a 500-calorie daily deficit and 150 minutes of activity per week.
The 6% difference in weight loss between those with and without diabetes highlights this challenge. Factors like age, weight, and medications like metformin were considered but didn’t fully explain the discrepancy.
Why is it tougher for those with diabetes to lose weight? Insulin resistance, reduced response to weight-loss medications, and complications like neuropathy might play a role.
Managing diabetes and obesity is complex. While losing weight helps manage diabetes, it’s often harder and slower. Focus on overall health rather than just numbers on the scale.
Thanks for watching and always remember: small tweaks lead to massive peaks!
- Dr. Dan
References:
▪️ Antoun G, Nikpay M, McPherson R, Harper ME, Dent R. Is Type 2 Diabetes in Adults Associated With Impaired Capacity for Weight Loss? Can J Diabetes. 2018 Jun;42(3):313-316.e1. doi: 10.1016/j.jcjd.2017.06.010. Epub 2017 Aug 8. PMID: 28800932.
▪️ Garvey WT, Frias JP, Jastreboff AM, le Roux CW, Sattar N, Aizenberg D, Mao H, Zhang S, Ahmad NN, Bunck MC, Benabbad I, Zhang XM; SURMOUNT-2 investigators. Tirzepatide once weekly for the treatment of obesity in people with type 2 diabetes (SURMOUNT-2): a double-blind, randomised, multicentre, placebo-controlled, phase 3 trial. Lancet. 2023 Aug 19;402(10402):613-626. doi: 10.1016/S0140-6736(23)01200-X. Epub 2023 Jun 26. PMID: 37385275.
▪️ Jastreboff AM, Aronne LJ, Ahmad NN, Wharton S, Connery L, Alves B, Kiyosue A, Zhang S, Liu B, Bunck MC, Stefanski A; SURMOUNT-1 Investigators. Tirzepatide Once Weekly for the Treatment of Obesity. N Engl J Med. 2022 Jul 21;387(3):205-216. doi: 10.1056/NEJMoa2206038. Epub 2022 Jun 4. PMID: 35658024.
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Watch my previous videos about how to fight obesity and about the best medicine for weight loss:
▪️ Watch This Before Taking Mounjaro: • Watch This Before Taki...
▪️ From Ozempic to Mounjaro: • How to Switch from Oze...
▪️ Muscle Loss with Ozempic, Wegovy & Mounjaro: • Muscle Loss with Ozemp...
▪️ Managing Nausea from Ozempic, Wegovy and Trulicity!: • Managing Nausea from O...
▪️ Ozempic: Stomach Paralysis Update: • Ozempic: Stomach Paral...
▪️ How to Switch from Ozempic (or Wegovy) to Mounjaro: • How to Switch from Oze...
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Disclaimer of Medical Liability. HEALTHCARE EVOLUTION INC. DOES NOT PROVIDE MEDICAL ADVICE. The content of this material is for general informational purposes only. The content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Reliance on any information provided here is solely at your own risk. Individual medical needs are very different; you should not assume that the information in this document concerning certain courses of treatment or outcomes will apply to you. Rather, you should evaluate your medical condition and make treatment decisions based upon consultation with your physician.
#Diabetes #WeightLoss #Obesity

[@theofficialdrdan]

Thanks for watching! Download my FREE 7-Day Best Weight Journal: eepurl.com/gdB2qn If you are looking for assistance in your journey to reach your weight loss goals, book a consultation with me: calendly.com/drdanconsult/he

[@Ofamiliamia85]

Yes, this has been my experience, my A1c went from 10.5 to 5.6 and lost 70 very slowly in 2yrs. i have been stuck for 4 months gaining and losing the same 4lbs. I do believe that those 70lbs came off from me doing keto and not MJ. But either way Im happy 😊

[@lisa9195]

Thank you! I have type 2 diabetes and on 10 mg Mounjaro in 3 months only lost 13 pounds.

[@johnlee-fg8ij]

Thank you. Informative video.👍

[@HealthAtAnyCost]

My son, daughter, and I are super-responders. I have had T2Diabetes for 29 years and in the 2 years on GLP-1 (Trulicty for a year) and GIP/GLP-1 (Mounjaro x 9 mo.), my HbA1c has gone from 9.0 to 5.1. It didn't take long to do that on Trulicity and I lost 86 lbs. which barely moved the scale as I started at 405 (BMI 76.5). In the 9 months on Mounjaro, my health has improved amazingly! Liver, Kidneys, Heart (I had complications from COVID), BP, Lipids, etc. are all stellar. Even my eGFR has climbed 10 points in the last 6 months. (And I know that with my CKD3a, it will never heal, but still, I and my Nephrologist are thrilled at the changes!) Of course, the most asked questions are: "How much have you lost?" And "What is your goal?" As I said, I am a super-reponder and have lost 220 lbs since starting GLP-1s in July 2022. BMI is now 34.0. All that is to say that I have to wonder why I respond so easily to the medications, including only having constipation that I take fiber for and it's fine. I mentioned my son and daughter as well. They are not diabetic, but have that gene (we are Latinos) and my son has lost 80 lbs. in 6 months and my daughter 100 lbs. in 10 months. They are both at their desired weight. Neither has side effects except slight constipation, too. I don't have a goal weight. I have goal activities, experiences, and great labs. A rhetorical questions: What gene do we have that gives us super-powers in the healing and weight loss arena? I think we should be studied. I love your channel! You're so bright and fun... and cuss like a normal human. Peace!

[@theofficialdrdan]

There are so many factors, but I have seen similar results in practice!

[@grumpyinbrooklyn6347]

Maybe not heal completely, but improve drastically it can! It will take a long time maintaining truly normal blood sugars, but it can happen.

[@ryant5067]

I am T2 and i have lost over 100 pounds in about 6 months only on metformin and making some serious lifestyle changes. Doctor putting my on mounjaro due to the cardiovascular protections these drugs have. Hoping tonsee the weight keep coming off the scale while continuing to get healthier. Great video as usual.

[@alisonbates4186]

Another very helpful video love your style of presenting thankyou

[@stacyeroussel3458]

Thank you so much for this discussion!

[@cloakster]

This vid deserves way more views than it’s gotten. 🤨

[@theofficialdrdan]

I agree lol

[@cloakster]

9:08 Brilliant. Definitely think you’re onto something there.💡

[@theofficialdrdan]

Its definitely interesting! We need more data!

[@Spatoes]

Thank you 🥰🙏

[@beleares]

This is good to know. I was already suspecting this going into Ozempic. Are there any strategies/solutions or diet tweaks that diabetics should follow?

[@theofficialdrdan]

I recommend my usual 4 principals: 1) Consume higher protein; 2) Eating consistent meals with protein over the day; 3) Eating an adequate amount of cals no 1200 cals/day; 4) Get plenty of fiber. Then finally I recommend increase the activity and get as much as you can in with more a focus on resistance training but both resistance and aerobic are important.

[@user-os6rw2rz7q]

I can't afford ozempic and stuff. Also i don't have to as i am just 10 kg additional from my goal weight but it is just not leaving my body. I started taking berberine and inositol for my pcos. The scale is finally moving after years and years of trying. Plz let me know what do yoi yhink about these two and also about L carnitine.

[@theofficialdrdan]

Inositol would be about the only one I would really recommend. I would talk with your Dr about metformin over berberine.

[@TC-zf1ji]

Weight loss protocol that works 100% of the time: Burn more calories than you consume.