Why They Can't Make an HIV Vaccine (They're Trying!)

[@cbw900]

I've participated in an HIV vaccine safety trial! I want to see this happen in my lifetime.

[@dianahuang4991]

Thank you for paving the road to new life saving treatments 🙏🌈 best of luck!

[@kitefan1]

🤗

[@anon58973]

You'll still get it bugchaser

[@RayZfox]

Did the auto reactivity at 4:05 make you nervous?

[@whyamiwastingmytimeonthis]

🫡

[@rhyanrose5524]

What a beautiful time we live in. There was a time where HIV was only said in whispered tones, and a diagnosis of it meant you should start making funeral plans. Now, we have so many methods of both HIV prevention and treatment. While there's still some stigma, we've come a long way. I am so grateful to the scientists who have saved so many lives through their hard work and not letting social pressures get in the way of creating things that matter and making life better for everyone. I hope we're able to find that vaccine, but until we are, I'm still so thankful HIV doesn't mean what it did in the 80s/90s. We're so blessed to have come this far and we have many more discoveries ahead!

[@jeanwonnacott2718]

I was born in 1963. I remember HIV...and Elizabeth Taylor. Thank her if you are surviving HIV today. No one fought harder than Elizabeth......😊

[@berniv7375]

We would have found a cure for HIV decades ago if we did not use other animals in our research. Now that we have all this advanced technology there is no excuse to torture other animals in laboratories.

[@kylelawson91]

​@@jeanwonnacott2718 what about Magic Johnson

[@raeperonneau4941]

Amen.

[@YunxiaoChu]

Ahh yes

[@Megaman634]

I lost my mother to HIV leading to AIDS in January of 2012. She was diagnosed with it in the early 90's after my brother was born, contracting it from her ex-heroin addict boyfriend (who HAD been clean for quite a long time) relapsing, getting it himself unknowingly, and eventually giving it to my mother. She was given 10 years to live, at most. As time went on, drugs obviously got better and better. Slowly extending her life as they improved. Giving her, not only that 10 years expectancy (At seemingly perfect health) as well as an additional 10 years. I'm super glad that people who are contracting it these days are now able to continue living a relatively normal life. But hearing about it is always bittersweet to me. She was just a little too early to be able to fully live out the rest of her life and I miss her dearly.

[@schrodingerscat4503]

I’m glad she got those extra years with you and your family

[@jamesdietz29]

Sorry for you loss. We lost my brother in 95'.

[@MoonThuli]

R.I.P

[@luxurypetscz]

I'm sorry for your loss. It's always tragic when someone passes early but it's even harder when they could have lived if only a few circumstances had been different

[@peteasmr2952]

I’m so sorry for your loss my deepest condolences big hugs

[@MarkTolmanMA]

PrEP has made a huge difference in our lives. If you don't know about it, and are sexually active, you should learn about it ASAP.

[@MxAmericanPi]

And PEP!

[@scouttyra]

+

[@anon58973]

Gross

[@RRRR-jr1gp]

Yeah I shouldn't bother

[@Blue-od7gy]

By sexually active you mean having orgies and having 100's of partners throughout your life? Degenerate and disgusting.

[@parthpatel2935]

It’s been truly gratifying watching Scishow over the years. I didn’t expect them to cover literally exactly the field of work I’m in. You guys did a fantastic job translating the esoteric science to a digestible and informative format for general audiences. I’ve literally met and chatted with and work for some of the authors in the papers you cited. I really want to share this video with them if I get the chance.

[@fyang1429]

This probably isn't one of those episodes. It's sad that people still think that vaccines can fully prevent transmission. Vaccines are a tool to prevent/reduce symptoms! They can reduce transmission but NO vaccines against any virus fully prevent it. If they are so wonderful why is the only disease we fully eradicated by mass vaccination (smallpox) is the disease that requires symptom to be infectious? Just look at poliovirus - that thing is still around in UK, US, and Israel (probably lot more other places too).

[@st20332]

Thank you for your scientific service, sir 🫡

[@oossgl]

Thank you and keep the great work!

[@imorca1994]

I really appreciate that the presenter took a slower pace than most of the SciShow videos. This is a complicated topic, and giving us a few more microseconds to process as we listen makes an important difference in our comprehension.

[@kitefan1]

There's a few I have to slow down to .75 speed 😁

[@Boris_Chang]

I believe they intentionally speed up the audio, along with editing out the pauses between sentences. Since KZbin allows you to change the playback speed faster or slower, the content producer should focus on normal speech, and let the end users decide.

[@chillsahoy2640]

The fact that in my lifetime HIV has gone from being a death sentence, to being something that you can manage long-term and have a fairly normal life, it gives me hope that if a vaccine is possible, we'll get there. It's proof of concept that if we put enough attention, resources and time to tackle a problem, we CAN solve it!

[@Orangexcounty]

There’s no “fairly normal life” after Covid. Same infections that were only exclusive for HIV/AIDS are also the same in Covid patients that die.

[@arnulfoaleman6999]

How old are you?

[@91722854]

problem is not whether we can or can't, it's whether there is an incentive

[@tdamiano1970]

Im sorry...I was 11 when HIV became a thing. Im now 54. They wont release the cure in my lifetime. I guarantee that!!! Same for Cancer! Its all about MONEY!

[@IonZezpaztraKenat]

We living in capitalism now, if vaccines solve it, the HIV and prep meds business won’t survive thats why they don’t make one 😊

[@thoughtfuldevil6069]

Even if they did make one, millions of Americans wouldn't take it.

[@kylerBD]

Oh I can already imagine the headlines and theories lol

[@RamonQuiro7]

Their choice and loss :( misinformation erodes trust

[@Some_Guy77]

Sounds like natural selection isn't done with humans just yet.

[@shahidally]

not only in America, it's a global problem now

[@Joegreen-r1i]

Self trimming of the herd.

[@TheNigelThornberry]

I’m currently part of a broadly neutralizing antibody (germline targeting) vaccine trial. I believe that it’s the trial mentioned in the video. We just got news that the first stage was surprisingly successful and are moving forward with boosters!

[@kitefan1]

Thank you!🤗

[@aliengeo]

Thank you for your service!

[@allisanche]

Is that trail for therapeutic or preventive usage?

[@peq42_]

Thank you for your contribution to save MILLIONS of people!

[@kishan6984]

How to sign up for it

[@hongjunbai6876]

I work on HIV-1 vaccine design. This is a really great summarization of where we are right now.

[@sophierobinson2738]

❤

[@mikem3219]

Look at car t engineering t cells

[@TV-xm4ps]

Besides vaccines and antibiotics, HIV is one of the major success stories of medicine. Never before has a deadly disease been understood so quickly and specifically targeted with medication to turn it from a death-sentence into a chronic but not lethal disease.

[@zullycelissuazo7439]

Yes! I remember growing up hearing about HIV on tv and sex ed in school. It was this life-ending catastrophe. Seeing so much progress in just my lifetime gives me hope for the future.

[@narutobankai]

It is good to be hopeful. But your statement isn't true

[@zullycelissuazo7439]

@@narutobankai how so? (not arguing, just wanna learn)

[@4203105]

Quickly? It took decades.

[@MoonThuli]

​@@4203105 Thats true but it took centuries for smallpox, leprosy, polio etc.

[@TechnicalTyler]

I pray I see a cure in my lifetime. As a person who’s been undetectable for years, it weighs heavy on you, people look at you differently when they know. It’s hard, but we’ll get through.

[@chibuikekenneth5063]

U can use herbal medicine to cure it

[@aaronkumpula7367]

I like the new changes in direction for Scishow! The new background sets are very attractive and I notice the gentler vocal tone of a lot of the new videos. I assume it’s for an updated demographic? Feels like a more mature video style overall!

[@sophierobinson2738]

Yeah, we dedicated viewers have definitely aged a bit. 😊

[@Youarat225]

these are my comfort videos for real

[@arseniohutagalung9733]

was diagnozed in 2020, I'm on my ARV Treatment :) I feel so healthy now. FYI, my viral load level is Undetectable ^_^ Yeaay!

[@peq42_]

To all the people participating in trials and/or even just helping inform people, know that you are help save MILLIONS of lives.

[@capt.bart.roberts4975]

HPV was a real killer of young woman when I started working. My better half is a nurse at our local HIV hospice.

[@binimbap]

HPV still is! a neighbor of mine has recently passed away in her 30s due to cervical cancer 😢

[@capt.bart.roberts4975]

@@binimbap For some reason, christian/abrahamic guilt about naughty sex! Has managed to block giving The HPV vaccine because of course teenagers are not going to be having sex before marriage. This just makes me want to bang my head against the wall! It's a truly horrible disease. The five-year survival rate is a lot better than it was when I started working in nursing forty five years ago. The cervix is not an easy thing to look at, at the best of times. The improvements in treatment, early detection of the precancerous lesions and cone biopsy of the cervix, gave us the chance to save people, but by all accounts a pap smear is not pleasant. I'm a man I don't have one, so it's not a thing I need to have opinion on. The whole idea having a parasite grow inside me, then expelling a new and separate person the size of a bowling ball out of another organ i don't earn, is a bit overwhelming. You ladies rock. Can you imagine the fuss we'd make about childbirth?

[@kenofken9458]

@@binimbap If enough young women take the vaccine, that will become a thing of the past.

[@itsgonnabeanaurfromme]

Good thing they are vaccines for HPV

[@nayminhtet3772]

1:58 HIV taking sugar coating to ultimate level. 😂😂 😅😢

[@feynstein1004]

Ba dum tss

[@thebeautifulanimal]

Not funny at all

[@yecto1332]

​@@thebeautifulanimal Why not butthurt

[@BaldAndCurious]

Reading the title: maybe boosting the body's immune response to something that attacks the body's immune response, is, to put it mildly, very very hard?

[@ACuriousTanuki]

2:12 part of it, yep

[@Imbrium66]

Very much the case. HIV targets T cells. T cells are the ones that typically tell the B cells to make antibodies. No T cells and B cells are just sitting around.

[@chromeshellking]

To add further to it, its just the virus itself is also fairly clever to surround itself with sugar molecules in the bloodstream so as it passes around the body does not detect that is a foreign body.

[@ArykSapien]

The setbacks are unfortunate, but i’m still optimistic about HIV MRNA vaccines in the future. Can’t wait for an MRNA common cold vaccine.

[@etialpti9930]

The common cold can be caused by upwards of hundreds of viruses so no single vaccine is going to fix it

[@shannonmanning6166]

It would have to be an annual, or even semiannual, and success would be random; the common cold is a master of mutation.

[@Samu2010lolcats]

@@shannonmanning6166 Besides, the common cold is not severe enough to warrant a vaccine. However there are annual and semi-annual vaccines for influenza.

[@kosmosXcannon]

Isn't covid from the same family of viruses as the common cold?

[@OfficialSamuelC]

The cold is rarely problematic enough for humans and not enough of a strain on the health service to warrant a vaccine. Colds are minor inconveniences. With how often they mutate, the funding required would be even higher than influenza because that is much more easy to manage and predict each year, and flu has higher risks of complications, especially those who are vulnerable. Very few suffer issues from colds.

[@Fearia6]

Science is so cool.

[@eshoo8000]

Slow too ( medically speaking)

[@Treasureoflearning]

This is such an important topic! 💔 It's heartbreaking to think about the challenges, but I'm glad researchers are dedicated to finding a solution. We need a vaccine!

[@StevenRud]

Really great video, superbly done, short and still very informative!!!👍🏻👍🏻👍🏻 Thanks for uploading. Really cool channel!😎 Best wishes from Switzerland ✌🏻

[@CrestedSaguaro520]

I firmly believe that as time progresses and medical technology continues to improve, there will eventually be cures for all viruses, infections, and diseases plus a much more efficient treatments for all types of cancer. Medical research should become a global priority. 🌐

[@wombat.6652]

If only the top 5% of rich people would invest in it. If only governments would invest in it.

[@TheAlkhemiaStudio]

cant wait to see the results of this new trials! i even would offer myself as test subjet if they had tests in my country!

[@teenygozer]

I want something that will kill herpes, which lives forever in your nerves once infected. I was infected at my baptismal, only 2 months old, and have come to realize I've had "long herpes" my whole sickly life.

[@kitefan1]

There are apparently approaches being developed. It's nasty and hides like HIV, according to Dr. Google.

[@peterg7764]

Brutal!

[@kenofken9458]

If you're getting outbreaks a lot, go on suppressive therapy. It won't eliminate the virus from your body but it will keep it in check.

[@BarryFoster-wc1ut]

I got gonnarreh from a tractor seat.

[@sophierobinson2738]

@@BarryFoster-wc1utHaving worked in a rural area in Alabama, I believe you.

[@aliengeo]

I appreciate that this episode was light on the jokes, since it's a serious topic.

[@anon58973]

AIDS is hilarious enough. No need to add jokes

[@taylor3022]

Thank you for the time & effort you put into these videos

[@FatalityPWN]

I just want a cure for my damn Crohn's Disease.

[@tesmith47]

I thought crohns was genetic

[@CrestedSaguaro520]

If you have not yet tried it, go on the carnivore diet. I helped a friend overcome serious Crohn's Disease by having him change his diet to a primarily meat-based diet. With this diet plan, your goal is to have your diet be composed of 90% meat and eggs. The other 10% can be foods such as cheese, almonds, walnuts, peanuts, and pumpkin seeds. Try to completely avoid sugar and carbs, even sugar from fruits. Two kinds of fruits that are okay to eat on the carnivore diet are avocados and bell peppers. Edit: seems I've made a few people upset, somehow. I'm not trying to talk over anyone or not listen to them. I'm not a doctor and all I did was offer an idea that helped my friend. If you don't like what I said, you're free to just ignore it. 😒

[@lornacy]

Hang in there ❤ Sorry you are dealing with it. 😢

[@michaelmayhem350]

​@@tesmith47it is lol

[@PatrickA474]

Maybe probiotics. But its going to take months to work if you can find a good strain . Try clostridium butyrate. That's the one I use.

[@evelyntodd9946]

When the search for an HIV vaccine started the medical community were told the study of FIV would be the answer. Yet I haven't heard anything about that work. Would love a video on where that research stands.

[@DM-ql6ps]

There is an FIV vaccine for cats on the market. Unfortunately, it’s not the most effective; not as good as we would want for a human vaccine. Neutering and keeping cats indoors is far more effective than the FIV vaccine in most cases and has many additional benefits. Indoor cats are obviously not likely to be exposed and neutered cats don’t fight as much or mate, so much less virus spread.

[@lars_larsen]

I have high hopes for research intoo virophages. Imagine having just a bunch of different specially made virophages shoved into your bloodstream, and then the target virus has to adapt to all of them, in addition to dealing with the human immune system, in order to survive its new circumstances. It would make it significantly harder to hide big tricks in those tiny sleeves.

[@sophierobinson2738]

I’ve seen lovely ads on tv about medicine that holds HIV inactive. It’s not gone, it’s just neutralized for a while, and you have to check often to make sure the medication is still working.

[@Koshrocreations]

So regular antiretroviral medication which people infected ALREADY take everyday...

[@TJtheBee]

I truly, truly hope that a vaccine for HIV can be created. I'm part of the LGBT community. The lives that HIV have devastated are beyond just those who get the illness . . . it affects family, friends, lovers, etc. We need to find a solution - not just for the people who live with it and are at risk for it now, but for those who have lived with it in the past.

[@milosstojanovic4623]

First find solution for your mental disorder. Then you can proceed for treatment that your "mental illness" caused. 🎉

[@AB-ee5tb]

@@DARTHFEAR0Nwhy are you here?

[@Blue-od7gy]

Clearly your lifestyle isn't possible without anti conception and medical cures, perhaps don't have sex with so many partners. It's degenerate and disgusting.

[@phooopy7941]

How's you being part of the LGBTQ community relevant in this?

[@3mar00ss6]

the solution is preventative self control.

[@JadaCol]

We need vaccines now for all diseases

[@Nemesis-db8fl]

We do but who’s going to develop them?

[@capt.bart.roberts4975]

I can remember when HIV first struck. A mate of mine worked at the arm of The Rubber Company that used make surgical gloves. He'd drop off piles of short dated condoms that me and my colleagues, would take turns dropping them off around pubs and clubs on weekend nights. It was a right pain, you couldn't drink. I soon figured out that if we were on call Friday or Saturday night, we did the job between call outs because you can't be pissed in a operating theatre.

[@dmcepeda]

Vaccines are not just good for the individual but for the collective good of the entire community. Infectious disease can't be eradicated unless you take the immunizations for prevention

[@erinmiller1433]

Also, some people _can’t_ get vaccinated, and they rely on the rest of us not to infect them.

[@giespel68]

Only if you believe the lies of big pharma and the hidden criminals that want to eradicate the human population

[@muhcharona]

There are obviously evolutionary arguments against that, "good" is not so simple.

[@wernersmidt3298]

I'm part of the BRILLIANT consortium and we're actively trying to get a cross-continent vaccine for Africa. bnAbs are central to this and they are absolutely fascinating. *There are some bits in the video that I think are at least partial inaccuracies, though. I have to check first

[@ikechiude]

We watch this news every year. When is soon, please?

[@NitroIndigo]

Reminds me, has anyone tried making a malaria vaccine, or is it actually impossible to vaccinate against eukaryotes?

[@normalchannel2185]

Malaria vaccine is in the works, but not a huge priority, because it can be treated, with good levels of survivability

[@sophiedowney1077]

There are actually 2 approved malaria vaccines! They don't prevent transmission, but they massively reduce serious side effects and death. They're like 70 and 77% effective. There's still a shortage because they haven't been able to produce as fast as they need, but they exist, and they've already saved likely thousands of lives. And once they're up to production, they will make life so much better for everyone who lives in malaria endemic places.

[@AykevanLaethem]

Also, malaria is very difficult to make a vaccine for. Just like with HIV, it's not for lack of trying.

[@NitroIndigo]

Are there any other widespread diseases caused by eukaryotes? The only ones I can think of are fungi that infect one part of the body.

[@AncientWildTV]

i think there is this RTS,S/AS01 vaccine

[@bluemax77]

Very informative presentation. Thank you.!!

[@Dellvmnyam]

Oh boy... I would rather have seven injections rather than taking pills every day or injections every month for life. But the HIV vacine research still looks a lot like the nuclear fusion research ^_^

[@sophiedowney1077]

Although, we actually are really close with nuclear fusion. They reached ignition (where more energy is produced than enters the pellet) a few years ago. We're getting there! Never before have we had as much understanding of either topic, and that understanding is taking us so much farther than we ever could have achieved before.

[@Dellvmnyam]

@@sophiedowney1077 I know that. Every moment we learn something new meaning that every moment becomes the moment we have better understanding than ever before. But also every moment we find out more things we need to understand to achieve the result we need. Ignition was certainly a breakthrough and a milestone, I remember how excited I was about it.

[@d-meth]

Do those pills have sideffects or do you just not like the idea of having to take pills?

[@kitefan1]

@@sophiedowney1077 But since I started paying attention, about the mid 1980s, fusion is supposed to be 10 years away. Pass the salt.

[@mgancarzjr]

​@@sophiedowney1077we are not close to fusion. The energy required to deliver that amount of energy to the target was many orders of magnitude greater than was released.

[@thehomeschoolinglibrarian]

It is amazing to think how far we have come in the last 44 years. It was not that long ago that HIV was both a death sentence and only wishpered about. It would be cool that in one life time we could go from death sentence to vaccine. It may not seem fast but if you look at how long we have taken to get where we are at this is fast and covid was done a ludicrous speed.

[@lornacy]

I remember when the AIDS epidemic first started; my (judge-y, smug) boss said, "The only way to get AIDS is doing something you shouldn't do."

[@GothicElf68]

​@lornacy People lime that self-righteous and judgemental boss you had, were and continue to be a major part of the problem. They created the stigma surrounding HIV/AIDS that still exists today. But, "doing something you shouldn't" isn't and never has been the only way to contract the virus. Especially in the early days, people got it through blood products. L I kewuse, someone can be a crime victim and get it. Also, emergency responders and medical personnel can get it through accidental, work related exposure, despite using PPE. That person was not only smug, they were ignorant.

[@kitefan1]

@@lornacy Like having open heart surgery as a 50 something to repair damage from rheumatic fever as a kid.

[@lornacy]

@@kitefan1 It's amazing how messed up victim blaming can get.

[@kitefan1]

@@lornacy yes. of course, part of it is/was fear. If it only happens to "other people" I/we am/are safe.

[@Imbrium66]

This video went into a lot of details about antibodies, there are actually vaccines being developed that aren't antibody mediated. I used to work on one using L.E.A.P.S. technology (Ligand Epitope Antigen Presentation System). These are not always antibody mediated, utilizing Th1 mediated cell killing of infected cells instead of Th2 (antibody) mediated means. I believe they were working on HIV, at least in part. I didn't work on that one personally though so I'm not 100% sure. Lots of different options available, many outside of conventional thinking.

[@MannyEspinola-q4t]

Thank you for this video

[@Palytoxine]

0:50 getting born into the world is already a death sentence

[@Jelly_Skelly]

Thank you for the irrelevant comment

[@mqb3gofjzkko7nzx38]

It's a life sentence.

[@AntonKryu]

1:11 So this is what they meant when they said that Batman can take anyone with enough prep

[@curiousnerdkitteh]

With BnAbs this sounds like the body is literally performing supervised machine learning to tackle the virus. This has a very "big data" feel.

[@JamesBarry-j7m]

HIV + since 1998 here

[@marccilliers4808]

Shame on you🤢🤮

[@bibikstar7131]

@@marccilliers4808 shame on YOU, you have no right to judge anyone. Honestly, look at your own life-I'm sure someone living with HIV is much happier and more fulfilled than you are.

[@thebeautifulanimal]

​​@@marccilliers4808 what kind of human are you? Shame on you!!

[@thefailure7789]

@@marccilliers4808 what the hell is wrong with you

[@marsallen4298]

@marccilliers4808 Troll

[@truee-nh2bc]

Feel bad for the people who have this.

[@jiancuervo820]

You should not be, nowadays they are living normal and healthy lives.

[@korshie-p7s]

We live a normal life like we are negative so… just relax and don’t feel bad for us

[@InquisMalleus]

They tried for decades to make a vaccine for RSV, and failed each time. Every inactive or attenuated vaccine failed every time. One of the very first tries of an mRNA vaccine worked. Very encouraging for HIV.

[@xoxo2008oxox]

Not just HIV but how about Herpes family (HSV1 and HSV2) as well as other STD that are now becoming too prevalent. Syphilis, Gonorrhea,...

[@chromeshellking]

Hsv is currently getting alot of attention as well since it falls into the same category of lifetime infection. Gene edits have shown through the FHC with Dr. Jerome they started with edits that made 1 cut then swapped to 2 cuts and have since refined the method to now only using 1 AAV and 1 mega nuclease and it its about 97 percent efficacious at removing latent viral particles hiding in the nerves. Which is massive at the 95+ percent range so likely will be seeing a cure for that VERY soon. Which in turn should accelerate the research to HIV being cured.

[@cajampa]

Very cool. Where can i learn more about this? Any space or site where i can follow the progress in more details like you seem to have? When i try to find info about these things i only seem to find press releases.

[@tru7hhimself]

hsv is difficult with so many different strains (might be a candidate for mrna vaccines though), syphilis and gonorrhea are easily treatable with antibiotics.

[@chromeshellking]

@@tru7hhimself Not sure if are aware but the strain for both syphilis and gono are becoming resistant to medications and could become no longer treatable if they dont figure something else out. Hsv may have strains but those strains would not be able to mutate fast enough to say gene edit's being used to treat/cure it as its outright ripping the viral body apart. And vaccines for it sadly just dont translate well to giving a lasting immune response to be enough to give some for of protection at the blood lvl. However they did rethink this after a few trials didnt give great results so they are thinking what about a skin effective vaccine instead. Will be interested to see how that plays out.

[@cajampa]

@@chromeshellking My question in this thread was meant for you. Do you have any hints of where I can learn more about such things and follow eventual progress. Every time I have tried I only find some sanitized press release with almost no details. And certainly not any juicy details about progress and such.

[@brylythhighlights4335]

PrEP is also stupidly expensive :(

[@laughterismedicine971]

Can you do one about why we have a lyme disease vaccine for dogs but not for people??

[@kennethgan78]

the one created prolong life was given a raised and promotion, the one created the cured was put to rest forever.

[@vansdan.]

we'd have figured it out by now if it benefited the oligarchs in any small way

[@markmuller7962]

Putting "coming soon" in the thumbnail it's maybe a little bit reckless

[@Elhuarache]

wasn't lenacapavir released to the public, like yesterday?

[@JCel]

Yes, it's such a big thing that I have wondered why they didn't talk about it.

[@DiKambingcorn]

I hope the humanity can develop a cure for cancer and diabetes.

[@thegoldenguy9777]

3:27 so just throwing stuff to the virus and see what sticks.

[@Funnyguyhithere]

Wow, this makes so much sense! When my infection hit the 6-7 year mark I had all types of auto immune reactions like thyroiditis, arthritis and celiac like disease but somehow I had a very low viral load the whole time. I wish I had tested for bNABs back then

[@billberg1264]

This might be a dumb question, but since these bNAbs are proteins (I think), and mRNA contains instructions for producing proteins, is it possible we could inject mRNA with instructions for producing the bNAbs?

[@lunkel8108]

No, I don't think that would really do anything long term. mRNA is temporary. The mRNA used in vaccines is modified to last longer but it's still not permanent. So the effect would be that some random cells throughout your body would start producing moderate amounts of antibodies for a few weeks and then stop again. Antibodies are relatively long-lived in the blood but they also don't last forever. Your immune system would not have learned to recognize any antigens. Even if the effect wasn't temporary, I don't think you would want your body to constantly be producing the huge amounts of antibodies actually needed in case of an infection. Not only would that be pretty resource intensive, the video mentioned that they can apparently also be autoreactive to a degree, so having them present in large amounts at all times seems not ideal to me. There's a reason why the B-cells that produce antibodies normally replicate very quickly once activated and then mostly die off again once the infection is gone. And I don't know whether that level of protein production is even feasible to achieve with the current technology we're talking about. That's all coming from the perspective of an alternative to a long-term vaccine. Something of that sort might have more promise as an alternative to monoclonal antibody treatments but I can't really say more about that

[@AncientWildTV]

@@lunkel8108 do you think there are any approaches for improving the longevity and effectiveness of mRNA vaccines in producing lasting immunity?

[@lunkel8108]

​@@AncientWildTVWell, that's a pretty broad topic and almost entirely distinct to what I'm talking about in the comment above. In an mRNA vaccine, the mRNA doesn't code for antibodies but rather the antigens that your immune system then develops immunity against. And you want the antigen production to be temporary. Of course there is a balance you have to strike with that. While I do work as a biochemist in drug discovery, I am very much not an expert on mRNA vaccines or immunology, so I don't think I'm the right person to ask about deeper reaching questions on this topic.

[@AncientWildTV]

@@lunkel8108 I know its a little off topic but your comment is fascinating. Thanks for your info

[@analyticalman4829]

Thanks!

[@niaschim]

Hearing about immunology reminds me of troubleshooting Linux without the internet.

[@dhillaz]

Difficulty: Gentoo

[@matthewtoohey4103]

"If anything, the success of COVID vaccines has only injected new hope into their search." I love the way Savannah really leans into the puns in their scripts but there's something endearing about the way Stefan barely skipped a beat with this pun.

[@johnd.5601]

If you're in America you can live but you're going to be homeless. I've had a few life saving operations. If you make 1 mistake in America you and everything you have learned and achieved will be taken.

[@paulgrey5345]

@@johnd.5601 better move to somalia just in case something happens 😂

[@sphinxspirit]

suggest to complement the explanation with the life cycle of hiv virus, think that will be more comprehensive. nonetheless good explanation for laymen 😊

[@nariu7times328]

"injected" new hope. Heh :)

[@vicvict4172]

Be safe and informed .

[@christianneotieno6951]

First time I've been this early to a scishow video

[@conditcatsog]

The best way to solve hiv/aids would be to convince each t cell along with the brain to correctly detect the corrupted cells and determine that they belong to a disease rather than to the human body

[@ianhall7513]

With the retroviral nature of the virus, I've always wondered if a gene therapy utilizing crispr cas-9 would be able to remove the segment of viral DNA from the genome. If only crispr were less ethically charged as a topic.

[@chromeshellking]

So the recent study for that while it didnt have the results we would have liked to see was a few silver linings. It didnt get all the retrograded cells but it did extend the 1 month viral rebound to 4 months. It just needs to be refined I feel.

[@geolinotag9502]

I really hope that they can fine the cure for hiv

[@bytchkovovihredino]

Through this channel you can get completely rid for HIV diseases. www.youtube.com/@dregobe

[@happyvirus6590]

0:42 that one Chinese doctor in 2018 💀

[@edwinku5651]

I know exactly what ure talking about 😢

[@gc31]

??

[@happyvirus6590]

@@gc31 this one, bro kzbin.info/www/bejne/rZPRmJ6CjZl8gbMfeature=shared

[@naknamfucha5758]

?

[@nikkithediva]

I work for the hongkong biotec HIV research team. And very soon we will have vaccine and cure. But we need all of your support and prayer that God gave us more wisdom. 2 trail successful. Working on final trial.

[@jakericcitelli8044]

I know that this episode is about an hiv vaccine, but I want to share that most dating apps tend to offer free access to prep. Home tests are even available so you don't have to leave the house.

[@anon58973]

Yuck

[@fullnewsky]

Good to know

[@NirvanaFan5000]

amazing to see how new tech like mRNA vaccines and AI are being used to rapidly advance medicine.

[@kenofken9458]

I was involved with the HVTN 505 trial about a dozen years ago. DNA prime with a booster delivered by an Ad5 vector. It was a conceptual evolution from the RV144 trial in Thailand which was reported to reduce infection by 30%, which seemed incredibly promising. Of course it flopped, but that's the nature of the problem. Most vaccines are ways to ramp up the body's natural immune response that defeats a virus. One problem is that the human immune system doesn't defeat the virus, with the exception of some elite controllers. I remain hopeful, but before we have a cure or vaccine, we have PREP medications that when taken properly effectively eliminate risk of infection.

[@SpaceXfan2005]

Ok

[@djksfhakhaks]

I thought there was one in clinical trials already.

[@reinpinebook825]

Even one makes one, the big companies won't let it. ART is a money printing machine.

[@macman2141]

It is more profitable for the pharmaceutical companies to treat HIV a persons entire life vs find a Cure SMH!!

[@tru7hhimself]

thankfully, most such research is carried out at universities with public funding. pharma companies are more interested in creating a derivate of something that's already proven to work, or develop an interesting lead that has been discovered at universities into a product. so if it's not pretty sure to work they won't pour in their money, they rather outsource risky research (like research on hiv) to be funded by the public. capitalism at work.

[@DAnthony14]

You’ve got the right idea. That’s why it was made sure to get the virus out here in the first place smh…..there’s cures out there for a lot…if you have the $ and know the right people. Don’t shoot the messenger

[@MoncœrCoyoteSmith]

Would it be more pheasible to create blood products with the antibodies or cells of a person who is immune?

[@AngryKittens]

Your own cells do not recognize the cells of another person and treat them the same as any other intruding pathogen. It's the reason why organ transplants are so difficult and fail over time. Also the reason why blood transfusions have to match blood types, or else it triggers a massive immune response, leading your immune cells to attempt to destroy ALL the foreign red blood cells. Often causing anaphylactic shock and widespread collateral damage on your body's healthy cells.

[@Furiends]

I can't rave about mRNA vaccines enough. I was lucky enough to have understood how these vaccines work and the research (that we were lucky enough to have in time for COVID) many year prior to the pandemic. What the approval process for COVID-19 has shown us is if there's a will we can absolutely get these things out. mRNA benefits are pretty much useless if most everyone isn't vaccinating despite being a massive advantage compared to traditional vaccines.

[@wombat.6652]

My understanding is that if More scientists are working on a problem it will get solved sooner. So yeah more funding would help with h.i.v and t.b.

[@xlr8techtv576]

WHY DO THEY HAVE A PATENT ON THE DISEASE IN THE FIRST PLACE.

[@deshaebeasley]

What does the HIV virus look like?

[@FirstLast-ll8zq]

@@deshaebeasley wh-what?

[@deshaebeasley]

@@FirstLast-ll8zq you know how sometimes there's a molecular structure model which shows how a virus looks? I couldn't find one for this virus.

[@lunkel8108]

@@deshaebeasley The incredible David Goodsell actually has a few pieces on HIV! He draws highly accurate and very beautiful images of molecular processes based on a lot of data like protein structures and concentration measurements. KZbin usually doesn't like posting links, so I'd just recommend you google "David Goodsell HIV" or something like that and take a look at the results

[@FirstLast-ll8zq]

@@deshaebeasley oh, sorry, I was expecting your reply to be “do they speak English in ‘what’?”

[@FirstLast-ll8zq]

@@deshaebeasley typically when you see imagery of a virus (specifically the spherical shape with protein spikes all over it), it’s that of the HIV virus, specifically. It’s the one that’s round with those protein “spikes” around it. I grabbed a link for you too: www.aids.gov.hk/pdf/g190htm/01.htm

[@aaronha994]

Currently ive been exploring frequencies that are tuned to destroy tageted cells, bacteria, or viruses. Each has there own unstable vibration. Finding ones that only destroy the target is the real trick. Perhaps layered amd or multidirectional delivery could overlap and be more effective.

[@thexanderthemander]

Yay, no mid roll ad.

[@JayKay9112000]

The genetic mutation that survivors of the Bubonic plague had makes them nearly immune to HIV. There were two embryos that were genetically altered to have this mutation in China (2018).

[@Siel-Lytle]

If everyone got tested and knew their status we would be that much closer to eridicating it

[@cjgparas3]

As long as magic johnson is alive. Hope is not lost.

[@WhiteMouse77]

Prevention first! Don't go intimate with anybody untested!

[@GothicElf68]

Not just making sure to get tested and have your potential partner also tested, but to use preventative such as condoms and dental dams. People can have HIV and still test negative.

[@stevenmugnaini2938]

aint nobody got time for that. thats way too many people to test all at one time. just make sure everyone has condoms

[@jaloswaggons2182]

Nonsense, in many developed countries it's trivial and affordable to get tested. Do the responsible thing and get tested

[@stevenmugnaini2938]

@@jaloswaggons2182 u want me to test 45 people at the same time?!?!?

[@antoniolum1506]

Well, here's to VAIDS and mRNA technology. I have great hope we'll be able to make them very cheaply and profitably like our current predecessors. God speed science we'll get through the caveats like frameshifting etc in a jiffy. One day we will have a cure just like for cancer. Seems like they'll be one and the same interestingly enough.

[@karlwilliams6227]

September 2018 rocked my family with the hurricane Florence. To lives and properties displaced we gave $45k. We also gave in 2020 COVID year. The "Treasure Principle" by Randy Alcorn helped my giving reason why getting $105k in two months is just evident of God's blessings on my household. God never faltered on his written and spoken promises over my household

[@stevenmike7775]

It was a tragic time to have been a victim but giving speaks volumes. Great post friend

[@MohammadDiluar4042]

This has got to be the nicest thing I've seen and read online today

[@MohammadDiluar4042]

How do you get so much in that period of time???

[@rubendavids]

That's humanity. We still have humanity in a cruel world. Thumbs up 👍

[@MohammadDiluar4042]

Still trying to wrap my head around this. Is it some retirement benefits?

[@StephanieMoir-s4h]

No thanks.

[@jameskaraganis2569]

Alas, cures are less profitable than lifelong treatments.

[@crocopie]

Hprep is already a great help in hiv prevention.

[@azadam001]

My opionion & plot twist... They already found hiv vaccine however they dont want to released it...😅

[@Lefkefb]

Why

[@damiboy65]

We got hiv vaccine before gta 6

[@jamesdietz29]

I wonder if scientists have looked at people who have over active immune systems to see if there is anything there that could help in the fight. People... including myself with Plague Psoriasis for example, have immune systems so aggressive that it actually attacks their own bodies, hence the plagues, sore joints and connective tissues. It's genetic, once these genes are turned on the immune system goes into over drive. If we could isolate what turns these genes on and target it to focus on HIV it might help those who immune systems were weakened by HIV. I'm no scientist, this is just something I thought of so I'm quite certain other more intelligent people must have thought the same or similar.

[@kitefan1]

I have other immune things. I am confused by the fact that I have a "compromised immune system" when it seems to be overworking quite well in at least one area.

[@claireg3429]

​@@kitefan1I create huge amounts of histamine in allergic reactions, I think every immune cell is in full battle mode during a flare up. It's like the battle of the Somme inside my blood stream.

[@kitefan1]

@@claireg3429 Yeah. I have to look more into what is going on. Celiac in particular is an inflammatory reaction but I'm not sure how much histamine is involved in the non-allergic immune reactions.

[@LeukeGast]

So they can't get totally immunity wuth mRNA vaccines? What about vaccine escape mutation variants?