Glad to find someone else who does. I swear they must put cocaine into it! ;)

I was very disappointed about it. Some people are saying maybe 30 days wasn't enough to judge the effects of it but I'd have to see the actual trial.

Cheers, thank you for the recs

I fully concur! Peter Deen is doing his best to get this start-up off the ground, always hard with ME/CFS to get funding, but he'll keep fighting on.

Oh my, what terribly sad news. I just looked up their update following reading your comment.

@me-cfs-strategiesforhealing yes it is. Big Pharma should invest, but they need profit calcs first = feasibility and unfortunately nothing happens so far.....

There are studies on the role of Muscarinic 4 receptors in addiction in humans too. Yes, we have a prefrontal cortex but that doesn't mean that M4 receptor dysfunction won't effect dopamine signalling in humans and therefore play a role in addiction. Note also that that part of the video was an attempt to inject some humour....

Yes, it is probably the lesser of two evils. I would not want to do it forever but for now, it makes a dramatic difference. In the context of an illness which itself causes salt loss, I often wonder at what point salt replacement might cause kidney problems.

​@@me-cfs-strategiesforhealing Are you referring to Hypovolemic POTS or ME/CFS causing salt loss?

Hypovolemia in both are significantly caused by salt loss due to RAAS suppression, although there are some other reasons for the hypovolemia too.

I don't measure the CO2 directly but you can use the 'control pause' test to measure current body oxygenation capacity. Patrick McKeown calls this the BOLT test - Body Oxygenation Level Test. Sitting quietly, take a normal breath in and out, hold your nose, count seconds till first urge to breathe. Of course, there are many factors in BOLT scores (for example, low blood volume reduces body oxygenation) beyond just CO2 but it is one of them. Interestingly CO2 has been found to be very low in Long Covid but the breathing patterns do not show the expected level of hyperventilation (for such a low CO2 level) suggesting that the low CO2 in these illnesses is primarily a problem of CO2 production being reduced in the cells rather than overbreathing.

Thanks for the tip

Thank you for the helpful advice. I agree that neither are ideal but the ORS is very helpful for quality of life at present and the chocolate....I'm a bit of a hopeless case but hopefully I'll drop it at some point.

Yes, I am aware of that problem but I'm not sure how to fix it. I'd assume higher fat but it seems your diet already was high in fat.

I haven't no, apart from recognising that mold can be a problem for many. Dr. Neil Nathan has a recent book all about mold. I notice that I feel worse in mouldy houses.

Waiting patiently!

Check out my video titled something like 'autoantibodies: no big deal' (published around the same time as this one) for counterarguments to your comment.

Best of luck with the tapering. I found it very hard as well. 'Slowly does it' was my mantra for getting off it. I haven't retested my thyroid labs and cortisol since stopping T3 five months ago but I plan to next month. I can feel my cortisol back in action again thankfully and I never want to lose that feeling again.

They often do sadly. It's been the story for me too, even when I was experiencing life-threatening episodes caused by ME.CFS

You are welcome Danielle. In relation to this and the other question, really I find Oral Rehydration Solution the most helpful treatment - mainly drinking it rather than normal water (for the most part). I add around four grams normal salt daily also to my food (in total, two grams to each of my two meals). Some people take Flurinef (a synthetic hormone which replaces aldosterone).

Hi Eric, unfortunately testing for microclots not available - I believe - apart from Pretorius' lab in South Africa and Jaeger's in Germany. Look at some of my other videos about microclots (published around same time as this one). Darker blood in a test tube, drawn from upper arm, and a very low ESR rate may be clues. Good luck

I have indeed but I haven't studied it in detail

@@me-cfs-strategiesforhealing thankyou for your reply. I have m.e and fibromyalgia and autoimmune hepatitis. Is fibromyalgia and m.e an autoimmune disease!! It's been an horrendous 10 years with these 3 diseases ....I absolutely pray for some treatment 🙏 I'm so glad I found your channel

Hi Christine. ME/CFS autoimmunity is different from other illnesses. The body is not attacking itself but the autoantibodies are instead blocking various functions to further heighten ME/CFS pathomechanisms. Not everybody with ME/CFS has the autoantibodies and, among those that do have them, the degree will be different. Testing can be done via cell trend lab (see my video on testing) though that is a little tricky if outside of Germany (though not impossible). So in ME/CFS, autoimmunity is best thought of as a secondary dysfunction that can be brought on by the illness and make the overall situation additionally worse, but the degree to which it does this will depend on person to person.

Hi Christine. ME/CFS autoimmunity is different from other illnesses. The body is not attacking itself but the autoantibodies are instead blocking various functions to further heighten ME/CFS pathomechanisms. Not everybody with ME/CFS has the autoantibodies and, among those that do have them, the degree will be different. Testing can be done via cell trend lab (see my video on testing) though that is a little tricky if outside of Germany (though not impossible). So in ME/CFS, autoimmunity is best thought of as a secondary dysfunction that can be brought on by the illness and make the overall situation additionally worse, but the degree to which it does this will depend on person to person.

That's a great question, Danielle. It's not definitively proved yet. In fact, as Wirth's pill would be correcting the dysfunction, it the response to the pill that can ultimately prove the theory one way or the other. What we do know however is that high intracellular sodium is an issue in ME/CFS and a dysfunctional sodium-potassium pump will be the reason for that. If we have have intracellular sodium, then you tend to get high intracellular calcium as well and that makes the cells even more dysfunctional and the muscles more painful. So the pill would potentially correct the high intracellular sodium and resulting high intracellular calcium.

@me-cfs-strategiesforhealing okay, gotcha. My understanding was that the muscle burning was caused by acidosis. Ron Davis' crew believes the problem is a shunted Krebs cycle. They say the resulting anaerobic metabolism is to blame for the acidosis. Is the mitodicure group's theory opposed to Ron Davis' research, or do they believe this potassium/sodium pump issue is just adding to the muscle pain? Thanks so much for the response!

Indeed, Wirth includes the acidosis part. The sodium-potassium pump issue is just one part of the cycle of dysfunctions at a cellular level but, for Wirth, the most important one to target. There is a KZbin channel for The Irish ME Trust (channel is called 'ME Ireland'). There you can find a talk I gave in January of this year (titled something like 'ME/CFS and hypoperfusion'). That outlines a bigger picture view of Wirth's research and where the cellular issues fit in. Interestingly Davis also suggested the excessive cellular stress of ME cells in response to a hypertonic solution as a biomarker for ME/CFS. That ties in with the idea of high intracellular sodium being at play.

@me-cfs-strategiesforhealing thanks so much for the response! I'll definitely look up that video.

Hi Danielle. It needs to be funded first and then there may be some announcement about trials. However Wirth is connected to Charite University Berlin which has a lot of ME/CFS patients. My guess is that that would be the cohort used (but I don't know)

You're welcome

More the muscle PEM and aches in my experience.

Thank you very much! Likewise, this is the pill is what gives me the greatest hope. But, as always, ME/CFS and money for funding is tricky to come by. But let's indeed manifest it and if you happen know of any billionaires, maybe mention it to them!

Unfortunately not

@@me-cfs-strategiesforhealing They're going to give their results in November in a Long Covid Conference. Seems unlikely to have completely negative results if they're going to present their findings in a Conference?

That seems likely

I've looked at it a bit before Angel. Might do a video on it some day but my feeling is that it is one just one dysfunction among many inter-related dysfunctions

Thank you for sharing.

Best of luck! I'd be interested to hear how you get on.

Yes but the context of my remark is about Ribose specifically. I find it hard to believe that women would only produce 2 grams of Ribose daily and men 18 grams, given how crucial ribose is in creating ATP, the body's energy currency molecule. So I'm not sure that the Norwegian booklet I read can be right.

I plan to do that video in the future but hard at work on a book at the moment. I'll be getting my full thyroid labs (and cortisol) this autumn and I'll include those. I think I'm doing okay thyroid wise. I might be a bit hypo but I don't think anywhere near as bad as I was some years ago. And I think I am doing well with my cortisol again, pending labs.

@@me-cfs-strategiesforhealing Thanks for the reply. Glad to hear you're better than you were before. Hopefully your labs reflect the changes. Look forward to your future video. I hope you can include dietary, supplement and meds that helped you.

You are welcome and thank you. I'm a carnivore these days which I find helpful (have a couple of videos on that).

Unfortunately, Klaus Wirth still needs funding for a trial. Keep an eye on Mitodicure's website for updates.

Es gibt keine Behandlung bis zum Abschluss der Phase 3. Es wird 5 bis 10 Jahre dauern bis alle gesetzlichen Vorgaben für neue Medikamente erfüllt wurden. Es ist eine großartige Nachricht, dass ein Pharma Gigant wie Sanofi Millionen in dieses Medikament investiert. Aber bis dahin gibt es keine Option behandelt zu werden. Tut mir leid. Das Gute ist, wenn das Medikament funktioniert, wird es eine Methode geben, dass Patienten und zukünftige Opfer dieser grausamen Erkrankung eine teils oder vollständig wirkende Behandlung bekommen. Alles erdenklich Gute für alle ME/cfs Patienten.

Around two weeks. And then again a few months in.

@@me-cfs-strategiesforhealing how many months exactly would you say? After the 2 weeks in what way did you feel better? More energy? Less waves of feeling ill and tired?

3 months. After the two weeks, my legs felt lighter. I could do 8,000 steps per day rather than 6.000. Crashes lasted half as long.

Thank you Mark for the kind words. I'm sorry to hear about your son having Long Covid. The vegan mindset is hard to break free from. There is a KZbinr - Ribeye Rach - who was very severe with POTS and who is doing very well now thanks to a mixture of brain retraining and carnivory. Also someone called Rebekah Heishman whose story of recovery is very powerful (I'm pretty sure she had ME amongst everything else) I'm giving a talk to the Irish ME Trust in a few days - which should be posted on their YT after (channel is called 'ME Ireland') - about why carnivory might help ME/CFS. I don't know if your son might be open to looking at those resources or not but just thought I'd mention in case. Positive examples of people improving can be more inspiring than anything else.

Thank you JP, that's kind of you! Yes, I'm fine. I haven't posted any videos in a while as I am working on a book about ME/CFS. I hope it will be out by November and - after a bit of a break - I'll be back on KZbin

@@me-cfs-strategiesforhealing oh that's great to hear! Wishing you goodluck with the writing! 👍

Thank you JP!

That's exactly the problem - the funding. Perhaps in any other illness, it would be a different story, but it is just hard to get the money in ME/CFS. It would help with post-Covid ME/CFS as well (and of course post 'poke in the arm' ME/CFS) so perhaps emphasising the Long Covid aspect more would help him in trying to find the funding.

No. My diastolic BP goes higher when I stand up though but that can happen in ME/CFS.

@@me-cfs-strategiesforhealing Heart rate remains normal?

​@@me-cfs-strategiesforhealingBecause POTS is defined by an abnormal increase in HR upon becoming upright in the absence of orthostatic hypotension can you please clarify why you're using your BP as an indicator as to whether or not you have POTS?

'No' was the answer to the POTS question. The rest of my comment was providing some information about the kind of orthostatic intolerance I nevertheless experience as part of my ME/CFS.

​@@me-cfs-strategiesforhealingThank you