2 Things to Supercharge Collagen Production by 50%!

[@Physionic]

2 NOTES Note 1: Some of you might be aware another study released indicating collagen supplementation did not change connective tissue synthesis (which was covered by Dr. Layne Norton recently). Several things to point out here: one, there is no doubt significant room for re-interpretation of some of the collagen research (it is not a 'sure thing' yet); two, that study (PMID: 39086044) was in younger individuals, so it might indicate collagen is only effective after a certain age (unknown, but suggestive). Note 2: I mention that collagen supplementation increased collagen synthesis in the body with both collagen conditions, but I made the mistake of not showing the AUC data, so the only data shown indicates a high dose is effective, but not the lower dose. The statement in the video is correct (both doses worked), but I should have shown the AUC data other than just the line data (as shown at 2:51). My apologies.

[@ConejoValley1A]

Thanks again! Your communication skills at making complex, unfamiliar science topics simple for us plebs to comprehend. Oh and keep up the Dad jokes😁

[@Physionic]

@@ConejoValley1A Thank you :)

[@ThingsYoudontwanttohear]

Were the collagen doses matched with different proteins like whey or was the control group (placebo-controlled I hope) given no protein replacement whatsoever? And how much more does the highest dose of collagen increase the marker for collagen production compared to strength training? (An educated guess would do. Obviously, no hard numbers exist.)

[@tgaudlol]

If you are interested, be aware that most studies on connective tissue synthesis are obsolete because it has been discovered that it start around 24h after effort. While most studies measurement take place just a few hours after effort. And collagen intake increase collagen synthesis in all the body, while exercise increase the synthesis only locally. But the effects arent additive Also its highly related to a glycine concurrency in the blood.

[@LK-pc4sq]

I have diabetes and like to know what can I do to reduce the join pain "I know, watch my carbs/sugar". What really blew me away, was not only was I ignorant "now I am not" on metabolic disease, but so was my mom, who was a LPN nurse of 40 years. I asked her "Why did the hospital teach you nurses of causes of obesity and metabolic disease" shockingly they did not! She did retired about 14 years ago from a hospital in the PNW. Between 1998 and 2020, NOT A SINGLE doctor or even Physiologist EVER asked me about my diet or my Obesity and how they can cause potential future Metabolic Syndrome. Now I have and makes me angry that I may have limited my life span by six or more years. The only way to know is to take a Telmere Test. BTW I was kicked out of Winco because I was recommdning healthier food options to customers. Do you have any research prior to 1975, how much of the Typical groshry store content were Highly processed foods and which were whole foods? My mom is now 80 years old and she has a healthier heart then me!! she NEVER snaked or ate after dinner. she was a nurse of 40 years "40 years of cardio" I told her because of that job, she is here and alive. She takes a mild amount of medication. I am recommending the supplements to her and asking her to goto the Gym to increase her ATP every three days!

[@Itisrealtalk]

I have seen NOBODY....not even a single researcher or scientist or any learned person like you talk about boosting "Elastin" synthesis naturally. Everyone talks about collagen boosting and related things but there's absolutely no discussion about elastin boosting in humans. We do lose elastin as well with increasing chronological age and with less of it, our skin sags. I'd love if you could be THAT FIRST PERSON to talk about "naturally boosting elastin production". Thank You!

[@ConniePretula]

One of my clients injured his ACL and MCL running, he was 66 at the time. I put him on Hydrolyzed Joint Collagen, Hyaluronic Acid and Boswellia. He stopped running to let everything heal. His doctor told him he would never run again 🤔 He walked regularly to stay fit. After a year, he decided to try running again and did not have any pain in his knee. He is running 5 days a week and some weeks a total of 40 km. His doctor was amazed at his recovery. This was enough for me to confirm the benefits of a quality collagen product. I should add, he did not have surgery to repair his ACL or MCL.

[@jmc8076]

Interesting and happy for him. I’m curious which product made the most diff. It’s why for me I intro one change at a time per advice of one of my specialist. It helps me to identify what’s causing neg effects if any or positive.

[@user82938]

The Hyaluronic Acid is injected?

[@ConniePretula]

@@jmc8076 I agree but based on his injury, he needed both to support the healing and the joint. I used to take both personally and stopped the hyaluronic acid and found that using collagen alone is enough to support my joint health.

[@ConniePretula]

@@user82938 no. It was a supplement form.

[@shar7508]

Can you tell us what Boswellia and hyaluronic acid you used and how much? Thanks!😊

[@zaya2041]

Taking 30g of collagen a day has helped my joint pain so much more than when I was taking 20-22ish grams. I felt the benefits of upping the dose almost instantly.

[@presence5426]

Interesting. I'd think you would see benefits with either dose.

[@Pokerface8899]

What collagen do you take

[@zaya2041]

@@presence5426 I thought so too but look up “Siim Land”’s video on megadosing collagen (30g). I upped my intake to 30g and saw more results in my joint pain when I’ve been taking 20grams for months.

[@zaya2041]

@@Pokerface8899 “Bulk Supplements” marine/chicken collagen. Originally I was taking collagen for skin benefits so I started off taking the marine only. I recently incorporated chicken because it’s high in type 2 collagen which is supposed to be better for joint. So 3 tablespoons of marine and 1 tablespoon of chicken has been working for me. And they’re on sale right now on Amazon for Black Friday!

[@quand_meme]

Take MSM.

[@greeneyeddevil1]

I am Sixty something and I remember my grandmother taking gelatin in fruit juice to help with osteoporosis

[@tijmenmolder]

Since collagen is mostly glycine, is there any research on the effect of glycine supplementation on collagen production?

[@Physionic]

Possibly, but I haven't looked. I'll check it out.

[@Nando_lifts2021]

I believe siim land has looked into this and glycine is super important. Good to here your take on it though!

[@alexxxO_O]

@@Physionic Physionic, please cover glycine's effects on collagen production! I've heard many people talk about how we can sometimes need up to THIRTY grams of glycine a day for optimal collagen synthesis!

[@TheSmiaf]

Also taking this (glycine)! Plus cheaper.

[@nieczerwony]

​@@PhysionicIt would be good if u could cover how glycine supplementation can cause depression, based on the research done on gpr 158 receptor.

[@scottymackay1801]

I've been on and off collagen several times testing it. Have seen zero benefit in skin improvement (although my skin is pretty good) but did notice the knees feeling better each time I went back on. It was enough to convince me to keep taking it.

[@msgirl01]

What kind r u taking

[@scottymackay1801]

@@msgirl01 Marine collagen

[@grunchidetrap476]

Crazy coincidence, just bought a high quality collagen supplement for the first time today

[@superpauleesworld8170]

OMG love your decor/pics for these vids! And that pink floor light shining up! lol! You are so funny, brilliant yes, funny too yes! And what IS that small pic? It looks like a dark scary mask on an alien or something! 🤣 But you get away with it all because you're so freekin' brilliant!! Love your vids - all of them bro!

[@dcjohnson2208]

I’m male(octogenarian). I notice significant skin improvement taking collagen with Hyaluronic Acid.

[@alaneverett9767]

High molecular weight or low molecular weight?

[@dcjohnson2208]

@ high

[@zack7smithey]

I’ve noticed a difference with this combination as well

[@GhrelonMelon]

What dosis Hyaluronic Acid?

[@MadLadsAnonymous]

@@dcjohnson2208 As sodium hyaluronate? Where did you find HW and at what dosage do you take it?

[@jaymehatfield9540]

Yet another topic we all need to learn and presented in your concise, methodical manner thanks

[@jenxsj3902]

Hi Dr Verhoeven. I do all that already. I am one of the most collagenased women I know.

[@livephysiology]

"It’s an important first step" seemed like a nice way of Physionic to describe the research at this stage.

[@presence5426]

Are you talking about research pertaining to "connective tissue" only?

[@pianogirl3870]

I gobble up your interesting findings....very much appreciated!

[@SapereAude1490]

Isn't collagen broken down in the stomach by pepsin and trypsin to amino acids? Wouldn't that mean we can simply take whey and be done with it?

[@Physionic]

No, it isn't. Check out some of my other collagen content - I cover the mechanisms there, including the studies indicating otherwise.

[@presence5426]

Mostly, not completely. Collagen protein is made up of unique chains of AA's: glycine, proline, hydroxyproline, etc. These chains are resistant to proteolysis. Therefore, small peptides make it to transporters the small intestine & can be absorbed into serum. A similar thing probably happens with whey. But collagen peptides have a unique structure & moa.

[@walter1824]

What about Elastin

[@gasparsigma]

I wish they had one more group for consuming high quality protein (like Whey) to compare against

[@Ruktiet]

Would gelatin consumption be equally good as collagen consumption? Thanks for the video

[@Physionic]

Covering that in a future video coming out soon :) - I need to finish looking over the topic

[@Ruktiet]

@@Physionic awesome to always see you engaging in the comments. Really good channel

[@presence5426]

Maybe. There are many studies looking at both gelatin (mostly porcine) and collagen peptides from various sources. Both sources will give you the aminos & short peptides.

[@KelvindeWolfe]

@@Physionic Taking ideas from the comment sections.😂

[@esther.f.g]

I can't mesure the impact on cartilage and connective tissue but I experience a very positive impact on my skin, hair and nails after using collagen, and I am not the only one. I think that there is a positive impact but it depends on what is the purpose of the use of collagen

[@JulAlxAU]

I take 5g Marine and 5g Avian collagen with Vitamin C to get a good balance of type1 and 2 collagens. Anecdotally speaking, my joints are really good. I am a long distance cyclist and ride 350 to 500k a week.

[@m4inline]

I don't know what i did but my 15 yr old shoulder problem, that caused my right hand to tingle and swell when walking, just disappeared. My body is more flexible and I feel faster and lighter. Nothing really changed I can think of to do this.

[@AnthonyBaldachino]

I would like to see a study comparing concentric vs eccentric resistance training in relation to collagen synthesis in the joint

[@TheCookiecupcakes]

I'll sprinkle some collagen in my joints.

[@Physionic]

:)

[@3rdrock]

What about in a vape ?

[@maladaptedmalarkey]

In my n=1, anecdotal experience, supplementing collagen seems to help my knees better endure running. But, as others have commented, perhaps lean, clean, protein would do just the same. I think my take away from this study is to make sure I keep doing my squats and lunges, and consume enough collagen and protein to repair.

[@pabloqueiroz7230]

Boosting collagen can be problematic depending on the inflammatory condition of the patient. More collagen would imply more fibrosis.

[@jackics6540]

Could you please elaborate on this? So you think for someone like with inflamatory arthritis, wouldn't be good?

[@geoff_onYT]

do more videos on preventing cartilage loss via supplements. e.g. glucosamine, chondroitin, avocado soy saponifables, undenatured type II collagen (chicken sternum), boron

[@LARRYNH1]

Good stuff subbed

[@gatesroyale]

Thanks for the videos! My fav learning related to health.

[@LK-pc4sq]

I suspect He is a INTJ personality "Master Mind/Strategist". I am a INTP "Scientist" like personality. I Fd up and never studied metabolic health while in Avionics Tech college or IT. I had NO idea that highly processed foods can cause long term metabolic disease and early death.

[@gatesroyale]

@ I’m ENTP so all our personalities mix related to deeper understanding. Yeah basically everything is society’s toxic. It’s crazy.

[@gatesroyale]

@ Also not having a facia routine can clog up your skin systems and causes lack of lymph node fluid to reach its areas and blood and nutrients. This can cause miss folding proteins and another complications

[@tgaudlol]

Btw, If you are interested, be aware that most studies on connective tissue synthesis are obsolete because it has been discovered that it start around 24h after effort. While most studies measurement take place just a few hours after effort. And collagen intake increase collagen synthesis in all the body, while exercise increase the synthesis only locally. But the effects arent additive Also its highly related to a glycine concurrency in the blood. Thats a lot of elements to take into considerations

[@Physionic]

I am interested. Can you send me the study or studies?

[@FyreRayne-cf5wh]

Great, thank you

[@janineclemons746]

I drink collagen as my first meal of the day. I was taking it before bed in hopes that it would help rebuild connective tissue. Not sure if it's working, but I have a torn rotator cuff that seems to be improving.

[@chamuuemura5314]

4:30 that’s the key. Compare this collagen vs total fasting to same calories of protein, butter, or apple and see if it’s calories or actually collagen itself.

[@motorbreath22]

I just started taking collagen from bulksu.... I did my bench press and curls to nuke them and my DOMS, has been reduced about 90 % of what it usually is. Im 42 and this is huge for me as recovery time has injury prevention is what keeps me from putting in more effort as i don't mind the pain but the recovery period overlaps into my next workout session if I do too much. This will increase my maximum allawable recovery volume / weight.

[@zachcain2639]

Did they match for protein intake between the 3 groups?

[@csolorio88]

My wife got a shoulder joint pain for months that we were confusing for something else, we went to different doctors while she was getting a lot of rest but there was no improvement. Finally, a traumatologist prescribed type 2 collagen and some rehabilitation exercises. Her pain went away in a week or so.

[@lisadisme]

right shoulder?

[@csolorio88]

@lisadisme yes, is there something else we should worry about? 🥲

[@lisadisme]

@@csolorio88 no don't worry..I tried to tell you why, but got deleted.

[@efx245precor3]

I use biosil and multi collagen

[@presence5426]

Me too. You getting results? Do you have to go to the nail salon twice as often, lol?

[@resourcesforteachersandver6264]

would have been nice if you told us how much collagen the study participants consumed...

[@pauls3075]

Your supposed to sign up to the pay channel for that.

[@ps7797]

I came across research about fasting, IF, and autophagy helping to preserve the chondrocytes that make cartilage. Multiply beneficial effects by combining all these joint friendly procedures.

[@thelovacluka]

So many questions in the comments😢 I want additional videos 😬😬

[@Physionic]

You bet your butt more videos are coming :)

[@i.ehrenfest349]

@@Physionicnow now now

[@lstanciu8503]

Type II collagen is one of the main proteins in cartilage.

[@VioletteToussaint]

Does it work with gelatin?

[@jacobdebernardi4385]

A repeat of the study with a piece of steak instead of collagen would be interesting. Would the break down of plain amino acids from food have the same effect?

[@katipohl2431]

How exactly was the resisrance training done? Greetings from Germany.

[@lisaearles4175]

4 sets of 10 reps on the leg press machine

[@TravisDrake-Beo007]

commenting to help the algorithm

[@laurafuller8528]

Liking

[@AyaneBKing]

🎉🎉

[@SessleIsosceles]

Watching this with a jenked up knee wondering if my glycine will suffice with vit C and MSM

[@presence5426]

What happened?

[@Sabrina-vc7zk]

What do you think about Tremella instead of collagen powder?

[@classicpinball9873]

Doesn't vitamin C help as well? from food or supplementation

[@peterwhite8424]

What about elastin?

[@ChrisGroggyCreaser]

Thanks.... :)

[@jackbuaer3828]

Biolayne just reviewed a study in the same area. Biolayne said that the study suggested that collagen peptides were ineffective at increasing collagen synthesis in connective tissue. One of these studies is likely wrong.

[@Physionic]

See pinned comment

[@presence5426]

"in connective tissue." There's the rub. Norton likes to do that. Because he sells protein other than collagen. There's plenty of evidence on collagen peptides having positive effects on skin, joints, bones, and yes, even some on muscle & intestines.

[@Macgee826]

If biolayne has said its ineffective id definitely wager it works a treat!

[@presence5426]

@@Macgee826 He's definitely good on some things. I'd believe what he says on leucine. But he's been wrong on collagen and glaringly so.

[@Macgee826]

@@presence5426 its all part of the game ,if hes good on some things then surely hes good on everything ,right?i mean he has a phd he must be right.

[@piratoraman]

But what type of collagen? 1,2,3 ?

[@Tottorul]

Collagen, both fish and bovine both make me incredibly sleepy, but not in a good way, more like I'm sick. It happens every time. I have also tried glycine alone, it does not work well with me either

[@MadLadsAnonymous]

Interesting. I wonder if this is a methylation issue with B vitamins that could be cofactors.

[@Tottorul]

@MadLadsAnonymous hehe, I probably don't understand that. But would that mean I'm too low on some b vitamins? I do take low dose vitamin b supplement

[@presence5426]

Try taking some tryptophan with the collagen, or tryptophan on its own. That could give you a clue. Glycine is a inhibitory neurotransmitter, so that could be what's going on. How about taking collagen before bed? Or if it just isn't for you, but you're still interested in the benefits, you could try UC-II. The dose is only 40-80mg. Empty stomach...

[@MadLadsAnonymous]

@ Many people have a gene mutation I believe called MHTR that means they can't convert certain forms of B vitamins, many of which are cofactors in important processes. This is why you see "methylated B complex" supplements. But there's also a chance of over-methylation, IIRC. I'm not well-versed on it but I know there are tests to determine methylation ability. Cheers!

[@Tottorul]

@@MadLadsAnonymous damn, iv'e seen this form of b vitamin mentioned before but didn't know what it was, i will have to look into that. maybe it can be tested with a gene test

[@AthleticHobo-br4qh]

Has anyone noticed collagen supplementation causing an explosion of grey hairs? This happened to me, coincidence perhaps, but in before and after photographs of people on collagen supplementation I notice definite skin improvements but in several you see a large increase in grey hairs.

[@Physionic]

My foot fell off when I ate some, but nothing serious like graying hair. (In seriousness, to answer your question: no, I haven't noticed anything, but that doesn't mean much considering my age)

[@dcjohnson2208]

I’m male(octogenarian). I notice skin improvement taking collagen with Hyaluronic Acid.

[@flashrun6093]

I have noticed a little increase. From none or only 1 to 5 or 10 hairs.

[@AnnAgurkis-d8o]

how much and what type of collagen? For arthritis?

[@presence5426]

UC-II and/or eggshell membrane for symptoms. 10-20g of mixed collagen peptides for promoting collagen synthesis. Both on empty stomach.

[@LK-pc4sq]

Try and remove highly processed foods and sugar/hfcs from your diet and then get back with us.

[@jingangquan]

Awesome, thank you! A 4th group that took whey would have been interesting. IF I remember correctly there was this study that compared intramuscular collagen production and whey was superior to collagen. Would be nice if it were the same for the joints.

[@vegtalk8920]

Exactly this. What was in the placebo? Were the calories and protein the same in placebo and collagen drinks? If there were no proteins in the placebo then comparing collagen to being fasted is strange at best...

[@cachaça_baby]

What is your opinion about hit training?

[@astrol4b]

Thank you for the video right now the only thing i saw that can reverse osteoarthritis in joints on rats and in vitro is paroxetine, but we can't take an antidepressant for joints, it would be great if they find something with the same mechanism.

[@D56t37-cu7ol]

Is loss of collagen related to advancing sarcopenia ? How does blocking IL-11 inhibit sarcopenia in mice ?...What dietary changes might we take to suppress IL-11. Food compounds that we would avoid and ones we may want to include..

[@Christopher-b1p]

Why do ypu want to avoid increasing g Il-11?

[@Mielina1390]

Cortisol First

[@homesignup]

It should also be noted though that increased joint usage also promotes mechanical wear and tear OA and joint cartilage breakdown so you will have to keep supplementing more than the wear and tear + hyaluronic acid + glucosamine and chondroitin, especially in older age and synthesis declines. Almost everyone gets some kind of joint OA by 80 years old, and it's greater in those who are overweight because you are bearing down your joints more Resistance exercise is important but needs to be done correctly. Runners also are at huge risk of cartilage breakdown especially those who have poor biomechanics and asymmetry in their legs - one leg will bear down more than the other and cause OA knee.

[@starfox300]

the wear and tear is somewhat hormetic though and causes more collagen production in that area. But of course if you are old and of bad health it's not gonna be efficient

[@karenkeiper1278]

Would this help my daughter's meniscus??

[@Physionic]

I would give it a shot, if it were me

[@karenkeiper1278]

@ thanks for the reply 😊

[@NitayNostrasifu]

Do a video on earthing please

[@eugen86]

Did not yet finish watching the video but on a totally different note I would love to see your take on alpha gpc

[@synthclub]

You can get better conversion of choline and save $$ by going with a choline bitartrate version over the very pricey Alpha-GPC (L-alpha-glycerylphosphorylcholine). I buy $8 centrum kids brain fuel bottle. Enjoy

[@ZappyOh]

Tip for getting extra collagen in your diet: Pork rinds. You are welcome :)

[@krashanb5767]

Pork hocks - golonka. 😊

[@3cardmonty602]

My 6 month old puppy just broke one of her rear fibula. I wonder if Collagen will help her heal?

[@Amun92]

Do collagen is essential for the immune cells migration?

[@megandowling8746]

Since collagen is a protein don’t these molecules get broken down in the stomach to constituent amino acids? I guess by collagen supplementation you are increasing the constituent amino acids needed to synthesize collagen or am I missing something?

[@presence5426]

You are. Di- and tri-peptides.

[@siclucealucks]

Any ideas about spine disc regeneration? For example, thinning due to natural wear and tear or overuse, such as work-related strain. I’ve heard that these issues are particularly challenging to heal or even regenerate

[@jonathonkibble8792]

As someone with degenerative discs, it’s something we just have to deal with for now Unless you wanna be a lab rat

[@presence5426]

I'd look into hyaluronic acid. You can try UC-II, eggshell membrane, or collagen peptides as well. You may very well have symptom improvement. But depending on the severity of your condition, actually regrowing tissue is a challenge.

[@chrispompano]

Watch video of Japanese Medical TV show called : Medical Frontiers Treating Lumbar Disc Hernias With a Single Shot. They talk about an injectable, but the 2nd 1/2 of video they study using NAC to treat oxidative stress inside the disc anulus. Take your NAC every day!😉

[@siclucealucks]

​@@jonathonkibble8792 Yes, mine is also shrinking. I'm not sure if it's due to my sedentary lifestyle as a desk worker or from incorrect movements and overuse at the gym

[@siclucealucks]

​@@chrispompano This would support my initial guess. I have started taking GlyNAC because of this. I'm also considering PDE-5 inhibitors, which should widen blood vessels, including those in the spinal discs. This could make nutrients more available, even if there is ongoing inflammation.

[@alexmacleod9727]

used to take collagen.... I'm natty now ...

[@samulmagnus1]

Does L Lysine help with collagen production like they sa

[@MadLadsAnonymous]

Glycine, yes, at 3-5g/day. Take with Vitamin C & sodium hyaluronate (100-200mg) Not a doctor. Not medical advice. Please do your research.

[@lisinbondi1240]

Themajor flaw in most collagen studies is using younger subjects. Collagen production is literally at peak under 40 so there is nothing to improve - however once you are 60+ there has been a 20-40% drop in production (depending on lifestyle exercise etc) and THAT is what we should be measuring. Especially post menopausal women. Many studies are quite old now but do point to improvements in skin functionality, bone density etc. PS this is the demographic with the most money as well.....just saying.....

[@totallyraw1313]

You, my friend, are a classic Poindexter! 😂

[@handlez411]

Trying to pay attention and not get distracted by your biceps

[@magnusemeritus]

Why legpress? The squat is better.

[@vegtalk8920]

Was the placebo containing any aminos equivalent to collagen or was it just being fasted vs getting some calories from protein in the form of collagen?

[@techwhiz6629]

What did i miss, the low dose has how much grams and high dose collagen? I had to google to find: after consuming 0 g, 15 g, or 30 g vitamin C-enriched HC

[@tryftryf1994]

I use gelatin in my drinks and i have seen improvements in my skin

[@bramblebop1904]

Bluish? Isn't it green?

[@Natalie-Bowen]

Random question but what are your thoughts on peptides like Epitalon or other peptides?

[@presence5426]

Really wish there were more published studies. I think there's big potential, especially with injectables. People say great things about BPC-157 anecdotally.

[@Natalie-Bowen]

​@@presence5426 I've seen a fair bit of studies on things like GHK-CU or PLLA which is the main component in Sculptra BPC-157 and TB500 I've seen touted on various forums but it's difficult to find much reputable information aside from "Bro Science" on KZbin

[@jjs2082]

The images of connecive tissue that you showed are largely of cartilage and not tendons and ligaments that you referred to. Presumably they were looking at meniscus fibrocartilage and not hyaline cartilage or tendons and ligament dense regular CT?

[@Slim934]

Wouldn't the proper comparison also included people who supplemented with whey protein as well? Why at mechanistic reason would we have to expect collagen (a low quality protein) to have any effect of joint collagen formation than whey, given that both just get broken down into amino acids in the stomach?

[@loganwolv3393]

All of this being done in fasted individuals dosen't make this very realistic because what if the individuals were not fasted, ate enough protein and that eliminate the difference in collagen synthesis?

[@unholyquail4560]

The issue which I have with collagen is the sourcing of it. MOst of the time is just grounded up animal bits and turned into powder. Not really a fresh product in my opinion. Where we are closer to making a non animal based collagen through alternative means, we cannot actually make sythesized collagen. Meaning we haven't really understood or unlocked the knowledge to create these ourselves. The data seems to be all over the place so I refrain from using grounded up animal pieces in my supplement routine because it MIGHT do something. The burder on climate and supply chain is just not worth the tradeoff for me. Seemingly high enough protein intake with all required nutrients and glycine related supplements seem a more superior route to take without having any of the ethical issues connected to it.

[@presence5426]

Injectable peptides might be for you. Efficient, potent (in theory), and vegan.

[@unholyquail4560]

@@presence5426 Injecting Peptides isn't quite as accessable as just taking a powder. Certainly for the level of evidence I would steer close from that. Seems execise is superior for collagen production and maintence beyond any of these intervention. With enough protein intake, that should be intervention number 1.

[@presence5426]

@@unholyquail4560 True enough. And there are other ways to pump up collagen production: glycine, which I believe can be found from a vegan source. BioSil, carotenoids, whole-food vitamin C. Hyaluronic acid is also very useful and is available vegan. In theory, you could have a compounding pharmacy create di-peptides found in collagen, and take them orally. Then there would be no need to make synthetic collagen.

[@adamscottv]

I use 40g of collagen peptides per day in my pre-workout mix. I resistance train daily. I also take 1g hyaluronic acid per day. These things are a no-brainer for someone who wants to have a long healthspan.

[@presence5426]

Has the collagen/HA helped you gain weight? When I bumped up my HA dose, I gained like 5 lbs. Water, I'd guess.

[@adamscottv]

@@presence5426 Not that I've noticed, but it's possible. Creatine puts a few pounds of water weight on me, but I take it year-round now, so I don't notice it.

[@Lactoferrina]

A more appropriate control besides vitamin C drink would have been a complete AAs drink with vitamin C, wouldn't you say? I fail to see how hydrolyzed collagen can be more meaningful in increasing collagen production than complete protein intake. Is this a flawed study of am I missing something?

[@biomimetical]

I don't take collagen, I take coolagen, my joints are the same, but I'm 32% more awesome now...

[@joe1071]

Collagen, isn’t that the one Costco carries?

[@nicknak5257]

I could do with some of that. I used to be way cooler but it seems to be decreasing with age.

[@marksavage1744]

Just take some awesomagen..... it's way cooler!

[@AnilSingh-rn3kx]

Hi Nick a topic away from what you are carrying out today. But i may have guillen barre syndrome is there anything i can do to recover thanks.

[@presence5426]

Was it brought on by infection? What treatments have you done?

[@AnilSingh-rn3kx]

@presence5426 nothing for now.

[@presence5426]

What type do you have, and how severe?

[@narkybark]

I would love to take collagen, but I'm scared of more kidney stones... ugh.

[@krashanb5767]

Can it cause kidney stones?

[@ginz9r]

​@@krashanb5767 no

[@thelovacluka]

Can I eat chicken legs with a lot of cartilage and tendons every day?

[@Physionic]

Sure

[@kygo]

"collagen supplementation seems to increase joint related collagen synthesis", that seems to go against all the other PHD health bros on here that keep saying that taking collagen does nothing, even though the comments are always full of anecdotal evidence saying it does 🤔

[@presence5426]

Listen to people who have actually read the 12 published systematic reviews on what collagen does.

[@Macgee826]

​@@presence5426personally id rather listen to multiple peoples anecdotal evidence and try it myself .

[@yureituesday]

Are those skin cells behind you?

[@markkubert8572]

Having an adequate amount of leucine appears to be necessary when trying to get muscle growth. I often take collagen and whey mixed together after a workout. To make sure the mix has sufficient leucine, I will usually take an extra gram or so of leucine. Is there any supplement (other than vit C) that plays a special role in collagen synthesis that is like leucine in muscle growth?

[@presence5426]

Not like leucine specifically, but there are nutrients that might pump up collagen synthesis: silica (BioSil) & carotenoids are two.

[@kirarichlin8003]

It would be very interesting to know what type of collagen is better for consumption for joints and cartilages , because there’s plenty of them and it’s not really clear 1&3 type is everywhere and research tell us that it works , but what about other types (2 or 4,for example) does they work the same , cause as I know there is a problem with their synthesis…

[@presence5426]

Good question. The type of collagen refers to the tissue where it's located. There are over 20 collagen types, some only found in specific places, like your eyes. They're all similar in structure, but not the same. Does this matter? Maybe. Because different amino acid sequences can yield different peptides after digestion. A good way to cover your bases/experiment is to consume collagen from multiple sources. Ancient Nutrition's Multi Collagen is a start.

[@Stormbringer81]

Forgive my ignorance but wouldn't collagen derived from grass-fed animals have a far improved amino acid profile? I take Forestleaf brand which is a blend of Type 1 & 3. I have less dry skin and less joint pain and I've repeated this test on myself plenty. I'm 33m and I definitely notice a difference between an 15g dose and a 30g dose. My lips start to get dry, which is the first cue I notice when I'm on a low or no dose. Then, my bombed out shoulder starts to hurt more. Also, I remembered watching a video on glycine from you a while back. In that video you noted it helps your body to prepare for rest by allowing your cells to release heat from your skin easier(something like this). Collagen is packed with it. I have ADHD so I have shit sleep problems. I can't say for certain, but I do believe it helps me sleep as I take it a few hours before bed.

[@freddunbar]

Have you tried GABA and Magnesium l-Threonate for sleep?

[@Stormbringer81]

@freddunbar I have tried magnesium L-Threonate yes. I didn't notice any difference magnesium glycine. It's far too expensive to justify further testing. GABA has been something I've been considering and has been in the back of my mind but I'm not sure the most effective delivery / supplement for increasing GABA.

[@presence5426]

Far improved? Unlikely. When an animal develops, the growth of collagenous tissue is controlled by genes. So we'd have to theorize that grass-feeding had a genetic influence. My guess would be that you analyze skin from a feedlot cow vs. a grass-fed cow, and you'd see no difference. Now wild animal skin (say, deer) vs. feedlot cow... that would be interesting.

[@JacobDMcGrew]

If you’re eating 1g per pound of lean body mass of protein in the form of animal products (steak, eggs, dairy) is taking collagen still effective or have you already gotten enough of all amino acids that your body can build all it wants of everything including collagen?

[@presence5426]

If you're getting plenty of protein, you're probably doing OK with getting plenty of AA's. And yes, this will help your body maintain/grow all kinds of tissues. Could collagen still be effective? Yes. Because it has a unique AA composition. Lots of glycine, proline, and hydroxyproline. And unique di-peptides not found elsewhere (gly-hyp). Also, undenatured collagen may have a unique anti-inflammatory effect.

[@susanb3989]

@@presence5426which collagen supplements do you take or recommend?

[@kymdaniels6676]

Red Light Therapy

[@thevibrancyreboot3835]

I noticed one of the studies focused solely on men. I always wonder how often women are getting excluded from this research, especially given that I'd put money on more women than men being interested in their collagen levels. I get that you were focusing more relative to joint collagen, but that being said, I would also presume that there might be inconsistencies between the 2 sexes relative to production levels and synthesis after training. Mens' and Womens' bodies just process differently, and it's not hard to see relative to aging. Collagen that supports the skin reveals that difference.

[@Physionic]

In the past, almost always. Now? Less so. Most research in the last 5-10 years has focused a lot more on women (the NIH has stipulations in their grant acceptance process that researchers have to look at women, or they favor studies designed including both). I'm hoping more research releases for women exclusively. That said, much of the collagen research (on skin) is in women, but I haven't looked at the joint research closely enough yet - I'll have to see. And yes, there might be differences - good point.

[@presence5426]

A lot of collagen research for skin health was done with female subjects.

[@chrispompano]

Can anyone explain what he's talking about! Just tell what to take. Or flavor of JELLO!😂

[@ThePiggiestOne]

I'm at the beginning, so before i watch, i want to guess glycine is one of them. Let me keep watching to see if I'm right.

[@markghorsley]

I’m not convinced. Collagen is a protein. When taken by mouth it would be broken down to amino acids before being absorbed. The subjects in the study referred to were fasting. I suspect you would see a similar increase in collagen production from any old protein supplement taken in these conditions