2015 T Cell Effector Function (TH1, TH2, TH17) and Cytokine Biology

This T cell video reviews the biologic functions and role of TH1, TH2, TH17 cells in autoimmune diseases. Visit www.ccfcme.org/... to claim CME credit or learn more about the Basic and Clinical Immunology series.
The immunology video features expert faculty member, Dr. Leonard Calabrese, of Cleveland Clinic.
The video was produced by the Cleveland Clinic Foundation Center for Continuing Education and Cleveland Clinic R.J. Fasenmyer Center for Clinical Immunology.
Interested in related CME education? Visit www.ccfcme.org/....

[@sissykomisch7898]

whats the role of Th9 cells and why don't you talk about them?

[@nystagmus]

It sounds like if your TH2 is overactive , then your TH1 is under-active. I looked up what histamine does to interleukins: histamine decreases IL-12 and therefore weakening of TH1 I suppose that is why famotidine (histamine 2 blocker) seems to help patients with covid 19 hospital patients over omeprazole in the hospital. Likely shifts things to the TH1 side (more IFN gamma IL-12 etc).

[@Littleprinceleon]

The mutual exclusion of Th1 and Th2 branches via IFN-& or IL-4 respectively is long known... Why would the Th1 related immunity be so helpful in hospitalised COVID patients? From what I learned: the more serious cases have to deal with cytokine storms - but what does that have to do with histamine release?

[@anidit88]

good info, but so much "uuuuhm" and "ahm" , its a bit irritating...

[@kkk-re7eb]

hahaha