2017 Nobel Prize for Circadian Rhythm Explained

Are you pumped about the 2017 Nobel Prize in Physiology or Medicine? Me too! Learn all about the work and why it was so impressive that it got the Nobel Prize! This video comes complete with fruit flies, molecular mechanisms, and a special history on molecular biology. Exciting stuff.
Discussion on the molecular basis for the circadian rhythm in fruit flies from:
1. Siwicki, Eastman, Petersen, Rosbash, and Hall. “Antibodies to the period gene product of Drosophila reveal diverse tissue distribution and rhythmic changes in the visual system” Neuron (1988). doi.org/10.1016/0896-6273(88)...
2. Liu, Zwiebel, Hinton, Benzer, Hall, and Rosbash. “The period gene encodes a predominantly nuclear protein in adult Drosophila” Journal of Neuroscience (1992). www.jneurosci.org/content/jneu...
3. Vosshall, Price, Sehgal, Saez, and Young. “Block in nuclear localization of period protein by a second clock mutation, timeless” Science (1994). doi.org/10.1126/science.8128247
4. Price, Blau, Rothenfluh, Abodeely, Kloss, and Young. “double-time is a novel Drosophila clock gene that regulates PERIOD protein accumulation” Cell (1998). dx.doi.org/10.1016/S0092-8674(...
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Music:
"Odyssey" Kevin MacLeod (incompetech.com)
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"Twisted" Kevin MacLeod (incompetech.com)
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[@ThoughtCatalyst]

Great work, love the "harder science" aspect of the channel rather than the soft science approach most channels take! Keep it up!

[@eleonorapatricolo2532]

Very interesting video! High quality and super linear and clear. I subscribed

[@daamu48]

Great work. Your efforts to make a highly complicated research into a simpler explanation for the sake of common is highly appreciated. A little bit more time could have been invested when you deal with the three kinds of genes .Thank you very much.Kindly post a lecture about plants , circadian rhythms and phytochromes.

[@klauspeter5353]

You are awesome! Loved the video and really appreciate the references to each study. It always amazes to stop and think about how fast science is able to progress having known certain things for so little. Keep up the good work! Greetings from Brasil o/

[@ultramegasuper11]

Yes Yes Yes. Thanks. How exciting ! I especially appreciate the explanation of the timeframe of the discoveries. :)

[@rishavmadhukalya2]

great video simple biologist. Thank you for the knowledge. You should keep making videos on science behind major discoveries and try to explain the science behind various other advanced research papers in simple terms so that common science enthusiasts like me can understand.

[@etidoudo3028]

Thanks for these videos that explain science behind many phenomena.

[@Huy_Nguyen_USA]

Why does every sentence end with a question mark?

[@janfritsche9636]

Thanks! Great explanation!

[@jibberoverjava]

Let them write a theory paper on why unborn babies have clear circadian rhythms that don't always match their mother in a dark lightless womb for almost a year. Most, nearly all babies have to be "broken" onto a "normal" schedule despite regular light exposure. Sometimes they never "break". And why DSPD people do just fine IF they get back on their own (non-insomnia) full night sleep that they can only achieve on their own natural circadian rythm that proves by their good/improved health that the "normal/typical" circadian sleep schedule can be detrimental to good health. Why they believe that Delayed Sleep pattern is a disorder and not a difference. How the Earth would go round if every creature and flora only produced clones. Why they promote differences as disorders when all the Different need is to be allowed to not live backward their entire existence because if it was a disorder they would not function betterbut they do. It's "cured" by not being oppressed. These "nobles" don't care what's true or not so long as they're able to receive noble glory now and will be dead before truth can be thrown in their face. Sickening. Mixing True with False for adoration and title falsely earned. I wonder if those deceased first pioners of circadian rythm would approve of the exploitation of their sincere hard work. These off the backs of truly devoted men.

[@CuriousCat0347]

Exactly!!! Truth is That We Develop Individual, Unique Rhythms Based on Our Genes...Experience, Lifestyle, Choices, Discipline, Environment... What Happens during 6Month Winters in Alaska or at the North Pole or in Antarctica??? Desert Dwellers Can't Be in the Sun for 30Minutes or they could get sunstroke... My Energy isn't Sun/Light Driven... Mental Work, Curiosity, Creating & Producing are Energy Producing Activities even at 2AM... Science Isn't the End All/Be All to Living... Everyone Builds their Own Rhythms...According To

[@jibberoverjava]

@@CuriousCat0347 I love the points you made! Thanks for your support. We see no one's trying to make the moon shine it's brightest during daylight or calling nocturnal species disordered. I read an article a few years ago on the spleep patterns of ancient people. It said they had what they used to call something like "a second night". It explained their days were split in half, each half having wake and sleep, so one day would have: Sunrise - wake, sleep, wake - Sunset- sleep , wake, sleep - Sunrise. It mentioned that modern sleep schedules we use today were imposed by industry more so at the industrial revolution. The industrial revolution also imposed changes in the ways meals were prepared and eaten, as well as things like coffee to forse-wake the mind and body, very scientifically planned out and implimented on the commoners. The historical split sleep pattern/schedule was the true natural rhythm, allowing the brain and body to correctly rest, restore and reset itself on it's own terms which had far greater complete health benefits. The moon is as powerful as the sun in its own properties, it's causes tides, grows fungi and other essential flora, arouses certain species so that the earth is never imbalanced by every living thing being awake and sleeping altogether at the same time... in this way, the earth never sleeps, nor the sun, nor the moon... they Rest. Rest is also like yeilding or giving another it's turn. Humans have forgotten their humility and purpose/position/role among all the other that exist. Now he selfishly dominates his fellows and all the rest... to their and his own oblivious injury. And... genes can change or switch on/off over time, so if we lived as long as the Very Ancients used to we might have lived to see ourselves and others change (or hand over their Turn to another for a Term) the sleep schedule/rhythm. Ugh, don't get me goin' ! Thanks again, I enjoyed your comment! Especially the point about the flexibility of sleep requirements affected by choices, Activities, etc. ... Someone I knew once said sleep is like a tax collector am I not ask you to pay back immediately but it will never forgive your debt you will have to pay up eventually. If we slept when we needed to and not on some schedule we wouldn't be in debt and miserable. The system doesn't allow us to sleep when we need to for as long as we need to... It's why we always feel at least a little hungover everyday.

[@kubad2012]

Nice and simple video! Thanks!

[@navneetkaushik2482]

I came from Science is Dope's channel, your video is great i instantly subscribed.

[@omarabdallah9959]

Great video and explanation

[@lloydjoseph4370]

Thank you! Great vid

[@eddierussellofficial8276]

There’s a song about the circadian rhythm on the davey Davis KZbin channel

[@govthospital2063]

Great video

[@abhay8437]

Hi, @ScienceIsDope sent me here

[@VRL369]

Great work🎉🎉

[@anedallagnol7700]

Amazing!

[@pukhrajmansion8445]

Good presentation 👏 👌 Please Hindi version

[@Allenfactsandinsider]

Video was uploaded 6 years ago

[@nivedithav7620]

Good Presentation

[@MaphinWoW]

Great video, nicely explained. Thank you for that. I am into researching how Circadian Rhythm in especially plants work, for a masters course I participate. What do you think are the major differences to the animals Circadian Rhythms?

[@SimpleBiologist]

That's a really interesting research topic! I would imagine that plants have an even more exaggerated difference between day and night since they depend on light for their food. I would think that there's a sequence of events that would have to take place every dawn and dusk to prepare the plant for night and day, and I'm not sure how much of that process is light driven versus circadian rhythm driven. Unfortunately more scientists study animals than plants, but there's got to be some research on whether plants still display circadian rhythm based molecular changes even without the sun. Sorry I couldn't be more help, but I wish you the best of luck with your research!

[@mahendrakamble797]

Nice explain..

[@mohammadshafiksheikh9778]

Wow amazing video 👍

[@dinonichas]

How about the gene name CLOCK? was that mentioned?

[@t8r507]

Hey! Get circadian rhythm! When you need to snooze! Come on! circadian rhythm when you need to💤

[@galaxyrider9599]

So... how does it help me with my circadian rhythm disorder?

[@ultronix764]

thanks

[@Anderson-ly9no]

So how do this work in real life?I mean when should I go to bed?Whenever I feel sleepy?Since the Circadian Rhythm is written in my DNA,is that mean I should just follow my body and go to bed when I feel tired instead of following the regular day-night routine?

[@yulianloaiza]

You can check out Shawn Stevenson, which has great information regarding this

[@atomoyoga]

Hatha yoga, that is what it means. Ha, Sun and Tha, Moon. It's all about balancing and harmony your systems and awareness. We are light !

[@fedoran2884]

Which influence have circadian rhytm on people? What use is it ? (Sorry for my bad english)

[@SimpleBiologist]

No worries about the English! Circadian rhythm plays a role in almost everything in your life. When you sleep and wake up, how alert you feel in general, when your liver regenerates, your sense of time passing, etc. You can feel the effects of defying your circadian rhythm any time you travel more than a couple time zones. An extreme change (such as a 12 hour difference) can make you feel mentally and physically ill.

[@fedoran2884]

SimpleBiologist Thank you for information))

[@casibari1537]

If Period shuts down its own production then who turns this back on?

[@KarthikD72]

This is how our grand parents where doing in India. Now billion dollar research proves it

[@atomoyoga]

Science can only make Yoga better and the other way around! Hari Om

[@lascrucesnm4117]

Well where’s the info????

[@lmezy25]

Can this cause hair loss

[@CuriousCat0347]

Remember!!! This was 6 years ago... I would add these truths to whatever these scientists Discovered... My Energy isn't Sunlight/Bright Light Driven. It's Driven by my Mind Working to Achieve or Accomplish Something From the Minute My eyes Open at any time of day. I'm not tired in the afternoon just because some scientist says it's "RHYTHMIC" by Nature. Plus... Desert Dwellers Aren't Most Active in the Sun because it's 120° out there... so they do better in the shade of tents. Circadian Rhythms are as Individual as the Person...I am awake for 20 hours on some days if I'm on a Creative Roll... Einstein Slept about 3-4 hours a day whenever he felt the need. Some people have rigid routines... I have Fundamental Foundations... I Don't Have to Repeat the Same Day Over & Over ad Nauseam... Every Day is New...& I Don't Need Sunlight To Energize me...I get my Sunlight When it's Available.

[@CarsSimplified]

Interesting stuff! I have always felt like I am on a 25-hour cycle; I wonder if that's all in my head or if some of these genes are different in me.

[@SimpleBiologist]

Hmmm... Maybe a little of both? People definitely react differently to varying amounts of sleep, like I need a full 8 hours to function like a human adult. Could be tied in? Would need more research to know for sure.

[@G0dlol]

I would say the circadian rhythm is a modification, that means it depends on the environment, living conditions, etc. That should explain why some people have worse jet lag than others (Modificability ruled by the genes). So the way you live decides your cycle, rather than the other way around. Please tell me if I'm wrong

[@terrepus9856]

@@G0dlol The circadian rythm is almost constant but you can shift the period with a "Zeitgeber". A "Zeitgeber" is basicaly factors which we recieve through our sensory organs such as eyes, ear, skin and so on. So an example for a Zeitgeber is the day and night cycle. First semester of neurobiology, so correct me if i am wrong.

[@scotttube]

turn off the background music, how can we hear you talk

[@corgikun2579]

I'll learn everything you say, you're beuatiful

[@susydyson1750]

when on the plane sit and meditate... you'll have no jet lag

[@Country-Gal-at-Heart]

I don't understand when somebody who is locked in a dark room (no access to sun or moon) eventually loses all track of time. What am I missing here. Confused lol

[@SimpleBiologist]

Your mind is a powerful thing and you can definitely overcome your circadian rhythm. My Dad works night shift which goes against the natural rhythm for humans. Some of my friends have pulled all-nighters to get work done, which also skips your rhythm. If you were in a relaxed state in that dark room and not totally freaking out, you might notice that you get sleepy at certain times and feel hungry at others. Unfortunately, your mind craves information and you can easily lose a lot when you don't have it. This video is about circadian rhythm on a molecular scale and how your cells keep track of time. How you actually experience the world and time might feel quite different.

[@Country-Gal-at-Heart]

SimpleBiologist Until today i had never heard of the circadian rhythm. I stumbled across your video whilst browsing KZbin. Such a facinating subject. I watched a lecture online by Michael Rosbash.. But it totally went over my head lol. Thank you for your explanation and reply.

[@atomoyoga]

@@SimpleBiologist completely agree! We do have lots of external outputs that react with the chemistry of the brain. Coffee, alcohol, weed, antidepresors, sleeping pills. We all have to find the way to balance our own experience! I find in Hatha Yoga which actually means this. Sun and Moon and the balance of the endocrine, respiratory, muscular, nervous and cardiovascular systems through different technics and physical practices.

[@kingabarbara1168]

Mice are nocturnal which means they sleep during the day and they are active during the night!

[@SimpleBiologist]

Yeah, I totally didn't think about it until later! I just like drawing mice, so I drew one.

[@zariffathurrahman6454]

how does this rhythm work at the other place that has more than 24 hours per day? like another planet?

[@SimpleBiologist]

Unfortunately we don't know of any creatures that live on other planets. It would be a super exciting question to look into when we do!

[@highvibee]

"Every animal follow the circadian clock" really, what about bats?

[@abundantwaves2164]

You have 666 subscribers

[@SimpleBiologist]

If only this had happened on Halloween! Get all the spookiness together in one day. 👻

[@Adamkww]

I Don’t get it lol, dunce

[@igorkhomenko9680]

Why do you need that annoying background music? It's just impossible to listen.

[@Lucidly222]

I love this video BUT I do have to agree with you. If any music soft classical would be a much better fit in my opinion💡

[@jugnu361]

This is common sense observation 😀

[@gmrfreakrip732]

God is great

[@humbertoherrera7406]

#FWallsBerlin.

[@shineisland7447]

I can tell you why. Shot in the dark?

[@rozitamb594]

We, muslims already know & been practising this from the Qur’an & prophet Muhammad pbuh, 1400 yrs ago..its really nothing new.

[@therealgroger4675]

#515 🖒 #15 🖓

[@fitandvirile]

Wow. Amazing explanations. But more importantly you looked soooo cute.

[@ManuFerrara]

Thanks a lot for the drawings which really help to understand. But... are you yankee youtubers all acting so unnaturally like Hank ? Is there a global tendancy of no-personality socially-suggested behavior ?

[@eddierussellofficial8276]

There’s a song about the circadian rhythm on the davey Davis KZbin channel