21.9 Robinson Annulation | Organic Chemistry

[@davidmansour1414]

God bless you! You have no idea how much this video helped me! Thank you Chad so much!!!!

[@ChadsPrep]

Glad it did, David - thank you!

[@peybak]

Thanks for the repost Chad. You're a real pro!

[@ChadsPrep]

You're welcome Peyman and thanks in return! I definitely don't want any errors out there confusing students. Super appreciate you catching my error!

[@abhishekkumarntsescholar5550]

Thanks u sir , this really help in my iit preparation

[@ChadsPrep]

You're welcome - Happy Studying!

[@PunmasterSTP]

Hey, how did iit end up going?

[@123xjd3n]

Hi Chad, Im wondering what your elementary biochemistry is. Btw thank you for your awesome videos

[@ChadsPrep]

Hello Quynh! You can check it out here: www.chadsprep.com/chads-elementary-biochemistry-videos/ There's a nice drop-down menu outlining the entire course. It was designed to follow a 1-semester survey course on biochemistry. Hope this helps!

[@user-qs8he1ml3k]

Excellent video. Just a quick question. We have to add heat here in step 3 because removing OH as a leaving group is so unfavorable right? Also, would we consider the red boxed in product thermodynamic and the other 2 kinetic?

[@ChadsPrep]

So step 3 is an intramolecular aldol condensation. We need the heat to favor the aldol condensation mechanism to form the alkene product - this is an elimination mechanism (which is favored by heat) where we lose H2O (hence the name condensation) from the OH and H (alpha carbon) which I discuss at 5:00 onwards. If we don't apply heat we would get the aldol product (with the OH group still attached).

[@strugglingcollegestudent]

Hi Chad, my organic chemistry class teaches one more chapter (carbohydrates and reactions of carbohydrates, etc) can you add to your playlist?

[@ChadsPrep]

Alright Sophia! I'll have the first one ready in the morning. 😊

[@PunmasterSTP]

How's your class been going?

[@PunmasterSTP]

Robinson Annulation? More like "Really great information!" 👍

[@ChadsPrep]

And another!

[@stephenmarvin2692]

If the product ends up creating another conjugated ketone, can you expect the reaction Robinson Annulation to occur again?

[@ChadsPrep]

Which example are you looking at?

[@stephenmarvin2692]

@@ChadsPrep It's less so from this video but more so hypothetical. Because at 8:12 I noticed that a conjugated ketone could have been formed so I was just wondering. Thank you!

[@ChadsPrep]

We have to consider both steric hindrance and the presence of donating groups (alkyl groups) in this case which reduce the electrophillic nature of the beta carbon

[@maxcrownover5989]

🙌

[@ChadsPrep]

Thanks - Happy Studying!