#30: Stress, Post SSRI Sexual Dysfunction | Robert Sapolsky Father-Offspring Interviews

[@ajs1998]

"What doesn't kill you makes you stronger is a luxury of the lucky" I love it

[@littlebitofhope1489]

If he ever sells merch, that needs to be on a Tee Shirt.

[@Oneiric_Benevolence]

​@@littlebitofhope1489He doesn't make these videos for profit, let's keep it that way.

[@user-vi6ro8bd4l]

He has so many gems like that over the years. Wouldn't hurt if someone came up with a Sapolsky Says t-shirt line...

[@littlebitofhope1489]

@@Oneiric_Benevolence Ok, so he could do like the Greens do and make 100% of the profit go to charity. Problem solved.

[@littlebitofhope1489]

@@Oneiric_Benevolence Then he could donate the profits. Some donate 100%. I tried to say who, but it was deleted, so we will leave it at that.

[@livthedream5885]

This one may be my favorite so far. Love you guys so much. This is such a great channel idea, it humanizes one of the greatest scientists of our time, and makes complex topics accessible and fun.

[@sc.1282]

PSSD has caused me an unbelievable amount of suffering for the past 3 years

[@simonwright6163]

Same, it's an absolute living nightmare.

[@user-vf8ti4dq3d]

Year 16 for me Hell is real yea

[@A.GAMBINO-i1j]

Same

[@Immolate666]

Dr. Saposlky has been my hero for over a decade! Absolutely amazing to see this content and great to introduce his family too!

[@susangravdahlparsons2684]

me too

[@maurice8180]

Wow! Can't believe you are talking about PSSD! I remember a couple of months ago when I was watching one of your lectures on KZbin about human behaviour. I was wondering what you would have to say about PSSD - and now I am listening to you talking about it. Thank you so much!

[@lpodverde]

I got a boost of whatever neurotransmitter makes you happy/excited, lol, when i heard my question. Thank you for answering!

[@Alex-js5lg]

I think that would largely be dopamine since it deals with anticipation and reward. I'd imagine there'd also be a bit of oxytocin involved with seeing a familiar face, a bit of norepinephrine (for the physiological excitement), and some serotonin - because serotonin is apparently involved with everything.

[@Kalks95]

Lucky you man, SSRIs completely wiped out my ability to feel any emotion whatsoever. Even though I've been off of the medication for 3 years. Cherish everything you feel.

[@lpodverde]

@@Kalks95 I'm sorry, dude. In my case i didn't have access to help of any kind when i needed it and my predispositions spiraled into a disorder. I ended up having to withdraw from any stressors and give up things completely just to cope. I eventually bounced back but it cost me a huge chunk of my life i will never get back. I sometimes wondered how my life would have played out if i had the help of medication, but it saddens me when i hear of the harm it causes people it was suppose to help.

[@Kalks95]

@@lpodverde I think you did the right thing. Maybe medication may have helped but if you had gotten PSSD then you would've landed yourself in permanent damage that people going 30 years still haven't recovered from and it would've cost you a lot more. I'm glad you are doing better man. I have tried anything but the emotional blunting and anhedonia Citalopram left on me doesn't budge. Sunny days feel no better than sitting in a graveyard when it's raining, movies are like watching paint dry and songs sound like scratches. Don't look back, just live it up.

[@hfud11]

Pssd ruined my life and many others

[@Emily-pi8xe]

I’m so happy to be getting consistent Dr Sapolsky content! I’ve been a big follower for years, and I love hearing his wealth of knowledge on in depth topics. I’m currently reading through Behave and plan to read his newest book next. Thank you both for doing these videos!

[@Turkeytoes8]

When I'm at work and there is bullying occurring, nursing is renowned for it..I start to visualise the hierarchy as a troop of baboons sitting in a tree pushing each other off the branches..😂..

[@christopherp.8868]

Thank you for talking about PSSD! I hope you talk more about this!

[@SapientCephalopod]

The phrase I didn't know I was waiting for my whole life. "Cliteral Engorgement" I love your dry humor Dr. Sapolski.

[@dianedevery2662]

Clitoral

[@toilletrebihterrabal9166]

Ain't no joke, just our lack of comfort with biological questions related to female anatomy in general. (I didn't find it funny, just a fact of life!). Did you know that the clitoris is litteraly the point of the iceberg in terms of "engorgement"? Look it up, women have cavernous tissues as big if not bigger than men, the clitoris being the tip, but in reality even the vagina gets "erect". It goes all around the vaginal opening and deeper inside, like a circling, pulsating, canal of love making XD.

[@Subfightr]

I honestly think that if Robert wanted to, he could be HILARIOUS! Imagine him in stand-up! What unique delivery. You would be absolutely engaged, learning stuff but with a comedic twist tossed in. He's clever enough he could absolutely do it.

[@whiteharee]

Dr. Sapolsky, I wanted to say that you inspired me to start my path to becoming a psychologist (getting my masters now, applying to clinical programs in a couple months) because of how engaging you make science and the study of the mind. Love this podcast!

[@gking407]

When I see a new Father-Offspring episode I am compelled to click quickly, no free will to make that choice! 😂

[@neonchamber]

Such a brilliant man… i get something out of every time he opens his mouth. Thank you Dr Sapolsky

[@cherylmillard2067]

As a long-term chronic pain person this talk has verified that opiates will cause an epigenetic change.

[@ShahadSalim-vb7rh]

بروفيسور سابولسكي لن تكرره الطبيعة الام مرتين شكرا لك حقا تغيرت وجه نضري حول نفسي وللعالم شكرا من القلب ❤

[@tracy9610]

Wow! I just learned so much about myself- from both topics! Thanks Team Sapolsky Congratulations on 30 episodes 🎉

[@Ooohhhppp]

Gracias por hablar del #PSSD. Es tan doloroso tener esto... Necesitamos gente como Tú.

[@Sánchez_ls]

Eres dé México?

[@Sánchez_ls]

Dé dónde eres?

[@Ooohhhppp]

@@Sánchez_ls España

[@lmy55931]

I have Pssd

[@BradC44]

Wednesdays my dopamine rises when I get to watch a new video from Doc. Thanks to you both for posting. 🧠

[@Kalks95]

Hi Robert, thank you for covering PSSD. Your explanation and way of breaking down neuroscience to the average reader is amazing. I just wanted to bring up a few points though. As someone who suffers PSSD, not all of us were given antidepressants or SSRIs for depression. Many of us in the PSSD community were given SSRIs for things like sleep, pain and even IBS. There's a few times you say that it's a trade off, though it isn't. We have people in our community who've been suicidal and sectioned who arguably say that even then, it doesn't compare to PSSD. The difference is, when you have depression you have multiple avenues for help. When you have PSSD, you have 0. There is no effective treatment or cure, you live with emotional blunting, anhedonia, no orgasm, genitalia that is completely dead, you cannot get drunk or high, you lose everything. The other issue is there's no informed consent that many of us would lose our emotions and sexual functioning forever. If I were told that, I wouldn't have touched the drugs, but even in 2024 with all the evidence and updates, doctors are still saying that SSRIs do not cause sexual dysfunction. There have been 12 suicides in the PSSD community in 18 months alone due to how bad the condition is and it's only going to get worse. Research is needed and so is a way to alleviate this symptoms because as it stand, death is the only way out.

[@briseboy]

Recommendation concerning getting drunk or "high": Don't. No long term upside, only SIGNIFICANT downside to self-medication. Alcohol appears to rather quickly, 3 years or skmetimes less, permanent excessive modulation/damping of whole-brain connectivity, even though the induced GABAergy is exogenous. Sensitization - GABAergic response when environmental/cognitive stressors occur, appear to induce avoidance of effective, prosocial response. " high", vague term that could mean the artificial enhancement of dopamine through cocaine or amphetamkne relatives. A dissociation from reality, and effective whole-brain response and some long-term reduction in endogenous production ability for this group, occurs. The supposed "high" of cannabinoids is associated with significantly elevated onset incidence of acute schizophrenic disociation from sensory reality.. While all is far mord complex than can be approached in comment, these substances are noxious to toxic. Do not expect your most responsive cells, neurons, which contingently express far more of your entire genome than do any other cells, to benefit from the disorientation, dissociation, and stimulation resulting from the dissociation from the whole-brain organismic, that is, including the cyclic whole body processes, wherein pleasure and the happiness valence state report and seek interaction with the perceived real world, including interoceptive world. Pleasure and happiness are different dimensions, the first more involved with that optimal exercise that induces strong catabolic and anabolic dominance, sleep-wake cycles being a general examp!e. One aspect of happiness is effective social interaction in humans; another can be recognized in confidence, skill acquisition. As yo see easily drugs of any kind are completely dissociating from any developmental cognitive or physical effort. It is the effort/consolidation cycle which produces reward, anticipation, keeping strss cycling from overextension into the traumatic.

[@0Linerider0forever0]

You mentioned that this side effect seems paradoxical to what SSRIs are supposed to do, I found an insane, similar thing. When I started taking sertraline (an SSRI) I was suffering with suicidal thoughts and ideation. Guess what the most common side effect of this drug is in the leaflet in the packet. Suicidal thoughts and ideation. For an antidepressant?! One that these doctors I had seen were recommending? I didn't get on with it at all for this reason. One other thing I appreciate you mentioning anhedonia after taking SSRIs, I have it over 10 years later, I feel permanently changed and not necessarily in a good way. Great topic thanks for the content.

[@macco66]

I was put on SSRI'S at 20 for panic attacks. All of a sudden, having never had depression before in my life, I wanted to kill myself. I ended up having to be hospitalised after having severe depression, a nervous breakdown and suicidal ideation. Some anti-depressants they were 👍

[@jimwilliams3816]

That’s the thing: the list of “serious side effects” for most psychoactive meds includes virtually issue they are used to treat. It speaks to how varied individual cognitive physiology is. In my case, they tended to block SI, which I have been told by a couple different practitioners is the biggest reason that they are prescribed. But there are a lot of people who did not have SI who develop it from taking them. I am grateful that psychoactive meds are available, but I’ve learned that they are far from perfect, and are not to be taken lightly, literally or figuratively.

[@0Linerider0forever0]

@@jimwilliams3816 no no but SI was like the number one most common, on its own at the top of the probability tree of symptoms

[@safapresley]

I don't have any issues . ALso vaxxed twice with Pfizer

[@hfud11]

@@safapresley Google Pssd, Antimicrobial Resistance, Tardive Dysphoria etc

[@Flow_with_G]

I love your work - your books, lectures, interviews, podcasts, everything. Your teachings must be introduced in schools and various organizations! Thank you for all that you are doing!

[@a.bodhichenevey1601]

Outstanding lecture. Dr. Sapolsky always knows how to present just the right amount of stimulation to make for a positive learning experience for this old guy! Thank you so much!

[@Redjamm90]

Really glad to see pssd is being talked about, I hope we find a cure

[@HumanFactorsLLC]

Best of breed content in every way including humor! Thank you for being the kind of people that do this! ❤

[@cindyscott8470]

Love this whole video series. Thank you Father/ Offspring for affording us amazing insights that are not easily attained. I am grateful ❤

[@debpoarch3881]

I could listen to him all day, every day.

[@unclefreddy2009]

I really love that you are doing this. I would love to hear more about the offspring and what they are up to now in life. I love the level of intelligence and fun you both have

[@tracy9610]

Yeah, that'd be cool. I suspect she's in school because she was home during the summer.

[@seckinsosyal]

That stress lecture filled a substantial gap in my mind!

[@inderbirsingh9711]

Thankyou for talking about PSSD. Unfortunately in some cases it can be much more severe and involve chronic fatigue, hypersomnia and cognitive issues lasting for years if not decades. Patients are still gaslighted by psychiatrists and neurologists. It is so wrong

[@tyrion9680]

Dear Dr and daughter. I've been rambling about your views on determinism vs predeterminism. Let me a questions: (1) The Schrödinger equation is a completely deterministic linear equation. When a measurement of a magnitude is made, the previous state of the system, that is, the function Ψ(x,y,z,t) does not determine the result of said measurement, but only allows the probability distribution of the measurement to be calculated but not the specific result. That is where the randomness is, in what happens to the system when we try to make a measurement on it, then it gives us a response that is usually random and different each time we do the experiment. (2)You seem to admit the possibility of a unique closed causal path purely phenomenological (according to the Bohm-type interpretation of quantum theory where complete causality is due to non-local hidden variables). But why do you advocate an open causal line with branches/bifurcations for the evolution of a system in future instead of a single path? (3)Does your conceptual denial of predeterminism imply that dynamics of system from causal first principles mixed with noise-induced effects (i.e. quantum randomness) can, obviously in complete absence of free will, alter the evolutionary fate in which total storyline vary stochastically over time. Or maybe something simply more like many-worlds interpretation (MWI)? (4) It seems that your hypothesis adapts a kind of nomological determinism for past space/time, i.e. is the notion that then the preceding dictated the future entirely and necessarily by rigid natural laws and that every occurrence inevitably turned out from prior events. (5) But why the same cannot be said about future space-time?, where (according to your hypothesis) would imply there would be several undefined timelines, where something like a Jonbar point would be reached and would allow for different new branching paths. (6) A system is deterministic if its future state is necessitated by its past state and the laws that govern its change over time. So you could have many deterministic classical universes with different future states so long as either their past states or the laws that govern them are different. So either we change laws, or initial states, or we introduce noise. There is no other way out. (7) You mention chaos or the three-body problem, perhaps as a source of stochasticity. But really, one thing is the human computational inability to subject a complex system to absolutely all the variables that define the variations (it makes it impossible to know exactly what future events will be), and another thing is to admit that chaos, per se, constitutes a source of stochasticity/randomness. (8) Such a position of (soft) determinism would be presentism or the growing block universe theory ( the past and present both exist, and the future as yet does not), in which at least the future is not the same as any other time. Thank you

[@marinecurie9520]

From what I can understand from his point of view (from the videos he talks about quantum physics), he believes that all events, including quantum ones, are governed by hidden variables or deterministic laws that we do not yet fully understand, and that the future is as fixed and determined as the past, even if we lack the ability to predict it with current knowledge.

[@tyrion9680]

@@marinecurie9520 I mean, the Professor claims that, let's take man X who is robbing a bank right now. We can go back in time by traveling along a deterministic causal line, all the way to the moment of his birth, back to when he was an embryo in the fallopian tube. At that time it was already determined that he would rob a bank. "This implies determinism." However, he says, right now let's take woman Y, rewind the time tape 13.7 billion years, seconds after the Big Bang. Press start again, and the particles will rearrange themselves differently. It is highly unlikely that we will play the tape forward and look at planet Earth and woman Y even exist: But "This implies indeterminism." He also argues, people should not surrender to fatalism and think that there is nothing to be done and everything is already decided, since the future is not written in stone: But "This implies indeterminism," where there is no unique causal path, but rather a branching tree of paths to the future. So God would be playing dice. I clarify my objections to that reasoning in more detail on my above post.

[@technicolorgiallo1111]

Thank you for continuing to make these. I've watched every episode so far.

[@Backyard.Archery]

My goodness… this is priceless content… thank you!

[@Maryan90]

For some anxiety i lost my iq memory vision sexual fuction and general health cause me xtreme brain damage not only pssd. I didnt even want to take this shit..was for presentation anxiety

[@Masterdesstruct]

You are not the only one...

[@Adrem37733]

Same here

[@zahariachirica5466]

What a Fantastic sense of humour that makes science so much more interesting😅

[@thomasmaddox5638]

SIMPLY brilliant. Many thanks indeed. Since discovering Prof Sapolsky and his lectures, books, etc., my life has taken a massive turn to an interest in everything genetic, epigenetic, etc. Wonderful. biological,

[@MatAzzopardi]

It would be really cool to hear Sapolsky’s take on self-sabotaging behaviours

[@Lesh_Georgiy]

Great podcast! I would also love to hear Dr. Sapolsky talk about schizophrenia

[@MilesCushion]

⚡⚡ EXCELLENT CONTENT ⚡⚡

[@BigMind98]

How do you manage to make each subsequent video more interesting, useful, and exciting? I am very grateful to the universe for your existence🙏🏻

[@KeithCooper-Albuquerque]

Great episode once again! I look forward to these videos so much!

[@christinley5213]

Thank you!! The amount of info you have put into my head is staggering lol!!:)

[@tyrion9680]

Dear Dr. Sapolsky and and daughter, let me a question. (1)Bateman principles explain sex roles and sexual dimorphism through sex-specific variance in mating success, reproductive success and their relationships within sexes (Bateman gradients). (2)Ecologically valid data sets prove that mate choices are more variable in males than in females, resulting in a steeper male Bateman gradient, consistent with Darwin-Bateman principles. Females have an optimum mating rate that is lower than the males, with high-rate fitness optima, and correspondingly high male optimal mating rate. (3) Human mate choice research (i.e. online dating big data) has found that most men find most women at least somewhat sexually attractive, whereas most women do not find most men sexually attractive at all. Mate skewed female choices tend towards bottlenecking abruptly effective population male size. Empirical tests of these principles come clearly under appropriate scrutiny (e.g. On Tinder, Men swipe right ("like") on 60% of females. Women like on only 4% of males). (4) Therefore we know women are much more selective than men. Less tolerant to opposite sex stimuli close to the population mean. There is a low average responsiveness to male stimuli, and a much higher differential respecting the value assigned to physical stimuli above the acceptance mate threshold (superstimulus trend) regarding to those unattractive ones. (An example power-law graph). (Question) Which are the neural mechanisms that are likely to be involved in such a wide human sex differences for epigamic traits (faces/bodies, size/height) processing and assigning subjective value to mates? Thanks.

[@enigmatic.grace4]

PSSD ruined my life. After taking Sertraline(Serta 50).

[@Adriell.h.b.]

This us amazing! Thank you so much sharing the knowledge.

[@northernclicker]

These are so great! love love love

[@chrisleon27]

Absolutely fantastic video

[@Subfightr]

Ssris "okaaaayy sooo, you don't orgasm but you're no longer crying alone in the bathroom stall" gotta love this man.

[@olajankowska1408]

i love this presentation on paper

[@leesgim]

Wow resilience is lucky plus luxury ❤

[@HolaT7h5]

I have Pssd 😔

[@NihilisticRealism]

as someone suffering through perpetual chronic stress, this is horrifying

[@Turkeytoes8]

Hello from Nz. Great, well explained .❤

[@user-pb3cf5ws8f]

Also from NZ do you have pssd as well?

[@kengilliland727]

Thanks for sharing !

[@kellyberry4173]

Thank you!!

[@theAmygdalaiLama]

awesome. Thank you.

[@andrewbaker8373]

Superb

[@margotholmes7857]

Thank you for this !!!

[@alXandrell77]

Vraiment cool, vous etes l'équivalent d'un p'tit espresso dans ma journée 🙂

[@hammersaw3135]

I love listening to these when my brain is in a certain place, it is very thought provoking. I know my brain is full of BDNF when I am constantly googling stuff to learn the science of the details as I listen to him riff. lol

[@Subfightr]

Regarding my statement if he could honestly do stand up if he put any effort. "Both penial and clitoral erections require vascular engorgement. Ever since I was a young child I've wanted to say that sentence". Just off the cuff without slipping a beat, delivered flat. Brilliant.

[@bradsillasen1972]

Wow, that was a plate full. Thanks :)

[@itachi_uchiha8783]

شكرا دكتور سابولكسي عظيم

[@user-vi6ro8bd4l]

I now hear Captain Picard's Shakespearean voice giving the command: Engorge! (showing my age but at this point, could be a worth a try...whatever works!)

[@Iza66]

Great topic you were talking about, thanks so much. I just wanted to know about the relation, if there are any, between too much stress and anhedonia. You mentioned anhedonia but finally without the explanation. Is there anything where I can find answers for this issue?

[@hfud11]

Anhedonia, emotional numbness, and inability to feel alchol and drugs, are common side effects of antidepressants.

[@jimwilliams3816]

I got my anhedonia diagnosis at the same time as my MDD. My own experience suggests not so much emotional numbness (which I’ve certainly experienced too) but more a dysphoric quality, which is probably why it so frequently accompanies depression. The diagnosis came at age 60, after a serious stress spiral, but I’d been prone to hypothymia (low mood) since about age 7, and I was seriously predisposed. My thoughts on anhedonia have evolved like this: I find it to be significantly influenced by lack of motivation. Pervasive sadness in depression can undermine the ability to feel pleasure, but the biggest factor in both depression and anhedonia, for me, is not so much doing something and no longer feeling pleasure in it, as just not doing anything at all. I emerged from depression much faster than from anhedonia, and what seems to be happening is that the desire to do something comes back first, and enjoyment in doing it only starts to creep back after actually doing things stimulates the rewards system enough to reestablish those neural responses. That’s my own theory from self analysis, and I do have ADHD and I think some alexithymia, so I can’t say how typical I am. What I experience as anhedonia is very different from emotional numbness. From the standpoint of environmental influences, I feel that a big driver of both my MDD and anhedonia were circumstances that caused me to develop learned helplessness. Sapolsky describes an unpleasant experiment where they induced learned helplessness in animals, in his Zebra book, and I found it very instructive and resonant.

[@Iza66]

@@jimwilliams3816 Thank you for sharing your experience. I am currently in this self diagnosing phase as talking to professionals here where I live does not help at all.

[@ScottMarc-RT1]

Very informative and accessible discussion. Question for future podcast: Can you explain the function of the vagus nerve. Does the vagus nerve play a role in stress ? Do other mammals have a vagus nerve ? Why is the vagus nerve partially mylenated ? Thanks !

[@jimwilliams3816]

Based on my own experience, I have hypothesized that the dynamic with SSRIs is indeed the sympathetic/parasympathetic dance. It was from Sapolsky that I learned that erections are stimulated by parasympathetic activity, and orgasm involves a switch to sympathetic response. Both the SSRIs I have taken - first for MDD and anhedonia, later for anxiety (which was there all along ) - seemed to me to downregulate my fight or flight. The first, the one with enteric properties, lifted a black fog remarkably quickly, and it felt like it was effectively blocking signaling from my amygdala. The second is less heavy handed but feels like it is reducing adrenal response, which is somewhat desirable for me as I am prone to high glucocorticoids. If some SSRIs are noradrenaline antagonists, this would make sense, and would also help explain the brain fog which is another common side effect. If they are noradrenaline reuptake inhibitors, it makes less intuitive sense. Dopamine and noradrenaline inhibition seems like a plausible theory for sexual dysfunction, insofar as there is one antidepressant on the market which focuses on inhibiting reuptake of those neurotransmitters, and a percentage of people taking that report excessive...well, horniness. Curiously, that one produces emotional deadening and the inability to cry in a percentage of patients. That was my experience. The notion that SSRIs can impact vasopressin negatively is a not so delightful idea for me, considering that emotional connection has quests been an issue for me. I recall Sapolsky saying that vasopressin is the male version of oxytocin, and if I interpret the implication correctly, I probably can’t afford to have any less than I’ve got. I would welcome Sapolsky talking about the physiology of emotional connection issues, because this is an area where people tend to presume the causes are all experiential, and I think that’s overstating the case.

[@DFish111]

Fascinating, as always, although acronyms and abbreviations aren't the same thing! 😎 On a less pedantic note, have you come across a possible connection between non-hormonal acne and hyper-awareness? Many thanks for the videos and info!!

[@jimwilliams3816]

I love being pedantic. Yes, SSRI and PSSD are technically initialisations, because you have to pronounce the letters. NATO would be an acronym, because it can be pronounced as a word.

[@DFish111]

@@jimwilliams3816 A chance for some pedantic gold: I think you mean 'initialisms.' 😉 (In all honesty, I had to look that up. I didn't know there was a third option in the words-to-letters world, so thanks for the info!)

[@Seongbin-0]

We should change the name PSSD. worst name ever. i experience no emotions, no thrill, no interest, no appetite, can't focus and study or work, nothing. Why would i even care about some numb genetles when these symptoms are dominating the condition? Why is it all generalized to be called just sexual dysfunctions? And it is not only just SSRIs that did this to people, I've also heard SNRIs/Anti psychotics harming plenty as well, the symptoms are almost identical. how are these medications not being put in the same category?i'm pretty sure most of us who's lifes are ruined in this subreddit, are not because they don't feel their genetles, but the brain damage done to us from the drugs. It's cruel to conclude our conditions with just numb genetles, how do you even explain all your symptioms to your family ot doctors when the name of the disorder is SSRI Sexual dysfuntion?I think PSSD is a very misleading name. it should be changed, like how ADD in the 90s then had another name to ADHD. It should be named something like PSBD(Post SSRI/SNRI Brain Disorder/dysfunction). Remember these type of dysfuntions isn't exclusive to SSRI/Snris neither. people that were put on mood stabilizer and anti psychotics experience almost the same effects as us. If we don't even have a proper name for the condition, of course they will say all of the extra conditons are all in our head, all made up. that's what my friends told me. before when can i have the right name for this condition, i think it will never be reconized and push forward with research.

[@JimTheCurator]

A potential suggestion for the name: PSMD. Post- Serotonergic Medication Disorder. Thoughts?

[@Seongbin-0]

@@JimTheCurator It is well beyond just serotonergic pathways, it should be something like PMBD Post psychiatric medication brain dysfunctions.

[@davorinrusevljan6440]

So in some cases, what does not kill you, at least cripples you.

[@aboutdawntoday]

It makes sense that where you start determines whether benefits occur or not. I could listen all day thankfully you know where to end... by the way is this a social experiment? 😄.

[@livthedream5885]

Can the post synaptic neuron down regulate its serotonin receptors over time?

[@dande3139]

"Erections in the animal kingdom come in two flavors"... That's how you know it's a top-tier podcast.

[@mrquasar2922]

My partner of 10 years is 3 month into this...i cant put in to words how much its broken her and our relationship has basically broken to...

[@FlaviusAurelianGrozoni]

Please recommend a book or a course where we can learn more in details about how neurons and synapses function and improve our knowledge about the brain, neurotransmitters, hormones, neuroscience in a more specific way. More structured. My neurones responsabile for appreciation for others are indulged by your presence here. :)

[@jimwilliams3816]

I highly recommend Sapolsky’s Human Behavioral Biology course, filmed in 2011 and available in its entirety (minus one lecture) on the Stanford KZbin channel. It’s maybe 40 hours total. If you don’t want to do the whole thing, the Limbic System lecture is probably the most useful in that area. A couple basic neuroscience lectures were done by TAs, and while not nearly as good as Sapolsky, they are still worth watching.

[@FlaviusAurelianGrozoni]

I did watch that course many times. :) I need more.

[@jimwilliams3816]

If you find more, let me know! :)

[@FlaviusAurelianGrozoni]

I watch some neuroscience courses about the brain but still there are things I don’t understand. They are not very clear.

[@PaigeWayland-r1d]

Dr. Sapolsky, can you address Idiopathic Hypersomnia in a future interview? I have this diagnosis, but it is so frustrating to explain or find effective treatments

[@ErikFindlingMusic]

PSSD got me good. I could care less about the sexual issues, I lost my eyesight about 30%, slight hearing, tremors, my cognitive and memory, my skin is totally dry and my skin and teeth have rotted due to the lack of oil production. Hair has thinned, chronic nausea and total fatigue. This condition is from hell

[@abrakadabraangelov1829]

Which ssri did you take and for how long

[@jesaispas1304]

Has there been any movement on social networks like #PSSD_ME_TOO ? If not, is it possible to do it ? Do you think it's a good idea ?

[@Anson120]

SSris and snris etc never helped my severe Anhedonia and loss of interest. They only helped blunt my negative emotions and extreme (for no purpose at all) negative thoughts. Anhedonia/loss of interest is the worst symptom of clinical depression for me. I call it "A.L.S of the brain". It will make you make that "permanent decision" cough cough. I take Effexor and a "thing" that is a member of the rubiaceae family. Those are the only things that help just a tiny bit. T.R.D is a horrific thing. Also , never hit your head multiple times throughout your life. That is what gave me T.r.d.

[@kristine6996]

Part of the problem or part of the goal.

[@dfinma]

9:17 We HAVE to see offspring's reaction to this!

[@alex_bakkalinskiy]

I do like a good stress. I ride over 500 hours per year, around 6% of lifetime spinning pedals (not counting stops, ride preparation, afterparty, sevice, bike sociality 😄). But most of those 500+ h are in light or moderate effort (120-140 bpm). So I feel quite stimulated (I have less colds, improved brain circulation, BMNF and things). Competitive amateurs who train like 20 h a weak, lots of highly intensive intervals and stuff, they get much more stress. They report light immunosuppression (like always catching colds) at time they reach their top competitive shape 😎

[@shakeyj4523]

All the (Garment who shall not be named) comments are gone!! Bummer.

[@littlebitofhope1489]

It's BACK!!!!!!

[@curiousreporter4292]

Good morning sir Sapolsky Shahid from India

[@thingamabitch]

Can you make a more detailed stand-alone video about PSSD? I have it and I have several ideas on how to help myself and others recover from it. I have been getting better over time, but I miss how I used to be. Maybe a scientist could explain the theories better than random Redditors who don't know what they're talking about. I have emotional blunting, low libido, weak arousal and low erogenous sensation. Last year I had all the symptoms and I felt like a hole in reality or something. That part is done, but I still don't feel like myself yet.

[@Adrem37733]

It's hell

[@brianhayford8320]

In my experience, SSRIs, and even worse SNRIs, are just not worth the side effects and the horrible withdrawals doctors don't believe happen.

[@MTVBrat]

Speaking of 9th grade... Biodome is a great movie 🍿🤪

[@r2c3]

😊😊 7:09

[@AyJay53810]

❤

[@AnneNicholson-yy5ro]

no free will and no free lunch!

[@margotholmes7857]

💯

[@chumangatang]

I'm on a SNRi and can get erections but have a hard time ejaculating. So what's the physiology behind that? Full disclosure: I'm 68 years old, my SNRI is working, and I know I should be grateful for the amount of function I have left.

[@jonahblock]

Haven’t ssris been proven not work?

[@RobBominaar]

No, they have not. For some people they work, for others they don't work.

[@hfud11]

​@@RobBominaar they are just little better than placebo.

[@jimwilliams3816]

Rob’s answer is correct. Depression treatment is still very primitive, and these are deeply imperfect drugs that do harm as well as good - but they are, in fact, helpful to a significant number of people. Unfortunately, cognitive physiology is highly variable, and the ability to make critical diagnostic distinctions is still more art than science.

[@safapresley]

They work very well

[@hfud11]

@@safapresley no, they are just little better than placebo

[@XYZ56771]

This observation kzbin.info/www/bejne/rnvcpampe7KAh8U relates a lot with kzbin.info/www/bejne/bWOkqoF7pNKths0 . Thank you Dr. Sapolsky!!!

[@NancyLebovitz]

As I understand it, nitric acid helps regulate blood pressure, so if antidepressants lower nitric acid, do they have a risk of raising blood pressure?

[@cookcookkkkk]

yes especially snris

[@SubJStan]

I’m certainly projecting here but it has to feel wired to hear your dad talk in detail about ejaculating and such

[@stevenlaube7535]

A species of bird that dose not fly has lymph fluid erection