A Novel Anti-Aging Molecule Geranylgeraniol | All You Need To Know

Here we look at geranylgeraniol an endogenous molecule which the body uses to make CoQ10 and Vitamin K2. It is also required in some protein synthesis.
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Beneficial effect of dietary geranylgeraniol on glucose homeostasis and bone microstructure in obese mice is associated with suppression of proinflammation and modification of gut microbiome
www.ncbi.nlm.nih.gov/pmc/arti...
The Effects of Geranylgeraniol on Blood Safety and Sex Hormone Profiles in Healthy Adults: A Dose-Escalation, Randomized, Placebo-Controlled Trial
www.mdpi.com/1661-3821/3/4/43
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#GG #CoQ10 #vitamink2

[@ModernHealthspan]

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[@metaphysicalArtist]

some foods that may contain geranylgeraniol: Rice bran oil Olive oil Pumpkin seeds Pistachios Fish (particularly mackerel) Beef Chicken Pork Tofu Wheat germ Sesame seeds Sunflower seeds Hazelnuts Almonds Walnuts Pine nuts Cashews Avocado Spinach Broccoli

[@abdelilahbenahmed4350]

Thx Richard for the excellent presentation.

[@ModernHealthspan]

Hi AbdelIlah, thank you!

[@joshlocher71]

@@ModernHealthspan hi i emailed you but you never responded just that you were reviewing it but you never replied after that

[@darkhorseman8263]

Longevity community acting like gerangylation, farnesylation, myristoylation, and sumolation of proteins; the donors that achieve this, are some new and revolutionary finds. P.S excessive palmitoylation of proteins leads to obesity due to excessive mitochondrial fission and lack of fusion. Myristoylation of proteins counter balances excessive Palmitoylation pushing you back towards metabolic hormesis. This is why they trial Myristoylglycine for weight loss therapy. Geranylgeroaniol is just a protein modification donor balancing out an imbalance in protein modifications probably driven by the modern western diet.

[@konagraziosi5574]

Very detailed and good presentation, RIchard! GG seems so promising, especially for muscle building!

[@nootri]

Not just the tail of any vitamin k2, but the proper form of k2. Which makes things way cooler. Thanks for touching on CoQ10 and steroid hormones too, that all gives a nice overview. I wasn't aware of these simple things. One of the best videos here as far as I'm concerned. 👍

[@KenOtwell]

1) I've started taking GG to correct for statin use which, by itself, will decrease COQ10 synthesis. 2) I've also started K2-Mk4 since the most popular, Mk7, has NOT been shown to help scavenge calcium from our arteries like Mk4 has. (Mk7 has a longer half-life, which is the only benefit I've seen stated for it over Mk4.) I put this rationale together from your prior videos and a bit of googling. Thanks for all this analysis and info!

[@KenOtwell]

p.s., I didn't know GG was also needed for protein synthesis and testosterone! Maybe I should up my dosage... lol. (Currently 150mg/day)

[@msplateaugal]

Thanks for sharing

[@jackbuaer3828]

Is there any RCT that shows MK-4 is better than MK-7 at anything? I did not think that such a study exists. Furthermore, it's my understanding that your body converts K1 and MK-7 into MK-4.

[@msplateaugal]

@@jackbuaer3828 Is there any reason you know not to take MK-4 instead of MK-7?

[@jackbuaer3828]

@@msplateaugal Perhaps. Absorption. I am not an expert, but I can certainly cite a study: "However, little is known about the bioavailability of nutritional MK-4. To investigate MK-4 and MK-7 bioavailability, nutritional doses were administered to healthy Japanese women." "However, in a previous rat study from our group [18], the intake of a nutritional dose of MK-4 did not increase the MK-4 levels in extrahepatic tissues, whereas MK-7 significantly increased MK-4 in extrahepatic tissues. Thus, MK-7 is a better supplier for MK-4 in vivo than MK-4 itself. "In this study, we demonstrated that a nutritional dose of MK-7 is well absorbed in human, and significantly increases serum MK-7 levels, whereas MK-4 had no effect on serum MK-4 levels. Therefore, the nutritional values of vitamin K2 homologues should be differentiated with regard to bioavailability and efficacy." Sato T, Schurgers LJ, Uenishi K. Comparison of menaquinone-4 and menaquinone-7 bioavailability in healthy women. Nutr J. 2012 Nov 12

[@jefflittle8913]

I didn't consider this before, but based on your discussion of vitamin K, it also seems very likely that vitamin K is needed in older people who are trying to fix sarcopenia.

[@ModernHealthspan]

Hi Jeff thanks for your comment. Vitamin K does seem to be required for muscle synthesis and it is used in Japan (as MK-4) as an intervention for sarcopenia.

[@aclearlight]

Great presentation on a fascinating, promising new agent. Please update us when new science about and sources of GG come online! Thanks for great work.

[@peterz53]

Apparently, olives (and olive oil) and flaxseed contain GG as do some herbs. Don't know levels though or how this compares to supplements. My TT is high, but can't say that it is due to my significant intake of olives and flaxseed.

[@ivanardila]

Thank you so much. I live in México, so it´s relatively easy to get anato directly. It´s name is Achiote. I didn´t know that GG comes from this plant too. God bless you!!!

[@davidchung1697]

Interesting video and the studies. I was sort of hoping that Richard gave GG a try and indicated what improvements he saw in his exercise performance.

[@paulcohen6727]

There may be no need to get GG through supplements; annatto is a very common cooking herb or spice here in Asia, and most likely other places and it’s dirt cheap too. It also is rich in The kind of vitamin E that you mentioned. I make a Vegetable stew every week or so with 3 tablespoons of annatto in it, ground to powder first. It appears that the expensive supplements you recommend Are merely fractional extracts of whole annatto and are probably inferior to it because of the processing and removal of healthy cofactors.

[@marcjames3487]

Thanks, great tip - I just ordered some :)

[@eduardoramos8317]

...Good food..Good health..better adviser...

[@ronm6585]

Hi Richard. Thank you.

[@ModernHealthspan]

Hi Ron, thanks!

[@tonycastani1560]

Thanks Richard, I'm keen to try G.G after watching your video. However, I'm messaging to find out where can I buy Ishige okamurae supplement from?

[@lancelaw5966]

I think this is maybe very important. Can't wait to try it.. Then i will know !

[@HuyPhan-tv6qt]

What is your favorite top 3 anti aging supplements ? Thank you

[@maestroharmony343]

I chose Designs for Health Annatto-GG 300. Use it with Thorne Vitamin K and NutriZing K2.

[@ModernHealthspan]

Hi thanks for sharing. Hope that it works for you.

[@maestroharmony343]

I will see in a month when I take another blood test. I noticed since I started taking a small dose of a statin my fasting insulin keeps raising. I will see if gg helps to reverse it.

[@Ardentic-aa]

​@@maestroharmony343Statin use is what is making you insulin resistant

[@lsd22252]

I have followed Dr. Barrie Tan for several years and been using GG Pure. I've recently switched to Xtend-Quninol which includes CoQ10. Good info thx Richard.

[@maestroharmony343]

Unfortunately dr Tan is more of a thrifty businessman than a doctor. He found a way to use the leftovers from the production of tocotrienols from annatto, before he just disposed this stuff. Nevertheless, it may still be useful.

[@lsd22252]

@@maestroharmony343 what are you saying? He is a doctor who is also a businessman?

[@newdata]

seems like gg is in olive oil and nuts like walnut and almond and pistachio. may account for some of their heart health benefits

[@isa-manuelaalbrecht2951]

Would the use of essenial oils be ok..😉

[@scottmiller2591]

I'll have to think about this one.

[@ModernHealthspan]

Hi Scott, thanks for the comment. Not sure if Oreos work the same way as statins!

[@scottmiller2591]

Joking, my friend. Keep up the good work.@@ModernHealthspan

[@SilverFan21k]

based video.

[@KenOtwell]

Did you mean "biased?" If so, can you please explain your evidence here?

[@ModernHealthspan]

Hi thanks for your comment. Assuming that you did mean biased, a couple of comments. Obviously I think that GG is interesting and potentially helpful with aging otherwise I would not have made the video but I did not research potential downsides enough. Which is a good point and I will look at that next time.

[@jb_1971]

@@ModernHealthspanHello, Richard, no worries, "based" is a slang way of saying that something is factual ("based on facts") - so, the opposite of "biased" :P

[@GM4ThePeople]

ggz all o/

[@newyorkskier]

I will believe it when you have proof in at least 3 different animal models, but human data would be best.

[@chrismarks7606]

Richard, I think it extraordinary that you can talk on this subject without once mentioning the name of Dr Barrie Tan, without whose work you would never have even heard of GG. Quite shameful actually!

[@aaronsuever4362]

There is a suggested video for Barrie Tan right at the end of this video! Showing up on the left half of the screen right at the end. About Tocotrienols.

[@smithcs790]

barrie tan was interviewed on this channel 3 months ago, he isn't being ignored

[@ModernHealthspan]

Hi Chris, thanks for your comment. We have had Dr Tan on for an interview before and certainly I heard of GG from Dr Tan. I wanted the video to be about the chemical but yes the credit for the raising the awareness should go to Dr Tan. I should have mentioned him.

[@someonelse48]

annatto seed is cheap

[@domenicotrimboli7206]

will stop following your KZbin channel due to pharmaceutical company sponsors who pose a conflict of interest with what you publish. A serious program that talks about anti-aging does not accept to sponsor supplements.